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1. 发明申请

WO9952947A3 TRANSFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译：转铁蛋白受体基因的MORAXELLA
公开(公告)号：WO9952947A3
公开(公告)日：1999-12-16
申请号：PCT/CA9900307
申请日：1999-04-12
申请人： CONNAUGHT LAB , MYERS LISA E , SCHRYVERS ANTHONY B , HARKNESS ROBIN E , LOOSMORE SHEENA M , RUN PAN DU , YANG YAN PING , KLEIN MICHEL H
发明人： MYERS LISA E , SCHRYVERS ANTHONY B , HARKNESS ROBIN E , LOOSMORE SHEENA M , DU RUN-PAN , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61K48/00 , C07K14/21 , C07K14/22 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/01 , G01N33/68 , C07K14/79
CPC分类号： C07K14/212 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51
摘要： Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码卡他莫拉菌M35,3和LES1的Tbp2蛋白。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组Tbp2蛋白。此外，核酸分子可以用于感染的诊断。

2. 发明申请

WO9640929A3 TRANSFERRIN RECEPTOR GENES 审中-公开
标题翻译：转铁蛋白受体基因
公开(公告)号：WO9640929A3
公开(公告)日：1997-03-06
申请号：PCT/CA9600399
申请日：1996-06-07
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , HARKNESS ROBIN E , SCHRYVERS ANTHONY B , CHONG PELE , GRAY OWEN SCOTT , YANG YAN PING , MURDIN ANDREW D , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , HARKNESS ROBIN E , SCHRYVERS ANTHONY B , CHONG PELE , GRAY-OWEN SCOTT , YANG YAN-PING , MURDIN ANDREW D , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/00 , A61K39/102 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/285 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/02 , C12N15/70 , C12N15/86
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C12N2799/021
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.

3. 发明申请

WO0055191A3 RECOMBINANT HAEMOPHILUS INFLUENZAE ADHESIN PROTEINS 审中-公开
标题翻译：重组HAEMOPHILUS INFLUENZAE粘蛋白蛋白
公开(公告)号：WO0055191A3
公开(公告)日：2001-08-02
申请号：PCT/CA0000289
申请日：2000-03-16
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/00 , A61K39/145 , A61P11/00 , A61P27/16 , A61P31/04 , A61P31/16 , C07K14/195 , C07K14/285 , C12N1/21 , C12P21/02 , C12R1/19 , A61K38/00 , C12N15/00
CPC分类号： C07K14/285 , A61K39/00
摘要： Recombinant production of Hia protein, in full-length and N-terminally truncated forms, of non-typeable strains of Haemophilus influenzae, is described. The nucleic acid and deduced amino acid sequences of Hia genes of various strains of non-typeable and type c Haemophilus influenzae also are described.
摘要翻译：描述了全长和N-末端截短形式的流感嗜血杆菌不可逆型菌株的Hia蛋白的重组产生。还描述了不同型和流感嗜血杆菌流感嗜血杆菌的各种不同菌株的Hia基因的核酸和推断的氨基酸序列。

4. 发明专利

AU1543900A Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease 未知
公开(公告)号：AU1543900A
公开(公告)日：2000-07-03
申请号：AU1543900
申请日：1999-12-15
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/102 , A61K39/116 , A61K39/13 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285 , A61K39/295
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

5. 发明申请

WO0105424A3 MULTI-COMPONENT VACCINE TO PROTECT AGAINST DISEASE CAUSED BY HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS 审中-公开
标题翻译：多元分子疫苗可以防止由海马流感引起的疾病和 MORAXELLA CATARRHALIS

公开(公告)号：WO0105424A3

公开(公告)日：2001-08-02

申请号：PCT/CA0000811

申请日：2000-07-11

申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H , SASAKI KEN

发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H , SASAKI KEN

IPC分类号： A61K39/116 , A61P31/04

CPC分类号： A61K39/102 , A61K39/1045 , A61K2039/55505 , A61K2039/70

摘要： A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis . Such composition comprises at least four antigens comprising at least one antigen from Haemophilus influenzae , and at least one antigen from Moraxella catarrhalis . Three of the antigens are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of Moraxella catarrhalis comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.

摘要翻译：多价免疫原性组合物赋予免疫宿主免受针对流感嗜血杆菌和卡他莫拉菌的<！ - SIPO - >引起的感染的保护。这样的组合物包含至少四种包含来自嗜血杆菌流感嗜血杆菌的至少一种抗原的抗原和至少一种来自卡他莫拉菌的抗原。三种抗原是粘附素。不可分泌的嗜血杆菌的高分子量（HMW）蛋白和流感嗜血杆菌粘附素（Hia）蛋白和卡他莫拉菌的200kDa外膜蛋白包含粘附素组分，而另一种抗原是Hin47蛋白的非蛋白水解类似物。每个成分不影响其他成分的免疫原性。多价免疫原性组合物可以与DTP组分疫苗组合，其也可以包括非毒性脊髓灰质炎病毒和PRP-T，以提供组分疫苗，而不损害其他抗原的免疫原性。

6. 发明申请

WO0035477A3 MULTI-COMPONENT VACCINE COMPRISING AT LEAST TWO ANTIGENS FROM HAEMOPHILUS INFLUENZAE 审中-公开
标题翻译：包含来自HAEMOPHILUS INFLUENZAE的至少两种抗原的多组分疫苗
公开(公告)号：WO0035477A3
公开(公告)日：2000-10-26
申请号：PCT/CA9901189
申请日：1999-12-15
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/102 , A61K39/116 , A61K39/13 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285 , A61K39/295
CPC分类号： A61K39/102
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.
摘要翻译：多组分免疫原性组合物赋予免疫宿主免受流感嗜血杆菌引起的感染的保护。这种组合物包含流感嗜血杆菌的至少两种不同的抗原，其中一种是粘附素。不可分型流感嗜血杆菌的高分子量（HMW）蛋白增强宿主中这种免疫原性组合物中Hin47蛋白的非蛋白水解类似物的免疫应答，其中一种成分不损害另一种免疫原性。嗜血杆菌疫苗可以与DTP组分疫苗组合以提供多价成分疫苗，而不损害其他抗原的免疫原性。

7. 发明申请

WO9855606A3 LACTOFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译： LACTOFERRIN受体基因的MORAXELLA
公开(公告)号：WO9855606A3
公开(公告)日：1999-03-04
申请号：PCT/CA9800544
申请日：1998-06-02
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , DU RUN-PAN , WANG QUIJUN , YANG YAN-PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , DU RUN-PAN , WANG QUIJUN , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P11/00 , A61P13/00 , A61P27/16 , A61P31/00 , C07K14/195 , C07K14/79 , C12N1/21 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/79 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode lactoferrin receptor proteins of Moraxella, such as M. catarrhalis, or a fragment or an analog of the lactoferrin receptor protein. The nucleic acid sequence may be used to produce recombinant lactoferrin receptor proteins Lbp1, Lbp2 or ORF3 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.

8. 发明申请

WO9603506A3 ANALOG OF HAEMOPHILUS HIN47 WITH REDUCED PROTEASE ACTIVITY 审中-公开
标题翻译：具有减少蛋白酶活性的HAEMOPHILUS HIN47的模拟物
公开(公告)号：WO9603506A3
公开(公告)日：1996-03-07
申请号：PCT/CA9500434
申请日：1995-07-21
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , CHONG PELE , OOMEN RAYMOND P , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , CHONG PELE , OOMEN RAYMOND P , KLEIN MICHEL H
IPC分类号： A61K39/00 , C07K14/285 , C12N9/52 , C12N15/31 , A61K39/102 , C07K19/00 , C12N1/21 , C12N15/70 , G01N33/569
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N9/52
摘要： The invention concerns isolated and purified analogs of Haemophilus influenza Hin47 protein with decreased protease activity (of less than 10 % of that of the natural protein) but preferably retaining substantially the same immunogenic properties as natural Hin47. Preferred analogs have mutations at Ser197, His91 and/or Asp121 positions and are possibly used as chimeric proteins with other immunogenic molecules. Also disclosed are nucleic acid encoding said analogs, recombinant plasmids and transformed host cells containing said modified genes, immunogenic compositions containing Hin47 analogs or their nucleic acid and their use for prophylactic, vaccine or diagnostic purposes.

9. 发明申请

WO0051633A2 MULTI-COMPONENT VACCINE COMPRISING AT LEAST THREE ANTIGENS TO PROTECT AGAINST DISEASE CAUSED BY HAEMOPHILUS INFLUENZAE 审中-公开
标题翻译：包含至少三种抗原的多组分疫苗可以防治HAEMOPHILUS INFLUENZAE引起的疾病
公开(公告)号：WO0051633A2
公开(公告)日：2000-09-08
申请号：PCT/CA0000207
申请日：2000-02-29
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： A61K39/102 , A61K39/116 , A61K39/295 , A61P31/04 , A61P31/16
CPC分类号： A61K39/102 , A61K2039/55505
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least three different antigens of Haemophilus influenzae, two of which are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus influenzae comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The Haemophilus vaccine may be combined with DTP component vaccines, which may contain inactivated poliovirus, including type 1, type 2 and/or type 3, and/or a conjugate of a capsular polysaccharide of Haemophilus influenzae and tetanus or diphtheria toxoid, including PRP-T, to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.
摘要翻译：多组分免疫原性组合物赋予免疫宿主免受流感嗜血杆菌引起的感染的保护。这种组合物包含流感嗜血杆菌的至少三种不同的抗原，其中两种是粘附素。不可分型流感嗜血杆菌的高分子量（HMW）蛋白和流感嗜血杆菌粘附素（Hia）蛋白包含粘附素组分，而另一种抗原是Hin47蛋白的非蛋白水解类似物。每个成分不影响其他成分的免疫原性。嗜血杆菌疫苗可以与DTP组分疫苗组合，其可以含有灭活的脊髓灰质炎病毒，包括1型，2型和/或3型，和/或流感嗜血杆菌和破伤风或白喉类毒素的荚膜多糖的缀合物，包括PRP- T，以提供多价成分疫苗，而不损害其他抗原的免疫原性。

10. 发明申请

WO0020609A3 PROTECTIVE RECOMBINANT HAEMOPHILUS INFLUENZAE HIGH MOLECULAR WEIGHT PROTEINS 审中-公开
标题翻译：保护性重组蛋白流感嗜血杆菌高分子量蛋白
公开(公告)号：WO0020609A3
公开(公告)日：2000-08-03
申请号：PCT/CA9900938
申请日：1999-10-07
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K9/127 , A61K9/14 , A61K9/48 , A61K39/00 , A61K39/102 , A61P31/04 , C07K14/195 , C07K14/285 , C12N1/12 , C12N1/13 , C12N1/21 , C12N15/31 , C12N15/70 , C12P21/02 , C12R1/93 , A61K31/70 , A61K38/16
CPC分类号： C07K14/285 , A61K39/00 , C12N15/70
摘要： Protective high molecular weight (HMW) proteins are produced recombinantly by expression from E. coli by using a promoter effective in E. coli and a nucleic acid molecule which contains a modified operon of a non-typeable strain of Haemophilus. The modified operon contains the portion only of the A region which encodes the mature HMW protein and the complete B and C regions of the operon. Enhanced levels of expression of the HMW proteins can be achieved by including the E. coli cer gene, a further copy of the portion of the A region of the operon encoding the mature protein or both, in the expression vector. Nucleotide and deduced amino acid sequences of the hmw1 and hmw2 genes and HMW1 and HMW2 proteins, respectively, of several non-typeable Haemophilus influenzae strain have been identified.
摘要翻译：通过使用在大肠杆菌中有效的启动子和含有嗜血杆菌不可分型菌株的修饰操纵子的核酸分子，通过大肠杆菌表达重组产生保护性高分子量（HMW）蛋白质。修饰的操纵子仅含有编码成熟HMW蛋白的A区和操纵子的完整B区和C区的部分。通过在表达载体中包含大肠杆菌cer基因，编码成熟蛋白或两者的操纵子的A区的部分的进一步拷贝，可以实现HMW蛋白表达水平的提高。已鉴定出几种不可分型的流感嗜血杆菌菌株的hmw1和hmw2基因以及HMW1和HMW2蛋白的核苷酸和推导的氨基酸序列。

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