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1. 发明申请

WO0020629A3 QUANTITATION OF RNA 审中-公开
标题翻译： RNA定量
公开(公告)号：WO0020629A3
公开(公告)日：2000-07-20
申请号：PCT/CA9900917
申请日：1999-10-04
申请人： CONNAUGHT LAB , PARRINGTON MARK , CATERINI JUDITH E , KLEIN MICHEL H
发明人： PARRINGTON MARK , CATERINI JUDITH E , KLEIN MICHEL H
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2561/113 , C12Q2545/113 , C12Q2521/107
摘要： An accurate method of determining the quantity of specific RNA in a tissue sample permits analysis of rare transcripts, such as cytokines, and is based on a modified RNA isolation procedure, RT-PCR in a single enzyme reaction, detection and quantification, preferably employing an RNA standard.
摘要翻译：确定组织样品中特定RNA的量的准确方法允许分析罕见转录物例如细胞因子，并基于修饰的RNA分离程序，在单一酶反应中的RT-PCR，检测和定量，优选使用 RNA标准。

2. 发明申请

WO9621465A2 IMMUNOGENIC CONJUGATE MOLECULES 审中-公开
标题翻译：免疫调节分子
公开(公告)号：WO9621465A2
公开(公告)日：1996-07-18
申请号：PCT/CA9600007
申请日：1996-01-05
申请人： CONNAUGHT LAB , YANG YAN PING , KANDIL ALI , GISONNI LUCY , FAHIM RAAFAT E F , KLEIN MICHEL H
发明人： YANG YAN-PING , KANDIL ALI , GISONNI LUCY , FAHIM RAAFAT E F , KLEIN MICHEL H
IPC分类号： A61P31/04 , C07K14/285 , C07K17/10 , A61K39/09 , A61K39/102 , A61K39/385 , G01N33/569
CPC分类号： C07K17/10 , A61K39/092 , A61K2039/55505 , A61K2039/6068 , C07K14/285 , Y10S424/831
摘要： Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus strain are provided in which the immunogenicity of the capsular polysaccharide is increased. Particularly capsular polysaccharide from Streptococcus pneumoniae are linked to an outer membrane protein of a Haemophilus influenzae strain, which protein may be the P1, P2 or particularly the P6 outer membrane protein. Conjugate molecules comprising the P6 protein linked to a capsular polysaccharide from an encapsulated pathogen other than Streptococcus are also described, in which the immunogenicity of the capsular polysaccharide is enhanced. Such conjugate molecules may be incorporated into immunogenic compositions for protecting a host against disease caused by the Streptococcus strain and preferably also the Haemophilus strain. The conjugate molecules and antibodies specific for the capsular polysaccharide or specific for the outer membrane protein may be employed in diagnostic procedures and kits. A process for individually isolating P1, P2 and P6 outer membrane proteins from a Haemophilus strain is also provided.
摘要翻译：提供包含与嗜血杆菌菌株的外膜蛋白的至少一部分连接的链球菌菌株的至少一部分荚膜多糖的免疫原性缀合物分子，其中荚膜多糖的免疫原性增加。特别是来自肺炎链球菌的荚膜多糖与流感嗜血杆菌菌株的外膜蛋白连接，该蛋白质可以是P1，P2或特别是P6外膜蛋白。还描述了包含与来自除链球菌以外的包囊病原体的荚膜多糖连接的P6蛋白的缀合物分子，其中荚膜多糖的免疫原性增强。这样的缀合物分子可以并入免疫原性组合物中，用于保护宿主免受由链球菌菌株引起的疾病，优选还有嗜血杆菌属菌株。对于荚膜多糖或对外膜蛋白特异的缀合物分子和抗体可用于诊断程序和试剂盒。还提供了从嗜血杆菌菌株单独分离P1，P2和P6外膜蛋白的方法。

3. 发明申请

WO0055191A3 RECOMBINANT HAEMOPHILUS INFLUENZAE ADHESIN PROTEINS 审中-公开
标题翻译：重组HAEMOPHILUS INFLUENZAE粘蛋白蛋白
公开(公告)号：WO0055191A3
公开(公告)日：2001-08-02
申请号：PCT/CA0000289
申请日：2000-03-16
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/00 , A61K39/145 , A61P11/00 , A61P27/16 , A61P31/04 , A61P31/16 , C07K14/195 , C07K14/285 , C12N1/21 , C12P21/02 , C12R1/19 , A61K38/00 , C12N15/00
CPC分类号： C07K14/285 , A61K39/00
摘要： Recombinant production of Hia protein, in full-length and N-terminally truncated forms, of non-typeable strains of Haemophilus influenzae, is described. The nucleic acid and deduced amino acid sequences of Hia genes of various strains of non-typeable and type c Haemophilus influenzae also are described.
摘要翻译：描述了全长和N-末端截短形式的流感嗜血杆菌不可逆型菌株的Hia蛋白的重组产生。还描述了不同型和流感嗜血杆菌流感嗜血杆菌的各种不同菌株的Hia基因的核酸和推断的氨基酸序列。

4. 发明申请

WO0053767A3 NUCLEIC ACID RESPIRATORY SYNCYTIAL VIRUS VACCINES 审中-公开
标题翻译：核酸呼吸道合胞病毒疫苗
公开(公告)号：WO0053767A3
公开(公告)日：2000-12-28
申请号：PCT/CA0000227
申请日：2000-03-03
申请人： CONNAUGHT LAB , LI XIAOMAO , EWASYSHYN MARY E , SAMBHARA SURYAPRAKASH , KLEIN MICHEL H
发明人： LI XIAOMAO , EWASYSHYN MARY E , SAMBHARA SURYAPRAKASH , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K39/155 , A61K39/245 , A61K39/395 , A61P11/00 , A61P31/12 , A61P31/14 , A61P37/04 , C07K14/135 , C12N15/45 , C12N15/85 , A61K48/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C07K2319/02 , C12N15/85 , C12N2760/18522 , C12N2800/108 , C12N2830/42 , C12N2840/20
摘要： Non-replicating vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described for in vivo immunization. The nucleotide sequence encoding the RSV F protein lacks a sequence encoding the homologous signal peptide but possesses a heterologous signal peptide enhancing RSV F protein expression. Such non-replicating vectors, including plasmids, also may contain a further nucleotide sequence located adjacent to the RSV F protein encoding sequence to enhance the immunoprotective ability of the RSV F protein when expressed in vivo. Such non-replicating vectors may be used to immunize a host against disease caused by infection with RSV, including a human host, by administration thereto, and may be formulated as immunogenic compositions with pharmaceutically-acceptable carriers for such purpose. Such vectors also may be used to produce antibodies for detection of RSV infection in a sample.
摘要翻译：描述了用于体内免疫的含有编码呼吸道合胞病毒（RSV）的F蛋白的核苷酸序列和该序列的启动子，优选巨细胞病毒启动子的非复制载体。编码RSV F蛋白的核苷酸序列缺少编码同源信号肽的序列，但具有增强RSV F蛋白表达的异源信号肽。包括质粒的这种非复制载体还可以含有位于RSV F蛋白编码序列附近的另一个核苷酸序列，以增强RSV F蛋白在体内表达时的免疫保护能力。这样的非复制载体可以用于免疫宿主抵抗由RSV（包括人宿主）感染引起的疾病，通过向其施用，并且可以配制为具有药学上可接受的载体用于此目的的免疫原性组合物。这样的载体也可以用于产生用于检测样品中RSV感染的抗体。

5. 发明申请

WO0014244A3 TREATMENT OF CERVICAL CANCER 审中-公开
标题翻译：治疗宫颈癌
公开(公告)号：WO0014244A3
公开(公告)日：2000-06-02
申请号：PCT/CA9900807
申请日：1999-09-03
申请人： CONNAUGHT LAB , GAJEWCZYK DIANE M , PERSSON ROY , YAO FEI LONG , CAO SHI XIAN , KLEIN MICHEL H , TARTAGLIA JAMES , MOINGEON PHILLIPE , ROVINSKI BENJAMIN
发明人： GAJEWCZYK DIANE M , PERSSON ROY , YAO FEI-LONG , CAO SHI-XIAN , KLEIN MICHEL H , TARTAGLIA JAMES , MOINGEON PHILLIPE , ROVINSKI BENJAMIN
IPC分类号： C12N15/09 , A61B5/026 , A61B5/029 , A61B5/055 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/12 , A61K39/245 , A61K39/39 , A61K48/00 , A61P31/20 , A61P35/00 , C07K14/025 , C12N15/37 , G06T7/00 , C12N15/86
CPC分类号： A61B5/055 , A61B5/0263 , A61B5/029 , A61B5/41 , A61K48/00 , A61K2039/51 , A61K2039/53 , C07K14/005 , C12N2710/20022 , C12N2710/20043 , Y10S977/804 , Y10S977/904 , Y10S977/916 , Y10S977/924
摘要： Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.
摘要翻译：用于针对宫颈癌的DNA免疫的载体包含编码人宫颈癌相关的人乳头瘤病毒（HPV）株的E6和/或E7抗原的至少一种无毒T-细胞表位的核酸分子，所述HPV- 16和启动子，所述启动子可操作地偶联于核酸分子，用于在施用了载体的宿主中表达核酸分子。

6. 发明申请

WO0035481A3 MULTIVALENT IMMUNOGENIC COMPOSITION CONTAINING RSV SUBUNIT COMPOSITION AND INFLUENZA VIRUS PREPARATION 审中-公开
标题翻译：含RSV亚基组合物和流感病毒制备物的多价免疫原性组合物
公开(公告)号：WO0035481A3
公开(公告)日：2000-10-26
申请号：PCT/CA9901194
申请日：1999-12-16
申请人： CONNAUGHT LAB , CATES GEORGE A , SAMBHARA SURYAPRAKASH , BURT DAVID , KLEIN MICHEL H
发明人： CATES GEORGE A , SAMBHARA SURYAPRAKASH , BURT DAVID , KLEIN MICHEL H
IPC分类号： C12N7/04 , A61K35/76 , A61K38/00 , A61K39/145 , A61K39/155 , A61K39/295 , A61K39/39 , A61P31/12 , A61P31/16 , C07K14/11 , C07K19/00 , C12R1/92
CPC分类号： A61K39/145 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/5254 , A61K2039/543 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/18534
摘要： Immunogenic compositions for administration to adults, particularly to the elderly, to protect them against disease caused by infection by respiratory syncytial virus and by influenza virus comprise an immunoeffective amount of a mixture of purified fusion (F) protein, attachment (G) protein and matrix (M) protein of RSV and an immunoeffective amount of a non-virulent influenza virus preparation. The components of the composition, when formulated as a vaccine for in vivo administration, do not impair the immunogenicity of each other. The immunogenic composition may also contain an adjuvant.
摘要翻译：用于向成年人，特别是老年人施用以保护它们免于由呼吸道合胞病毒和流感病毒感染引起的疾病的免疫原性组合物包含免疫有效量的纯化融合（F）蛋白质，附着（G）蛋白质和基质（M）RSV蛋白和免疫有效量的非毒性流感病毒制剂。当配制成用于体内施用的疫苗时，组合物的组分不会损害彼此的免疫原性。免疫原性组合物还可以含有佐剂。

7. 发明申请

WO9952947A3 TRANSFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译：转铁蛋白受体基因的MORAXELLA
公开(公告)号：WO9952947A3
公开(公告)日：1999-12-16
申请号：PCT/CA9900307
申请日：1999-04-12
申请人： CONNAUGHT LAB , MYERS LISA E , SCHRYVERS ANTHONY B , HARKNESS ROBIN E , LOOSMORE SHEENA M , RUN PAN DU , YANG YAN PING , KLEIN MICHEL H
发明人： MYERS LISA E , SCHRYVERS ANTHONY B , HARKNESS ROBIN E , LOOSMORE SHEENA M , DU RUN-PAN , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61K48/00 , C07K14/21 , C07K14/22 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/01 , G01N33/68 , C07K14/79
CPC分类号： C07K14/212 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51
摘要： Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码卡他莫拉菌M35,3和LES1的Tbp2蛋白。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组Tbp2蛋白。此外，核酸分子可以用于感染的诊断。

8. 发明申请

WO9855606A3 LACTOFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译： LACTOFERRIN受体基因的MORAXELLA
公开(公告)号：WO9855606A3
公开(公告)日：1999-03-04
申请号：PCT/CA9800544
申请日：1998-06-02
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , DU RUN-PAN , WANG QUIJUN , YANG YAN-PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , DU RUN-PAN , WANG QUIJUN , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P11/00 , A61P13/00 , A61P27/16 , A61P31/00 , C07K14/195 , C07K14/79 , C12N1/21 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/79 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode lactoferrin receptor proteins of Moraxella, such as M. catarrhalis, or a fragment or an analog of the lactoferrin receptor protein. The nucleic acid sequence may be used to produce recombinant lactoferrin receptor proteins Lbp1, Lbp2 or ORF3 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.

9. 发明申请

WO9603506A3 ANALOG OF HAEMOPHILUS HIN47 WITH REDUCED PROTEASE ACTIVITY 审中-公开
标题翻译：具有减少蛋白酶活性的HAEMOPHILUS HIN47的模拟物
公开(公告)号：WO9603506A3
公开(公告)日：1996-03-07
申请号：PCT/CA9500434
申请日：1995-07-21
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , CHONG PELE , OOMEN RAYMOND P , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , CHONG PELE , OOMEN RAYMOND P , KLEIN MICHEL H
IPC分类号： A61K39/00 , C07K14/285 , C12N9/52 , C12N15/31 , A61K39/102 , C07K19/00 , C12N1/21 , C12N15/70 , G01N33/569
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N9/52
摘要： The invention concerns isolated and purified analogs of Haemophilus influenza Hin47 protein with decreased protease activity (of less than 10 % of that of the natural protein) but preferably retaining substantially the same immunogenic properties as natural Hin47. Preferred analogs have mutations at Ser197, His91 and/or Asp121 positions and are possibly used as chimeric proteins with other immunogenic molecules. Also disclosed are nucleic acid encoding said analogs, recombinant plasmids and transformed host cells containing said modified genes, immunogenic compositions containing Hin47 analogs or their nucleic acid and their use for prophylactic, vaccine or diagnostic purposes.

10. 发明申请

WO0105424A3 MULTI-COMPONENT VACCINE TO PROTECT AGAINST DISEASE CAUSED BY HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS 审中-公开
标题翻译：多元分子疫苗可以防止由海马流感引起的疾病和 MORAXELLA CATARRHALIS

公开(公告)号：WO0105424A3

公开(公告)日：2001-08-02

申请号：PCT/CA0000811

申请日：2000-07-11

申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H , SASAKI KEN

发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H , SASAKI KEN

IPC分类号： A61K39/116 , A61P31/04

CPC分类号： A61K39/102 , A61K39/1045 , A61K2039/55505 , A61K2039/70

摘要： A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis . Such composition comprises at least four antigens comprising at least one antigen from Haemophilus influenzae , and at least one antigen from Moraxella catarrhalis . Three of the antigens are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of Moraxella catarrhalis comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.

摘要翻译：多价免疫原性组合物赋予免疫宿主免受针对流感嗜血杆菌和卡他莫拉菌的<！ - SIPO - >引起的感染的保护。这样的组合物包含至少四种包含来自嗜血杆菌流感嗜血杆菌的至少一种抗原的抗原和至少一种来自卡他莫拉菌的抗原。三种抗原是粘附素。不可分泌的嗜血杆菌的高分子量（HMW）蛋白和流感嗜血杆菌粘附素（Hia）蛋白和卡他莫拉菌的200kDa外膜蛋白包含粘附素组分，而另一种抗原是Hin47蛋白的非蛋白水解类似物。每个成分不影响其他成分的免疫原性。多价免疫原性组合物可以与DTP组分疫苗组合，其也可以包括非毒性脊髓灰质炎病毒和PRP-T，以提供组分疫苗，而不损害其他抗原的免疫原性。

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