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1. 发明申请

WO2008125747A3 FLUORESCENT EMULSIONS FOR OPTICAL IMAGING 审中-公开
标题翻译：用于光学成像的荧光乳液
公开(公告)号：WO2008125747A3
公开(公告)日：2009-03-19
申请号：PCT/FR2008000196
申请日：2008-02-14
申请人： COMMISSARIAT ENERGIE ATOMIQUE , CENTRE NAT RECH SCIENT , UNIV PARIS CURIE , GOUTAYER MATHIEU , TEXIER-NOGUES ISABELLE , FATTACCIOLI JACQUES , BIBETTE JEROME , DA SILVA ANABELA
发明人： GOUTAYER MATHIEU , TEXIER-NOGUES ISABELLE , FATTACCIOLI JACQUES , BIBETTE JEROME , DA SILVA ANABELA
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
摘要翻译：本发明涉及荧光乳剂，含有该荧光乳剂的诊断试剂及其在制备用于体内荧光成像的诊断试剂中的用途。

2. 发明申请

WO2008104717A3 METHOD FOR PREPARING NANO-EMULSIONS 审中-公开
标题翻译：制备纳米乳液的方法
公开(公告)号：WO2008104717A3
公开(公告)日：2009-02-19
申请号：PCT/FR2008050249
申请日：2008-02-14
申请人： COMMISSARIAT ENERGIE ATOMIQUE , BIBETTE JEROME , GOUTAYER MATHIEU , TEXIER-NOGUES ISABELLE
发明人： BIBETTE JEROME , GOUTAYER MATHIEU , TEXIER-NOGUES ISABELLE
IPC分类号： B01F17/14 , B01F3/08 , B01F17/42 , B01J13/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a method for preparing nano-emulsions including at least one continuous aqueous phase and at least one dispersed oily phase, said method comprising the steps of : (i) preparing the oily phase containing at least one amphiphilic lipid and at least one solubilising lipid; (ii) dispersing the oily phase into an aqueous phase under the action of a shear force sufficient for forming a nano-emulsion; and (iii) recovering the nano-emulsion thus obtained.
摘要翻译：本发明涉及一种制备包括至少一个连续水相和至少一个分散的油相的纳米乳液的方法，所述方法包括以下步骤：（i）制备含有至少一种两亲脂质和至少一种增溶脂质; （ii）在足以形成纳米乳液的剪切力的作用下将油相分散到水相中; 和（iii）回收由此获得的纳米乳液。

3. 发明申请

WO2012120043A3 METHOD FOR FORMING DROPS OF A FIRST PHASE DISPERSED IN A SECOND PHASE SUBSTANTIALLY IMMISCIBLE WITH THE FIRST PHASE 审中-公开
标题翻译：在第一相中形成第一相分散的第一相的速率的方法，其主要不可能与第一相
公开(公告)号：WO2012120043A3
公开(公告)日：2013-12-05
申请号：PCT/EP2012053917
申请日：2012-03-07
申请人： CAPSUM , GOUTAYER MATHIEU , BIBETTE JEROME
发明人： GOUTAYER MATHIEU , BIBETTE JEROME
IPC分类号： B01J13/10 , A23K1/00 , A23P1/04 , A61K8/11 , A61K9/50 , C11D3/50
CPC分类号： A61K8/8147 , A23D7/0053 , A23D7/02 , A23P10/30 , A61K8/062 , A61K8/11 , A61K8/31 , A61K8/891 , A61K8/922 , A61K9/10 , A61K9/5026 , A61K47/32 , A61K47/34 , A61K2800/412 , A61Q19/00 , B01J13/10
摘要： In the disclosed method, a first fluid (36) comprising the first phase and a first precursor polymer of the coacervate in the first phase is supplied, and drops of the first fluid (36) are formed in a second fluid (40) that is to form the second phase (16). The method includes the steps of introducing a second precursor polymer of the coacervate into the second fluid (40), and creating the coacervate layer by having the first precursor polymer interact with the second precursor polymer at the interface between the first phase (14) and the second phase (16) when each drop (12) is formed or once each drop (12) has been formed.
摘要翻译：在所公开的方法中，提供包含第一相和第一相中凝聚层的第一前体聚合物的第一流体（36），第一流体（36）的液滴形成在第二流体（40）中，第二流体以形成第二阶段（16）。该方法包括以下步骤：将凝聚层的第二前体聚合物引入第二流体（40）中，并通过使第一前体聚合物与第二前体聚合物在第一相（14）和当形成每个液滴（12）时，第二阶段（16）或每个液滴（12）已经形成。

4. 发明申请

WO0185319A9 METHOD FOR PREPARING A MONODISPERSED DOUBLE EMULSION 审中-公开
标题翻译：制备单一乳液的方法
公开(公告)号：WO0185319A9
公开(公告)日：2008-10-02
申请号：PCT/FR0101397
申请日：2001-05-09
申请人： CENTRE NAT RECH SCIENT , LEAL CALDERON FERNANDO , GORRIA PHILIPPE , BIBETTE JEROME
发明人： LEAL CALDERON FERNANDO , GORRIA PHILIPPE , BIBETTE JEROME
IPC分类号： B01F3/08 , B01F9/10
CPC分类号： B01F9/103 , B01F3/0811 , B01F3/0819 , B01F3/0853
摘要： The invention concerns a method for preparing a monodispersed double water/oil/water emulsion, characterised in that it consists in: a) subjecting a polydispersed oil-in-water emulsion Ei comprising 55 to 99 wt. % of an aqueous phase, to a controlled shearing so that a common maximum shearing is applied to the entire emulsion, so as to obtain the corresponding monodispersed invert emulsion; b) adding to said emulsion, without phase inversion, the necessary amount of diluting oil phase so that the aqueous phase of the resulting emulsion represents at least 50 wt. % of the emulsion total weight; and c) introducing the resulting emulsion into a high pressure homogenizer, together with a continuous aqueous phase, the respective amounts of said emulsion and said continuous aqueous phase being such that the resulting double emulsion comprises up to 50 wt. % of invert emulsion droplets relative to the emulsion total weight, said continuous aqueous phase comprising a hydrophilic surfactant concentration not more that 0.02 times the critical micellar concentration.
摘要翻译：本发明涉及一种制备单分散双水/油/水乳液的方法，其特征在于：其包括：a）将多分散的水包油乳液Ei进行包含55至99wt。％的水相，进行受控的剪切，使得对整个乳液施加共同的最大剪切，以获得相应的单分散的反相乳液; b）在没有相转化的情况下向所述乳液中加入所需量的稀释油相，使得所得乳液的水相至少为50重量％。乳液总重量的百分比; 和c）将所得乳液与连续水相一起引入高压均化器中，所述乳液和所述连续水相的相应量使得所得双重乳液包含至多50重量％相对于乳液总重量的反相乳液液滴的百分比，所述连续水相包含亲水性表面活性剂浓度不超过临界胶束浓度的0.02倍。

5. 发明申请

WO2009029229A3 FERROFLUID EMULSIONS, PARTICLES, AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译： FERROFLUID乳液，颗粒和用于制造和使用其的系统和方法
公开(公告)号：WO2009029229A3
公开(公告)日：2009-04-16
申请号：PCT/US2008010020
申请日：2008-08-22
申请人： HARVARD COLLEGE , SANTANACH CARRERAS ENRIC , BIBETTE JEROME , WEITZ DAVID A
发明人： SANTANACH CARRERAS ENRIC , BIBETTE JEROME , WEITZ DAVID A
IPC分类号： B01J13/04
CPC分类号： B01F3/0807 , B01F13/0062 , B01J2219/005
摘要： The present invention generally relates to ferrofluid emulsions and/or magnetically susceptible particles. In some cases, such emulsions and particles can be produced in a microfluidic system. In one aspect, an emulsion containing a ferrofluid can be produced, and in certain cases, the emulsion is substantially monodisperse. In some embodiments, the emulsion also contains a precursor that can be solidified, for example, a polymer precursor. The emulsion may also contain an emulsion stabilizing agent and/or a viscous agent. In another aspect of the present invention, the ferrofluid emulsion may be hardened to form particles, for example, by removing a fluid from the emulsion and/or by solidifying a precursor, such as a polymer precursor, around the emulsion. For example, the ferrofluid may be formed from an organic solvent containing nanoparticles, and the organic solvent removed such that the nanoparticles form magnetically susceptible particles. The particles may also be further manipulated, for example, using a magnet. For instance, in one set of embodiments, the particles may be moved from one fluid stream to another fluid stream using the magnet, for example, for further processing, reaction, analysis, etc., of the particles. In some cases, the particles may be formed "on demand," e.g., for a variety of different applications.
摘要翻译：本发明一般涉及铁磁流体乳液和/或磁敏颗粒。在一些情况下，这种乳液和颗粒可以在微流体系统中生产。一方面，可以生产含有铁磁流体的乳液，并且在某些情况下，乳液基本上是单分散的。在一些实施方案中，乳液还含有可以固化的前体，例如聚合物前体。该乳液还可以含有乳液稳定剂和/或粘稠剂。在本发明的另一个方面中，例如通过从乳液中除去流体和/或通过在乳液周围固化前体如聚合物前体，铁磁流体乳液可以被硬化以形成颗粒。例如，铁磁流体可以由含有纳米颗粒的有机溶剂形成，并且去除有机溶剂使得纳米颗粒形成磁敏颗粒。例如，还可以使用磁体来进一步处理颗粒。例如，在一组实施例中，可以使用磁体将颗粒从一个流体流移动到另一个流体流，例如用于颗粒的进一步处理，反应，分析等。在一些情况下，颗粒可以“按需”形成，例如用于各种不同的应用。

6. 发明专利

FR3031914A1 PROCEDE D'ENCAPSULATION 未知
公开(公告)号：FR3031914A1
公开(公告)日：2016-07-29
申请号：FR1550617
申请日：2015-01-27
申请人： BIBETTE JEROME , WALTERS JAMIE DEAN
发明人： BIBETTE JEROME , WALTERS JAMIE DEAN
IPC分类号： B01J13/16
摘要： La présente invention concerne un procédé de préparation de capsules solides comprenant un composé A, dispersées dans une composition C4.

7. 发明专利

NO20042579L 未知
公开(公告)号：NO20042579L
公开(公告)日：2004-06-18
申请号：NO20042579
申请日：2004-06-18
申请人： BIBETTE JEROME
发明人： ROUSSEAU ALAIN , BAUDRY JEAN , BIBETTE JEROME
IPC分类号： G01N33/553 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/569
摘要： Detecting and/or quantifying (M1) at least one analyte (A) in a liquid comprising using colloidal magnetic particles (B), functionalized on the surface with at least one ligand (L) specific for (A), is new. M1 comprises: (a) combining test sample and (B); (b) applying a magnetic field strong enough to structure (B) as chains; (c) maintaining the field for long enough to allow coupling/association of (I) with at least two (L), present on two adjacent particles in the chain; (d) turning of the field; and (e) detecting presence/absence of (I), and optionally its concentration, from the presence/absence of permanent chains of (B). An Independent claim is also included for a reagent kit containing (B).

8. 发明专利

FR2959820B1 PROCEDE DE DOSAGE D'UN ANALYTE DANS UN MILIEU LIQUIDE 未知
公开(公告)号：FR2959820B1
公开(公告)日：2013-03-15
申请号：FR1053630
申请日：2010-05-10
申请人： BERTIN TECHNOLOGIES SA , BAUDRY JEAN , BIBETTE JEROME
发明人： BAUDRY JEAN , BIBETTE JEROME , BRIENT-LITZLER ELODIE , COMPAIN ERIC , BONHOMME CATHERINE
IPC分类号： G01N33/543

9. 发明专利

FR2959820A1 PROCEDE DE DOSAGE D'UN ANALYTE DANS UN MILIEU LIQUIDE 未知
公开(公告)号：FR2959820A1
公开(公告)日：2011-11-11
申请号：FR1053630
申请日：2010-05-10
申请人： BERTIN TECHNOLOGIES SA , BAUDRY JEAN , BIBETTE JEROME
发明人： BAUDRY JEAN , BIBETTE JEROME , BRIENT-LITZLER ELODIE , COMPAIN ERIC , BONHOMME CATHERINE
IPC分类号： G01N33/543
摘要： Procédé de dosage d'un analyte dans un milieu liquide par réaction avec des ligands portés par des particules magnétiques, le procédé consistant à faire agir sur le milieu liquide un champ magnétique de réaction pour former des amas de particules, et à mesurer la valeur ou la variation de paramètres tels que la densité optique ou les propriétés polarimétriques de la solution suite à l'application, la modification ou la coupure d'un champ magnétique de mesure.

10. 发明专利

AT431553T 未知
公开(公告)号：AT431553T
公开(公告)日：2009-05-15
申请号：AT02796851
申请日：2002-11-20
申请人： STAGO DIAGNOSTICA , BIBETTE JEROME
发明人： BIBETTE JEROME , BAUDRY JEAN , ROUSSEAU ALAIN
IPC分类号： G01N33/543 , G01N33/553 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/566 , G01N33/569
摘要： Detecting and/or quantifying (M1) at least one analyte (A) in a liquid comprising using colloidal magnetic particles (B), functionalized on the surface with at least one ligand (L) specific for (A), is new. M1 comprises: (a) combining test sample and (B); (b) applying a magnetic field strong enough to structure (B) as chains; (c) maintaining the field for long enough to allow coupling/association of (I) with at least two (L), present on two adjacent particles in the chain; (d) turning of the field; and (e) detecting presence/absence of (I), and optionally its concentration, from the presence/absence of permanent chains of (B). An Independent claim is also included for a reagent kit containing (B).

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