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1. 发明申请

WO9952947A3 TRANSFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译：转铁蛋白受体基因的MORAXELLA
公开(公告)号：WO9952947A3
公开(公告)日：1999-12-16
申请号：PCT/CA9900307
申请日：1999-04-12
申请人： CONNAUGHT LAB , MYERS LISA E , SCHRYVERS ANTHONY B , HARKNESS ROBIN E , LOOSMORE SHEENA M , RUN PAN DU , YANG YAN PING , KLEIN MICHEL H
发明人： MYERS LISA E , SCHRYVERS ANTHONY B , HARKNESS ROBIN E , LOOSMORE SHEENA M , DU RUN-PAN , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61K48/00 , C07K14/21 , C07K14/22 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/01 , G01N33/68 , C07K14/79
CPC分类号： C07K14/212 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51
摘要： Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码卡他莫拉菌M35,3和LES1的Tbp2蛋白。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组Tbp2蛋白。此外，核酸分子可以用于感染的诊断。

2. 发明申请

WO2005076696A3 PNEUMOLYSIN DERIVATIVES 审中-公开
公开(公告)号：WO2005076696A3
公开(公告)日：2005-08-25
申请号：PCT/IB2005/001052
申请日：2005-02-11
申请人： SANOFI PASTEUR LIMITED , OCHS, Martina , FEGARAS, Fotula , WANG, Shaojiu , CARPICK, Bruce , QI, Wei-Wei , YUAN, Tao , MYERS, Lisa, E. , TARTAGLIA, James , CHAWLA, Davinder , PERSON, Roy , JAMES, Olive , MATHESON, Kimberly , PEDYCZAK, Artur , MILLAR, Amamda
发明人： OCHS, Martina , FEGARAS, Fotula , WANG, Shaojiu , CARPICK, Bruce , QI, Wei-Wei , YUAN, Tao , MYERS, Lisa, E. , TARTAGLIA, James , CHAWLA, Davinder , PERSON, Roy , JAMES, Olive , MATHESON, Kimberly , PEDYCZAK, Artur , MILLAR, Amamda
IPC分类号： C12N15/31
摘要： The present invention relates to recombinant DLA molecules encoding pneumolysin or derivatives thereof, polypeptides produced therefrom, and pharmaceutically acceptable compositions thereof.

3. 发明申请

WO1997032980A1 TRANSFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译：转铁蛋白受体基因的MORAXELLA
公开(公告)号：WO1997032980A1
公开(公告)日：1997-09-12
申请号：PCT/CA1997000163
申请日：1997-03-07
申请人： CONNAUGHT LABORATORIES LIMITED , MYERS, Lisa, E. , SCHRYVERS, Anthony, B. , HARKNESS, Robin, E. , LOOSMORE, Sheena, M. , DU, Run-Pan , YANG, Yan-Ping , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/212 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as M. catarrhalis or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码莫拉氏菌的转铁蛋白受体蛋白，例如卡他莫拉菌或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组转铁蛋白受体蛋白质Tbp1和Tbp2。此外，核酸分子可以用于感染的诊断。

4. 发明申请

WO1996012733A1 MAJOR OUTER MEMBRANE PROTEIN CD OF MORAXELLA 审中-公开
标题翻译： MORAXELLA主要外膜蛋白CD
公开(公告)号：WO1996012733A1
公开(公告)日：1996-05-02
申请号：PCT/CA1995000604
申请日：1995-10-23
申请人： CONNAUGHT LABORATORIES LIMITED , YANG, Yan-Ping , HARKNESS, Robin, E. , MYERS, Lisa, E. , McGUINNESS, Ursula , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C07K14/22
CPC分类号： C07K14/212 , A61K39/00
摘要： An isolated and purified non-denatured outer membrane protein CD which is that of or corresponds to that isolatable from a Moraxella strain, particularly M. catarrhalis, is isolated from a bacterial strain by fractionating a cell lysate formed by disrupting a cell mass of the bacterial strain by centrifugation to provide a pellet and a discard supernatant containing a large proportion of soluble bacterial proteins. The pellet is selectively extracted to remove the remaining soluble proteins, the membrane proteins other than CD and other contaminants such as lipopolysaccharide and phospholipids. The remaining CD-containing pellet is dispersed and solubilized and then fractionated by centrifugation to remove the remaining cell debris. The CD protein is useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces CD protein or produces a protein capable of inducing antibodies in a host specifically reactive with CD protein.
摘要翻译：分离纯化的非变性外膜蛋白CD，其是与莫拉氏菌属菌株特别是卡他莫拉菌可分离的非变性外膜蛋白质CD，通过分离通过破坏细菌的细胞块而形成的细胞裂解物从细菌菌株中分离通过离心以提供含有大部分可溶性细菌蛋白质的沉淀物和丢弃上清液。选择性提取沉淀物以除去剩余的可溶性蛋白质，除CD以外的膜蛋白质和其它污染物如脂多糖和磷脂。剩余的含有CD的颗粒被分散和溶解，然后通过离心分离分离以除去剩余的细胞碎片。 CD蛋白可用于诊断应用和免疫原性组合物，特别是用于体内施用宿主，以产生由产生CD蛋白的细菌病原体引起的疾病的保护，或产生能够在与CD蛋白特异性反应的宿主中诱导抗体的蛋白质。

5. 发明申请

WO2005076696A2 PNEUMOLYSIN DERIVATIVES 审中-公开
标题翻译：气泡衍生物
公开(公告)号：WO2005076696A2
公开(公告)日：2005-08-25
申请号：PCT/IB2005001052
申请日：2005-02-11
申请人： SANOFI PASTEUR LTD , OCHS MARTINA , FEGARAS FOTULA , WANG SHAOJIU , CARPICK BRUCE , QI WEI-WEI , YUAN TAO , MYERS LISA E , TARTAGLIA JAMES , CHAWLA DAVINDER , PERSON ROY , JAMES OLIVE , MATHESON KIMBERLY , PEDYCZAK ARTUR , MILLAR AMAMDA
发明人： OCHS MARTINA , FEGARAS FOTULA , WANG SHAOJIU , CARPICK BRUCE , QI WEI-WEI , YUAN TAO , MYERS LISA E , TARTAGLIA JAMES , CHAWLA DAVINDER , PERSON ROY , JAMES OLIVE , MATHESON KIMBERLY , PEDYCZAK ARTUR , MILLAR AMAMDA
IPC分类号： A61K39/00 , A61K39/09 , C07K14/315
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The present invention relates to vaccines against bacterial pathogens. particular, the invention relates to modified epitopes of bacterial antigens.
摘要翻译：本发明涉及抗细菌病原体的疫苗。具体地，本发明涉及细菌抗原的修饰表位。

6. 发明申请

WO1997013785A1 TRANSFERRIN RECEPTOR PROTEIN OF MORAXELLA 审中-公开
标题翻译：转铁蛋白受体蛋白
公开(公告)号：WO1997013785A1
公开(公告)日：1997-04-17
申请号：PCT/CA1996000684
申请日：1996-10-11
申请人： CONNAUGHT LABORATORIES LIMITED , YANG, Yan-Ping , MYERS, Lisa, E. , HARKNESS, Robin, E. , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C07K14/22
CPC分类号： A61K39/39 , A61K39/00 , A61K2039/55505 , A61K2039/55516 , A61K2039/5555 , A61K2039/55555 , A61K2039/55577 , A61K2039/55594 , C07K14/212
摘要： An isolated and purified non-denatured transferrin receptor protein of a Moraxella strain, particularly M. catarrhalis, has an apparent molecular mass of about 80 to about 90 kDa, as determined by SDS-PAGE. The transferrin receptor protein or a fragment analog thereof is useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a strain of Moraxella.
摘要翻译： Moraxella菌株，特别是卡他莫拉氏菌的分离和纯化的非变性转铁蛋白受体蛋白质通过SDS-PAGE测定具有约80至约90kDa的表观分子量。转铁蛋白受体蛋白或其片段类似物可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予由莫拉氏菌引起的疾病的保护作用。

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