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1. 发明专利

ZA918644B NOVEL COMPOUNDS,PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 未知
公开(公告)号：ZA918644B
公开(公告)日：1992-10-28
申请号：ZA918644
申请日：1991-10-30
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , KALMAN TAKACS , OERI JANOS , JANOS OERI , KOERMOECZY PETER SZEKELY , PETER SZEKELY KOERMOECZY , SZEREDY-NEE-VARGA JUDIT , JUDIT SZEREDY NEE VARGA , KISS-NEE-AJZERT ILONA , ILONA KISS NEE AJZERT , PAP MARIA H , MARIA H PAP , SZABO MARIA , MARIA SZABO , DEBRECZENI LORAND , LORAND DEBRECZENI , HERMECZ ISTVAN , ISTVAN HERMECZ , BENCZE ZSOLT , ZSOLT BENCZE , VERTESI CSABA , CSABA VERTESI , GAAL JOZSEF , JOZSEF GAAL , KAPUI ZOLTAN , ZOLTAN KAPUI
IPC分类号： A61K31/33 , A61K31/472 , A61K31/4725 , A61K31/47 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26 , C07D , C07B , A61K
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

4. 发明专利

EE02961B1 未知
公开(公告)号：EE02961B1
公开(公告)日：1997-02-17
申请号：EE9400162
申请日：1994-08-26
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： PETER SZEKELY KAERMAECZY , KALMAN TAKACS , ILONA KISS , ISTVAN HERMECZ , JANOS OERI , MARIA H PAP , ZSOLT BENCZE , MARIA SZABO , JUDIT SZEREDY , CSABA VERTESI , LORAND DEBRECZENI , JOZSEF GAAL , ZOLTAN KAPUI
IPC分类号： A61K31/33 , A61K31/472 , A61K31/47 , A61K31/4725 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

5. 发明专利

ZA918998B 3H-PURINES,THEIR PREPARATION AND USE 未知
公开(公告)号：ZA918998B
公开(公告)日：1992-11-25
申请号：ZA918998
申请日：1991-11-13
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： KORBONITS DEZSOE , DEZSOE KORBONITS , MINKER EMIL , EMIL MINKER , KOERMOECZY PETER , PETER KOERMOECZY , TOTH-NEE-IRO KATALIN , KATALIN TOTH NEE IRO , HEJA GERGELY , GERGELY HEJA , DEBRECZENI LORAND , LORAND DEBRECZENI , SZABO MARIA , MARIA SZABO , MARMAROSI-NEE-KELLNER KATALIN , KATALIN MARMAROSI NEE KELLNER , SZOMOR-NEE-WENDELE MARIA , MARIA SZOMOR NEE WENDELE , VIRAG SANDOR , SANDOR VIRAG , SZATMARI ISTVAN , ISTVAN SZATMARI
IPC分类号： A61K31/52 , A61K31/522 , A61P7/02 , A61P11/14 , C07D473/06 , A61K , C07D
摘要： The invention relates to novel 3H-purines of the general formula I in which R denotes H or C1-4-alkyl, and their physiologically tolerable salts, as well as their preparation and medicaments which contain the compounds of the general formula I and their salts. The compounds of the formula I are highly active broncholytics and antiasthmatics, whose particular advantage is that they do not have any undesired side effects on the central nervous system or any undesired cardiac effects.

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