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1. 发明申请

WO2011100552A1 DEVICES, METHODS AND SYSTEMS FOR ESTABLISHING SUPPLEMENTAL BLOOD FLOW IN THE CIRCULATORY SYSTEM 审中-公开
标题翻译：在循环系统中建立补充血液流动的装置，方法和系统
公开(公告)号：WO2011100552A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024533
申请日：2011-02-11
申请人： CIRCULTE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61B2017/00252 , A61F2210/0076 , A61M1/10 , A61M1/1008 , A61M1/12 , A61M1/3653 , A61M1/3659
摘要： A cannula (50) for insertion through a biologic tissue. The cannula (50) includes a shaft (120) having proximal and distal end portions (124, 126) with a lumen (122) therebetween. The cannula (50) further includes a tip (110) having a proximal end portion (114), a distal tip end (142), and a lumen (112) therebetween. The proximal end portion (114) of the tip (110) is secured to the distal end portion (126) of the shaft (120) so that the lumen (112) of the tip (110) is in fluid communication with the lumen (122) of the shaft (120). The tip (110) includes an opening (146) that extends proximally relative to the distal tip end (142) to permit the flow of fluid into the lumen (112) of the tip (110) even in the event that the distal tip end (142) becomes obstructed.
摘要翻译：用于插入通过生物组织的套管（50）。套管（50）包括具有在其间具有内腔（122）的近端部分（124,126）的轴（120）。套管（50）还包括具有近端部分（114），远端末端（142）和其间的内腔（112）的尖端（110）。尖端（110）的近端部分（114）固定到轴（120）的远端部分（126），使得尖端（110）的内腔（112）与内腔 122）。尖端（110）包括相对于远侧末端（142）向近侧延伸的开口（146），以允许流体流入尖端（110）的内腔（112），即使在远端尖端（142）变得阻塞。

2. 发明申请

WO2011100552A8 DEVICES, METHODS AND SYSTEMS FOR ESTABLISHING SUPPLEMENTAL BLOOD FLOW IN THE CIRCULATORY SYSTEM 审中-公开
公开(公告)号：WO2011100552A8
公开(公告)日：2011-08-18
申请号：PCT/US2011/024533
申请日：2011-02-11
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61M1/12
摘要： A cannula (50) for insertion through a biologic tissue. The cannula (50) includes a shaft (120) having proximal and distal end portions (124, 126) with a lumen (122) therebetween. The cannula (50) further includes a tip (110) having a proximal end portion (114), a distal tip end (142), and a lumen (112) therebetween. The proximal end portion (114) of the tip (110) is secured to the distal end portion (126) of the shaft (120) so that the lumen (112) of the tip (110) is in fluid communication with the lumen (122) of the shaft (120). The tip (110) includes an opening (146) that extends proximally relative to the distal tip end (142) to permit the flow of fluid into the lumen (112) of the tip (110) even in the event that the distal tip end (142) becomes obstructed.

3. 发明申请

WO2009045624A1 DEVICES, METHODS AND SYSTEMS FOR ESTABLISHING SUPPLEMENTAL CIRCULATORY BLOOD FLOW 审中-公开
标题翻译：用于建立补充循环血液流动的装置，方法和系统
公开(公告)号：WO2009045624A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/071938
申请日：2008-08-01
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61M5/00
CPC分类号： A61M1/122 , A61B17/3415 , A61M1/1008 , A61M1/12 , A61M25/04 , A61M25/0662 , A61M25/09
摘要： A blood circulation assist system comprising an inflow cannula (12) having a lumen and an insertion device (200) configured to be received therein and to facilitate insertion of a portion of the inflow cannula (12) into a heart chamber. The insertion device (200) includes a shaft (206) having distal and proximal end portions (208, 210) and a plurality of lumens (212, 214). A first lumen (212) is configured to receive a guidewire and a second lumen (214) is configured to receive a pressurized fluid. A tip (220) connected to the distal end portion (208) of the shaft (206) is configured for insertion into the heart chamber. The tip (220) has a hollow interior (226) communicating with the first shaft lumen (212). An inflatable member (224) is coupled to the distal end portion (208) of the shaft (206) and includes a hollow interior (254) in fluid communication with the second shaft lumen (214). The inflatable member (224) is movable between deflated and inflated configurations for releasably securing the insertion device (200) to the inflow cannula (12).
摘要翻译：一种血液循环辅助系统，包括具有内腔的入口插管（12）和被配置为容纳在其中的插入装置（200），并且有助于将一部分流入插管（12）插入心室。插入装置（200）包括具有远侧和近端部分（208,210）和多个管腔（212,214）的轴（206）。第一管腔（212）构造成接收导丝，并且第二管腔（214）构造成接收加压流体。连接到轴（206）的远端部分（208）的尖端（220）构造成用于插入心室。尖端（220）具有与第一轴腔（212）连通的中空内部（226）。可膨胀构件（224）联接到轴（206）的远端部分（208）并且包括与第二轴腔（214）流体连通的中空内部（254）。可膨胀构件（224）可在放气和膨胀构型之间移动，以将插入装置（200）可释放地固定到流入套管（12）。

4. 发明申请

WO2008034068A3 INTRAVASCULAR BLOOD PUMP AND CATHETER 审中-公开
公开(公告)号：WO2008034068A3
公开(公告)日：2008-03-20
申请号：PCT/US2007/078507
申请日：2007-09-14
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61M1/12 , A61F2/06
摘要： An intravascular system (10, 160) for pumping blood from a chamber of a heart and through an associated blood vessel coupled in fluid communication therewith. The system (10, 160) includes a pump device (12, 162) configured to be inserted into a blood vessel. The system further includes a catheter (14, 166) having a proximal end coupled to the pump device (12, 162) and a distal end configured to collect blood within or exiting from the chamber. The catheter (14, 166) further includes a pre-formed shape corresponding to the vessel to at least assist with stabilization and positioning of the pump device (12, 162) in the vessel.

5. 发明申请

WO2011059908A1 CANNULA STABILIZER 审中-公开
标题翻译：肛门稳定器
公开(公告)号：WO2011059908A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055800
申请日：2010-11-08
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61M25/00
CPC分类号： A61M25/04 , A61M2025/0233
摘要： An apparatus and method for stabilizing a cannula (68) to a vascular structure. The stabilizer (66) includes a ring (78) that circumferentially surrounds the cannula (68). Three or more struts (80) extend distally from the ring (78) and are outwardly-deflected by a first angle relative to a first axis that is parallel to a lengthwise central axis of the cannula (68). Each strut (80) includes a contact pad (82) that radially extends from the strut (80) and is distally-deflected by a second angle relative to a second axis that is orthogonal to the first axis. Three or more arms (84) extend proximally from the ring (78) and each arm (84) opposes one of the struts (80). The arms (84) are inwardly- deflected by a third angle relative to the first axis. The stabilizer (66) is configured to move relative to the cannula (68) until the contact pads (82) engage the vascular structure (67), causing the arms (84) to engage and resist further movement of the stabilizer (66) relative to the cannula (68).
摘要翻译：一种用于将插管（68）稳定到血管结构的装置和方法。稳定器（66）包括周向围绕套管（68）的环（78）。三个或更多个支柱（80）从环（78）向远侧延伸并且相对于平行于套管（68）的纵向中心轴线的第一轴向外偏转第一角度。每个支柱（80）包括从支柱（80）径向延伸并且相对于与第一轴正交的第二轴向第二角度向远侧偏转的接触垫（82）。三个或更多个臂（84）从环（78）向近侧延伸，并且每个臂（84）与一个支柱（80）相对。臂（84）相对于第一轴线向内偏转第三角度。稳定器（66）构造成相对于套管（68）移动，直到接触垫（82）接合血管结构（67），使得臂（84）接合并抵抗稳定器（66）相对的进一步移动到套管（68）。

6. 发明申请

WO2013022420A1 CANNULA LINED WITH TISSUE IN-GROWTH MATERIAL AND METHOD OF USING THE SAME 审中-公开
标题翻译：带有组织生长材料的肛门及其使用方法
公开(公告)号：WO2013022420A1
公开(公告)日：2013-02-14
申请号：PCT/US2011/046772
申请日：2011-08-05
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61N1/362
CPC分类号： A61M1/3653 , A61M1/3659
摘要： A cannula (92) for moving fluids between a pump (50 and the circulatory system of a patient (14). The cannula (92) includes a liner (94) having an intermediate portion (96) between a proximal portion (98) and a distal portion (100), and a lumen (1 02) extending between the proximal and distal portions (98, 100). At least the intermediate portion (96) of the liner (94) is constructed from a tissue in-growth material for supporting the growth of endothelial cells. A jacket (1 10) surrounds at least part of the liner (94).
摘要翻译：一种用于在泵（50和患者（14）的循环系统之间）移动流体的套管（92），所述套管（92）包括衬垫（94），所述衬套（94）具有在近端部分（98）和远侧部分（100）和在近端部分（远端部分）和远端部分之间延伸的内腔（102），衬垫（94）的至少中间部分（96）由组织生长材料用于支撑内皮细胞的生长。护套（110）围绕衬垫（94）的至少一部分。

7. 发明申请

WO2011100568A1 CANNULA LINED WITH TISSUE IN-GROWTH MATERIAL AND METHOD OF USING THE SAME 审中-公开
标题翻译：带有组织生长材料的肛门及其使用方法
公开(公告)号：WO2011100568A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024558
申请日：2011-02-11
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61B2017/00252 , A61F2210/0076 , A61M1/10 , A61M1/1008 , A61M1/12 , A61M1/3653 , A61M1/3659
摘要： A cannula (92) for moving fluids between a pump (50) and the circulatory system of a patient (14). The cannula (92) includes a liner (94) having an intermediate portion (96) between a proximal portion (98) and a distal portion (100), and a lumen (102) extending between the proximal and distal portions (98, 100). At least the intermediate portion (96) of the liner (94) is constructed from a tissue in-growth material for supporting the growth of endothelial cells. A jacket (1 10) surrounds at least part of the liner (94).
摘要翻译：一种用于在泵（50）和患者（14）的循环系统之间移动流体的套管（92）。插管（92）包括在近端部分（98）和远端部分（100）之间具有中间部分（96）的衬套（94）和在近端部分（远端部分）和远端部分之间延伸的内腔（102））。衬垫（94）的至少中间部分（96）由用于支持内皮细胞生长的组织生长材料构成。护套（110）围绕衬套（94）的至少一部分。

8. 发明申请

WO2009029387A1 CANNULA INSERTION DEVICES, SYSTEMS, AND METHODS INCLUDING A COMPRESSIBLE MEMBER 审中-公开
标题翻译：肛门插入装置，系统和包括可压缩构件的方法
公开(公告)号：WO2009029387A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/071922
申请日：2008-08-01
申请人： CIRCULITE, INC. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61M5/178
CPC分类号： A61M1/122 , A61B17/3415 , A61M1/1008 , A61M1/12 , A61M25/04 , A61M25/0662
摘要： An insertion device (100) for inserting a cannula (158) through tissue generally comprises an inner shaft (102), a tip member (108) coupled to a distal end portion (104) of the inner shaft (102), a hollow outer shaft (120) slidably received over the inner shaft (102), and a compressible member (1 16) received over the inner shaft (102) between the tip member (108) and the outer shaft (120). The compressible member (1 16) is configured to be received in a lumen (160) of the cannula (158), and the inner shaft (102) is movable relative to the outer shaft (120) along an axial direction to compress the compressible member (1 16) between the tip member (108) and the outer shaft (120) so that the compressible member (1 16) expands in a generally radially outward direction. The radial expansion of the compressible member (1 16) releasably secures the insertion device (100) to the cannula (158).
摘要翻译：用于将组件（158）插入组织的插入装置（100）通常包括内轴（102），联接到内轴（102）的远端部分（104）的尖端构件（108）可滑动地容纳在所述内轴（102）上的轴（120）以及容纳在所述内轴（102）之间的所述末端构件（108）和所述外轴（120）之间的可压缩构件（116）。可压缩构件（116）构造成容纳在套管（158）的内腔（160）中，并且内轴（102）可沿着轴向相对于外轴（120）移动，以压缩可压缩构件所述端部构件（108）和所述外轴（120）之间的所述构件（116）使得所述可压缩构件（116）在大致径向向外的方向上膨胀。可压缩构件（116）的径向膨胀将插入装置（100）可释放地固定到套管（158）上。

9. 发明申请

WO2008027869A3 DEVICES, METHODS AND SYSTEMS FOR ESTABLISHING SUPPLEMENTAL BLOOD FLOW IN THE CIRCULATORY SYSTEM 审中-公开
公开(公告)号：WO2008027869A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/076956
申请日：2007-08-28
申请人： CIRCULITE, INC. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61B5/04
摘要： Devices, systems and methods for establishing a blood flow conduit between a chamber (14) in a heart (15) of a patient and a remote location. A blood inflow cannula (12) having an outer surface and proximal and distal end portions (12b, 12a). The distal end portion (12a) is configured for insertion into the chamber (14) of the heart (15). First and second anchor elements (80, 82) have respective maximum width dimensions extending outwardly from the outer surface of the cannula (12). The first anchor element (80) is positioned more distally than the second anchor element (82) defining a tissue receiving space therebetween. The maximum width dimension of the first anchor element (80) may be larger than the maximum width dimension of the second anchor element (82) in use. The first anchor element (80) is configured to be positioned inside the heart chamber (14) and the second anchor element (82) is configured to be positioned outside the heart chamber (14) with heart tissue held in the tissue receiving space therebetween.

10. 发明申请

WO2007090050A2 HEART ASSIST SYSTEM 审中-公开
标题翻译：心脏辅助系统
公开(公告)号：WO2007090050A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/061118
申请日：2007-01-26
申请人： CIRCULITE, INC. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang , SCHUMACHER, Oliver
发明人： MARSEILLE, Oliver , KERKHOFFS, Wolfgang , SCHUMACHER, Oliver
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/127 , A61M1/101 , A61M1/1086 , A61M1/12 , A61M2205/3334 , A61N1/362
摘要： A supplemental blood flow system (10, 10a-e) for assisting with blood circulation in a patient. The system includes a supplemental blood flow device (12) implantable in the patient and a controller (18) for directing electrical power to the supplemental blood flow device (12) and controlling the flow rate of blood through the device (12). The controller (18) includes first and second power inlets (38, 40) and a power outlet (41). The power outlet (41 ) is adapted to be coupled to an electrical line (20) leading to the supplemental blood flow device (12). A portable programming module (70) may be coupled to at least one of the first and second power inlets (38, 40) and operable to aiEow pump operating parameters stored in the controller (18) to be changed according to the needs of the patient.
摘要翻译：一种用于辅助患者血液循环的辅助血液流动系统（10,10a-e）。系统包括可植入患者的补充血液流动装置（12）和用于将电力引导到补充血液流动装置（12）并控制血液通过装置（12）的流量的控制器（18）。控制器（18）包括第一和第二功率入口（38,40）和电源插座（41）。电源插座（41）适于耦合到通向补充血液流动装置（12）的电线（20）。便携式编程模块（70）可以耦合到第一和第二功率入口（38,40）中的至少一个，并且可操作以根据患者的需要来改变存储在控制器（18）中的泵操作参数。

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