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1. 发明专利

AU4675000A Probes for a gas phase ion spectrometer 未知
公开(公告)号：AU4675000A
公开(公告)日：2000-11-17
申请号：AU4675000
申请日：2000-04-27
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： RICH WILLIAM E , UM PIL-JE , VOIVODOV KAMEN , YIP TAI-TUNG , BEECHER JODY
IPC分类号： H01J49/16 , C08F20/10 , C08F20/56 , G01N1/28 , G01N27/62 , G01N27/64 , H01J49/04 , H01J49/12
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.

2. 发明专利

AU2002241535C1 Method for analyzing mass spectra 未知
公开(公告)号：AU2002241535C1
公开(公告)日：2002-06-03
申请号：AU2002241535
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： RICH WILLIAM E , PAULSE CHRIS D , FUNG ERIC T , BRAGINSKY LEONID , GAVIN EDWARD J
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.

3. 发明专利

AU2003243350A8 Comparative proteomics of progressor and nonprogressor populations 未知
公开(公告)号：AU2003243350A8
公开(公告)日：2003-12-19
申请号：AU2003243350
申请日：2003-05-30
申请人： AARON DIAMOND AIDS RES CT , UNIV ROCKEFELLER , CIPHERGEN BIOSYSTEMS INC
发明人： RICH WILLIAM E , HO DAVID D , ZHANG LINQI
IPC分类号： G01N33/543 , G01N33/68

4. 发明专利

CA2429327A1 METHOD FOR ANALYZING MASS SPECTRA 未知
公开(公告)号：CA2429327A1
公开(公告)日：2003-04-17
申请号：CA2429327
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC , EASTERN VIRGINIA MED SCHOOL
发明人： WRIGHT JR GEORGE L , FUNG ERIC T , GAVIN EDWARD J , BRAGINSKY LEONID , RICH WILLIAM E
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40 , B01D59/44
摘要： A method that analyzes mass spectra using a digital computer is disclosed. T he method includes entering into a digital computer a data set (27) obtained fr om mass spectra from a plurality of samples. Each sample is, or is to be assign ed to a class within a class set having two or more classes (30) and each class is characterized by a different biological status. A classification model (5 4) is then formed. The classification model discriminates between classes in th e class set.

5. 发明专利

CA2453409A1 TIME-DEPENDENT DIGITAL SIGNAL SIGNAL SCALING PROCESS 未知
公开(公告)号：CA2453409A1
公开(公告)日：2003-01-23
申请号：CA2453409
申请日：2002-07-10
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： GAVIN EDWARD , YOUNGQUIST MICHAEL G , RICH WILLIAM E
IPC分类号： G01N27/62 , B01D59/44 , H01J49/02 , H01J49/26 , H01J49/40 , G06F17/00
摘要： A method and apparatus for processing time dependent signal data in a time o f flight mass spectrometer. Analyte ions are received by a detector (26) and time dependent data are received by a high speed time-to-digital converter (24) and sent to a digital software processing means (25).

6. 发明专利

AU2002314715B2 Method for correlating gene expression profiles with protein expression profiles 未知
公开(公告)号：AU2002314715B2
公开(公告)日：2006-07-27
申请号：AU2002314715
申请日：2002-02-15
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： RICH WILLIAM E , HUTCHENS T WILLIAM
IPC分类号： C12Q1/00 , G01N27/62 , C12N15/09 , C12Q1/68 , C12Q1/6809 , G01N27/447 , G01N27/64 , G01N33/50 , G01N33/53 , G01N37/00
摘要： The present invention relates to methods for correlating gene and protein expression in a cell.

7. 发明专利

AU2002245043A1 Method for analyzing mass spectra 未知
公开(公告)号：AU2002245043A1
公开(公告)日：2003-04-22
申请号：AU2002245043
申请日：2001-11-15
申请人： EASTERN VIRGINIA MED SCHOOL , CIPHERGEN BIOSYSTEMS INC
发明人： RICH WILLIAM E , FUNG ERIC T , WRIGHT JR GEORGE L , GAVIN EDWARD J , BRAGINSKY LEONID
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40 , B01D59/44
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.

8. 发明专利

CA2429633A1 METHOD FOR ANALYZING MASS SPECTRA 未知
公开(公告)号：CA2429633A1
公开(公告)日：2002-05-30
申请号：CA2429633
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： FUNG ERIC T , RICH WILLIAM E , BRAGINSKY LEONID , PAULSE CHRIS D , GAVIN EDWARD J
IPC分类号： G01N27/62 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40 , G01N33/48
摘要： A method that analyzes mass spectra using a digital computer is disclosed. T he method includes entering into a digital computer a data set obtained from ma ss spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is th en formed. The classification model discriminates between the classes in the class set.

9. 发明申请

WO03102542A2 COMPARATIVE PROTEOMICS OF PROGRESSOR AND NONPROGRESSOR POPULATIONS 审中-公开
标题翻译：进展者和非生殖者人口的比较保护
公开(公告)号：WO03102542A2
公开(公告)日：2003-12-11
申请号：PCT/US0317149
申请日：2003-05-30
申请人： CIPHERGEN BIOSYSTEMS INC , AARON DIAMOND AIDS RES CT , UNIV ROCKEFELLER , RICH WILLIAM E , HO DAVID D , ZHANG LINQI
发明人： RICH WILLIAM E , HO DAVID D , ZHANG LINQI
IPC分类号： G01N33/543 , G01N33/68 , G01N
CPC分类号： G01N33/6803 , G01N33/543
摘要： The invention identifies polypeptide biomarkers of disease progression or nonprogression by comparative protein profiling of samples from progressors and nonprogressors subpopulations of a population exposed to the pathogen or sharing a risk facto causing the disease. The polypeptides, their ligands, and modulators find use as diagnostic, prognostic, and therapeutic agents.
摘要翻译：本发明通过比较来自暴露于病原体的群体的进展者和非进展者亚群体的样品的比较蛋白质谱分析来识别疾病进展或非进展的多肽生物标志物，或共享引起疾病的风险事实。多肽，其配体和调节剂可用作诊断，预后和治疗剂。

10. 发明专利

AU2002241535B2 Method for analyzing mass spectra 未知
公开(公告)号：AU2002241535B2
公开(公告)日：2006-05-18
申请号：AU2002241535
申请日：2001-11-15
申请人： CIPHERGEN BIOSYSTEMS INC
发明人： RICH WILLIAM E , PAULSE CHRIS D , FUNG ERIC T , BRAGINSKY LEONID , GAVIN EDWARD J
IPC分类号： G01N27/62 , G01N33/48 , C12N15/00 , G01N27/64 , G01N31/00 , G01R23/16 , G06F19/00 , H01J49/00 , H01J49/40
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.

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