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1. 发明申请

WO2005011535A3 PROSTHETIC VALVE FOR IMPLANTATION IN A BODY VESSEL 审中-公开
标题翻译：用于植入体内的浮选阀
公开(公告)号：WO2005011535A3
公开(公告)日：2006-03-16
申请号：PCT/US2004024969
申请日：2004-07-30
申请人： COOK INC , CASE BRIAN C , OSBORNE THOMAS A , FLAGLE JACOB A , PARKER FRED T
发明人： CASE BRIAN C , OSBORNE THOMAS A , FLAGLE JACOB A , PARKER FRED T
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的假体瓣膜。根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

2. 发明申请

WO2006041972A2 MEDICAL DEVICE WITH BIOACTIVE AGENT 审中-公开
标题翻译：具有生物活性剂的医疗器械
公开(公告)号：WO2006041972A2
公开(公告)日：2006-04-20
申请号：PCT/US2005035912
申请日：2005-10-06
申请人： COOK INC , OSBORNE THOMAS A , FLAGLE JACOB A , CASE BRIAN C , OBERMILLER JOSEPH F , PAUL RAM H
发明人： OSBORNE THOMAS A , FLAGLE JACOB A , CASE BRIAN C , OBERMILLER JOSEPH F , PAUL RAM H
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.
摘要翻译：提供具有一种或更多生物活性剂的医疗装置用于调节通过身体血管的流体流动。根据本发明的医疗装置可以包括包括生物活性剂的人造瓣膜。

3. 发明申请

WO2007147127A2 METHODS, SYSTEMS, AND DEVICES FOR THE DELIVERY OF ENDOLUMINAL PROSTHESES 审中-公开
标题翻译：方法，系统和用于输送内镜前列腺的装置
公开(公告)号：WO2007147127A2
公开(公告)日：2007-12-21
申请号：PCT/US2007071360
申请日：2007-06-15
申请人： COOK INC , PAUL RAM H , CASE BRIAN C , FLAGLE JACOB A
发明人： PAUL RAM H , CASE BRIAN C , FLAGLE JACOB A
CPC分类号： A61B17/12031 , A61B17/12022 , A61B17/12109 , A61B17/12181 , A61B17/1219 , A61B2017/00778 , A61B2017/00867 , A61B2017/00898 , A61B2017/1205 , A61B2017/22038
摘要： Described are devices, methods, and systems for achieving occlusion of vascular vessels. Further described are certain reduced or low profile procedures and devices for the percutaneous occlusion of the saphenous vein, such as in the treatment of a varicose vein condition caused by venous reflux.
摘要翻译：描述了用于实现血管血管闭塞的装置，方法和系统。进一步描述了用于经皮闭塞隐静脉的某些缩减或低调程序和装置，例如用于治疗由静脉回流引起的静脉曲张病症。

4. 发明申请

WO2004075789A2 PROTHESIS ADAPTED FOR PLACEMENT UNDER EXTERNAL IMAGING 审中-公开
标题翻译：适用于外部成像放置的标准
公开(公告)号：WO2004075789A2
公开(公告)日：2004-09-10
申请号：PCT/US2004005750
申请日：2004-02-26
申请人： COOK INC , CASE BRIAN C , FLAGLE JACOB A , GARRISON MICHAEL L , HOFFA ANDREW K , LEONARD RAY II
发明人： CASE BRIAN C , FLAGLE JACOB A , GARRISON MICHAEL L , HOFFA ANDREW K , LEONARD RAY II
IPC分类号： A61B19/00 , A61F2/00 , A61F2/06 , A61F2/24 , A61F2/02
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： A expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel. In another embodiment, the imageable structure is configured to permit an aperture located about a stent graft to be oriented with a anatomical feature of the vessel, such as a branch vessel opening. The invention includes a method for using imageable structure to confirm that the orientation of the prosthesis within a delivery apparatus is consistent the desired delivery approach to be used.
摘要翻译：一种具有可成像结构的可扩张假体，其包括可由外部（例如，射线照相或超声）成像系统在视觉上区分的一个或多个元件，所述结构围绕与假体的结构特征对应的第一轴定位，所述第一轴被配置为执行特定于该轴的特定功能。可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣结构的孔，使得孔可以在成像下具有特定的解剖特征，诸如将孔与容器的长轴对齐。在另一个实施例中，可成像结构被配置为允许围绕支架移植物定位的孔与容器的解剖特征（例如分支血管开口）定向。本发明包括一种使用可成像结构来确认假体在输送装置内的取向与所要使用的输送方法一致的方法。

5. 发明申请

WO2006062862A8 INFLATABLE OCCLUSION DEVICES, METHODS, AND SYSTEMS 审中-公开
标题翻译：可充气的装置，方法和系统
公开(公告)号：WO2006062862A8
公开(公告)日：2006-08-17
申请号：PCT/US2005043822
申请日：2005-12-06
申请人： COOK INC , FLAGLE JACOB A , PAUL RAM H , CASE BRIAN C
发明人： FLAGLE JACOB A , PAUL RAM H , CASE BRIAN C
IPC分类号： A61L29/00
CPC分类号： A61L29/005 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括经由经皮程序展开和填充可充气闭塞装置，从而封闭或消除血管容器的一部分。

6. 发明申请

WO2005099628A3 IMPLANTABLE FRAME WITH VARIABLE COMPLIANCE 审中-公开
标题翻译：可变框架与变量符合
公开(公告)号：WO2005099628A3
公开(公告)日：2005-12-08
申请号：PCT/US2005012421
申请日：2005-04-11
申请人： COOK INC , CASE BRIAN C , FLAGLE JACOB A , AGNEW CHARLES W
发明人： CASE BRIAN C , FLAGLE JACOB A , AGNEW CHARLES W
IPC分类号： A61F2/00 , A61F2/02 , A61F2/24 , A61F2/86 , A61F2/90 , A61F2/06
CPC分类号： A61F2/86 , A61F2/07 , A61F2/2418 , A61F2/2475 , A61F2/848 , A61F2/89 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. Embodiments of the invention relate to medical devices comprising a frame having a compliance that can change upon implantation of the medical device within the lumen of a body vessel. Controlled fracture of bioabsorption of frame material can, in some embodiments, increase the compliance of a frame after implantation. Medical devices comprising a frame and one or more valve members adapted to regulate fluid flow in a body vessel, such as a vein, are also provided.
摘要翻译：提供了用于植入身体血管中的医疗设备，以及使用和制造该设备的方法。本发明的实施例涉及医疗装置，其包括具有柔顺性的框架，所述柔顺性能够在将所述医疗装置植入身体血管的管腔内时改变。在一些实施例中，框架材料的生物吸收的控制断裂可以在植入后增加框架的柔顺性。还提供了包括框架和一个或多个阀构件的医疗装置，所述阀构件适于调节身体血管（例如静脉）中的流体流动。

7. 发明申请

WO2004082530B1 DELIVERY SYSTEMS FOR DEPLOYING EXPANDABLE INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：用于配置可扩展的内窥镜医疗器械的输送系统
公开(公告)号：WO2004082530B1
公开(公告)日：2005-01-06
申请号：PCT/US2004008507
申请日：2004-03-19
申请人： COOK INC , GARRISON MICHAEL L , CASE BRIAN C , HOFFA ANDREW K , FLAGLE JACOB A , PAVCNIK DUSAN
发明人： GARRISON MICHAEL L , CASE BRIAN C , HOFFA ANDREW K , FLAGLE JACOB A , PAVCNIK DUSAN
IPC分类号： A61F2/01 , A61F2/06 , A61F2/84
CPC分类号： A61F2/95 , A61F2/013 , A61F2/966 , A61F2002/011 , A61F2002/015 , A61F2230/0006 , A61F2230/005
摘要： Methods and devices for delivering and deploying expandable intraluminal medical devices (22) at a desired point of treatment within a body vessel are provided. A portion of a delivery device is spaced from an interior wall surface of the body vessel prior to deployment of the expandable intraluminal device.
摘要翻译：提供了用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置（22）的方法和装置。在部署可膨胀的管腔内装置之前，输送装置的一部分与身体血管的内壁表面间隔开。

8. 发明申请

WO2004082530A3 DELIVERY SYSTEMS FOR DEPLOYING EXPANDABLE INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：用于配置可扩展的内窥镜医疗器械的输送系统
公开(公告)号：WO2004082530A3
公开(公告)日：2004-11-11
申请号：PCT/US2004008507
申请日：2004-03-19
申请人： COOK INC , GARRISON MICHAEL L , CASE BRIAN C , HOFFA ANDREW K , FLAGLE JACOB A , PAVCNIK DUSAN
发明人： GARRISON MICHAEL L , CASE BRIAN C , HOFFA ANDREW K , FLAGLE JACOB A , PAVCNIK DUSAN
IPC分类号： A61F2/01 , A61F2/06 , A61F2/84
CPC分类号： A61F2/95 , A61F2/013 , A61F2/966 , A61F2002/011 , A61F2002/015 , A61F2230/0006 , A61F2230/005
摘要： Methods and devices for delivering and deploying expandable intraluminal medical devices (22) at a desired point of treatment within a body vessel are provided. A portion of a delivery device is spaced from an interior wall surface of the body vessel prior to deployment of the expandable intraluminal device.
摘要翻译：提供了用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置（22）的方法和装置。在部署可膨胀的管腔内装置之前，输送装置的一部分与身体血管的内壁表面间隔开。

9. 发明申请

WO2004082528A3 VASCULAR VALVE WITH REMOVABLE SUPPORT COMPONENT 审中-公开
标题翻译：具有可拆卸支撑部件的血管瓣
公开(公告)号：WO2004082528A3
公开(公告)日：2005-08-11
申请号：PCT/US2004008176
申请日：2004-03-17
申请人： COOK INC , OSBORNE THOMAS A , CASE BRIAN C , LESSARD DAVID R , FEARNOT NEAL E
发明人： OSBORNE THOMAS A , CASE BRIAN C , LESSARD DAVID R , FEARNOT NEAL E
IPC分类号： A61F20060101 , A61F2/00 , A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Described are vascular valve devices having valve elements formed of flexible material and at least one removable frame element. Also described are methods for using such devices in the vascular system and in particular in the venous system to treat venous insufficiency.
摘要翻译：描述了具有由柔性材料形成的阀元件和至少一个可移除的框架元件的血管瓣膜装置。还描述了在血管系统中，特别是在静脉系统中使用这种装置来治疗静脉功能不全的方法。

10. 发明申请

WO2007047945A2 ARTIFICIAL VALVE WITH CENTER LEAFLET ATTACHMENT 审中-公开
标题翻译：人造阀带中心叶片附件
公开(公告)号：WO2007047945A2
公开(公告)日：2007-04-26
申请号：PCT/US2006041075
申请日：2006-10-19
申请人： COOK INC , COOK BIOTECH INC , CASE BRIAN C , OBERMILLER JOSEPH F
发明人： CASE BRIAN C , OBERMILLER JOSEPH F
IPC分类号： A61F2/24 , A61F2/86
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0067 , A61F2230/008 , A61F2230/0095
摘要： The present invention provides self-expanding or otherwise expandable artificial valve prostheses for deployment within a bodily passageway, such as a vessel or duct of a patient. The valve prostheses include a support structure having an outer frame and supporting a valve leaflet.
摘要翻译：本发明提供自膨式或其他可膨胀的人造瓣膜假体，用于展开在身体通道（例如患者的血管或导管）内。瓣膜假体包括具有外部框架并支撑瓣膜小叶的支撑结构。

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