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1. 发明申请

WO2009038385A3 NOVEL COMPOUNDS HAVING INDAZOLE FRAMEWORKS, METHODS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：具有异构体框架的新型化合物，其制备方法和包含其的药物组合物
公开(公告)号：WO2009038385A3
公开(公告)日：2009-06-18
申请号：PCT/KR2008005555
申请日：2008-09-19
申请人： CHOONGWAE PHARMA CORP , KIM JEOM-YONG , MA MI-RA , JUNG KYUNG-YUN , CHOI JIN-SEOK , CHO YOUNG-SEOK , LEE SANG-HAK
发明人： KIM JEOM-YONG , MA MI-RA , JUNG KYUNG-YUN , CHOI JIN-SEOK , CHO YOUNG-SEOK , LEE SANG-HAK
IPC分类号： C07D471/04 , A61K31/4162 , A61K31/506 , A61P3/10 , A61P9/10 , A61P25/18 , C07D403/02
CPC分类号： C07D471/04
摘要： Novel compounds having indazole frameworks, as well as a method for preparing the same and a pharmaceutical composition comprising the same are provided. The compounds of the present invention can inhibit protein kinase activity and thus the pharmaceutical composition of the present invention can be used to prevent or treat diseases or disorders which are related to protein kinase activity.
摘要翻译：提供了具有吲唑骨架的新型化合物及其制备方法和包含其的药物组合物。本发明的化合物可以抑制蛋白激酶活性，因此本发明的药物组合物可用于预防或治疗与蛋白激酶活性相关的疾病或病症。

2. 发明申请

WO2009051399A3 NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF (1) 审中-公开
标题翻译：反向转换的新型化合物及其用途（1）
公开(公告)号：WO2009051399A3
公开(公告)日：2009-06-04
申请号：PCT/KR2008006072
申请日：2008-10-15
申请人： CHOONGWAE PHARMA CORP , CHUNG JAE UK , JUNG HEE-KYUNG , JUNG KYUNG-YUN , JEONG MIN-WOOK , LA HYUN-JU , LEE SANG-HAK , KIM HOE-MOON
发明人： CHUNG JAE UK , JUNG HEE-KYUNG , JUNG KYUNG-YUN , JEONG MIN-WOOK , LA HYUN-JU , LEE SANG-HAK , KIM HOE-MOON
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/53
摘要： Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as derivatives thereof including prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.
摘要翻译：公开了具有新颖性并且模拟生物活性肽和蛋白质的逆转转区的二级结构并具有双环框架的构象约束化合物，以及其衍生物，包括前药。这种反转模拟结构和前药在广泛的领域中具有实用性，包括用作诊断和治疗剂。本发明还涉及这种化合物在制备用于治疗或预防包括急性骨髓性白血病的癌症的药物中的用途。

3. 发明申请

WO2012050393A3 NOVEL COMPOUND OF A REVERSE-TURN MIMETIC AND A PRODUCTION METHOD AND USE THEREFOR 审中-公开
标题翻译：反转式的新型化合物及其生产方法及其用途
公开(公告)号：WO2012050393A3
公开(公告)日：2012-07-26
申请号：PCT/KR2011007667
申请日：2011-10-14
申请人： JW PHARMACEUTICAL CORP , CHUNG JAE-UK , KIM MI-JUNG , LEE YONG-SIL , MA SANG-HO , CHO YOUNG-SEOK , LEE SANG-HAK , NA YOUNG-JUN , KANG MYOUNG-JOO , PARK WOUL-SEONG
发明人： CHUNG JAE-UK , KIM MI-JUNG , LEE YONG-SIL , MA SANG-HO , CHO YOUNG-SEOK , LEE SANG-HAK , NA YOUNG-JUN , KANG MYOUNG-JOO , PARK WOUL-SEONG
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/02
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to a novel compound of a reverse-turn mimetic, having pyrazino-triazinone for its basic structure, and to a production method therefor, and the invention relates to use of the compound as a therapeutic agent for diseases having an anticancer effect or the like and, in particular, as a therapeutic agent for acute myeloid leukaemia.
摘要翻译：本发明涉及一种逆转模拟物的新型化合物，其基本结构为吡嗪并三嗪酮及其制备方法，本发明涉及该化合物作为具有抗癌作用的疾病的治疗剂的用途特别是作为急性骨髓性白血病的治疗剂。

4. 发明申请

WO2011037127A3 NANOCRYSTAL TITANIUM ALLOY AND PRODUCTION METHOD FOR SAME 审中-公开
标题翻译：纳米钛合金及其制造方法
公开(公告)号：WO2011037127A3
公开(公告)日：2011-06-03
申请号：PCT/JP2010066379
申请日：2010-09-22
申请人： NHK SPRING CO LTD , UNIV TOHOKU , LEE SANG-HAK , ONO YOSHIKI , IKAI KAZUYA , MATSUMOTO HIROAKI , CHIBA AKIHIKO
发明人： LEE SANG-HAK , ONO YOSHIKI , IKAI KAZUYA , MATSUMOTO HIROAKI , CHIBA AKIHIKO
IPC分类号： C22C14/00 , C22F1/00 , C22F1/18
CPC分类号： C22F1/183 , C22C1/02 , C22C14/00 , C22F1/00
摘要： Disclosed is a Ti alloy having high strength and excellent workability, and which is suitable for materials for various types of manufacturing such as vehicle manufacturing. Also disclosed is a production method for the Ti alloy. The a' martensitic phase structure of the alloy is hot worked under conditions in which dynamic recrystallisation occurs. The processing conditions are that the temperature is increased at a heating rate of 50-800°C/sec, the strain rate at 700-800°C is 0.01-10/sec, the strain rate between 800°C and 1000°C noninclusive is 0.1-10/sec, and the strain is 0.5 or more. Thus, equiaxed crystals with an average crystal grain diameter below 1000nm are obtained.
摘要翻译：公开了一种具有高强度和优异的加工性的Ti合金，适用于车辆制造等各种制造材料。还公开了一种Ti合金的制造方法。在发生动态再结晶的条件下，对该合金的a'马氏体相结构进行热加工。加工条件是以50-800℃/秒的升温速度升温，700-800℃的应变速率为0.01-10 /秒，应变速率为800〜1000℃ 为0.1-10 /秒，应变为0.5以上。因此，得到平均晶粒直径小于1000nm的等轴晶体。

5. 发明公开

EP2201011A4 NOVEL COMPOUNDS HAVING INDAZOLE FRAMEWORKS, METHODS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新的连接INDAZOLGERÜSTEN，工艺因为，为了产生与药物组合物
公开(公告)号：EP2201011A4
公开(公告)日：2011-01-05
申请号：EP08832020
申请日：2008-09-19
申请人： CHOONGWAE PHARMA CORP
发明人： KIM JEOM-YONG , MA MI-RA , JUNG KYUNG-YUN , CHOI JIN-SEOK , CHO YOUNG-SEOK , LEE SANG-HAK
IPC分类号： C07D471/04 , A61K31/4162 , A61K31/506 , A61P3/10 , A61P9/10 , A61P25/18 , C07D403/02
CPC分类号： C07D471/04

6. 发明公开

EP2212329A4 NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF (1) 有权
标题翻译：新的反向MIME连接及其使用（1）
公开(公告)号：EP2212329A4
公开(公告)日：2011-11-30
申请号：EP08839568
申请日：2008-10-15
申请人： CHOONGWAE PHARMA CORP
发明人： CHUNG JAE UK , JUNG HEE-KYUNG , JUNG KYUNG-YUN , JEONG MIN-WOOK , LA HYUN-JU , LEE SANG-HAK , KIM HOE-MOON
IPC分类号： C07D487/04 , A61K31/53
CPC分类号： C07D487/04 , A61K31/53

7. 发明专利

ES2509042T3 Nuevos compuestos de miméticos de giro inverso y el uso de los mismos (1) 未知
公开(公告)号：ES2509042T3
公开(公告)日：2014-10-16
申请号：ES08839568
申请日：2008-10-15
申请人： CHOONGWAE PHARMA CORP
发明人： CHUNG JAE UK , JUNG HEE-KYUNG , JUNG KYUNG-YUN , JEONG MIN-WOOK , LA HYUN-JU , LEE SANG-HAK , KIM HOE-MOON
IPC分类号： C07D487/04 , A61K31/53
摘要： Un compuesto que tiene la estructura de fórmula (III):**Fórmula** en la que: R1 es seleccionado del grupo que consiste en 2-metil-2H-indazolilo, 1-metil-5 1H-indazolilo, 3-ciclopropilcarbonil-1H-indazolilo, 1-hidroxietil-1H-indazolilo, 1H- indazolilo, 2-ciclopropilmetil-2H-indazolilo, 3-amino-1H-indazolilo, 1-bencil-1H-indazolilo, 3-cloro-1H-indazolilo, 6- cloro-1H-indazolilo, 3-fenil-1H-indazolilo, 1-bencil-3-fenil-1H-indazolilo, 1-nitrobencil-1H-indazolilo, 1-aminobencil-1H-indazolilo, 2-metil-3-ciclopropilcarbonil-2H-indazolilo, 1-metil-3-aminocarbonil-1H-indazolilo, carbonil-indazolilo, 2-isopropil-2H-indazolilo, 2-aminocarbonilmetil-2H-indazolilo, 1-cianometil-3-ciclopropilcarbonil-1H-indazolilo, 2-cianometil-3-ciclopropilcarbonil-2H-indazolilo, 1-morfolinil-N-etil-1H-indazolilo, 2-morfolinil-N-etil-2H-indazolilo, 2-dimetilaminocarbonilmetil-2H-indazolilo, 2-metoxietilpropionamida-2H-indazolilo, 1-etoxicarbonilmetil-1H-indazolilo, 2-etoxicarbonilmetil-2H-indazolilo y 1-acetoxietil-1H-indazolilo; R4 es alilo; R6 es fenilo o fenilo sustituido que tiene uno o más sustituyentes seleccionados de forma independiente de: halógeno, hidroxilo, ciano, alquilo C1-6, acetilenilo y alcoxi C1-6; o piridilo o piridilo sustituido que tiene uno o más sustituyentes seleccionados de forma independiente de: Halógeno, hidroxilo, ciano, alquilo C1-6 y alcoxi C1-6; X1 es hidrógeno, hidroxilo o halógeno; y cada uno de X2 y X3 es, de forma independiente, hidrógeno, hidroxilo, fosfato, dimetilaminoacetato, (2-dimetilaminoetil)carbamato, dietilfosfonoacetamido o halógeno).

8. 发明专利

CA2702461C NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF (1) 未知
公开(公告)号：CA2702461C
公开(公告)日：2012-12-11
申请号：CA2702461
申请日：2008-10-15
申请人： CHOONGWAE PHARMA CORP
发明人： CHUNG JAE UK , JUNG HEE-KYUNG , JUNG KYUNG-YUN , JEONG MIN-WOOK , LA HYUN-JU , LEE SANG-HAK , KIM HOE-MOON
IPC分类号： C07D487/04
摘要： Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as derivatives thereof including prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

9. 实用新型

KR870000084Y1 관권기의 원사절단장치 失效
公开(公告)号：KR870000084Y1
公开(公告)日：1987-02-07
申请号：KR840004685
申请日：1984-05-19
申请人： YU YONG DAL , LEE SANG HAK
发明人： YU YONG-DAL , LEE SANG-HAK
IPC分类号： B65H54/22 , B65H54/71

10. 实用新型

KR870000580Y1 관권기의 목관착탈 장치 失效
公开(公告)号：KR870000580Y1
公开(公告)日：1987-02-21
申请号：KR860013589
申请日：1986-09-01
申请人： YU YONG DAL , LEE SANG HAK
发明人： YU YONG-DAL , LEE SANG-HAK
IPC分类号： B65H54/22 , B65H54/71

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