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    • 8. 发明申请
    • NON-NATURAL PROTEINACEOUS SCAFFOLD MADE OF THREE NON-COVALENTLY ASSOCIATED PEPTIDES
    • 三非相关肽的非天然蛋白质组蛋白
    • WO2009030780A2
    • 2009-03-12
    • PCT/EP2008/061886
    • 2008-09-08
    • COMPLIX NVDESMET, JohanLASTERS, Ignace
    • DESMET, JohanLASTERS, Ignace
    • C07K14/435
    • C07K1/00C07K7/08C07K14/001C07K2318/20
    • The present invention is related to a non- natural, thermodynamically stable, proteinaceous scaffold consisting of three non-covalently associated peptides, wherein each peptide sequence comprises less than fifty amino acid residues and wherein at least 50% of the said residues are substitutable amino acids into at least ten different amino acid residue types. The present invention is further related to a non-natural, triple-stranded, parallel alpha-helical coiled coil scaffold wherein each of the three constituting peptide sequences comprise between 2 and 7 consecutive heptad repeats, wherein at least 50% of the core residues are isoleucines, wherein all non-core residues are alanines, and wherein the constituting peptide sequences remain associated under physical conditions that are significantly different from physiological conditions.
    • 本发明涉及由三种非共价相关肽组成的非天然的热力学稳定的蛋白质支架,其中每个肽序列包含少于五十个氨基酸残基,并且其中至少50%的所述残基是可取代的氨基酸 至少十种不同的氨基酸残基类型。 本发明进一步涉及非天然的,三链的平行的α-螺旋卷曲的线圈支架,其中三个构成的肽序列中的每一个包含2-7个连续的七重复重复序列,其中至少50%的核心残基是 异亮氨酸,其中所有非核残基是丙氨酸,并且其中构成的肽序列在与生理条件显着不同的物理条件下保持相关。