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1. 发明申请

WO2012093172A1 ALPHABODIES SPECIFICALLY BINDING TO CYTOKINES OR GROWTH FACTORS AND/OR CYTOKINE OR GROWTH FACTOR RECEPTORS 审中-公开
标题翻译： ALPHABODIES特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体
公开(公告)号：WO2012093172A1
公开(公告)日：2012-07-12
申请号：PCT/EP2012/050193
申请日：2012-01-06
申请人： COMPLIX NV , LASTERS, Ignace , DESMET, Johan , HENDERIKX, Maria , WEHNERT, Anita , MEERSSEMAN, Geert
发明人： LASTERS, Ignace , DESMET, Johan , HENDERIKX, Maria , WEHNERT, Anita , MEERSSEMAN, Geert
IPC分类号： C07K16/24 , C07K14/00
CPC分类号： C07K14/001 , C07K16/244 , C07K16/2866 , C07K2317/33 , C07K2318/20
摘要： Alphabodies that specifically bind to cytokines or growth factor and/or their receptors, as well as polypeptides that comprise or essentially consist of such Alphabodies. Further nucleic acids encoding such Alphabodies; methods for preparing such Alphabodies and polypeptides; host cells expressing or capable of expressing such Alphabodies and polypeptides; compositions, and in particular pharmaceutical compositions, that comprise such Alphabodies, polypeptides, nucleic acids and/or host cells; and uses of such Alphabodies or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：与细胞因子或生长因子和/或其受体特异性结合的抗体，以及包含或基本上由此类Alphabody组成的多肽。编码这样的阿片受体的另外的核酸; 制备此类抗体和多肽的方法; 表达或能够表达此类α受体和多肽的宿主细胞; 组合物，特别是药物组合物，其包含这样的阿片受体，多肽，核酸和/或宿主细胞; 以及这些阿拉伯抗体或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

2. 发明申请

WO2011003935A1 PARATHYROID HORMONE RELATED PROTEIN ANTAGONISTS 审中-公开
标题翻译： PARATHYROID HORMONE相关蛋白质拮抗剂
公开(公告)号：WO2011003935A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059713
申请日：2010-07-07
申请人： COMPLIX NV , LOVERIX, Stefan , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie , VAN GELDER, Patrick
发明人： LOVERIX, Stefan , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie , VAN GELDER, Patrick
IPC分类号： C07K1/00 , C07K7/08 , C07K14/00
CPC分类号： C07K14/001 , C07K14/635 , C07K2318/20 , G01N33/574 , G01N2333/635
摘要： The present invention relates to PTHrP-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted 'Alphabodies', nucleic acids encoding said Aiphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of cancer using said Alphabodies.
摘要翻译：本发明涉及表示为“Alphabodies”，编码所述Aiphabodies的核酸，包含所述核酸的宿主细胞以及包含所述Alphabody的药物组合物的PTHrP结合单链3-链α-螺旋卷曲螺旋分子，以及方法用于使用所述的Alphabodies来治疗，预防和诊断癌症。

3. 发明申请

WO2012092971A1 ALPHABODIES SPECIFICALLY BINDING TO VIRAL PROTEINS AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译：特异性绑定到病毒蛋白质的方法及其生产方法
公开(公告)号：WO2012092971A1
公开(公告)日：2012-07-12
申请号：PCT/EP2011/050137
申请日：2011-01-06
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace , MEERSSEMAN, Geert , DEROO, Sabrina
发明人： DESMET, Johan , LASTERS, Ignace , MEERSSEMAN, Geert , DEROO, Sabrina
IPC分类号： C07K16/10 , C07K14/00
CPC分类号： C07K16/08 , A61K39/00 , C07K16/1063 , C07K2317/92 , C07K2318/20 , G01N33/56988
摘要： The invention provides methods for the production of single-chain Alphabody polypeptides having detectable binding affinity for, or detectable in vitro activity on, a viral protein of interest, which comprising the step of producing a single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein said variegated amino acid residue positions are located at specific positions in one or more of the alpha-helices of the Alphabody or the linker fragment connecting two consecutive alpha-helices of the Alphabody polypeptides. The invention further provides Alphabodies obtainable by the methods of the invention and uses thereof.
摘要翻译：本发明提供了生产具有对感兴趣的病毒蛋白质具有可检测的结合亲和力或可检测的体外活性的单链阿拉伯糖苷多肽的方法，其包括产生包含至少100个不同序列的单链Alphabody文库的步骤，序列单链Alphabody多肽，其中所述Alphabody多肽在限定的5至20个杂化氨基酸残基位置中的至少一个中彼此不同，并且其中所述杂色氨基酸残基位置位于一个或多个的Alphabody的α-螺旋或连接Alphabody多肽的两个连续的α-螺旋的连接子片段。本发明还提供了可通过本发明的方法获得的阿尔培布本及其用途。

4. 发明申请

WO2012092970A1 ALPHABODY LIBRARIES AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译： ALPHABODY LIBRARIES及其生产方法
公开(公告)号：WO2012092970A1
公开(公告)日：2012-07-12
申请号：PCT/EP2011/050135
申请日：2011-01-06
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace , HENDERIKX, Maria , WEHNERT, Anita
发明人： DESMET, Johan , LASTERS, Ignace , HENDERIKX, Maria , WEHNERT, Anita
IPC分类号： C07K16/24 , C07K14/00 , C12N15/10
CPC分类号： C07K16/244 , C07K14/001 , C07K16/00 , C07K16/005 , C07K2317/33 , C07K2318/20 , C12N15/1037 , C12N15/1055 , C40B40/10 , C40B50/12
摘要： The invention provides single-chain Alphabody library comprising at least 100 different- sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.
摘要翻译：本发明提供了包含至少100个不同序列的单链Alphabody多肽的单链Alphabody文库，其中所述Alphabody多肽在至少一个定义的5至20个杂化氨基酸残基位置中彼此不同，并且其中在至少70％但不是全部所述杂色氨基酸残基位置位于Alphabody的环，螺旋表面或连接区中。本发明进一步提供了通过本发明方法可获得的使用阿尔法抗体文库和阿尔培布氏体的方法。

5. 发明申请

WO2012093013A1 ALPHABODIES SPECIFICALLY BINDING TO CLASS-I VIRAL FUSION PROTEINS AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译：字体特殊绑定到类别的病毒融合蛋白及其生产方法
公开(公告)号：WO2012093013A1
公开(公告)日：2012-07-12
申请号：PCT/EP2011/071634
申请日：2011-12-02
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace , MEERSSEMAN, Geert , DEROO, Sabrina
发明人： DESMET, Johan , LASTERS, Ignace , MEERSSEMAN, Geert , DEROO, Sabrina
IPC分类号： C07K16/10 , C07K14/00
CPC分类号： C07K14/00 , C07K16/1027 , C07K16/1063 , C07K2317/76 , C07K2317/92 , C07K2318/20
摘要： Single-chain Alphabodies that comprise an alpha-helical binding region which mediates binding to a first fusion-driving region of a class- 1 viral fusion protein and which structurally mimics a second fusion - driving region of said class-1 viral fusion protein, wherein said first and second fusion - driving regions of said class-1 viral fusion protein are regions which interact to drive the fusion between a virus displaying said class- 1 viral fusion protein and a target cell.
摘要翻译：单链抗体，其包含介导与第1类病毒融合蛋白的第一融合驱动区结合并且结构上模拟所述1类病毒融合蛋白的第二融合驱动区的α螺旋结合区，其中所述1类病毒融合蛋白的第一和第二融合驱动区域是相互作用以驱动显示所述1类病毒融合蛋白的病毒与靶细胞之间的融合的区域。

6. 发明申请

WO2010066740A1 SINGLE-CHAIN ANTIPARALLEL COILED COIL PROTEINS 审中-公开
标题翻译：单链抗纤维线圈蛋白
公开(公告)号：WO2010066740A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066640
申请日：2009-12-08
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace , LOVERIX, Stefan
发明人： DESMET, Johan , LASTERS, Ignace , LOVERIX, Stefan
IPC分类号： C07K1/00 , C07K7/08 , C07K14/00
CPC分类号： C07K1/1075 , C07K14/001 , C07K2318/20 , G01N33/6845
摘要： The present invention relates to single-chain proteins of the formula HRS1-L1-HRS2-L2-HRS3, wherein HRS1, HRS2 and HRS3 are heptad repeat sequences and L1 and L2 are structurally flexible linker sequences, and wherein HRS1, HRS2 and HRS3 form a thermodynamically stable triple-stranded, antiparallel, alpha-helical coiled coil structure in aqueous solution. The invention also relates to amino acid sequence variants, conditions and methods to obtain such proteins and variants, and usages thereof, especially their usage as scaffolds and as therapeutic products.
摘要翻译：本发明涉及式HRS1-L1-HRS2-L2-HRS3的单链蛋白，其中HRS1，HRS2和HRS3是七重复序列，L1和L2是结构上柔性的接头序列，其中HRS1，HRS2和HRS3形成在水溶液中的热力学稳定的三股，反向平行的α-螺旋卷曲螺旋结构。本发明还涉及获得这种蛋白质和变体的氨基酸序列变体，条件和方法，以及其用途，特别是其作为支架和用作治疗产品的用途。

7. 发明申请

WO2011003936A1 ALPHABODIES FOR HIV ENTRY INHIBITION 审中-公开
标题翻译：用于艾滋病毒入侵抑制的字体
公开(公告)号：WO2011003936A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059714
申请日：2010-07-07
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie
发明人： DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/1063 , C07K2318/20 , C12N2740/16122 , G01N33/56988 , G01N2333/162 , G01N2500/00
摘要： The present invention relates to HIV- 1 gρ41-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted "Alphabodies", nucleic acids encoding said Alphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of HIV infection using said Alphabodies.
摘要翻译：本发明涉及表示为“Alphabodies”的编码所述Alphabody的核酸，包含所述核酸的宿主细胞以及药物组合物的HIV-1β1-结合单链3链α-螺旋卷曲螺旋分子，以及包含阿拉伯人，以及使用所述阿拉伯人治疗，预防和诊断艾滋病毒感染的方法。

8. 发明申请

WO2009030780A2 NON-NATURAL PROTEINACEOUS SCAFFOLD MADE OF THREE NON-COVALENTLY ASSOCIATED PEPTIDES 审中-公开
标题翻译：三非相关肽的非天然蛋白质组蛋白
公开(公告)号：WO2009030780A2
公开(公告)日：2009-03-12
申请号：PCT/EP2008/061886
申请日：2008-09-08
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace
发明人： DESMET, Johan , LASTERS, Ignace
IPC分类号： C07K14/435
CPC分类号： C07K1/00 , C07K7/08 , C07K14/001 , C07K2318/20
摘要： The present invention is related to a non- natural, thermodynamically stable, proteinaceous scaffold consisting of three non-covalently associated peptides, wherein each peptide sequence comprises less than fifty amino acid residues and wherein at least 50% of the said residues are substitutable amino acids into at least ten different amino acid residue types. The present invention is further related to a non-natural, triple-stranded, parallel alpha-helical coiled coil scaffold wherein each of the three constituting peptide sequences comprise between 2 and 7 consecutive heptad repeats, wherein at least 50% of the core residues are isoleucines, wherein all non-core residues are alanines, and wherein the constituting peptide sequences remain associated under physical conditions that are significantly different from physiological conditions.
摘要翻译：本发明涉及由三种非共价相关肽组成的非天然的热力学稳定的蛋白质支架，其中每个肽序列包含少于五十个氨基酸残基，并且其中至少50％的所述残基是可取代的氨基酸至少十种不同的氨基酸残基类型。本发明进一步涉及非天然的，三链的平行的α-螺旋卷曲的线圈支架，其中三个构成的肽序列中的每一个包含2-7个连续的七重复重复序列，其中至少50％的核心残基是异亮氨酸，其中所有非核残基是丙氨酸，并且其中构成的肽序列在与生理条件显着不同的物理条件下保持相关。

9. 发明申请

WO2004092207A3 RESPIRATORY SYNCYTIAL VIRUS (RSV) PEPTIDES 审中-公开
公开(公告)号：WO2004092207A3
公开(公告)日：2004-10-28
申请号：PCT/EP2004/004061
申请日：2004-04-16
申请人： ALGONOMICS N.V. , LASTERS, Ignace , DESMET, Johan , STEGMANN, Toon
发明人： LASTERS, Ignace , DESMET, Johan , STEGMANN, Toon
IPC分类号： C07K14/135
摘要： The present invention relates to peptides which are suitable for inducing an immune response to RSV and to the use of said peptides for the preparations of vaccines, compositions and in methods of diagnosis.

10. 发明申请

WO2003105058A3 METHOD FOR PREDICTING THE BINDING AFFINITY OF MHC/PEPTIDE COMPLEXES 审中-公开
公开(公告)号：WO2003105058A3
公开(公告)日：2003-12-18
申请号：PCT/EP2003/006049
申请日：2003-06-10
申请人： ALGONOMICS N.V. , LASTERS, Ignace , DESMET, Johan
发明人： LASTERS, Ignace , DESMET, Johan
IPC分类号： G06F19/00
摘要： The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immunotherapeutic agents.

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