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1. 发明申请

WO2006002236A1 N- (1- (1-BENZYL -4-PHENYL-1H-IMIDAZOL-2-YL) -2,2-DYMETHYLPROPYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS KINESIN SPINDLE PROTEIN (KSP) INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译： N-（1-（1-苄基-4-苯基-1H-咪唑-2-基）-2,2-二甲基丙基）苯甲酰胺衍生物及相关化合物作为治疗癌症的KINESIN主轴蛋白（KSP）抑制剂
公开(公告)号：WO2006002236A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/022062
申请日：2005-06-20
申请人： CHIRON CORPORATION , WANG, Weibo , BARSANTI, Paul, A. , XI, Yi , BOYCE, Rustum, S. , PECCHI, Sabina , BRAMMEIER, Nathan , PHILLIPS, Megan , MENDENHALL, Kris , WAYMAN, Kelly , LAGNITON, Liana, Marie , CONSTANTINE, Ryan , YANG, Hong , MIEULI, Elizabeth , RAMURTHY, Savithri , JAZAN, Elisa , SHARMA, Anu , RAMA, Jain , SABRAMANIAN, Sharadha , RENHOWE, Paul , BAIR, Kenneth, Walter , DUHL, David , WALTER, Annette , ABRAMS, Tinya , HUH, Kay , MARTIN, Eric , KNAPP, Mark , LE, Vincent
发明人： WANG, Weibo , BARSANTI, Paul, A. , XI, Yi , BOYCE, Rustum, S. , PECCHI, Sabina , BRAMMEIER, Nathan , PHILLIPS, Megan , MENDENHALL, Kris , WAYMAN, Kelly , LAGNITON, Liana, Marie , CONSTANTINE, Ryan , YANG, Hong , MIEULI, Elizabeth , RAMURTHY, Savithri , JAZAN, Elisa , SHARMA, Anu , RAMA, Jain , SABRAMANIAN, Sharadha , RENHOWE, Paul , BAIR, Kenneth, Walter , DUHL, David , WALTER, Annette , ABRAMS, Tinya , HUH, Kay , MARTIN, Eric , KNAPP, Mark , LE, Vincent
IPC分类号： C07D233/54
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： This invention is directed to substituted imidazole compounds which modulate the activity of KSP and are useful for the treatment of cancer and are represented by the formula (I) wherein: R 1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo; R 2 is selected from the group consisting of hydrogen, alkyl, and aryl; R 3 is selected from the group consisting of hydrogen and -X-A, wherein X is selected from the group consisting of-C(O)-, -C(S)-, -S(O)-, -S(O) 2 -, and -S(O)2-N(R)-, where R is hydrogen or alkyl; and A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents; R 5 is selected from the group consisting of L-A 1 , wherein L is selected from the group consisting of-S(O) q - where q is one or two, and C 1 to C 5 alkylene optionally substituted with hydroxy, halo, or acylamino; and A 1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl; and one of either R 6 or R 7 is selected from the group consisting of heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with -(R 8 ) m where R 8 is as defined herein and m is an integer from 1 to 3, and the other Of R 6 or R 7 is selected from the group consisting of hydrogen, halo, and alkyl; or R 6 and R 7 are both hydrogen; the other substituents are defined in the claims.
摘要翻译：本发明涉及调节KSP活性并且可用于治疗癌症并由式（I）表示的取代的咪唑化合物，其中：R 1选自氨基酰基酰基氨基，羧基，羧基酯，芳基和任选被羟基或卤素取代的烷基; R 2选自氢，烷基和芳基; R 3选自氢和-XA，其中X选自-C（O） - ， - C（S） - ， - S（O） - ，-S（O）2 - 和-S（O）2 -N（R） - ，其中R是氢或烷基; 并且A选自氢，任选取代的烷基，任选取代的烷氧基，任选取代的芳基，羧基，羧基酯，氨酰基，任选取代的杂芳基，任选取代的杂环和任选取代的环烷基，其中任选取代的基团被取代具有1至4个取代基; R 5选自LA 1，其中L选自-S（O）q - ，其中 q是一个或两个，并且C 1至C 5亚烷基，其任选被羟基，卤素或酰基氨基取代; 并且A 1选自芳基，取代的芳基，杂芳基，取代的杂芳基，杂环，取代的杂环，环烷基和取代的环烷基; 且R 6或R 7中的一个选自杂环，芳基和杂芳基，其全部可以任选地被 - （R' 其中R 8如本文所定义，m是1至3的整数，R 6中的另一个或R 7选自氢，卤素和烷基; 或R 6和R 7都是氢; 其它取代基在权利要求中限定。

2. 发明申请

WO2007095588A1 PI-3 KINASE INHIBITORS AND METHODS OF THEIR USE 审中-公开
标题翻译： PI-3激酶抑制剂及其使用方法
公开(公告)号：WO2007095588A1
公开(公告)日：2007-08-23
申请号：PCT/US2007/062157
申请日：2007-02-14
申请人： NOVARTIS AG , NI, Zhi-jie , PECCHI, Sabina , BURGER, Matthew , HAN, Wooseok , SMITH, Aaron , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , VERHAGEN, Joelle , ZHANG, Yanchen , IWANOWICZ, Ed , HENDRICKSON, Tom , KNAPP, Mark , MERRITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , LEGRAND, Darren Mark , BRUCE, Ian , DALE, James , LAN, Jiong , LEVINE, Barry , COSTALES, Abran , LIU, Jie , PICK, Teresa , MENEZES, Daniel
发明人： NI, Zhi-jie , PECCHI, Sabina , BURGER, Matthew , HAN, Wooseok , SMITH, Aaron , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , VERHAGEN, Joelle , ZHANG, Yanchen , IWANOWICZ, Ed , HENDRICKSON, Tom , KNAPP, Mark , MERRITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , LEGRAND, Darren Mark , BRUCE, Ian , DALE, James , LAN, Jiong , LEVINE, Barry , COSTALES, Abran , LIU, Jie , PICK, Teresa , MENEZES, Daniel
IPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61K31/5025 , A61K31/428 , A61P35/00
CPC分类号： C07D487/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.
摘要翻译：磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途受体和磷酸酶。

3. 发明申请

WO2007084786A1 PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS 审中-公开
标题翻译：用作PI-3激酶抑制剂的吡嗪衍生物
公开(公告)号：WO2007084786A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/001708
申请日：2007-01-22
申请人： NOVARTIS AG , BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULLIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia
发明人： BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULLIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia , PICK, Teresa , BARSANTI, Paul , IWANOWICZ, Edwin , FANTL, Wendy , HENDRYCKSON, Tom , KNAPP, Mark , MERITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , XIN, Xiahua
IPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

4. 发明申请

WO2006063338A1 MOLDED GASKET AND METHOD OF MAKING 审中-公开
标题翻译：模具垫圈及其制造方法
公开(公告)号：WO2006063338A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/044887
申请日：2005-12-07
申请人： KNAPP, Mark , SMITH, Jeffrey, Michael
发明人： KNAPP, Mark , SMITH, Jeffrey, Michael
IPC分类号： B29C45/16 , F16L55/17
CPC分类号： B29C45/1676 , B29C45/1671 , B29L2031/265 , F16L21/03
摘要： The present invention is directed to an annular gasket (16) for providing a fluid-tight seal between an inner pipe (14) and an outer pipe (12), when the pipes are in a relative surrounded and surrounding relationship. The gasket (16) includes a gasket portion configured to sealingly engage the inner and outer pipes when the pipes are in a relative surrounded and surrounding relationship. The gasket (16) includes a low coefficient of friction surface (32), which is applied to the gasket portion. The gasket (16) may be formed by a method in which a low coefficient of friction film (32) is inserted into a mold (51) before injection of compounds used to form the gasket (16).
摘要翻译：本发明涉及一种环形垫片（16），用于当管道处于相对包围和周围的关系时，在内管（14）和外管（12）之间提供流体密封。垫圈（16）包括垫圈部分，其构造成当管道处于相对包围和周围的关系时密封地接合内管和外管。垫圈（16）包括施加到垫圈部分的低摩擦系数表面（32）。垫圈（16）可以通过在注入用于形成垫圈（16）的化合物之前将低摩擦系数膜（32）插入模具（51）中的方法形成。

5. 发明申请

WO2017046676A1 POLYOMAVIRUS NEUTRALIZING ANTIBODIES 审中-公开
标题翻译：多瘤病毒中和抗体
公开(公告)号：WO2017046676A1
公开(公告)日：2017-03-23
申请号：PCT/IB2016/055339
申请日：2016-09-08
申请人： NOVARTIS AG , ABEND, Johanna , DRAGIC, Zorica , FEIRE, Adam Lloyd , KNAPP, Mark , KOVACS, Steven , TRAGGIAI, Elisabetta , WANG, Lichun , WANG, Yongqiang , WU, Danqing , WU, Qilong , XU, Fangmin
发明人： ABEND, Johanna , DRAGIC, Zorica , FEIRE, Adam Lloyd , KNAPP, Mark , KOVACS, Steven , TRAGGIAI, Elisabetta , WANG, Lichun , WANG, Yongqiang , WU, Danqing , WU, Qilong , XU, Fangmin
IPC分类号： C07K16/08
CPC分类号： C07K16/084 , A61K39/42 , A61K45/06 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
摘要翻译：本发明涉及抗VP1抗体，抗体片段及其用于预防和治疗多瘤病毒感染及相关疾病的用途。

6. 发明申请

WO2009151938A1 PIPE COUPLING ASSEMBLY 审中-公开
标题翻译：管接头总成
公开(公告)号：WO2009151938A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/045114
申请日：2009-05-26
申请人： SPRINGSEAL INC. , KNAPP, Mark
发明人： KNAPP, Mark
IPC分类号： F16L19/00
CPC分类号： F16L17/025 , F16L21/03 , F16L25/0036 , F16L25/0054 , F16L25/12 , F16L25/14 , F16L27/1085 , F16L27/1136 , F16L2201/10
摘要： A coupler assembly (10) and method of manufacture (10) for use with pipe comprising a unitary annular body (20) forming first and second cylindrical openings for surrounding a pipe or piping sections to facilitate forming a fluid-tight seal therein. The unitary annular body (20) comprises a medial portion (64) formed from a first material having a first durometer and first and second lateral portions (56, 58) integrally connected to opposite ends of the medial portion (64). The first and second lateral portions (56, 58) are made from a second material having a second durometer relatively higher than the first durometer of the first material. The coupler assembly (10) further comprises at least one clamping assembly (26) surrounding the unitary annular body member (20) adapted for compressing the coupler assembly (10) into a fluid- tight seal.
摘要翻译：一种与管子一起使用的联接器组件（10）和制造方法（10），其包括形成第一和第二圆柱形开口的整体环形体（20），用于围绕管或管道部分以便于在其中形成流体密封。整体式环形体（20）包括由具有第一硬度的第一材料形成的中间部分（64）和与内侧部分（64）的相对端部一体连接的第一和第二侧向部分（56,58）。第一和第二侧部分（56,58）由具有比第一材料的第一硬度计相对高的第二硬度的第二材料制成。联接器组件（10）还包括围绕整体式环形主体构件（20）的至少一个夹紧组件（26），适于将联接器组件（10）压缩成流体密封的密封件。

7. 发明申请

WO2007130044A1 PERMANENTLY LUBRICATED FILM GASKET AND METHOD OF MANUFACTURE 审中-公开
标题翻译：永久润滑膜垫片及其制造方法
公开(公告)号：WO2007130044A1
公开(公告)日：2007-11-15
申请号：PCT/US2006/017512
申请日：2006-05-05
申请人： SPRINGSEAL, INC. , KNAPP, Mark
发明人： KNAPP, Mark
IPC分类号： F16L21/02 , F16L17/06 , F16L17/025
CPC分类号： F16L25/0054 , F16J15/027 , F16L17/025 , F16L21/035 , F16L25/0036 , Y10S285/903
摘要： A permanently lubricated film gasket for providing a fluid-tight seal between a corrugated pipe (12) and a smooth annular section of an outer pipe (20) or section when the corrugated pipe and the outer pipe or section are in a relative surrounded and surrounding relationship. A first portion (24) of the gasket is shaped to fit within a groove (22) or recess of the corrugated pipe. A second portion (13a) of the gasket extends from the first portion. The second portion is at least partially comprised of permanently lubricated film (50) for facilitating in the connection of the pipes along a single direction.
摘要翻译：一种永久润滑的薄膜垫片，用于在波纹管和外管（20）或部分的平滑环形部分之间提供流体密封，当波纹管和外管或部分处于相对包围和围绕关系。垫圈的第一部分（24）成形为装配在波纹管的凹槽（22）或凹槽内。垫圈的第二部分（13a）从第一部分延伸。第二部分至少部分地由永久润滑的膜（50）组成，用于沿着单个方向促进管道的连接。

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