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1. 发明申请

WO2005011758A3 USE OF SUBSTITUTED 2,4-BIS (ALKYLAMINO) PYRIMIDINES OR -QUINAZOLINES AS ANTIMICROBIALS 审中-公开
标题翻译：取代的2,4-BIS（烷基氨基）嘧啶或间苯二酚作为抗微生物剂的使用
公开(公告)号：WO2005011758A3
公开(公告)日：2005-04-28
申请号：PCT/EP2004051516
申请日：2004-07-16
申请人： CIBA SC HOLDING AG , MARQUAIS-BIENEWALD SOPHIE , HOELZL WERNER , PREUSS ANDREA , MEHLIN ANDREAS
发明人： MARQUAIS-BIENEWALD SOPHIE , HOELZL WERNER , PREUSS ANDREA , MEHLIN ANDREAS
IPC分类号： A01N43/54 , A61K8/49 , A61L2/16 , A61L2/18 , A61Q11/00 , A61Q17/00 , C11D3/28 , C11D3/48 , D06M13/355 , A61K31/505 , C07D239/48 , C07D239/95
CPC分类号： A61Q17/005 , A01N43/54 , A61K8/4953 , A61L2/16 , A61L2/18 , A61Q11/00 , C11D3/28 , C11D3/48 , D06M13/355 , Y10T442/2525
摘要： The use of 2,4-bis(alkylamino)pyrimidines of formula (1) R1 is C1-C12alkyl or C6-C10laryl; R2 is hydrogen or C1-C12alkyl; or R1 and R2 together forma radical of formula (1 a) R' and R" are each independently of the other hydrogen, C1-C6alkyl or C1-C6alkoxy, R3 and R5 are each independently of the other hydrogen or C1-C8alkyl; R4 is C1-C20alkyl, unsubstituted phenyl, C6-C10aryl, C6-C10aryl-C1-C6alkyl, hydroxy-C1-C6alkyl, di-C1-C6al-kylamino-C1-C6aIkyl, mono-C1-C6alkylamino-C1-C6alkyl, -(CH2)2-(O-(CH2)2)1-4-OH or -(CH2)2-(O-(CH2)2)1-4-NH2; R6 is C1-C20alkyl, C6-C10aryl, C6-C10aryl-C1-C6alkyl, hydroxy-C1-C6alkyl, di-C1C6alkylamino-C1-C6alkyl, mono-C1-C6alkylamino-C1-C6alkyl, -(CH2)2-(O-(CH2)2)1-4-OH or -(CH2)2-(O-(CH2)2)1-4-NH2; or R3 and R4 and/or R5 and R6, together form a pyrrolidine, piperidine, hexamethyleneimine or morpholine ring; in the antimicrobial treatment of surfaces.
摘要翻译：式（1）R 1的2,4-双（烷基氨基）嘧啶的用途是C 1 -C 12烷基或C 6 -C 10芳基; R2是氢或C1-C12烷基; 或者R 1和R 2一起形成式（1a）的基团，R'和R“各自独立地为另一个氢，C 1 -C 6烷基或C 1 -C 6烷氧基，R 3和R 5各自独立地为另一个氢或C 1 -C 8烷基; R 4 是C 1 -C 20烷基，未取代的苯基，C 6 -C 10芳基，C 6 -C 10芳基-C 1 -C 6烷基，羟基-C 1 -C 6烷基，二-C 1 -C 6烷基氨基-C 1 -C 6烷基，单C 1 -C 6烷基氨基-C 1 -C 6烷基， - （ CH2）2-（O-（CH2）2）1-4-OH或 - （CH2）2-（O-（CH2）2）1-4-NH2; R6是C1-C20烷基，C6-C10芳基， C 1 -C 10芳基-C 1 -C 6烷基，羟基-C 1 -C 6烷基，二-C 1 -C 6烷基氨基-C 1 -C 6烷基，单-C 1 -C 6烷基氨基-C 1 -C 6烷基， - （CH 2）2 - （O-（CH 2）2）1-4 -OH或 - （CH2）2-（O-（CH2）2）1-4-NH2;或R3和R4和/或R5和R6一起形成吡咯烷，哌啶，六亚甲基亚胺或吗啉环;在表面的抗微生物处理中。

2. 发明申请

WO2006015959A3 USE OF FLUORESCENT WHITENING AGENTS AS ANTIMICROBIALS 审中-公开
标题翻译：使用荧光白剂作为抗微生物剂
公开(公告)号：WO2006015959A3
公开(公告)日：2006-05-04
申请号：PCT/EP2005053780
申请日：2005-08-03
申请人： CIBA SC HOLDING AG , HOELZL WERNER , PREUSS ANDREA , WALLQUIST OLOF
发明人： HOELZL WERNER , PREUSS ANDREA , WALLQUIST OLOF
IPC分类号： A61K8/40 , A61K8/41 , A61K8/46 , A61K8/49 , A61Q11/00 , A61Q11/02
CPC分类号： A61K8/41 , A01N61/00 , A61K8/40 , A61K8/46 , A61K8/466 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4966 , A61K8/498 , A61Q11/00 , A61Q11/02 , C11D3/42 , C11D3/48 , D21H21/36
摘要： Use of fluorescent whitening agents for whitening and the antimicrobial treatment of surfaces, and preservation of cosmetics, household products, personal care products, textiles, paper and starting materials of paper, plastics and disinfectants.
摘要翻译：使用荧光增白剂进行美白和表面的抗微生物处理，以及化妆品，家用产品，个人护理产品，纺织品，纸张，塑料和消毒剂原料的保存。

3. 发明申请

WO0162082A3 USE OF PHENYLETHYLAMINE DERIVATIVES FOR THE ANITMICROBIAL TREATMENT OF SURFACES 审中-公开
标题翻译：苯乙烯衍生物用于治疗表面抗微生物剂的用途
公开(公告)号：WO0162082A3
公开(公告)日：2002-05-02
申请号：PCT/EP0101561
申请日：2001-02-13
申请人： CIBA SC HOLDING AG , HAAP WOLFGANG , HOELZL WERNER , OCHS DIETMAR , PUCHTLER KARIN , SCHNYDER MARCEL
发明人： HAAP WOLFGANG , HOELZL WERNER , OCHS DIETMAR , PUCHTLER KARIN , SCHNYDER MARCEL
IPC分类号： A61K8/30 , A01N33/10 , A01N35/04 , A01N37/34 , A01N37/36 , A01N37/38 , A01N39/00 , A01N39/02 , A01N39/04 , A61K8/00 , A61K8/41 , A61K8/44 , A61K31/138 , A61K31/225 , A61K31/24 , A61K31/277 , A61P1/02 , A61P17/00 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q3/02 , A61Q3/04 , A61Q5/02 , A61Q5/04 , A61Q5/08 , A61Q5/10 , A61Q9/04 , A61Q11/00 , A61Q15/00 , A61Q17/02 , C07C213/06 , C07C217/60 , C07C253/30 , C07C255/54 , C09D11/00 , C09D201/00 , C11D3/48 , D06M13/328 , D21H21/36
CPC分类号： A01N39/00 , A01N33/10 , A01N37/38 , A01N39/02 , A01N39/04 , C07C217/60 , C07C255/54 , C07C2601/08
摘要： The use of compounds of formula (1) is described, in which compounds R1, R2 and R3 are each independently of the others hydrogen; C1-C20alkyl; C3-C7cycloalkyl; C2-C20alkenyl; C4-C7cycloalkenyl; C2-C20alkynyl; C4-C7cycloalkynyl; or unsubstituted or C1-C5alkyl-, C3-C7cylcoalkyl-, C1-C5alkoxyl-, C3-C7cycloakoxy-, halo-, oxo-, carboxy-, carboxy-C1-C7alkyl ester-, carboxy-C3-C7cylcloalkyl ester-, cyano-, trifluoromethyl-, pentafluoroethyl-, amino-, N,N-mono- or di-C1-C20alkylamino- or nitro-substituted phenyl-C1-C5alkyl, naphthyl-C1-C5alkyl, phenylcarbonyl-C1-C5alkyl, naphthylcarbonyl-C1-C5alkyl, pyrrolylalkyl, furanylalkyl, thiophenylalkyl, pyrazolylalkyl, imidazolylalkyl, oxazolylalkyl, thiazolylalkyl, isoxazolylalkyl, isothiazolylalkyl, 1,2,3-triazolylalkyl, 1,2,4-triazolylalkyl, 1,2,3-oxadiazolylalkyl, 1,3,4-oxadiazolylalkyl, 1,2,3-thiadiazolylalkyl, 1,3,4-thiadiazolylalkyl, indolylalkyl, pyridylalkyl, pyridazinylalkyl, pyrimidinylalkyl, pyridazinylalkyl, quinolinylalkyl, isoquinolinylalkyl, pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, indolyl, pyridyl, pyridazinyl, pyrimidinyl, pyridazinyl, quinolinyl or isoquinolinyl; R4, R5, R6 and R7 are each independently of the others hydrogen; C1-C20alkyl; C3-C7 cycloalky; C2-C20 alkenyl; C4-C7 cycloalkenyl; C2-C20 alkynyl; or C4-C7 cycloalkynyl; and m and n are each independently of the other 0 or 1, for antimicrobial treatment of surfaces. The compounds exhibit a pronounced activity against pathogenic gram-positive and gram-negative bacteria, and also against yeasts and moulds. They are accordingly suitable for the antimicrobial treatment, especially preservation and disinfection, of surfaces.
摘要翻译：描述了式（1）化合物的用途，其中化合物R1，R2和R3各自独立地为氢; C1-C20烷基; C3-C7环烷基; C2-C20alkenyl; C4-C7cycloalkenyl; C2-C20alkynyl; C4-C7cycloalkynyl; 或未取代的或C 1 -C 5烷基 - ，C 3 -C 7烷基烷基 - ，C 1 -C 5烷氧基 - ，C 3 -C 7环烷氧基 - ，卤代 - ，氧代 - ，羧基 - ，羧基-C 1 -C 7烷基酯 - ，羧基-C 3 -C 7环烷基酯 - 氰基 - 三氟甲基 - ，五氟乙基 - ，氨基 - ，N，N-单或二-C 1 -C 20烷基氨基或硝基取代的苯基-C 1 -C 5烷基，萘基-C 1 -C 5烷基，苯基羰基-C 1 -C 5烷基，萘基羰基-C 1 -C 5烷基，吡咯基烷基，呋喃基烷基，噻吩基烷基，吡唑基烷基，咪唑基烷基，恶唑基烷基，噻唑烷基，异恶唑基烷基，异噻唑基烷基，1,2,3-三唑基烷基，1,2,4-三唑基烷基，1,2,3-恶二唑基烷基，1,3,4-恶二唑基烷基 1,2,3-噻二唑基烷基，1,3,4-噻二唑基烷基，吲哚基烷基，吡啶基烷基，哒嗪基烷基，嘧啶基烷基，哒嗪基烷基，喹啉基烷基，异喹啉基烷基，吡咯基，呋喃基，噻吩基，吡唑基，咪唑基，恶唑基，噻唑基，异恶唑基，异噻唑基，，2,3-三唑基，1,2,4-三唑基，1,2,3-恶二唑基，1,3,4-恶二唑基，1,2,3-噻二唑基，1,3,4-噻二唑基，吲哚基，吡啶基，哒嗪基，嘧啶基，哒嗪基，喹啉基或异喹啉基; R4，R5，R6和R7各自独立地为氢; C1-C20烷基; C3-C7环状; C2-C20烯基; C4-C7环烯基; C2-C20炔基; 或C 4 -C 7环炔基; m和n各自独立地为0或1，用于表面的抗微生物处理。该化合物对病原性革兰氏阳性菌和革兰氏阴性细菌以及酵母和霉菌均表现出明显的活性。因此它们适用于表面的抗菌处理，特别是保存和消毒。

4. 发明申请

WO02058016A3 SILANYL PHENOLS AND NAPHTHOLS 审中-公开
标题翻译： SILANYL苯酚和萘酚
公开(公告)号：WO02058016A3
公开(公告)日：2002-12-19
申请号：PCT/EP0200192
申请日：2002-01-10
申请人： CIBA SC HOLDING AG , HOELZL WERNER , HAAP WOLFGANG , KOPPOLD JUERGEN
发明人： HOELZL WERNER , HAAP WOLFGANG , KOPPOLD JUERGEN
IPC分类号： A61L12/14 , C07C39/19 , C07C39/225 , C07F7/08 , C07F7/18 , D21H25/18
CPC分类号： C07F7/0852 , C07F7/0818
摘要： There are described silanyl phenols and naphthols of formula (1a) or (1b), wherein R1 is hydrogen; halogen; hydroxy; C1-C20alkyl; C3-C12cycloalkyl; C1-C20alkoxy; trifluoromethyl; pentafluoroethyl; mono- or di-C1-C5alkylamino; hydroxy-C1-C5alkyl; or phenyl, phenyl-C1-C20alkyl, phenoxy, phenyl-C1-C20alkoxy, naphthyl or naphthyl-C1-C20alkyl each unsubstituted or substituted by C1-C5alkyl, C3-C12cycloalkyl, C1-C5alkoxy, C3-C12cycloalkoxy, halogen, oxo, carboxy, carboxy-C1-C7alkyl ester, carboxy-C3-C12cycloalkyl ester, cyano, trifluoromethyl, pentafluoroethyl, amino, N,N-mono- or di-C1-C20alkylamino or by nitro; R2, R3 and R4 are each independently of the others hydrogen; C1-C20alkyl; or C3-C12-cycloalkyl; R5, R6 and R7 are each independently of the others C1-C20alkyl, C5-C10aryl, C1-C20alkoxy, phenyl-C1-C20alkyl, phenyl-C1-C20alkoxy, C2-C5alkenyl, -O-Si-(C1-C5alkyl)3; or O-Si-(C1-C5alkyl)2-O-Si(C1-C5alkyl)3 and n is 0 or 1. The compounds exhibit a pronounced activity against Gram positive and Gram negative bacteria, and also against yeasts and moulds.
摘要翻译：描述了式（1a）或（1b）的硅烷基酚和萘酚，其中R 1是氢; 卤素; 羟基; C1-C20烷基; C3-C12环烷基; C1-C20alkoxy; 三氟甲基; 五氟; 单 - 或二-C 1 -C 5烷基氨基; 羟基C1-C5烷基; 或苯基，苯基-C 1 -C 20烷基，苯氧基，苯基-C 1 -C 20烷氧基，萘基或萘基-C 1 -C 20烷基，各自为未取代的或被C 1 -C 5烷基，C 3 -C 12环烷基，C 1 -C 5烷氧基，C 3 -C 12环烷氧基，卤素，氧代，，羧基-C 1 -C 7烷基酯，羧基-C 3 -C 12环烷基酯，氰基，三氟甲基，五氟乙基，氨基，N，N-单或二-C 1 -C 20烷基氨基或被硝基取代; R2，R3和R4各自独立为氢; C1-C20烷基; 或C 3 -C 12 - 环烷基; R5，R6和R7各自独立地为C1-C20烷基，C5-C10芳基，C1-C20烷氧基，苯基-C1-C20烷基，苯基-C1-C20烷氧基，C2-C5链烯基，-O-Si-（C1-C5烷基）3 ; 或O-Si-（C 1 -C 5烷基）2 -O-Si（C 1 -C 5烷基）3并且n是0或1.所述化合物对革兰氏阳性菌和革兰氏阴性菌表现出显着的活性，并且还针对酵母菌和霉菌。

5. 发明申请

WO2008132045A2 SUBSTRATES WITH BIOCIDAL COATING 审中-公开
标题翻译：具有生物涂层的基材
公开(公告)号：WO2008132045A2
公开(公告)日：2008-11-06
申请号：PCT/EP2008054519
申请日：2008-04-15
申请人： CIBA HOLDING INC , DEISENROTH TED , HENDRICKS-GUY CARMEN , MUEHLEBACH ANDREAS , PREUSS ANDREA , HOELZL WERNER , HUANG XINYU
发明人： DEISENROTH TED , HENDRICKS-GUY CARMEN , MUEHLEBACH ANDREAS , PREUSS ANDREA , HOELZL WERNER , HUANG XINYU
IPC分类号： A01N33/12 , A01N25/10 , A01P1/00
CPC分类号： A01N37/12 , A01N25/10 , A01N25/34 , A01N33/12 , A61L15/46 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/208 , A61L2300/404 , A61L2300/606 , C09D4/00 , A01N37/44 , C08F220/34
摘要： The present invention provides a process for coating the surface of a substrate comprises the following steps (i) oxidizing the surface of the substrate (ii) applying a composition comprising one or more quaternary ammonium compounds carrying one or more ethylenically unsaturated groups onto the oxidized surface of the substrate and (iii) curing the composition in order to form a coating layer, and substrates obtainable by the latter process.
摘要翻译：本发明提供一种涂覆基材表面的方法，包括以下步骤（i）氧化基材表面（ii）将包含一种或多种带有一个或多个烯键式不饱和基团的季铵化合物的组合物施加到氧化表面上和（iii）固化组合物以形成涂层，以及通过后一工艺可获得的底物。

6. 发明专利

JP2001039958A 4-HYDROXYISOTHIAZOLE COMPOUND 失效
公开(公告)号：JP2001039958A
公开(公告)日：2001-02-13
申请号：JP2000141344
申请日：2000-05-15
申请人： CIBA SC HOLDING AG
发明人： HOELZL WERNER , HAAP WOLFGANG , OCHS DIETMAR , PUCHTLER KARIN , SCHNYDER MARCEL , DINESH NARENDRA , PAL SITARAM , MAHTRE ASAWARI BHIKAJI , KULKARNI SURENDRA UMESH , RADHAKRISHNA ARAKALI SRINIVASA
IPC分类号： C07D275/02 , A01N43/80 , A61K8/00 , A61K8/49 , A61K31/425 , A61P31/04 , A61Q5/00 , A61Q5/02 , A61Q11/00 , A61Q19/10 , C07D275/03 , C08K5/46 , C08L101/00 , C11D3/34 , C11D3/48 , D06M13/35 , A61K7/075 , A61K7/16 , A61K7/50
摘要： PROBLEM TO BE SOLVED: To use a specific compound stable to temperatures and having low volatility, extremely low migrating properties and antimicrobial activity for an antimicrobial finish, etc. of a polymeric compound exposed to an environment contaminated with microorganisms. SOLUTION: This compound represented by formula I or II [R1 and R2 are each H, a (substituted)1-10C alkyl, a (substituted)1-10C acyl, a (substituted)6-10C aryl or a (substituted)6-10C arylcarbonyl] is used as an antimicrobial agent. The compound represented by formula I is obtained by a method, etc. for reacting, e.g. acetic anhydride with an acetic acid in which the carbon atom at the α-position is substituted with R1 or R2, reacting the resultant ketone represented by formula III (R4 is R1 or R2) with hydroxylamine hydrochloride, providing an oxime represented by formula IV, then reacting the prepared oxime with tosyl chloride in an aromatic solvent, affording a tosylate dissolving the resultant tosylate in an ethereal solvent, adding the formed solution into a cooled solution of metallic potassium in a dried alcohol, producing an aminoketone represented by formula V and reacting the produced aminoketone with thionyl chloride.

7. 发明专利

JP2001011005A HYDROXYDIPHENYL ETHER COMPOUND 失效
公开(公告)号：JP2001011005A
公开(公告)日：2001-01-16
申请号：JP2000142621
申请日：2000-05-16
申请人： CIBA SC HOLDING AG
发明人： HOELZL WERNER , HAAP WOLFGANG , OCHS DIETMAR , PUCHTLER KARIN , SCHNYDER MARCEL , KULKARNI SURENDRA UMESH , RADHAKRISHNA ARAKALI SRINIVASA , SAWANT MANGESH SHIVRAM , MAHTRE ASAWARI BHIKAJI
IPC分类号： A61K8/30 , A01N31/14 , A01N31/16 , A01N35/04 , A61K8/00 , A61K8/34 , A61K8/35 , A61K31/075 , A61K31/085 , A61K31/11 , A61K31/12 , A61P1/02 , A61P17/00 , A61P17/16 , A61P31/04 , A61Q5/00 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q19/00 , A61Q19/10 , C07B61/00 , C07C41/16 , C07C41/18 , C07C43/23 , C07C43/295 , C07C45/46 , C07C45/54 , C07C45/67 , C07C47/575 , C07C49/84 , C11D3/48 , C11D7/26 , C11D7/32 , D06M13/02 , D06M13/152 , A61K7/00 , A61K7/06 , A61K7/16 , A61K7/40 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound with thermal stability, low volatility and effective antimicrobial activity, having greatly reduced migration tendency, and useful as an antimicrobial agent for plastics, coating materials or the like exposed to environment contaminated with microorganisms. SOLUTION: This compound is a compound of formula I (R1 and R2 are each H, OH or the like, R3 is H, a 1-20C alkyl or the like, R4 is H, formyl or the like, when OH is at the para-position with respect to the ether linkage; R2 is H, 1-20C alkyl or the like, R1 and R3 are each H, 1-6C alkylcarbonyl or the like, R4 is H, OH or the like, when OH is at a meta-position with respect to the ether linkage; R7 is H, 1-6C alkylcarbonyl or the like, R4 is H, acetonitrile or the like, R2 and R3 are each H, a 1-20C alkyl or the like, when OH is at an ortho-position with respect to the ether linkage; however, excluding e.g. a compound wherein OH is at the para-position with respect to the ether linkage, R1 and R3 are both H, and also R2 is methoxy or methyl) (e.g. a compound of formula II). This compound of formula I is used as an antimicrobial agent also used, for example, for antimicrobial treatment of the skin, hair or the like.

8. 发明专利

JP2003226678A ALKOXYBENZYLAMINE 审中-公开
公开(公告)号：JP2003226678A
公开(公告)日：2003-08-12
申请号：JP2002292455
申请日：2002-10-04
申请人： CIBA SC HOLDING AG
发明人： HAAP WOLFGANG , HOELZL WERNER , PETZOLD KARIN
IPC分类号： A61F13/49 , A01N33/10 , A01N37/18 , A01N43/36 , A01N43/40 , A01N43/46 , A01N43/60 , A01N43/84 , A61F13/00 , A61F13/15 , A61F13/472 , A61K8/00 , A61K8/40 , A61K8/41 , A61K8/49 , A61L2/16 , A61L2/18 , A61L9/01 , A61Q5/02 , A61Q11/00 , A61Q17/00 , A61Q19/10 , C07C213/02 , C07C217/58 , C07D213/36 , C07D213/38 , C07D295/08 , C07D295/096 , C07D295/18 , C07D295/185 , C11D7/32 , D06M13/328 , D06M13/335 , A61K7/075 , A61K7/22 , A61K7/40 , A61K7/50
摘要： PROBLEM TO BE SOLVED: To provide a new alkoxybenzylamine having an anti-bacterial activity. SOLUTION: This compound is expressed by formula (1) [wherein, R 1 , R 2 are each H, a 1-20C alkyl, a 2-20C alkenyl, a 2-20C alkynyl, a 3-12C cycloalkyl, a 3-7C cycloalkyl-a 1-20C alkyl, a 1-6C alkoxy-a 1-20C alkyl, a 1-12C alkoxycarbonyl, phenyl or phenyl-a 1-20C alkyl, carboxyl or pyridino-a 1-5C alkyl, or form a 5-7-membered single heterocyclic ring together with N atom bonded with them; R 3 , R 4 are each a 1-20C alkyl; and (n) is 0 or 1]. COPYRIGHT: (C)2003,JPO

9. 发明申请

WO2009138341A3 POLYOL DERIVED ANTI-MICROBIAL AGENTS AND COMPOSITIONS 审中-公开
标题翻译：聚氨酯衍生的抗微生物剂和组合物
公开(公告)号：WO2009138341A3
公开(公告)日：2010-04-22
申请号：PCT/EP2009055453
申请日：2009-05-06
申请人： BASF SE , ELDER STEWART TODD , KHAWAM FADI , HUANG XINYU , HOELZL WERNER
发明人： ELDER STEWART TODD , KHAWAM FADI , HUANG XINYU , HOELZL WERNER
IPC分类号： A01P1/00
CPC分类号： A01N37/36 , A01N37/44 , C07C229/12
摘要： Anti-microbial compositions are provided which comprise as an antimicrobial agent at least one compound derived from a select polyol containing at least 3 hydroxy groups wherein one or more, and often two or more, of the hydroxyls are derivitized to form certain ether, ester, carbonate or carbamate groups which groups may bear additional functionality. Antimicrobial compounds of this class are also provided. The compositions are effective against a variety of pathogens including fungi, Gram positive bacteria and Gram negative bacteria and are expected to have low human toxicity. Applications for the polyglycerol anti-microbial agents and compositions include those involving human and plant contact, such as cosmetics, hair care products, textiles and plant protections, as well as in applications with much less human contact, such as plastics, coatings, wood, paper and other materials of construction.
摘要翻译：提供抗微生物组合物，其包含作为抗微生物剂的至少一种衍生自包含至少3个羟基的选择多元醇的化合物，其中一个或多个，并且通常两个或更多个羟基被衍生以形成某些醚，酯，碳酸酯或氨基甲酸酯基，这些基团可以具有附加的功能。还提供了这一类的抗微生物化合物。该组合物对各种病原体有效，包括真菌，革兰氏阳性菌和革兰氏阴性细菌，预计其毒性低。聚甘油抗微生物剂和组合物的应用包括涉及人和植物接触的那些，例如化妆品，护发产品，纺织品和植物保护，以及在人类接触少得多的应用中，例如塑料，涂料，木材，纸等施工材料。

10. 发明申请

WO9931036A2 O-DERIVATIVES OF HALOGENATED DIPHENYL ETHER COMPOUNDS 审中-公开
标题翻译：氢化二苯醚化合物的O-衍生物
公开(公告)号：WO9931036A2
公开(公告)日：1999-06-24
申请号：PCT/EP9807997
申请日：1998-12-09
申请人： CIBA GEIGY AG , HOELZL WERNER , HUEGLIN DIETMAR , MAIER THOMAS , MAO JIANWEN , OCHS DIETMAR
发明人： HOELZL WERNER , HUEGLIN DIETMAR , MAIER THOMAS , MAO JIANWEN , OCHS DIETMAR
IPC分类号： A01N31/16 , C07C25/02 , C07C39/24 , C07C41/00 , C07D251/00 , C07F9/12 , C07H15/203
CPC分类号： C07H15/203 , A01N31/16 , C07C25/02 , C07C39/24 , C07D251/00 , C07F9/12
摘要： The invention describes O-derivatives of halogenated diphenyl ether compounds of formula (1), in which R1 and R2 independently of one another are F, Cl or Br; Y is a radical of formula (1a); (1b); (1c); (1d); (1e) or (1f); R3 is C1-C22alkyl; C1-C22alkoxy; phenyl; phenyl-C1-C4alkyl; --(CH2)p4-A R5R6R7; the radical of formula (I); R4 C1-C22alkyl; R5, R6, R7 and R8 independently of one another are hydrogen; C1-C4alkyl; sulfo-C1-C4alkyl; or R5 and R6 together with A form a cyclic radical unsubstituted or substituted by sulfo groups; or R7 and R8 together with N form a cyclic radical unsubstituted or substituted by sulfo groups; A is N or P; Z1 is fluorine, chlorine, the radical of formula (1g); Z2 is fluorine, chlorine, C1-C22alkoxy, C1-C22alkylthio or C1-C22-monoalkylamino or C1-C22dialkylamino; each of which is unsubstituted or substituted by OH, NH2 or sulfo; C6-C12aryloxy, C6-C12arylthio or C6-C12monoarylamino or C6-C12diarylamino, each of which is unsubstituted or substituted by OH, NH2 or sulfo; m is from 1 to 3; n is 1 or 2; and p1, p2, p3, p4 and p5 independently of one another are 1-4. The diphenyl ether derivatives according to the invention have excellent antimicrobial properties and are stable to migration.
摘要翻译：本发明描述了式（1）的卤代二苯醚化合物的O-衍生物，其中R 1和R 2彼此独立地是F，Cl或Br; Y是式（1a）的基团; （1B）; （1C）; （1D）; （1e）或（1f）; R3是C1-C22烷基; C1-C22alkoxy; 苯基; 苯基-C1-C4烷基; - （CH2）P4-A <+> R5R6R7; 式（I）的基团; R4 C1-C22烷基; R5，R6，R7和R8彼此独立地是氢; C1-C4烷基; 磺基C1-C4烷基; 或R 5和R 6与A一起形成未取代或被磺基取代的环状基团; 或R 7和R 8与N一起形成未取代或被磺基取代的环状基团; A是N或P; Z1是氟，氯，式（1g）的基团; Z 2是氟，氯，C 1 -C 22烷氧基，C 1 -C 22烷硫基或C 1 -C 22单烷基氨基或C 1 -C 22二烷基氨基; 其各自是未取代的或被OH，NH 2或磺基取代; C 6 -C 12芳氧基，C 6 -C 12芳硫基或C 6 -C 12单芳基氨基或C 6 -C 12二芳基氨基，其各自未被取代或被OH，NH 2或磺基取代; m为1〜3; n为1或2; 而p1，p2，p3，p4和p5彼此独立地为1-4。根据本发明的二苯醚衍生物具有优异的抗菌性能并且对迁移稳定。

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