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1. 发明申请

WO0242733A9 METHOD FOR ANALYZING MASS SPECTRA 审中-公开
标题翻译：分析大量光谱的方法
公开(公告)号：WO0242733A9
公开(公告)日：2003-04-24
申请号：PCT/US0144843
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC , PAULSE CHRIS D , GAVIN EDWARD J , BRAGINSKY LEONID , RICH WILLIAM E , FUNG ERIC T
发明人： PAULSE CHRIS D , GAVIN EDWARD J , BRAGINSKY LEONID , RICH WILLIAM E , FUNG ERIC T
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40 , G01N33/48
CPC分类号： H01J49/0036 , G06F19/18 , G06F19/24
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.
摘要翻译：公开了使用数字计算机分析质谱的方法。该方法包括从数个计算机输入从多个样本的质谱图获得的数据集。每个样本是或将被分配给具有两个或更多个类的类集合中的类，并且每个类的特征在于不同的生物学状态。然后形成分类模型。分类模型区分类集中的类。

2. 发明申请

WO0242733A2 METHOD FOR ANALYZING MASS SPECTRA 审中-公开
标题翻译：分析大量光谱的方法
公开(公告)号：WO0242733A2
公开(公告)日：2002-05-30
申请号：PCT/US0144843
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC , PAULSE CHRIS D , GAVIN EDWARD J , BRAGINSKY LEONID , RICH WILLIAM E , FUNG ERIC T
发明人： PAULSE CHRIS D , GAVIN EDWARD J , BRAGINSKY LEONID , RICH WILLIAM E , FUNG ERIC T
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40 , G01N
CPC分类号： H01J49/0036 , G06F19/18 , G06F19/24
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.
摘要翻译：公开了使用数字计算机分析质谱的方法。该方法包括从数个计算机输入从多个样本的质谱图获得的数据集。每个样本是或将被分配给具有两个或更多个类的类集合中的类，并且每个类的特征在于不同的生物学状态。然后形成分类模型。分类模型区分类集中的类。

3. 发明申请

WO0070648A9 VARIABLE WIDTH DIGITAL FILTER FOR TIME-OF-FLIGHT MASS SPECTROMETRY 审中-公开
标题翻译：用于飞行时间质谱的可变宽度数字滤波器
公开(公告)号：WO0070648A9
公开(公告)日：2002-06-27
申请号：PCT/US0013153
申请日：2000-05-12
申请人： CIPHERGEN BIOSYSTEMS INC , GAVIN EDWARD J , BRAGINSKY LEONID
发明人： GAVIN EDWARD J , BRAGINSKY LEONID
IPC分类号： G01N27/62 , H01J49/06 , H01J49/40
CPC分类号： H01J49/40
摘要： A method and system of detecting mass to charge ratio of ions. The method includes producing charged ions in a vacuum, accelerating the charged ions in an electric field into a free flight tube and detecting the charged ions at a detector associated with the free flight tube. A control system selects a bandwidth for filtering a signal produced by the detector and the signal produced by the detector is then filtered with a variable width digital filter based upon the selected bandwidth. The bandwidth for filtering the signal may be selected from a look-up table within the control system based upon the mass to charge ratio of an ion of interest. Alternatively, a peak bandwidth within the signal produced by the detector may be determined and the signal produced by the detector may then be filtered with the variable width digital filter based upon the determined peak bandwidth.
摘要翻译：一种检测离子质荷比的方法和系统。该方法包括在真空中产生带电离子，将电场中的带电离子加速到自由飞行管中，并在与自由飞行管相关联的检测器处检测带电离子。控制系统选择用于对由检测器产生的信号进行滤波的带宽，然后基于所选择的带宽，用可变宽度数字滤波器对由检测器产生的信号进行滤波。用于过滤信号的带宽可以根据感兴趣的离子的质量与电荷比从控制系统内的查找表中选择。或者，可以确定由检测器产生的信号内的峰值带宽，然后基于所确定的峰值带宽，用可变宽度数字滤波器对由检测器产生的信号进行滤波。

4. 发明申请

WO0070648A2 VARIABLE WIDTH DIGITAL FILTER FOR TIME-OF-FLIGHT MASS SPECTROMETRY 审中-公开
标题翻译：用于飞行时间质谱的可变宽度数字滤波器
公开(公告)号：WO0070648A2
公开(公告)日：2000-11-23
申请号：PCT/US0013153
申请日：2000-05-12
申请人： CIPHERGEN BIOSYSTEMS INC , GAVIN EDWARD J , BRAGINSKY LEONID
发明人： GAVIN EDWARD J , BRAGINSKY LEONID
IPC分类号： G01N27/62 , H01J49/06 , H01J49/40
CPC分类号： H01J49/40
摘要： A method and system of detecting mass to charge ratio of ions. The method includes producing charged ions in a vacuum, accelerating the charged ions in an electric field into a free flight tube and detecting the charged ions at a detector associated with the free flight tube. A control system selects a bandwidth for filtering a signal produced by the detector and the signal produced by the detector is then filtered with a variable width digital filter based upon the selected bandwidth. The bandwidth for filtering the signal may be selected from a look-up table within the control system based upon the mass to charge ratio of an ion of interest. Alternatively, a peak bandwidth within the signal produced by the detector may be determined and the signal produced by the detector may then be filtered with the variable width digital filter based upon the determined peak bandwidth.
摘要翻译：检测离子质荷比的方法和系统。该方法包括在真空中产生带电离子，将电场中的带电离子加速到自由飞行管中，并在与自由飞行管相关联的检测器处检测带电离子。控制系统选择用于对由检测器产生的信号进行滤波的带宽，然后基于所选择的带宽，用可变宽度数字滤波器对由检测器产生的信号进行滤波。用于过滤信号的带宽可以根据感兴趣的离子的质荷比来从控制系统内的查找表中选择。或者，可以确定由检测器产生的信号内的峰值带宽，然后基于所确定的峰值带宽，用可变宽度数字滤波器对由检测器产生的信号进行滤波。

5. 发明申请

WO2005074481A3 METHOD FOR CLUSTERING SIGNALS IN SPECTRA 审中-公开
标题翻译：在频谱中聚类信号的方法
公开(公告)号：WO2005074481A3
公开(公告)日：2006-09-21
申请号：PCT/US2005001397
申请日：2005-01-13
申请人： CIPHERGEN BIOSYSTEMS INC , HO PATRICK , GAVIN EDWARD J
发明人： HO PATRICK , GAVIN EDWARD J
IPC分类号： C12P17/18 , G06F15/00 , H01J49/04
CPC分类号： H01J49/0036
摘要： Methods for processing spectra are disclosed. The method includes obtaining a plurality of spectra (26), each spectrum in the plurality of spectra comprising a signal including a signal strength as a function of time-of-flight, mass-to-charge ratio, or a value derived from time-of-flight or mass-to-charge ratio. Then, a signal cluster is formed by clustering signals from the plurality of spectra with time-of-flights, mass-to-charge ratios, or values derived from time-of-flights or mass-to-charge ratios that are within a window that is defined using an expected signal width value (32).
摘要翻译：公开了处理光谱的方法。该方法包括获得多个光谱（26），所述多个光谱中的每个光谱包括包括作为飞行时间的函数的信号强度的信号，质荷比或从时间 - 飞行或质量比。然后，通过使来自多个频谱的信号聚集来自飞行中的时间，质荷比或从窗口内的飞行时间或质量 - 荷载比导出的值来形成信号簇其使用期望的信号宽度值（32）来定义。

6. 发明申请

WO2004070523A2 DATA MANAGEMENT SYSTEM AND METHOD FOR PROCESSING SIGNALS FROM SAMPLE SPOTS 审中-公开
标题翻译：数据管理系统和从样本SPOTS处理信号的方法
公开(公告)号：WO2004070523A2
公开(公告)日：2004-08-19
申请号：PCT/US2004001149
申请日：2004-01-15
申请人： CIPHERGEN BIOSYSTEMS INC , GAVIN EDWARD J , ENDERWICK CYNTHIA , HO PATRICK , THOMSEN NIELS KIRK
发明人： GAVIN EDWARD J , ENDERWICK CYNTHIA , HO PATRICK , THOMSEN NIELS KIRK
IPC分类号： G01T1/24 , G06F20060101 , G06F19/24 , G06F19/28 , H01J49/00 , H01J49/16 , H01J49/40 , G06F
CPC分类号： H01J49/0036 , G06F19/24 , G06F19/28
摘要： One embodiment of the invention is directed to a method of processing a plurality of spectra. The method includes receiving values associated with a plurality of sample spots on one or more sample chips, wherein the values were entered using graphic elements representing the sample spots, the graphic elements being displayed on a graphical user interface. Data representing a plurality of signals are received. Each signal in the plurality of signals is annotated with a set of values associated with the sample spot from which the signal is generated.
摘要翻译：本发明的一个实施例涉及一种处理多个光谱的方法。该方法包括接收与一个或多个样本芯片上的多个样本点相关联的值，其中使用表示采样点的图形元素输入值，图形元素显示在图形用户界面上。接收表示多个信号的数据。多个信号中的每个信号用与生成信号的采样点相关联的一组值来注释。

7. 发明专利

CA2429327A1 METHOD FOR ANALYZING MASS SPECTRA 未知
公开(公告)号：CA2429327A1
公开(公告)日：2003-04-17
申请号：CA2429327
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC , EASTERN VIRGINIA MED SCHOOL
发明人： WRIGHT JR GEORGE L , FUNG ERIC T , GAVIN EDWARD J , BRAGINSKY LEONID , RICH WILLIAM E
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40 , B01D59/44
摘要： A method that analyzes mass spectra using a digital computer is disclosed. T he method includes entering into a digital computer a data set (27) obtained fr om mass spectra from a plurality of samples. Each sample is, or is to be assign ed to a class within a class set having two or more classes (30) and each class is characterized by a different biological status. A classification model (5 4) is then formed. The classification model discriminates between classes in th e class set.

8. 发明专利

AU2002241535C1 Method for analyzing mass spectra 未知
公开(公告)号：AU2002241535C1
公开(公告)日：2002-06-03
申请号：AU2002241535
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： RICH WILLIAM E , PAULSE CHRIS D , FUNG ERIC T , BRAGINSKY LEONID , GAVIN EDWARD J
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.

9. 发明专利

AU4847000A Variable width digital filter for time-of-flight mass spectrometry 未知
公开(公告)号：AU4847000A
公开(公告)日：2000-12-05
申请号：AU4847000
申请日：2000-05-12
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： GAVIN EDWARD J , BRAGINSKY LEONID
IPC分类号： H01J49/40

10. 发明专利

AT346376T 未知
公开(公告)号：AT346376T
公开(公告)日：2006-12-15
申请号：AT00930695
申请日：2000-05-12
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： GAVIN EDWARD J , BRAGINSKY LEONID
IPC分类号： G01N27/62 , H01J49/06 , H01J49/40
摘要： A method and system of detecting mass to charge ratio of ions. The method includes producing charged ions in a vacuum, accelerating the charged ions in an electric field into a free flight tube and detecting the charged ions at a detector associated with the free flight tube. A control system selects a bandwidth for filtering a signal produced by the detector and the signal produced by the detector is then filtered with a variable width digital filter based upon the selected bandwidth. The bandwidth for filtering the signal may be selected from a look-up table within the control system based upon the mass to charge ratio of an ion of interest. Alternatively, a peak bandwidth within the signal produced by the detector may be determined and the signal produced by the detector may then be filtered with the variable width digital filter based upon the determined peak bandwidth.

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