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1. 发明申请

WO2011100552A1 DEVICES, METHODS AND SYSTEMS FOR ESTABLISHING SUPPLEMENTAL BLOOD FLOW IN THE CIRCULATORY SYSTEM 审中-公开
标题翻译：在循环系统中建立补充血液流动的装置，方法和系统
公开(公告)号：WO2011100552A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024533
申请日：2011-02-11
申请人： CIRCULTE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61B2017/00252 , A61F2210/0076 , A61M1/10 , A61M1/1008 , A61M1/12 , A61M1/3653 , A61M1/3659
摘要： A cannula (50) for insertion through a biologic tissue. The cannula (50) includes a shaft (120) having proximal and distal end portions (124, 126) with a lumen (122) therebetween. The cannula (50) further includes a tip (110) having a proximal end portion (114), a distal tip end (142), and a lumen (112) therebetween. The proximal end portion (114) of the tip (110) is secured to the distal end portion (126) of the shaft (120) so that the lumen (112) of the tip (110) is in fluid communication with the lumen (122) of the shaft (120). The tip (110) includes an opening (146) that extends proximally relative to the distal tip end (142) to permit the flow of fluid into the lumen (112) of the tip (110) even in the event that the distal tip end (142) becomes obstructed.
摘要翻译：用于插入通过生物组织的套管（50）。套管（50）包括具有在其间具有内腔（122）的近端部分（124,126）的轴（120）。套管（50）还包括具有近端部分（114），远端末端（142）和其间的内腔（112）的尖端（110）。尖端（110）的近端部分（114）固定到轴（120）的远端部分（126），使得尖端（110）的内腔（112）与内腔 122）。尖端（110）包括相对于远侧末端（142）向近侧延伸的开口（146），以允许流体流入尖端（110）的内腔（112），即使在远端尖端（142）变得阻塞。

2. 发明申请

WO2009045624A1 DEVICES, METHODS AND SYSTEMS FOR ESTABLISHING SUPPLEMENTAL CIRCULATORY BLOOD FLOW 审中-公开
标题翻译：用于建立补充循环血液流动的装置，方法和系统
公开(公告)号：WO2009045624A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/071938
申请日：2008-08-01
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61M5/00
CPC分类号： A61M1/122 , A61B17/3415 , A61M1/1008 , A61M1/12 , A61M25/04 , A61M25/0662 , A61M25/09
摘要： A blood circulation assist system comprising an inflow cannula (12) having a lumen and an insertion device (200) configured to be received therein and to facilitate insertion of a portion of the inflow cannula (12) into a heart chamber. The insertion device (200) includes a shaft (206) having distal and proximal end portions (208, 210) and a plurality of lumens (212, 214). A first lumen (212) is configured to receive a guidewire and a second lumen (214) is configured to receive a pressurized fluid. A tip (220) connected to the distal end portion (208) of the shaft (206) is configured for insertion into the heart chamber. The tip (220) has a hollow interior (226) communicating with the first shaft lumen (212). An inflatable member (224) is coupled to the distal end portion (208) of the shaft (206) and includes a hollow interior (254) in fluid communication with the second shaft lumen (214). The inflatable member (224) is movable between deflated and inflated configurations for releasably securing the insertion device (200) to the inflow cannula (12).
摘要翻译：一种血液循环辅助系统，包括具有内腔的入口插管（12）和被配置为容纳在其中的插入装置（200），并且有助于将一部分流入插管（12）插入心室。插入装置（200）包括具有远侧和近端部分（208,210）和多个管腔（212,214）的轴（206）。第一管腔（212）构造成接收导丝，并且第二管腔（214）构造成接收加压流体。连接到轴（206）的远端部分（208）的尖端（220）构造成用于插入心室。尖端（220）具有与第一轴腔（212）连通的中空内部（226）。可膨胀构件（224）联接到轴（206）的远端部分（208）并且包括与第二轴腔（214）流体连通的中空内部（254）。可膨胀构件（224）可在放气和膨胀构型之间移动，以将插入装置（200）可释放地固定到流入套管（12）。

3. 发明申请

WO2011100552A8 DEVICES, METHODS AND SYSTEMS FOR ESTABLISHING SUPPLEMENTAL BLOOD FLOW IN THE CIRCULATORY SYSTEM 审中-公开
公开(公告)号：WO2011100552A8
公开(公告)日：2011-08-18
申请号：PCT/US2011/024533
申请日：2011-02-11
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver , KERKHOFFS, Wolfgang
IPC分类号： A61M1/12
摘要： A cannula (50) for insertion through a biologic tissue. The cannula (50) includes a shaft (120) having proximal and distal end portions (124, 126) with a lumen (122) therebetween. The cannula (50) further includes a tip (110) having a proximal end portion (114), a distal tip end (142), and a lumen (112) therebetween. The proximal end portion (114) of the tip (110) is secured to the distal end portion (126) of the shaft (120) so that the lumen (112) of the tip (110) is in fluid communication with the lumen (122) of the shaft (120). The tip (110) includes an opening (146) that extends proximally relative to the distal tip end (142) to permit the flow of fluid into the lumen (112) of the tip (110) even in the event that the distal tip end (142) becomes obstructed.

4. 发明申请

WO2008034068A3 INTRAVASCULAR BLOOD PUMP AND CATHETER 审中-公开
公开(公告)号：WO2008034068A3
公开(公告)日：2008-03-20
申请号：PCT/US2007/078507
申请日：2007-09-14
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61M1/12 , A61F2/06
摘要： An intravascular system (10, 160) for pumping blood from a chamber of a heart and through an associated blood vessel coupled in fluid communication therewith. The system (10, 160) includes a pump device (12, 162) configured to be inserted into a blood vessel. The system further includes a catheter (14, 166) having a proximal end coupled to the pump device (12, 162) and a distal end configured to collect blood within or exiting from the chamber. The catheter (14, 166) further includes a pre-formed shape corresponding to the vessel to at least assist with stabilization and positioning of the pump device (12, 162) in the vessel.

5. 发明申请

WO2013022420A1 CANNULA LINED WITH TISSUE IN-GROWTH MATERIAL AND METHOD OF USING THE SAME 审中-公开
标题翻译：带有组织生长材料的肛门及其使用方法
公开(公告)号：WO2013022420A1
公开(公告)日：2013-02-14
申请号：PCT/US2011/046772
申请日：2011-08-05
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61N1/362
CPC分类号： A61M1/3653 , A61M1/3659
摘要： A cannula (92) for moving fluids between a pump (50 and the circulatory system of a patient (14). The cannula (92) includes a liner (94) having an intermediate portion (96) between a proximal portion (98) and a distal portion (100), and a lumen (1 02) extending between the proximal and distal portions (98, 100). At least the intermediate portion (96) of the liner (94) is constructed from a tissue in-growth material for supporting the growth of endothelial cells. A jacket (1 10) surrounds at least part of the liner (94).
摘要翻译：一种用于在泵（50和患者（14）的循环系统之间）移动流体的套管（92），所述套管（92）包括衬垫（94），所述衬套（94）具有在近端部分（98）和远侧部分（100）和在近端部分（远端部分）和远端部分之间延伸的内腔（102），衬垫（94）的至少中间部分（96）由组织生长材料用于支撑内皮细胞的生长。护套（110）围绕衬垫（94）的至少一部分。

6. 发明申请

WO2011100568A1 CANNULA LINED WITH TISSUE IN-GROWTH MATERIAL AND METHOD OF USING THE SAME 审中-公开
标题翻译：带有组织生长材料的肛门及其使用方法
公开(公告)号：WO2011100568A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024558
申请日：2011-02-11
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61B2017/00252 , A61F2210/0076 , A61M1/10 , A61M1/1008 , A61M1/12 , A61M1/3653 , A61M1/3659
摘要： A cannula (92) for moving fluids between a pump (50) and the circulatory system of a patient (14). The cannula (92) includes a liner (94) having an intermediate portion (96) between a proximal portion (98) and a distal portion (100), and a lumen (102) extending between the proximal and distal portions (98, 100). At least the intermediate portion (96) of the liner (94) is constructed from a tissue in-growth material for supporting the growth of endothelial cells. A jacket (1 10) surrounds at least part of the liner (94).
摘要翻译：一种用于在泵（50）和患者（14）的循环系统之间移动流体的套管（92）。插管（92）包括在近端部分（98）和远端部分（100）之间具有中间部分（96）的衬套（94）和在近端部分（远端部分）和远端部分之间延伸的内腔（102））。衬垫（94）的至少中间部分（96）由用于支持内皮细胞生长的组织生长材料构成。护套（110）围绕衬套（94）的至少一部分。

7. 发明申请

WO2011059908A1 CANNULA STABILIZER 审中-公开
标题翻译：肛门稳定器
公开(公告)号：WO2011059908A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055800
申请日：2010-11-08
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , MARSEILLE, Oliver
发明人： FARNAN, Robert, C. , MARSEILLE, Oliver
IPC分类号： A61M25/00
CPC分类号： A61M25/04 , A61M2025/0233
摘要： An apparatus and method for stabilizing a cannula (68) to a vascular structure. The stabilizer (66) includes a ring (78) that circumferentially surrounds the cannula (68). Three or more struts (80) extend distally from the ring (78) and are outwardly-deflected by a first angle relative to a first axis that is parallel to a lengthwise central axis of the cannula (68). Each strut (80) includes a contact pad (82) that radially extends from the strut (80) and is distally-deflected by a second angle relative to a second axis that is orthogonal to the first axis. Three or more arms (84) extend proximally from the ring (78) and each arm (84) opposes one of the struts (80). The arms (84) are inwardly- deflected by a third angle relative to the first axis. The stabilizer (66) is configured to move relative to the cannula (68) until the contact pads (82) engage the vascular structure (67), causing the arms (84) to engage and resist further movement of the stabilizer (66) relative to the cannula (68).
摘要翻译：一种用于将插管（68）稳定到血管结构的装置和方法。稳定器（66）包括周向围绕套管（68）的环（78）。三个或更多个支柱（80）从环（78）向远侧延伸并且相对于平行于套管（68）的纵向中心轴线的第一轴向外偏转第一角度。每个支柱（80）包括从支柱（80）径向延伸并且相对于与第一轴正交的第二轴向第二角度向远侧偏转的接触垫（82）。三个或更多个臂（84）从环（78）向近侧延伸，并且每个臂（84）与一个支柱（80）相对。臂（84）相对于第一轴线向内偏转第三角度。稳定器（66）构造成相对于套管（68）移动，直到接触垫（82）接合血管结构（67），使得臂（84）接合并抵抗稳定器（66）相对的进一步移动到套管（68）。

8. 发明申请

WO2011056280A1 BIFURCATED OUTFLOW CANNULAE 审中-公开
标题翻译：双重溢流肛门
公开(公告)号：WO2011056280A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/046793
申请日：2010-08-26
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , BUDRIS, John, P.
发明人： FARNAN, Robert, C. , BUDRIS, John, P.
IPC分类号： A61M1/00
CPC分类号： A61M1/1008 , A61M1/10 , A61M1/101 , A61M1/12 , A61M1/122
摘要： A bifurcated cannula (64) for directing blood into the arterial system. The bifurcated cannula (64) including an ingress channel (68) and first and second egress channels (70, 72). The first egress channel (70) directs a first portion of the blood entering the bifurcated cannula (64) into the arterial system in a first direction. The second egress channel (72) directs a second portion of the blood entering the bifurcated cannula (64) into the arterial system in a direction that opposes the first direction.
摘要翻译：用于将血液引导到动脉系统中的分叉插管（64）。分叉插管（64）包括入口通道（68）和第一和第二出口通道（70,72）。第一出口通道（70）将进入分叉插管（64）的血液的第一部分沿着第一方向引导到动脉系统中。第二出口通道（72）将进入分叉插管（64）的血液的第二部分沿与第一方向相反的方向引导到动脉系统中。

9. 发明申请

WO2013036588A1 CANNULA TIPS, TISSUE ATTACHMENT RINGS, AND METHODS OF DELIVERING AND USING THE SAME 审中-公开
标题翻译：肛门提示，组织附件环，以及交付和使用它们的方法
公开(公告)号：WO2013036588A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053891
申请日：2012-09-06
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , DRUMMOND, Arielle , BRIGHTBILL, Jerry , ROBINSON, Timothy, Walter , WISDOM, Richard , O'KEEFE, Jonathan , ABRAHAM, Richard , KOSTANSKI, Sarah , FRITZ, Bryan
发明人： FARNAN, Robert, C. , DRUMMOND, Arielle , BRIGHTBILL, Jerry , ROBINSON, Timothy, Walter , WISDOM, Richard , O'KEEFE, Jonathan , ABRAHAM, Richard , KOSTANSKI, Sarah , FRITZ, Bryan
IPC分类号： A61M15/00
CPC分类号： A61M1/1008 , A61B17/11 , A61B17/32 , A61B2017/00243 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61M1/12 , A61M1/122
摘要： A surgical cannula system. The surgical cannula system includes a cannula (60) having a proximal end, a distal end, and a lumen (82) extending therebetween. A tissue attachment ring (110), being configured to be coupled to a biological tissue (74), includes a lumen (117) extending therethrough. A locking mechanism (119) has a first locking state, in which the cannula (60) is configured to move with respect to the tissue attachment ring (110), and a second locking state, in which movement of the cannula (60) with respect to the tissue attachment ring (110) is resisted.
摘要翻译：手术插管系统。手术插管系统包括具有近端，远端和在其间延伸的内腔（82）的套管（60）。构造成联接到生物组织（74）的组织附接环（110）包括延伸穿过其中的内腔（117）。锁定机构（119）具有第一锁定状态，其中套管（60）被配置成相对于组织附接环（110）移动;以及第二锁定状态，其中套管（60）与相对于组织附着环（110）被抵抗。

10. 发明申请

WO2009055651A1 TRANSSEPTAL CANNULA, TIP, DELIVERY SYSTEM, AND METHOD 审中-公开
标题翻译：转运肛门，提示，输送系统和方法
公开(公告)号：WO2009055651A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081082
申请日：2008-10-24
申请人： CIRCULITE, INC. , FARNAN, Robert, C. , OLSON, Scott, A. , JUNG, Elizabeth , DUSBABEK, Andrew, J. , HUDGINS, Robert, G.
发明人： FARNAN, Robert, C. , OLSON, Scott, A. , JUNG, Elizabeth , DUSBABEK, Andrew, J. , HUDGINS, Robert, G.
IPC分类号： A61N1/362
CPC分类号： A61M1/3653 , A61M1/1008 , A61M1/12 , A61M1/3659 , A61M1/3666 , A61M1/3667 , A61M25/04 , A61M25/10 , A61M2025/0233
摘要： A transseptal cannula assembly (224) for directing blood from the heart (104) of a patient and a minimally invasive method of implanting the same. The transseptal cannula assembly (224) includes a flexible cannula body (226) having proximal and distal portions with a lumen there between, a tip (228) coupled to the distal portion of the flexible cannula body (226), and first and second anchors (230, 232) coupled to the tip (228). The anchors (230, 232) can be configured to be deployed from a contracted state to an expanded state and are configured to engage opposite sides of the heart tissue (102) when in the expanded state. The anchors (230, 232) resist movement of the cannula assembly (224) along a lengthwise central axis of the flexible cannula body (226).
摘要翻译：用于引导来自患者的心脏（104）的血液的经插管组件（224）和植入该患者的微创方法。经套管组件（224）包括柔性插管主体（226），其具有近端和远端部分，其间具有内腔，联接到柔性插管主体（226）的远端部分的尖端（228）和第一和第二锚（230,232），其联接到所述尖端（228）。锚定件（230,232）可以构造成从收缩状态展开到膨胀状态，并且构造成在处于膨胀状态时接合心脏组织（102）的相对侧。锚定件（230,232）抵抗插管组件（224）沿着柔性插管主体（226）的纵向中心轴线的移动。

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