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    • 6. 发明申请
    • POLYSILOXANE ANTIMICROBIALS
    • 多晶硅抗微生物
    • WO2008006744A2
    • 2008-01-17
    • PCT/EP2007056703
    • 2007-07-04
    • CIBA SC HOLDING AGMARQUAIS-BIENEWALD SOPHIEWALLQUIST OLOFPREUSS ANDREAELDER STEWART TODD
    • MARQUAIS-BIENEWALD SOPHIEWALLQUIST OLOFPREUSS ANDREAELDER STEWART TODD
    • A01N55/10A01P1/00C07F7/08C08G77/38C08G77/388
    • C08G77/388A01N55/00
    • Disclosed are oligo- or polysiloxanes, which are characterized by containing at least 3, for example 4 - 3000, Si atoms in the main chain, and wherein at least one thereof is contained in a moiety of the formula (I) whose open bond of the O atom is linked to another Si atom of the oligo- or polysiloxane main chain, and whose open bond of the Si atom is linked either to another O atom of the oligo- or polysiloxane main chain or to R' 1, where R 1 and R' 1 independently are C 1 -C 10 alkyl, R 2 and R 3 independently are C 1 -C 18 alkylene, X is a divalent spacer group selected from O, NR 4, N(COR' 5 ), CONR' 4, OCONR' 4; .Y is selected from OCOR 5, NHCOR 5, NHR 4 , COOR 5, CONHR 4, NR' 4 R 4; R 4 is selected from C 6 -C 18 organic residues containing at least one aryl moiety; R' 4 is as defined for R 4; or is selected from H, C 1 -C 20 alkyl, C 7 -C 20 phenylalkyl, C 4 - C 12 cycloalkyl; R 5 is R 7 -Z; R' 5 is as defined for R 5; or is selected from H, C 1 -C 20 alkyl, C 7 -C 20 phenylalkyl, C 4 - C 12 cycloalkyl; R 7 is C 1 -C 20 alkylene, which may be interrupted by phenylene, C 4 -C 12 cycloalkylene, O, NR' 4; or is unsubstituted or substituted phenylene or C 4 -C 12 cycloalkylene; Z is halogen or N+R 8 R 9 R 10; R 8 , R 9 and R 10 independently are selected from C 1 -C 20 alkyl, C 7 -C 20 phenylalkyl, C 4 - C 12 cycloalkyl, unsubstituted or substituted aryl; or 2 of R 8 , R 9 and R 10 are linked together to form a quaternized aliphatic, substituted or unsubstituted N-heterocyclic ring of 4-6 carbon atoms such as a piperidine ring; or all of R 8 , R 9 and R 10 are linked together to form, together with the nitrogen atom they are bonding to, a substituted or unsubstituted N-heterocyclic ring system of 4-7 carbon atoms. The novel compounds are effective as antimicrobials.
    • 公开了低聚或聚硅氧烷,其特征在于在主链中含有至少3个,例如4-3000个Si原子,并且其中至少一个包含在式(I)的部分中,其开环键 O原子连接到寡硅烷或聚硅氧烷主链的另一个Si原子,并且其Si原子的开环键连接到寡聚或聚硅氧烷主链的另一个O原子或R'1, 其中R 1和R'1个独立地是C 1 -C 10烷基, R 2和R 3独立地是C 1 -C 18亚烷基,X是选自O, NR 4,N(COR'5 5),CONR 4,OCONR 4等; Y选择 来自OCOR 5,NHCOR 5,NHR 4,COOR 5,CONHR 4,/ SUB > NR'4 R 4; R 4选自C 6 -C 18烷基, SUB>含有至少一个芳基的有机残基 iety; R 4'如对R 4所定义;或者选自H,C 1 -C 20烷基 C 7 -C 20烷基,C 4 -C 12环烷基,C 1 -C 12烷基, R 5是R 7 -Z; R 5'如对R 5所定义;或者选自H,C 1 -C 20烷基 C 7 -C 20烷基,C 4 -C 12环烷基,C 1 -C 12烷基, R 7是C 1 -C 20亚烷基,其可以被亚苯基中间,C 4 -C 20亚烷基, O,NR'4;或未取代或取代的亚苯基或C 4 -C 12亚环烷基; Z是卤素或N + R 8 R 9 R 10; R 8,R 9, R 1和R 2独立地选自C 1 -C 20烷基,C 7 -C 20烷基, C 20 -C 20烷基,C 1-4烷基,未取代或取代的芳基; 或2个R 8,R 9和R 10连接在一起形成季铵化的脂族,取代或未取代的4-杂环 -6个碳原子,如哌啶环; 或全部R 8,R 9和R 10连接在一起,与它们键合的氮原子一起形成取代的 或未取代的4-7个碳原子的N-杂环系统。 新型化合物作为抗微生物剂是有效的。