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1. 发明申请

WO1994012641A1 HAEMOPHILUS OUTER MEMBRANE PROTEIN 审中-公开
标题翻译： HAEMOPHILUS外膜蛋白
公开(公告)号：WO1994012641A1
公开(公告)日：1994-06-09
申请号：PCT/CA1993000501
申请日：1993-11-23
申请人： CONNAUGHT LABORATORIES LIMITED , CHONG, Pele , THOMAS, Wayne , YANG, Yan-Ping , LOOSMORE, Sheena , SIA, Dwo, Yuan, Charles , KLEIN, Michel
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/31
CPC分类号： C07K14/285 , A61K39/00 , C07K16/1242 , C07K2317/34
摘要： Purified and isolated nucleic acid from specific strains of Haemophilus influenzae is provided which encodes at least a portion of the D15 outer membrane protein of Haemophilus. The nucleic acid is used to produce peptides, polypeptides and proteins free of contaminant associated with Haemophilus for purposes of diagnosis and medical treatment. Furthermore, the nucleic acid may be used in the diagnosis of Haemophilus infection. Antisera obtained following immunization with the nucleic acid D15 outer membrane protein or peptides also may be used for the purpose of diagnosis and medical treatment.
摘要翻译：提供了来自流感嗜血杆菌的特异性菌株的纯化和分离的核酸，其编码嗜血杆菌D15外膜蛋白的至少一部分。核酸用于产生与嗜血杆菌相关的污染物的肽，多肽和蛋白质，用于诊断和治疗。此外，核酸可用于诊断嗜血杆菌感染。用核酸D15外膜蛋白或肽免疫后获得的抗血清也可用于诊断和治疗的目的。

2. 发明申请

WO1996003506A2 ANALOG OF HAEMOPHILUS HIN47 WITH REDUCED PROTEASE ACTIVITY 审中-公开
标题翻译：具有减少蛋白酶活性的HAEMOPHILUS HIN47的模拟物
公开(公告)号：WO1996003506A2
公开(公告)日：1996-02-08
申请号：PCT/CA1995000434
申请日：1995-07-21
申请人： CONNAUGHT LABORATORIES LIMITED , LOOSMORE, Sheena, M. , YANG, Yan-Ping , CHONG, Pele , OOMEN, Raymond, P. , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/31
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N9/52
摘要： The invention concerns isolated and purified analogs of Haemophilus influenza Hin47 protein with decreased protease activity (of less than 10 % of that of the natural protein) but preferably retaining substantially the same immunogenic properties as natural Hin47. Preferred analogs have mutations at Ser197, His91 and/or Asp121 positions and are possibly used as chimeric proteins with other immunogenic molecules. Also disclosed are nucleic acid encoding said analogs, recombinant plasmids and transformed host cells containing said modified genes, immunogenic compositions containing Hin47 analogs or their nucleic acid and their use for prophylactic, vaccine or diagnostic purposes.
摘要翻译：本发明涉及具有降低的蛋白酶活性（小于天然蛋白质的10％）的嗜血杆菌流感Hin47蛋白的分离和纯化的类似物，但优选保持与天然Hin47基本上相同的免疫原性。优选的类似物在Ser197，His91和/或Asp121位置具有突变，并且可能用作其它免疫原性分子的嵌合蛋白。还公开了编码所述类似物，重组质粒和含有所述修饰基因的转化宿主细胞的核酸，含有Hin47类似物或其核酸的免疫原性组合物及其用于预防，疫苗或诊断目的的用途。

3. 发明申请

WO1995013370A1 HAEMOPHILUS TRANSFERRIN RECEPTOR GENES 审中-公开
标题翻译： HAEMOPHILUS转铁蛋白受体基因
公开(公告)号：WO1995013370A1
公开(公告)日：1995-05-18
申请号：PCT/CA1994000616
申请日：1994-11-07
申请人： CONNAUGHT LABORATORIES LIMITED , LOOSMORE, Sheena , HARKNESS, Robin , SCHRYVERS, Anthony , CHONG, Pele , GRAY-OWEN, Scott , YANG, Yan-Ping , MURDIN, Andrew , KLEIN, Michel
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C07K16/2881 , C07K2317/34 , C12N2799/021 , Y02A50/466
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
摘要翻译：提供纯化和分离的核酸，其编码嗜血杆菌菌株的转铁蛋白受体蛋白或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗目的，核酸序列可用于产生不含通常含有Tbp1或Tbp2蛋白的细菌的不含污染物的肽。此外，核酸分子可以用于感染的诊断。还提供了重组Tbp1或Tbp2及其纯化方法。提供了表达转铁蛋白受体蛋白表位的活载体用于疫苗接种。

4. 发明申请

WO1996040929A2 TRANSFERRIN RECEPTOR GENES 审中-公开
标题翻译：转铁蛋白受体基因
公开(公告)号：WO1996040929A2
公开(公告)日：1996-12-19
申请号：PCT/CA1996000399
申请日：1996-06-07
申请人： CONNAUGHT LABORATORIES LIMITED , LOOSMORE, Sheena, M. , HARKNESS, Robin, E. , SCHRYVERS, Anthony, B. , CHONG, Pele , GRAY-OWEN, Scott , YANG, Yan-Ping , MURDIN, Andrew, D. , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/31
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C12N2799/021
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
摘要翻译：提供纯化和分离的核酸，其编码嗜血杆菌菌株的转铁蛋白受体蛋白或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含通常含有Tbp1或Tbp2蛋白的细菌的不含污染物的肽。此外，核酸分子可以用于感染的诊断。还提供了重组Tbp1或Tbp2及其纯化方法。提供了表达用于疫苗接种的转铁蛋白受体蛋白表位的活载体。

5. 发明申请

WO1990013564A1 SYNTHETIC PEPTIDES FOR AN HIV-1 VACCINE 审中-公开
标题翻译： HIV-1疫苗的合成肽
公开(公告)号：WO1990013564A1
公开(公告)日：1990-11-15
申请号：PCT/CA1990000146
申请日：1990-05-03
申请人： CONNAUGHT LABORATORIES LIMITED , SIA, Dwo, Yuan, Charles , CHONG, Pele , KLEIN, Michel
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C07K07/08
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16222 , C12N2740/16234
摘要： The invention discloses the identification, characterisation and use of a synthetic peptide, GPKEPFRDYVDRFYK (p24E), as a T-cell carrier for the appropriate assembly, with defined B-cell epitopes of the HIV-1 envelope protein, for the construction of potential synthetic vaccine candidates against HIV.
摘要翻译：本发明公开了合成肽GPKEPFRDYVDRFYK（p24E）作为适合组装的T细胞载体与HIV-1包膜蛋白的定义的B细胞表位的鉴定，表征和用途，用于构建潜在的合成针对艾滋病毒的疫苗候选人。

6. 发明申请

WO1997032980A1 TRANSFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译：转铁蛋白受体基因的MORAXELLA
公开(公告)号：WO1997032980A1
公开(公告)日：1997-09-12
申请号：PCT/CA1997000163
申请日：1997-03-07
申请人： CONNAUGHT LABORATORIES LIMITED , MYERS, Lisa, E. , SCHRYVERS, Anthony, B. , HARKNESS, Robin, E. , LOOSMORE, Sheena, M. , DU, Run-Pan , YANG, Yan-Ping , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/212 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as M. catarrhalis or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码莫拉氏菌的转铁蛋白受体蛋白，例如卡他莫拉菌或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组转铁蛋白受体蛋白质Tbp1和Tbp2。此外，核酸分子可以用于感染的诊断。

7. 发明申请

WO1996034960A1 HIGH MOLECULAR WEIGHT MAJOR OUTER MEMBRANE PROTEIN OF MORAXELLA 审中-公开
标题翻译：高分子量主要外膜蛋白质MORAXELLA
公开(公告)号：WO1996034960A1
公开(公告)日：1996-11-07
申请号：PCT/CA1996000264
申请日：1996-04-29
申请人： CONNAUGHT LABORATORIES LIMITED , SASAKI, Ken , HARKNESS, Robin, E. , LOOSMORE, Sheena, M. , CHONG, Pele , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/31
CPC分类号： C07K14/212 , A61K39/00 , A61K2039/53 , C07K2319/02 , C12N2799/022 , C12N2799/023 , Y02A50/466 , Y10S424/803
摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.
摘要翻译：提供分离和纯化的具有约200kDa分子量的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白。大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外界的细菌病原体引起的疾病的保护产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。

8. 发明申请

WO1991006652A1 OUTER MEMBRANE PROTEIN P1 AND PEPTIDES OF HAEMOPHILUS INFLUENZAE TYPE B 审中-公开
标题翻译：外膜蛋白P1和HAEMOPHILUS流感病毒B型胶原蛋白
公开(公告)号：WO1991006652A1
公开(公告)日：1991-05-16
申请号：PCT/CA1990000374
申请日：1990-10-31
申请人： CONNAUGHT LABORATORIES LIMITED , WASHINGTON UNIVERSITY, ST. LOUIS , MUNSON, Robert, S., Jr. , GRASS, Susan , CHONG, Pele , YANG, Yan-Ping , FAHIM, Raafat , STA, Dwo, Yan, Charles , McVERRY, Patrick , KLEIN, Michel
发明人： CONNAUGHT LABORATORIES LIMITED , WASHINGTON UNIVERSITY, ST. LOUIS
IPC分类号： C12N15/31
CPC分类号： C07K14/285 , A61K39/00
摘要： The gene for outer membrane protein P1 of Haemophilus influenzae b is expressed in E. coli. Methods for expression and demonstration of the immunogenicity of recombinant P1 and portions thereof are disclosed, along with an improved method for the purification of P1. The nucleotide sequence of the P1 gene and the derived amino acid sequence of the P1 protein of Haemophilus influenzae type b are disclosed and the methods used to determine the same. Also disclosed are the methods used to clone and express the P1 gene as well as the purification protocol for the P1 gene products (recombinant P1 and P1 fusion proteins). Fourteen peptides are synthesized corresponding to specific sequences of the mature P1 protein. The use of the P1 protein as n immunogens for immunization against the disease caused by Haemophilus influenzae type b and the use of the protein as a carrier for conjugation with an oligosaccharide derived from Haemophilus to generate a potentially efficacious vaccine against the disease, are described. Also disclosed is the use of P1 peptide-conjugates as immunizing agents to elicit anti-Haemophilus influenzae type b antibodies.
摘要翻译：流感嗜血杆菌b的外膜蛋白P1的基因在大肠杆菌中表达。公开了用于表达和证明重组P1及其部分的免疫原性的方法以及用于纯化P1的改进方法。公开了P1型基因的核苷酸序列和B型流感嗜血杆菌的P1蛋白的衍生氨基酸序列，并且用于确定它们的方法。还公开了用于克隆和表达P1基因的方法以及P1基因产物（重组P1和P1融合蛋白）的纯化方案。对应于成熟P1蛋白的特异性序列合成14个肽。描述了使用P1蛋白作为免疫原免疫针对由流感嗜血杆菌b型引起的疾病的免疫，以及使用蛋白质作为与源自嗜血杆菌的寡糖缀合的载体以产生针对该疾病的潜在有效疫苗。还公开了使用P1肽缀合物作为免疫剂以引发抗流感嗜血杆菌b型抗体。

9. 发明申请

WO1996026282A1 EXPRESSION OF GENE PRODUCTS FROM GENETICALLY MANIPULATED STRAINS OF BORDETELLA 审中-公开
标题翻译：表达来自BORDETELLA的遗传操作菌株的基因产物
公开(公告)号：WO1996026282A1
公开(公告)日：1996-08-29
申请号：PCT/CA1996000107
申请日：1996-02-23
申请人： CONNAUGHT LABORATORIES LIMITED , LOOSMORE, Sheena, M. , YACOOB, Reza, Khayyam , ZEALEY, Gavin, R. , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/74
CPC分类号： C07K14/285 , C07K14/28 , C07K2319/02 , C12N15/74
摘要： An expression system for expressing gene products from recombinant Bordetella strains and specific nucleic acid molecules useful in transforming Bordetella strains for such expression are described. A nucleic acid molecule may comprise a Bordetella promoter operatively coupled to a heterologous gene encoding a non-Bordetella gene product with the heterologous gene transcriptionally regulated by the Bordetella promoter. The nucleic acid molecule may further comprise a further nucleic acid molecule encoding a leader sequence for secretion of the non-Bordetella gene product. Another nucleic acid molecule may comprise a Bordetella promoter coupled to a nucleic acid sequence encoding a non-Bordetella leader sequence for secretion of a gene product, which may be a Bordetella gene product or a non-Bordetella gene product.
摘要翻译：描述了用于表达来自重组博德特氏菌属菌株的基因产物和用于转化博德氏菌属菌株用于这种表达的特异性核酸分子的表达系统。核酸分子可以包含与编码非博德特氏菌基因产物的异源基因操作性偶联的博德特氏菌启动子与由博德特氏杆菌启动子转录调节的异源基因。核酸分子还可以包含编码用于分泌非博德特氏菌基因产物的前导序列的另外的核酸分子。另一种核酸分子可以包含与编码用于分泌基因产物的非博德特氏菌前导序列的核酸序列偶联的博德特氏菌启动子，其可以是博德特氏菌属基因产物或非博德特氏菌基因产物。

10. 发明申请

WO1994029339A1 TANDEM SYNTHETIC HIV-1 PEPTIDES 审中-公开
标题翻译： TANDEM合成HIV-1肽
公开(公告)号：WO1994029339A1
公开(公告)日：1994-12-22
申请号：PCT/CA1994000317
申请日：1994-06-08
申请人： CONNAUGHT LABORATORIES LIMITED , SIA, Charles, D., Y. , CHONG, Pele , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C07K07/08
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , G01N33/56988 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，它们是针对HIV-1的候选疫苗，可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，特别是p24E直接与HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列连接并含有序列GPGR，和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

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