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1. 发明申请

WO0185319A9 METHOD FOR PREPARING A MONODISPERSED DOUBLE EMULSION 审中-公开
标题翻译：制备单一乳液的方法
公开(公告)号：WO0185319A9
公开(公告)日：2008-10-02
申请号：PCT/FR0101397
申请日：2001-05-09
申请人： CENTRE NAT RECH SCIENT , LEAL CALDERON FERNANDO , GORRIA PHILIPPE , BIBETTE JEROME
发明人： LEAL CALDERON FERNANDO , GORRIA PHILIPPE , BIBETTE JEROME
IPC分类号： B01F3/08 , B01F9/10
CPC分类号： B01F9/103 , B01F3/0811 , B01F3/0819 , B01F3/0853
摘要： The invention concerns a method for preparing a monodispersed double water/oil/water emulsion, characterised in that it consists in: a) subjecting a polydispersed oil-in-water emulsion Ei comprising 55 to 99 wt. % of an aqueous phase, to a controlled shearing so that a common maximum shearing is applied to the entire emulsion, so as to obtain the corresponding monodispersed invert emulsion; b) adding to said emulsion, without phase inversion, the necessary amount of diluting oil phase so that the aqueous phase of the resulting emulsion represents at least 50 wt. % of the emulsion total weight; and c) introducing the resulting emulsion into a high pressure homogenizer, together with a continuous aqueous phase, the respective amounts of said emulsion and said continuous aqueous phase being such that the resulting double emulsion comprises up to 50 wt. % of invert emulsion droplets relative to the emulsion total weight, said continuous aqueous phase comprising a hydrophilic surfactant concentration not more that 0.02 times the critical micellar concentration.
摘要翻译：本发明涉及一种制备单分散双水/油/水乳液的方法，其特征在于：其包括：a）将多分散的水包油乳液Ei进行包含55至99wt。％的水相，进行受控的剪切，使得对整个乳液施加共同的最大剪切，以获得相应的单分散的反相乳液; b）在没有相转化的情况下向所述乳液中加入所需量的稀释油相，使得所得乳液的水相至少为50重量％。乳液总重量的百分比; 和c）将所得乳液与连续水相一起引入高压均化器中，所述乳液和所述连续水相的相应量使得所得双重乳液包含至多50重量％相对于乳液总重量的反相乳液液滴的百分比，所述连续水相包含亲水性表面活性剂浓度不超过临界胶束浓度的0.02倍。

2. 发明申请

WO2010007307A3 METHOD AND DEVICE FOR READING AN EMULSION 审中-公开
标题翻译：用于读取乳剂的方法和装置
公开(公告)号：WO2010007307A3
公开(公告)日：2010-04-08
申请号：PCT/FR2009051396
申请日：2009-07-13
申请人： UNIV PARIS CURIE , CENTRE NAT RECH SCIENT , BAUDRY JEAN , SYLVESTRE JULIEN , BIBETTE JEROME , BOITARD LAURENT , BREMOND NICOLAS
发明人： BAUDRY JEAN , SYLVESTRE JULIEN , BIBETTE JEROME , BOITARD LAURENT , BREMOND NICOLAS
IPC分类号： B01F13/00 , G01N15/14
CPC分类号： G01N15/1475 , G01N2015/003 , G01N2015/0092
摘要： The present invention relates to a method for reading an emulsion (3) comprising drops and a continuous phase surrounding the drops, wherein said method comprises: two-dimensional scanning of the emulsion (3), and construction of a two-dimensional image of the emulsion (3) on the basis of said scanning. Preferably, the drops do not move during the scanning, this being achieved, for example, by solidifying the continuous phase or by using a compact or semi-compact two-dimensional network of drops. The method according to the invention may also comprise monitoring over time a chemical or biological reaction taking place in at least one of the drops. The invention also relates to a device which implements this method. Use in the detection and/or sorting of microdrops playing the role of microreactors or containing specific cells or molecules, in fields such as gene expression or diagnosis.
摘要翻译：本发明涉及一种用于读取包含液滴和液滴周围的连续相的乳液（3）的方法，其中所述方法包括：对乳液（3）进行二维扫描，并且构建二维图像乳剂（3）基于所述扫描。优选地，液滴在扫描期间不移动，这例如通过固化连续相或通过使用紧凑或半紧凑的液滴二维网络来实现。根据本发明的方法还可以包括随时间监测在至少一个液滴中发生的化学或生物反应。本发明还涉及实现该方法的设备。用于基因表达或诊断等领域中检测和/或分选微滴反应器中发挥微反应器作用或含有特定细胞或分子的微滴。

3. 发明申请

WO2008125747A3 FLUORESCENT EMULSIONS FOR OPTICAL IMAGING 审中-公开
标题翻译：用于光学成像的荧光乳液
公开(公告)号：WO2008125747A3
公开(公告)日：2009-03-19
申请号：PCT/FR2008000196
申请日：2008-02-14
申请人： COMMISSARIAT ENERGIE ATOMIQUE , CENTRE NAT RECH SCIENT , UNIV PARIS CURIE , GOUTAYER MATHIEU , TEXIER-NOGUES ISABELLE , FATTACCIOLI JACQUES , BIBETTE JEROME , DA SILVA ANABELA
发明人： GOUTAYER MATHIEU , TEXIER-NOGUES ISABELLE , FATTACCIOLI JACQUES , BIBETTE JEROME , DA SILVA ANABELA
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
摘要翻译：本发明涉及荧光乳剂，含有该荧光乳剂的诊断试剂及其在制备用于体内荧光成像的诊断试剂中的用途。

4. 发明申请

WO2009029229A3 FERROFLUID EMULSIONS, PARTICLES, AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译： FERROFLUID乳液，颗粒和用于制造和使用其的系统和方法
公开(公告)号：WO2009029229A3
公开(公告)日：2009-04-16
申请号：PCT/US2008010020
申请日：2008-08-22
申请人： HARVARD COLLEGE , SANTANACH CARRERAS ENRIC , BIBETTE JEROME , WEITZ DAVID A
发明人： SANTANACH CARRERAS ENRIC , BIBETTE JEROME , WEITZ DAVID A
IPC分类号： B01J13/04
CPC分类号： B01F3/0807 , B01F13/0062 , B01J2219/005
摘要： The present invention generally relates to ferrofluid emulsions and/or magnetically susceptible particles. In some cases, such emulsions and particles can be produced in a microfluidic system. In one aspect, an emulsion containing a ferrofluid can be produced, and in certain cases, the emulsion is substantially monodisperse. In some embodiments, the emulsion also contains a precursor that can be solidified, for example, a polymer precursor. The emulsion may also contain an emulsion stabilizing agent and/or a viscous agent. In another aspect of the present invention, the ferrofluid emulsion may be hardened to form particles, for example, by removing a fluid from the emulsion and/or by solidifying a precursor, such as a polymer precursor, around the emulsion. For example, the ferrofluid may be formed from an organic solvent containing nanoparticles, and the organic solvent removed such that the nanoparticles form magnetically susceptible particles. The particles may also be further manipulated, for example, using a magnet. For instance, in one set of embodiments, the particles may be moved from one fluid stream to another fluid stream using the magnet, for example, for further processing, reaction, analysis, etc., of the particles. In some cases, the particles may be formed "on demand," e.g., for a variety of different applications.
摘要翻译：本发明一般涉及铁磁流体乳液和/或磁敏颗粒。在一些情况下，这种乳液和颗粒可以在微流体系统中生产。一方面，可以生产含有铁磁流体的乳液，并且在某些情况下，乳液基本上是单分散的。在一些实施方案中，乳液还含有可以固化的前体，例如聚合物前体。该乳液还可以含有乳液稳定剂和/或粘稠剂。在本发明的另一个方面中，例如通过从乳液中除去流体和/或通过在乳液周围固化前体如聚合物前体，铁磁流体乳液可以被硬化以形成颗粒。例如，铁磁流体可以由含有纳米颗粒的有机溶剂形成，并且去除有机溶剂使得纳米颗粒形成磁敏颗粒。例如，还可以使用磁体来进一步处理颗粒。例如，在一组实施例中，可以使用磁体将颗粒从一个流体流移动到另一个流体流，例如用于颗粒的进一步处理，反应，分析等。在一些情况下，颗粒可以“按需”形成，例如用于各种不同的应用。

5. 发明专利

FR3082440B1 METHODE DE TRANSFERT DE MATIERE DANS UN DISPOSITIF MICROFLUIDIQUE OU MILLIFLUIDIQUE 未知
公开(公告)号：FR3082440B1
公开(公告)日：2020-12-11
申请号：FR1855240
申请日：2018-06-14
申请人： PARIS SCIENCES LETTRES QUARTIER LATIN , CENTRE NAT RECH SCIENT , ECOLE SUPERIEURE PHYSIQUE & CHIMIE IND VILLE DE PARIS
发明人： DUPIN JEAN-BAPTISTE , CHAURASIA ANKUR SHUBHLAL , BIBETTE JEROME , BREMOND NICOLAS , BAUDRY JEAN
IPC分类号： B01L3/00
摘要： La présente invention concerne une méthode de transfert de matière, dans un dispositif microfluidique ou millifluidique, entre une goutte d'un premier train de gouttes et une goutte d'un deuxième train de gouttes, ainsi que l'utilisation de cette méthode pour la préparation d'échantillons biologiques ou chimiques, la mise en œuvre de réactions biologiques ou chimiques, le criblage de molécule d'origine synthétique ou biologique, ou le criblage ou la culture de microorganismes. La présente invention concerne également un dispositif microfluidique ou millifluidique apte à mettre en œuvre la méthode selon l'invention.

6. 发明专利

FR3050212A1 PROCEDE DE DETECTION ET/OU DE CARACTERISATION DE CELLULES TUMORALES ET APPAREIL ASSOCIE 未知
公开(公告)号：FR3050212A1
公开(公告)日：2017-10-20
申请号：FR1653383
申请日：2016-04-15
申请人： CHU MONTPELLIER , ECOLE SUPERIEURE PHYSIQUE & CHIMIE IND VILLE DE PARIS , CENTRE NAT RECH SCIENT , UNIV MONTPELLIER
发明人： ALIX - PANABIERES CATHERINE MICHELE MARILOU , GRIFFITHS ANDREW DAVID , DOINEAU RAPHAEL CLEMENT LI-MING , NIZAK CLEMENT , NGHE PHILIPPE CHI-THANH , BAUDRY JEAN-MARIE PIERRE , BRIENT-LITZLER ELODIE MICHELE CHRISTINE , EYER KLAUS , BIBETTE JEROME
IPC分类号： C12Q1/04 , G01N33/50 , G01N33/574 , G01N33/68
摘要： La présente invention s'inscrit dans le domaine du diagnostic biologique en cancérologie. Elle a pour objet un procédé et un appareil de détection et/ou de caractérisation de cellules tumorales par détection d'un ou plusieurs éléments du sécrétome de cellule tumorale, en particulier un ou plusieurs peptides ou protéines, et notamment un ou plusieurs marqueurs tumoraux. L'invention concerne également, des gouttes de détection et/ou de caractérisation de cellules tumorales et leur procédé de préparation.

7. 发明专利

DE60010500T2 未知
公开(公告)号：DE60010500T2
公开(公告)日：2005-05-12
申请号：DE60010500
申请日：2000-11-06
申请人： BIO MERIEUX MARCY L ETOILE , CENTRE NAT RECH SCIENT
发明人： ELAISSARI ABDELHAMID , BOSC ERIC , PICHOT CHRISTIAN , MANDRAND BERNARD , BIBETTE JEROME , MONDAIN-MONVAL OLIVIER
IPC分类号： G01N33/545 , A61K9/51 , A61K31/7088 , A61K45/00 , A61K47/02 , A61K47/04 , A61K47/32 , A61K47/48 , A61K48/00 , A61P43/00 , C09D11/00 , G01N33/543 , G01N33/546

8. 发明专利

ES2227188T3 PROCEDIMIENTO DE PREPARACION DE UNA EMULSION DOBLE MONDISPERSA. 未知
公开(公告)号：ES2227188T3
公开(公告)日：2005-04-01
申请号：ES01931824
申请日：2001-05-09
申请人： CENTRE NAT RECH SCIENT
发明人： LEAL CALDERON FERNANDO , GORRIA PHILIPPE , BIBETTE JEROME
IPC分类号： B01F3/08 , B01F9/10
摘要： Procedimiento de preparación de una emulsión doble monodispersa, de tipo agua en aceite en agua, caracterizado porque comprende las etapas que consisten en: a) someter una emulsión de tipo agua en aceite, polidispersa, que comprende de 50 a 99% en peso de una fase acuosa, a un cizallamiento controlado de tal manera que un mismo cizallamiento máximo se aplique al conjunto de la emulsión, de tal modo que se obtenga la emulsión inversa monodispersa correspondiente; b) añadir a dicha emulsión, sin inversión de fase, la cantidad necesaria de una fase aceitosa de dilución de tal manera que la fase acuosa de la emulsión resultante represente menos del 50% en peso del peso total de la emulsión; y c) introducir la emulsión resultante en un homogeneizador de alta presión, junto con una fase acuosa continua, siendo las cantidades respectivas de dicha emulsión y de dicha fase acuosa continua de tal manera que la emulsión doble resultante comprende hasta el 50% en peso de gotitas de emulsión inversacon respecto al peso total de la emulsión, comprendiendo dicha fase acuosa continua una concentración en tensioactivo hidrófilo inferior o igual a 0, 02 veces la concentración micelar crítica.

9. 发明专利

DE69723460D1 未知
公开(公告)号：DE69723460D1
公开(公告)日：2003-08-14
申请号：DE69723460
申请日：1997-11-28
申请人： CENTRE NAT RECH SCIENT
发明人： MAYER PASCAL , BIBETTE JEROME , VIOVY JEAN-LOUIS
IPC分类号： B01D57/02 , B03C1/32 , B03C5/00 , C12N15/09 , G01N27/447
摘要： The invention concerns a method for separating particles or molecules whereby these particles or molecules are introduced in a separating medium and a moving force is applied to them in said medium. The method is characterised in that the separating medium is a ferrofluid, i.e. a colloidal suspension of magnetic particles and a magnetic field is applied to this ferrofluid generating therein at least an alternation of a zone rich in magnetic particles and a zone poor in magnetic particles, part at least of the region of the ferrofluid in which this alternation is generated is passed through by the particles or molecules to be separated during their migration.

10. 发明专利

AU2735899A Method for preparing an aqueous dispersion of at least one platelet inorganic compound with improved rheological properties 未知
公开(公告)号：AU2735899A
公开(公告)日：1999-11-01
申请号：AU2735899
申请日：1999-03-16
申请人： CENTRE NAT RECH SCIENT
发明人： BIBETTE JEROME , BERNON ROLAND , GORRIA PHILIPPE
IPC分类号： B01F3/12 , B01F7/16 , B01J2/30 , C01B3/22
摘要： The invention concerns a method for preparing a concentrated aqueous dispersion of at least one platelet inorganic compound with controlled and improved rheological properties consisting in shearing a primary aqueous dispersion with at least a platelet compound concentration, characterised in that: said primary aqueous dispersion has a sufficient inorganic compound concentration to enable a sufficient mechanical load being applied for delaminating said inorganic compound while it is being sheared; the shearing applied to said dispersion is a controlled shearing, that is such that the whole dispersion is subjected to a minimal common shearing; and said shearing is performed with sufficient intensity to result in an aqueous dispersion with at least a platelet powder inorganic compound concentration whereof the critical shearing threshold is significantly increased compared to that of the primary aqueous dispersion.

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