专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

NO179041C 未知
公开(公告)号：NO179041C
公开(公告)日：1996-07-24
申请号：NO914452
申请日：1991-11-13
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , KISS ILONA , HERMECZ ISTVAN , ORI JANOS , PAP MARIA H , BENCZE ZSOLT , KORMOCZY PETER SZEKELY , SZABO MARIA , SZEREDY JUDIT , VERTESI CSABA , DEBRECZENI LORAND , GAAL JOZSEF , KAPUI ZOLTAN
IPC分类号： A61K31/33 , A61K31/47 , A61K31/472 , A61K31/4725 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

2. 发明专利

NO914452D0 未知
公开(公告)号：NO914452D0
公开(公告)日：1991-11-13
申请号：NO914452
申请日：1991-11-13
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , KISS ILONA , HERMECZ ISTVAN , ORI JANOS , PAP MARIA H , BENCZE ZSOLT , KOERMOECZY PETER SZEKELY , SZABO MARIA , SZEREDY JUDIT , VERTESI CSABA , DEBRECZENI LORAND , GAAL JOZSEF , KAPUI ZOLTAN
IPC分类号： A61K31/33 , A61K31/47 , A61K31/472 , A61K31/4725 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26 , C07D401/00
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

3. 发明专利

PL166695B1 METHOD OF OBTAINING NOVEL ISOQUINOLINE DERIVATIVES 未知
公开(公告)号：PL166695B1
公开(公告)日：1995-06-30
申请号：PL29237191
申请日：1991-11-13
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , KISSNE ILONA NEE AJZERT , HERMECZ ISTVAN , ORI JANOS , PAP MARIA H , BENCZE ZSOLT , SZABO MARIA , SZEREDI JUDIT NEE VARGANE , VERTESI CSABA , DEBRECZENI LORAND , GAAL JOZSEF , KAPUI ZOLTAN , SZEKELY PETER NEE KORMOCZY
IPC分类号： A61K31/33 , A61K31/472 , A61K31/4725 , A61K31/47 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26 , C07D217/22 , C07D401/12 , C07D413/12
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

5. 发明专利

MX174641B 未知
公开(公告)号：MX174641B
公开(公告)日：1994-05-30
申请号：MX9102419
申请日：1991-12-06
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： ORI JANOS , PAP MARIA H , BENCZE ZSOLT , KORMOCZY PETER SZEKELY , SZABO MARIA , SZEREDY JUDIT , VARTESI CSABA , DEBRECZENI LORAND , GAAL JOZSEFF , KAPUI ZOALTAN , TAKACS KALMAN , KISS ILONA , HERMECZ ISTVAN
IPC分类号： A61K31/47 , C07D217/16 , C07D217/26

6. 发明专利

ZA918644B NOVEL COMPOUNDS,PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 未知
公开(公告)号：ZA918644B
公开(公告)日：1992-10-28
申请号：ZA918644
申请日：1991-10-30
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , KALMAN TAKACS , OERI JANOS , JANOS OERI , KOERMOECZY PETER SZEKELY , PETER SZEKELY KOERMOECZY , SZEREDY-NEE-VARGA JUDIT , JUDIT SZEREDY NEE VARGA , KISS-NEE-AJZERT ILONA , ILONA KISS NEE AJZERT , PAP MARIA H , MARIA H PAP , SZABO MARIA , MARIA SZABO , DEBRECZENI LORAND , LORAND DEBRECZENI , HERMECZ ISTVAN , ISTVAN HERMECZ , BENCZE ZSOLT , ZSOLT BENCZE , VERTESI CSABA , CSABA VERTESI , GAAL JOZSEF , JOZSEF GAAL , KAPUI ZOLTAN , ZOLTAN KAPUI
IPC分类号： A61K31/33 , A61K31/472 , A61K31/4725 , A61K31/47 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26 , C07D , C07B , A61K
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

8. 发明专利

SI9111799A Novel isoquinoline derivatives, pharmaceutical preparations containing them and procedure for their preparation 未知
公开(公告)号：SI9111799A
公开(公告)日：1998-08-31
申请号：SI9111799
申请日：1991-11-14
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , HERMECZ ISTVAN , ORI JANOS , BENCZE ZSOLT , SZEKELY KOERMOECZY PETER , SZABO MARIA , SZEREDY NEE VARGA JUDIT , VERTESI CSABA , DEBRECZENI LORAND , GAAL JOZSEF , KAPUI ZOLTAN , KISS NEE AJZERT ILONA , PAP H MARIA
IPC分类号： A61K31/395 , A61K31/47 , C07D217/12 , C07D217/16 , C07D217/22 , C07D401/12
摘要： The invention refers to new compounds with the following general formula (I) where R denotes hydrogen or an unbranched or branched C1-6-alkoxy group; R1 denotes hydrogen or an unbranched or branched C1-6-alkyl group; R2 denotes hydrogen or an unbranched or branched C1-6-alkyl group; R3 denotes hydrogen or an unbranched or branched C1-6-alkyl group substituted, if desired, with a 1 or 2 hydroxy and/or a 1 or 2 unbranched or branched C1-4-alkoxy groups; or a C4-7-cycloalkyl group; R4 denotes hydrogen or an unbranched or branched C1-6-alkyl group substituted, if desired, with a 1 or 2 hydroxy and/or a 1 or 2 unbranched or branched C1-4-alkoxy groups; or a C4-7-cycloalkyl group; or R3 and R4 together with a nitrogen atom to which they are bound creating a 4-8-link cyclic group with the formula (II) substituted, if desired, with a 1 or 2 unbranched or branched C1-4-alkoxy groups and/or a 1 or 2 unbranched or branched C1-4-alkyl groups where, if desired, an oxygen or sulfur atom or a N-R5 group are substituted with a carbon ring atom where R5 denotes hydrogen or an unbranched or branched C1-6-aliphatic alkyl group where a 4-8-link ring is, if desired, condensed with a benzene ring; R6 denotes hydrogen or a C1-10-acyl group, and to their salts and hydrates as well as to pharmaceutical preparations containing them. The compounds in the sense of the invention are antagonizing the effects of contraction mediators such as histamine, acetylcholine or serotonin; they are exhibiting an antiallergic reaction and an antiinflammatory effect. Thus, these compounds may be applied therapeutically as bronchodilatators as well as antiallergic or antiinflammatory medicaments, especially in the case of bronchial asthma treatment.

9. 发明专利

RO112614B1 ISOQUINOLINE DERIVATIVES, METHOD FOR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES 未知
公开(公告)号：RO112614B1
公开(公告)日：1997-11-28
申请号：RO14872691
申请日：1991-11-12
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , KISS ILONA , HERMECZ ISTVAN , ORI JANOS , PAP H MARIA , BENCZE ZSOLT , KORMOCZY SZEKELY PETER , SZABO MARIA , SZEREDY JUDIT , VERTESI CSABA , DEBRECZENI LORAND , GAAL JOZSEF , KAPUI ZOLTAN
IPC分类号： A61K31/33 , A61K31/472 , A61K31/47 , A61K31/4725 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

10. 发明专利

NO179041B 未知
公开(公告)号：NO179041B
公开(公告)日：1996-04-15
申请号：NO914452
申请日：1991-11-13
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： TAKACS KALMAN , KISS ILONA , HERMECZ ISTVAN , ORI JANOS , PAP MARIA H , BENCZE ZSOLT , KORMOCZY PETER SZEKELY , SZABO MARIA , SZEREDY JUDIT , VERTESI CSABA , DEBRECZENI LORAND , GAAL JOZSEF , KAPUI ZOLTAN
IPC分类号： A61K31/33 , A61K31/47 , A61K31/472 , A61K31/4725 , A61P11/08 , A61P29/00 , A61P37/08 , C07D217/12 , C07D217/16 , C07D217/26
摘要： The invention relates to novel compounds of the general formula (I), wherein R means hydrogen or a straight or branched chain C1-6alkoxy group; R stands for hydrogen or a straight or branched chain C1-6alkyl group; R represents hydrogen or a straight or branched chain C1-6alkyl group: R means hydrogen: a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; R stands for hydrogen or a straight or branched chain C1-6alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C1-4alkoxy group(s): or a C4-7cycloalkyl group; or R and R together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula optionally substituted by one or two straight or branched chain C1-4alkoxy and/or one or two straight or branched chain C1-4alkyl group(s), where optionally an oxygen or sulfur atom or an N-R group may be substituted for a ring carbon atom, where R means hydrogen or a straight or branched chain C1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring; R stands for hydrogen or a C1-10acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds. The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式