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1. 发明申请

WO2011112906A3 NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF 审中-公开
公开(公告)号：WO2011112906A3
公开(公告)日：2011-09-15
申请号：PCT/US2011/028052
申请日：2011-03-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , LU, Yingjie , MOFFITT, Kristin L.
发明人： MALLEY, Richard , LU, Yingjie , MOFFITT, Kristin L.
IPC分类号： C07K1/02 , C07K14/195 , A61K39/00 , G01N33/53
摘要： The present application is generally directed to methods for identifying immunogens from organisms and pathogens, and in particular for identifying immunogens which when administered as vaccines elicit a cellular and/or humoral immune response. The present application is also directed to pneumococcal T-cell immunogens, and vaccine compositions comprising one or a combination of pneumococcal immunogens and methods for treating or preventing pneumococcal infections using the vaccines thereof. The present invention also encompasses use of the pneumococcal immunogens for diagnostic purposes to identify a subject with a pneumococcal infection.

2. 发明申请

WO2012155007A1 MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION, AND METHODS AND USES THEREOF 审中-公开
标题翻译：多种抗原呈递免疫组合物，其方法及用途
公开(公告)号：WO2012155007A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037412
申请日：2012-05-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , LU, Yingjie , ZHANG, Fan
发明人： MALLEY, Richard , LU, Yingjie , ZHANG, Fan
IPC分类号： A61K31/00 , A61K39/02 , A61P37/02 , A61P37/04 , A61K39/39 , A61K38/00
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20 , Y02A50/484
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
摘要翻译：本实施方案提供了一种免疫原性多抗原呈递系统，其包含抗体通过互补亲和分子与之相关的聚合物。例如，聚合物可以是来自相同或不同病原体的蛋白质或肽抗原间接连接的多糖或抗原性多糖。本发明的免疫原性组合物可以同时引起对一种或多种抗原的体液和细胞免疫应答。

3. 发明申请

WO2011044576A2 SELECTIVELY DISRUPTED WHOLE-CELL VACCINE 审中-公开
标题翻译：选择性破坏全细胞疫苗
公开(公告)号：WO2011044576A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/052298
申请日：2010-10-12
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , ANDERSON, Porter , LU, Yingjie , PATH VACCINE SOLUTIONS , ALDERSON, Mark , ROBERTSON, George A. , MAISONNEUVE, Jean-Francois Lucien , TATE, Andrea Maria
发明人： MALLEY, Richard , ANDERSON, Porter , LU, Yingjie , ALDERSON, Mark , ROBERTSON, George A. , MAISONNEUVE, Jean-Francois Lucien , TATE, Andrea Maria
IPC分类号： A61K39/395 , A61K39/09 , A61K39/02 , A61P31/00
CPC分类号： A61K39/092 , A61K2039/521 , A61K2039/543 , A61K2039/55505 , A61K2039/55544
摘要： The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
摘要翻译：本发明提供免疫原性组合物和方法，用于通过以诱导主要抗体应答的可溶性级分的方式选择性地破坏全细胞细菌制剂来产生具有杀死的全细胞肺炎链球菌的多种免疫诱导级分的免疫原性组合物，并且诱导主要抗体非依赖性应答的细胞部分保留在免疫原性组合物中。

4. 发明申请

WO2012155053A1 MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS 审中-公开
标题翻译：改性生物蛋白结合蛋白，其融合蛋白及其应用
公开(公告)号：WO2012155053A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037541
申请日：2012-05-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , LU, Yingjie , ZHANG, Fan
发明人： MALLEY, Richard , LU, Yingjie , ZHANG, Fan
IPC分类号： A61K31/00 , A61K39/085 , A61P37/02 , A61K38/00 , A61P31/00 , A61P37/04
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20 , Y02A50/484
摘要： The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.
摘要翻译：本公开提供修饰的生物素结合蛋白，其可以在细菌中以高产率在可溶形式中表达。还提供了包含修饰的生物素结合蛋白和抗原的融合蛋白。本公开还提供了来自金黄色葡萄球菌的α-溶血素的非溶血性变体和包含α-溶血素的非溶血性变体和生物素结合结构域的融合蛋白。还公开了包含蛋白质的免疫原性组合物，并且还公开了用于诱导免疫应答或接种受试者的这种免疫原性组合物的用途。

5. 发明申请

WO2018183475A1 A MULTIPLE ANTIGEN PRESENTING SYSTEM (MAPS)-BASED STAPHYLOCOCCUS AUREUS VACCINE, IMMUNOGENIC COMPOSITION, AND USES THEREOF 审中-公开
公开(公告)号：WO2018183475A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/024810
申请日：2018-03-28
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： MALLEY, Richard , ZHANG, Fan , LU, Yingjie
IPC分类号： A61K39/02 , C07K16/12
摘要： The present embodiments provide for an S. aureus (SA) Multiple Antigen Presenting System (MAPS) immunogenic composition comprising an immunogenic polysaccharide which induces an immune response, where at least one S. aureus (SA) peptide or polypeptide antigen is associated to the immunogenic polysaccharide by complementary affinity molecules. In some embodiments, the immunogenic polysaccharide can be an antigenic capsular polysaccharide of a Type 5 or Type 8 from S. aureus, or alternatively, a different immunogenic capsular or noncapsular polysaccharide, and where the protein or peptide SA antigens are indirectly linked via an affinity binding pair. The present SA-MAPS immunogenic compositions can elicit both humoral and cellular immune responses to the immunogenic polysaccharide and one or multiple SA antigens at the same time.

6. 发明申请

WO2020056127A1 PNEUMOCOCCAL FUSION PROTEIN VACCINES 审中-公开
公开(公告)号：WO2020056127A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/050800
申请日：2019-09-12
申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人： MALLEY, Richard , LU, Yingjie , ZHANG, Fan
IPC分类号： A61K39/09 , A61K39/116
摘要： Technologies for the prevention and/or treatment of pneumococcal infections.

7. 发明申请

WO2017192801A1 METHODS TO PURIFY AVIDIN-LIKE PROTEINS AND FUSION PROTEINS THEREOF 审中-公开
标题翻译：纯化类毒素蛋白质及其融合蛋白质的方法
公开(公告)号：WO2017192801A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030969
申请日：2017-05-04
申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人： ZHANG, Fan , MALLEY, Richard , LU, Yingjie
IPC分类号： C07K17/14 , G01N33/543
摘要： The present invention generally relates to separation matrix comprising a lipoic acid (LA) compound or derivative thereof for use in a method for purifying and isolating a biotin-binding protein, including fusion proteins and complexes thereof. Embodiments described herein relate to methods for reversible binding of a biotin-binding protein, e.g., rhizavidin, including fusion proteins and complexes thereof to a matrix comprising a lipoic acid (LA) compound or derivative thereof immobilized to a solid support, where the biotin-binding protein can be detached from the matrix, making it possible to isolate the biotin-binding protein efficiently and quickly and under a mild conditions while minimizing protein denaturation and maximizing protein purification and isolation.
摘要翻译：本发明一般涉及包含硫辛酸（LA）化合物或其衍生物的分离基质，用于纯化和分离生物素结合蛋白（包括融合蛋白及其复合物）的方法中。本文所述的实施方案涉及生物素结合蛋白（例如，rhizavidin，包括融合蛋白及其复合物）与包含固定于固体支持物上的硫辛酸（LA）化合物或其衍生物的基质的可逆结合的方法，其中所述生物素 - 结合蛋白可从基质分离，使得有可能在温和条件下有效且快速地分离生物素结合蛋白，同时最小化蛋白质变性并最大化蛋白纯化和分离。

8. 发明申请

WO2018217564A1 COMBINED VACCINE AGAINST MYCOBACTERIUM TUBERCULOSIS 审中-公开
公开(公告)号：WO2018217564A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033380
申请日：2018-05-18
申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人： ZHANG, Fan , MALLEY, Richard , LU, Yingjie
IPC分类号： A61K39/04 , C07K14/35 , C07K14/31 , C07K14/195
摘要： The present embodiments provide for a Mycobacterium tuberculosis (M. tuberculosis) Multiple Antigen Presenting System (MAPS) immunogenic composition comprising an immunogenic polysaccharide which induces an immune response, where at least one M. tuberculosis peptide or polypeptide antigen is associated to the immunogenic polysaccharide by complementary affinity molecules. In some embodiments, the immunogenic polysaccharide can be an antigenic capsular polysaccharide of a Mycobacterium tuberculosis, Type 5 (CP5) or Type 8 (CP8), or a combination of Type 5 or Type 8 capsular polysaccharide from Staphylococcus aureus, or alternatively, a different immunogenic capsular or noncapsular polysaccharide, and where the protein or peptide M. tuberculosis antigens are indirectly linked via an affinity binding pair. The present M. tuberculosis-MAPS immunogenic compositions can elicit both humoral and cellular immune responses to the immunogenic polysaccharide and one or multiple M. tuberculosis antigens at the same time.

9. 发明申请

WO2014124228A1 PROTEIN ANTIGENS THAT PROVIDE PROTECTION AGAINST PNEUMOCOCCAL COLONIZATION AND/OR DISEASE 审中-公开
标题翻译：提供针对肺结核和/或疾病的保护的蛋白质抗原
公开(公告)号：WO2014124228A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/015254
申请日：2014-02-07
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： MALLEY, Richard , LU, Yingjie , ZHANG, Fan
IPC分类号： A61K38/00
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/6087 , A61K2039/625 , C07K14/3156 , Y02A50/484
摘要： The present application is generally directed to novel pneumococcal polypeptide antigens and nucleic acids encoding such antigens, and immunogenic compositions comprising such antigens for treating and preventing pneumococcal infection. The present invention further provides method of using the antigens to elicits an immune response (e.g., IL-17A response, a T cell-mediated and/or B-cell-mediated immune responses). The present invention also provides methods of prophylaxis and/or treatment of pneumococcal-mediated diseases, such as sepsis, comprising administering an immunogenic composition including one or more of a combination of pneumococcal antigens or functional fragments thereof as disclosed herein. In some embodiments, one or more pneumococcal antigens can be present in a polysaccharide conjugate. The compositions induce an anti-pneumoccocus immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individualand/or therapeutically to induce a thereapeutic immune response to an infected individual.
摘要翻译：本申请一般涉及新型肺炎球菌多肽抗原和编码这种抗原的核酸，以及包含用于治疗和预防肺炎球菌感染的这种抗原的免疫原性组合物。本发明还提供了使用抗原引发免疫应答（例如IL-17A应答，T细胞介导的和/或B细胞介导的免疫应答）的方法。本发明还提供了预防和/或治疗肺炎球菌介导的疾病如败血症的方法，其包括施用免疫原性组合物，其包括本文公开的肺炎球菌抗原或其功能片段的组合中的一种或多种。在一些实施方案中，一种或多种肺炎球菌抗原可以存在于多糖缀合物中。当给予哺乳动物时，该组合物诱导抗肺结核免疫应答。组合物可以预防性地用于个体接种和/或治疗性地诱导对感染个体的治疗性免疫应答。

10. 发明公开

EP3881836A1 MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION, AND METHODS AND USES THEREOF 审中-公开
公开(公告)号：EP3881836A1
公开(公告)日：2021-09-22
申请号：EP21156431.5
申请日：2012-05-11
申请人： Children's Medical Center Corporation
发明人： MALLEY, Richard , LU, Yingjie , ZHANG, Fan
IPC分类号： A61K31/00 , A61K39/02 , A61P37/02 , A61P37/04 , A61K39/39 , A61K38/00
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.

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