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1. 发明申请

WO2009146369A1 DEVICES AND METHODS FOR TREATING RECTOVAGINAL AND OTHER FISTULAE 审中-公开
标题翻译：用于治疗重建和其他造影剂的装置和方法
公开(公告)号：WO2009146369A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/045467
申请日：2009-05-28
申请人： COOK BIOTECH INCORPORATED , PATEL, Umesh, H. , OBERMILLER, F., Joseph
发明人： PATEL, Umesh, H. , OBERMILLER, F., Joseph
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641
摘要： Provided by certain aspects of the invention are methods for treating fistulae and various fistula graft assemblages useful in this regard. Illustratively, some inventive methods are useful in treating fistulae having at least a first fistula opening, a second fistula opening and a fistula tract extending therebetween. In one step, a first capping member is positioned over the first fistula opening such that a first pulling member, which extends from the first capping member, passes through the fistula tract. In another step, a second capping member is positioned over the second fistula opening such that a second pulling member, which extends from the second capping member, passes through the fistula tract. A first pulling force is applied to the first pulling member, and a second pulling force is applied to the second pulling member, for maintaining the first capping member over the first fistula opening and for maintaining the second capping member over the second fistula opening, respectively.
摘要翻译：由本发明的某些方面提供的是用于治疗瘘管和各种瘘移植物组合物的方法。说明性地，一些本发明的方法可用于治疗具有至少第一瘘开口，第二瘘开口和在其间延伸的瘘管道的瘘。在一个步骤中，第一封盖构件定位在第一瘘开口上方，使得从第一封盖构件延伸的第一牵引构件穿过瘘管道。在另一步骤中，第二封盖构件定位在第二瘘开口上方，使得从第二封盖构件延伸的第二牵引构件穿过瘘管道。第一拉力被施加到第一牵引构件，并且第二拉力施加到第二牵引构件，用于将第一封盖构件保持在第一瘘开口上方并且用于将第二封盖构件分别保持在第二瘘开口上方。

2. 发明申请

WO2007011443A2 FISTULA GRAFT WITH DEFORMABLE SHEET-FORM MATERIAL 审中-公开
标题翻译：具有可变形材料的FISTULA GRAFT
公开(公告)号：WO2007011443A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/016233
申请日：2006-04-28
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , PATEL, Umesh, H. , OBERMILLER, F., Joseph , FETTE, Clay, D. , GRAHAM, Matthew, R.
发明人： PATEL, Umesh, H. , OBERMILLER, F., Joseph , FETTE, Clay, D. , GRAHAM, Matthew, R.
IPC分类号： A61K35/22 , A61K35/38
CPC分类号： A61L27/3604 , A61B17/0057 , A61B2017/00641 , A61K35/22 , A61K35/38 , A61L31/005
摘要： Described are medical products, systems, and methods for treating fistulae having a primary opening, such as in the alimentary canal. Certain methods of the invention include providing an implantable material including a compliant sheet form biocompatible material, and forcing this sheet form biocompatible material into the primary opening so as to deform the sheet form biocompatible material to conform to and block the primary opening. The biocompatible material preferably comprises a remodelable material, for example, a remodelable extracellular matrix material such as submucosa .
摘要翻译：描述了用于治疗具有初级开口的瘘的医疗产品，系统和方法，例如在消化道中。本发明的某些方法包括提供可植入材料，其包括顺应性片材形式的生物相容性材料，并且迫使该片材形成生物相容性材料进入主要开口，以使片材形式的生物相容性材料变形以符合和阻止初级开口。生物相容性材料优选包含可重塑材料，例如可重塑的细胞外基质材料，例如粘膜下层。

3. 发明申请

WO2007002260A3 IMPLANTABLE GRAFT TO CLOSE A FISTULA 审中-公开
公开(公告)号：WO2007002260A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/024260
申请日：2006-06-21
申请人： COOK INCORPORATED , COOK BIOTECH, INC. , ARMSTRONG, David, N. , BATES, Brian, L. , BLEYER, Mark, W. , OBERMILLER, F., Joseph , PATEL, Umesh, H.
发明人： ARMSTRONG, David, N. , BATES, Brian, L. , BLEYER, Mark, W. , OBERMILLER, F., Joseph , PATEL, Umesh, H.
IPC分类号： A61B17/00
摘要： An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.

4. 发明申请

WO2011146729A2 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 审中-公开
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：WO2011146729A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037173
申请日：2011-05-19
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , PAUL, Ram, H. , STANLEY, Cleon , BATES, Brian, L. , OBERMILLER, F., Joseph , OSBORNE, Thomas, A. , CHAMBERS, Sean
发明人： PAUL, Ram, H. , STANLEY, Cleon , BATES, Brian, L. , OBERMILLER, F., Joseph , OSBORNE, Thomas, A. , CHAMBERS, Sean
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/3468 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶状密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在容器内部的适当位置。

5. 发明申请

WO2009064839A1 FISTULA GRAFTS AND RELATED METHODS AND SYSTEMS USEFUL FOR TREATING GASTROINTESTINAL AND OTHER FISTULAE 审中-公开
标题翻译： FISTULA GRAFTS及相关方法和系统有助于治疗胃肠炎和其他原因
公开(公告)号：WO2009064839A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083329
申请日：2008-11-13
申请人： COOK BIOTECH INCORPORATED , OBERMILLER, F., Joseph , CHEN, Steve
发明人： OBERMILLER, F., Joseph , CHEN, Steve
IPC分类号： A61B17/00 , A61B19/00
CPC分类号： A61B17/0057 , A61B90/39 , A61B2017/00004 , A61B2017/00477 , A61B2017/00641 , A61B2017/00663 , A61B2017/00668 , A61B2090/0811
摘要： Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.
摘要翻译：描述了用于治疗瘘，特别是肠外瘘的医疗移植产品，系统和方法。本发明的某些产品被配置为具有驻留在消化道壁的主瘘开口内和周围的部分。一种这样的产品包括生物相容性移植物体，其构造成至少阻挡初级开口。移植物主体包括连接到细长插塞构件的封盖构件。封盖构件被构造成接触与初级开口相邻的消化道壁的部分，并且细长插塞构件构造成延伸到至少一部分瘘管中。这种接枝产品可以特别适于允许封盖构件的一部分定位在插塞构件的外部侧表面旁边，例如当放置在输送装置内腔中时。这种封盖构件可以铰接地或非铰接地联接到细长插塞构件。

6. 发明申请

WO2012174234A2 FISTULA CLOSURE DEVICES AND METHODS 审中-公开
标题翻译： FISTULA闭合装置和方法
公开(公告)号：WO2012174234A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042448
申请日：2012-06-14
申请人： COOK MEDICAL TECHNOLOGIES LLC , COOK BIOTECH INCORPORATED , OBERMILLER, F., Joseph , AGNEW, Charles, W. , CHEN, Steve , HUNT, James, B.
发明人： OBERMILLER, F., Joseph , AGNEW, Charles, W. , CHEN, Steve , HUNT, James, B.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00588 , A61B2017/00641
摘要： Described are methods and systems for treating fistulae and other passageways and openings in the body. In certain aspects, an anchored suture is provided that extends from at or near a first fistula opening and through a fistula tract toward a second fistula opening. Various modes of anchoring may be used in this regard including, in some modes, having the suture extend from a deployed anchoring member positioned in and/or around the first opening. The anchored suture, which has a more slender cross sectional dimension relative to the fistula tract through which it extends, is capable of receiving an optional fill substance therealong in the tract. A fill substance can be or include a variety of biodegradable and/or non-biodegradable objects and materials including flowable and non-flowable materials.
摘要翻译：描述了用于治疗瘘管和身体其他通道和开口的方法和系统。在某些方面，提供一种锚固缝合线，其从第一瘘开口处或附近延伸并且通过瘘管道朝向第二瘘开口延伸。在这方面可以使用各种锚固模式，包括在一些模式中，缝合线从位于第一开口中和/或周围的展开的锚定构件延伸。相对于其延伸的瘘管具有更细长的横截面尺寸的锚定缝合线能够在管道中接收可选的填充物质。填充物质可以是或包括各种可生物降解和/或不可生物降解的物体和材料，包括可流动和不可流动的材料。

7. 发明申请

WO2010056535A1 VASCULAR PLUGS 审中-公开
标题翻译：血管插管
公开(公告)号：WO2010056535A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/062517
申请日：2009-10-29
申请人： COOK BIOTECH INCORPORATED , COOK INCORPORATED , OBERMILLER, F., Joseph , DECKARD, Michael, D. , EVERT, Kathryn , HARDERT, Michael, W.
发明人： OBERMILLER, F., Joseph , DECKARD, Michael, D. , EVERT, Kathryn , HARDERT, Michael, W.
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/12109 , A61B17/0057 , A61B17/12022 , A61B17/12031 , A61B17/12159 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/12054
摘要： Certain aspects of the present invention provide devices for occluding vascular vessels. In some preferred forms, these devices are able to move from a first condition to a less compact, second condition in a vascular vessel so as to fully or partially prevent fluid from passing through the vessel. One such device includes a frame and a flexible sheet material. The device also includes an occluding material that is located in an interior region of the frame. The flexible sheet material and frame are associated with one another such that when the device is in the second condition in the vascular vessel, the sheet material is positioned in the vessel lumen so as to block fluid flow through the lumen.
摘要翻译：本发明的某些方面提供用于阻塞血管的装置。在一些优选的形式中，这些装置能够在血管容器中从第一状态移动到较不致密的第二状态，以便完全或部分地防止流体通过血管。一种这样的装置包括框架和柔性片材。该装置还包括位于框架的内部区域中的阻塞材料。柔性片材和框架彼此相关联，使得当装置在血管容器中处于第二状态时，片材材料被定位在血管腔中，以阻止流体流过管腔。

8. 发明申请

WO2003002168A1 POROUS SPONGE MATRIX MEDICAL DEVICES AND METHODS 审中-公开
标题翻译：多孔海绵矩阵医疗设备和方法
公开(公告)号：WO2003002168A1
公开(公告)日：2003-01-09
申请号：PCT/US2002/020462
申请日：2002-06-28
申请人： COOK BIOTECH INCORPORATED , OBERMILLER, F., Joseph , HILES, Michael, C.
发明人： OBERMILLER, F., Joseph , HILES, Michael, C.
IPC分类号： A61L31/04
CPC分类号： A61L31/146 , A61B10/0233 , A61B17/0057 , A61B17/12022 , A61B17/1219 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00898 , A61L26/0033 , A61L26/0085 , A61L27/24 , A61L27/56 , A61L31/044 , A61L2400/04
摘要： Described are hemostasis devices useful for implantation in biopsy tracts, which devices comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge matrices exhibiting high density and rigidity in combination with high volumetric expandability when wetted. Also described are methods for making and using such devices.
摘要翻译：描述了可用于植入活组织切片的止血装置，该装置包括高密度，干燥的止血海绵元件。优选的装置还包括表现出高密度和刚度的压实海绵基质，同时在润湿时具有高体积膨胀性。还描述了制造和使用这些装置的方法。

9. 发明申请

WO2009006509A1 FISTULA GRAFTS HAVING A DEFLECTABLE GRAFT BODY PORTION 审中-公开
标题翻译：具有可弃置的格子部分的FISTULA GRAFTS
公开(公告)号：WO2009006509A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068984
申请日：2008-07-02
申请人： COOK BIOTECH INCORPORATED , CHEN, Steve , METZ, Jeremy , OBERMILLER, F., Joseph
发明人： CHEN, Steve , METZ, Jeremy , OBERMILLER, F., Joseph
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B90/39 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654 , A61B2017/00893 , A61B2090/3983 , A61L27/3604 , A61L27/3641
摘要： This invention provides devices and methods for treating fistulae. In one embodiment, an inventive device includes an elongate graft body (31) having a proximal end (32) and a distal end (33). The graft body is configurable to a first condition and a second condition, the second condition including the distal end deflected laterally relative to its position in the first condition of the body. The device also includes a tether (36), which is connected to the graft body, and is configured to traverse proximally along the body. The tether is manipulable to convert the graft body from the first condition to the second condition. Such a device may also include one or more additional tethers connected to the graft body. For instance, a second tether (38) can be configured to extend distally from the distal end of the graft body, and may be effective in pulling the graft body along a fistula tract (42).
摘要翻译：本发明提供了治疗瘘的装置和方法。在一个实施例中，本发明的装置包括具有近端（32）和远端（33）的细长移植体（31）。移植物主体可配置为第一状态和第二状态，所述第二状态包括远端在身体的第一状态中相对于其位置横向偏转的状态。该装置还包括连接到移植物主体的系绳（36），并被配置为沿身体向近侧横向移动。系绳可操作以将移植物体从第一状态转换到第二状态。这种装置还可以包括连接到移植物主体的一个或多个附加系绳。例如，第二系绳（38）可构造成从移植物体的远端向远端延伸，并且可有效地沿着瘘管（42）拉动移植物体。

10. 发明申请

WO2005077433A1 STENT GRAFT DEVICES HAVING COLLAGEN COATING 审中-公开
标题翻译：具有胶原蛋白涂层的支架装置
公开(公告)号：WO2005077433A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/003967
申请日：2005-02-09
申请人： COOK BIOTECH INCORPORATED , OBERMILLER, F., Joseph , FETTE, Clay
发明人： OBERMILLER, F., Joseph , FETTE, Clay
IPC分类号： A61L31/10
CPC分类号： A61L27/3633 , A61F2/07 , A61F2/88 , A61F2/90 , A61F2/915 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61L27/34 , A61L27/3629 , A61L27/3691 , C08L89/06
摘要： Described are stent graft devices and methods for their preparation and use. Expandable stent graft devices of the invention include inner and/or outer coverings uniquely applied and associated with surfaces of the stent. In certain described embodiments, bioremodelable materials such as ECM materials are vacuum pressed onto and/or around elements of a stent in the manufacture of a stent graft device.
摘要翻译：描述了覆膜支架装置及其制备和使用的方法。本发明的可扩张支架移植物装置包括独特地施加并与支架表面相关联的内部和/或外部覆盖物。在某些描述的实施方案中，在支架移植物装置的制造中，诸如ECM材料的生物可重塑材料被真空挤压到支架的元件上和/或围绕元件的周围。

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