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1. 发明申请

WO2012155007A1 MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION, AND METHODS AND USES THEREOF 审中-公开
标题翻译：多种抗原呈递免疫组合物，其方法及用途
公开(公告)号：WO2012155007A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037412
申请日：2012-05-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , LU, Yingjie , ZHANG, Fan
发明人： MALLEY, Richard , LU, Yingjie , ZHANG, Fan
IPC分类号： A61K31/00 , A61K39/02 , A61P37/02 , A61P37/04 , A61K39/39 , A61K38/00
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20 , Y02A50/484
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
摘要翻译：本实施方案提供了一种免疫原性多抗原呈递系统，其包含抗体通过互补亲和分子与之相关的聚合物。例如，聚合物可以是来自相同或不同病原体的蛋白质或肽抗原间接连接的多糖或抗原性多糖。本发明的免疫原性组合物可以同时引起对一种或多种抗原的体液和细胞免疫应答。

2. 发明申请

WO2011112906A3 NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF 审中-公开
公开(公告)号：WO2011112906A3
公开(公告)日：2011-09-15
申请号：PCT/US2011/028052
申请日：2011-03-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , LU, Yingjie , MOFFITT, Kristin L.
发明人： MALLEY, Richard , LU, Yingjie , MOFFITT, Kristin L.
IPC分类号： C07K1/02 , C07K14/195 , A61K39/00 , G01N33/53
摘要： The present application is generally directed to methods for identifying immunogens from organisms and pathogens, and in particular for identifying immunogens which when administered as vaccines elicit a cellular and/or humoral immune response. The present application is also directed to pneumococcal T-cell immunogens, and vaccine compositions comprising one or a combination of pneumococcal immunogens and methods for treating or preventing pneumococcal infections using the vaccines thereof. The present invention also encompasses use of the pneumococcal immunogens for diagnostic purposes to identify a subject with a pneumococcal infection.

3. 发明申请

WO2013177760A1 MODULE AND CAPACITANCE DETECTING METHOD 审中-公开
标题翻译：模块和电容检测方法
公开(公告)号：WO2013177760A1
公开(公告)日：2013-12-05
申请号：PCT/CN2012/076262
申请日：2012-05-30
申请人： MURATA MANUFACTURING CO., LTD. , NAGUMO, Shoji , NAKAZATO, Masashi , DAI, Yujie , ZHANG, Xiaoxing , LU, Yingjie
发明人： NAGUMO, Shoji , NAKAZATO, Masashi , DAI, Yujie , ZHANG, Xiaoxing , LU, Yingjie
IPC分类号： G01R27/26
CPC分类号： G01R27/2605 , H03K17/955 , H03K2217/960745
摘要： A module (5) includes a capacitance detecting circuit (10). The capacitance detecting circuit (10) includes a constant current source (20) supplying a constant current to a voltage detection point (P), a time measuring unit (28) measuring time of charge until the voltage of the voltage detection point (P) attains to a prescribed voltage, a storage unit (30) and an operation unit (32). The storage unit (30) stores a first data obtained in advance as the time of charge of a capacitance element having a known capacitance value, and a second data obtained in advance as the time of charge of a capacitance component (Cp). The operation unit (32) generates a third data representing the time of charge of an object of detection (Cs) from a difference between the first measurement value of the time measuring unit (28) when the capacitance component (Cp) is connected to the voltage detection point (P) and the second data, and based on the ratio between the third data and the first data and on the known capacitance value, calculates the capacitance value of the object of detection (Cs).
摘要翻译：模块（5）包括电容检测电路（10）。电容检测电路（10）包括向电压检测点（P）提供恒定电流的恒流源（20），测量充电时间直到电压检测点（P）的电压的时间测量单元（28）达到规定电压，存储单元（30）和操作单元（32）。存储单元（30）将预先获得的第一数据存储为具有已知电容值的电容元件的充电时间和预先获得的作为电容分量（Cp）的充电时间的第二数据。操作单元（32）当电容分量（Cp）连接到时间测量单元（28）的第一测量值与第二测量单元（28）的第一测量值之间的差时，产生表示检测对象（Cs）的充电时间的第三数据电压检测点（P）和第二数据，并且基于第三数据与第一数据之间的比率和已知电容值，计算检测对象（Cs）的电容值。

4. 发明申请

WO2012155053A1 MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS 审中-公开
标题翻译：改性生物蛋白结合蛋白，其融合蛋白及其应用
公开(公告)号：WO2012155053A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037541
申请日：2012-05-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , LU, Yingjie , ZHANG, Fan
发明人： MALLEY, Richard , LU, Yingjie , ZHANG, Fan
IPC分类号： A61K31/00 , A61K39/085 , A61P37/02 , A61K38/00 , A61P31/00 , A61P37/04
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20 , Y02A50/484
摘要： The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.
摘要翻译：本公开提供修饰的生物素结合蛋白，其可以在细菌中以高产率在可溶形式中表达。还提供了包含修饰的生物素结合蛋白和抗原的融合蛋白。本公开还提供了来自金黄色葡萄球菌的α-溶血素的非溶血性变体和包含α-溶血素的非溶血性变体和生物素结合结构域的融合蛋白。还公开了包含蛋白质的免疫原性组合物，并且还公开了用于诱导免疫应答或接种受试者的这种免疫原性组合物的用途。

5. 发明申请

WO2011112906A2 NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF 审中-公开
标题翻译：新型免疫调节剂及其发现和筛选方法
公开(公告)号：WO2011112906A2
公开(公告)日：2011-09-15
申请号：PCT/US2011028052
申请日：2011-03-11
申请人： CHILDRENS MEDICAL CENTER , MALLEY RICHARD , LU YINGJIE , MOFFITT KRISTIN L
发明人： MALLEY RICHARD , LU YINGJIE , MOFFITT KRISTIN L
CPC分类号： A61K39/092 , A61K2039/55544 , A61K2039/55583 , A61K2039/70 , C07K14/3156 , C07K2319/00
摘要： The present application is generally directed to methods for identifying immunogens from organisms and pathogens, and in particular for identifying immunogens which when administered as vaccines elicit a cellular and/or humoral immune response. The present application is also directed to pneumococcal T-cell immunogens, and vaccine compositions comprising one or a combination of pneumococcal immunogens and methods for treating or preventing pneumococcal infections using the vaccines thereof. The present invention also encompasses use of the pneumococcal immunogens for diagnostic purposes to identify a subject with a pneumococcal infection.
摘要翻译：本申请一般涉及从生物体和病原体鉴定免疫原的方法，特别是鉴定当作为疫苗引起细胞和/或体液免疫应答时的免疫原的鉴定方法。本申请还涉及肺炎球菌T细胞免疫原，以及包含肺炎球菌免疫原的一种或组合的疫苗组合物，以及使用其疫苗治疗或预防肺炎球菌感染的方法。本发明还包括用于诊断目的的肺炎球菌免疫原用于识别患有肺炎球菌感染的受试者的用途。

6. 发明申请

WO2011044576A3 SELECTIVELY DISRUPTED WHOLE-CELL VACCINE 审中-公开
标题翻译：选择性破坏的全细胞疫苗
公开(公告)号：WO2011044576A3
公开(公告)日：2011-08-18
申请号：PCT/US2010052298
申请日：2010-10-12
申请人： CHILDRENS MEDICAL CENTER , MALLEY RICHARD , ANDERSON PORTER , LU YINGJIE , PATH VACCINE SOLUTIONS , ALDERSON MARK , ROBERTSON GEORGE A , MAISONNEUVE JEAN-FRANCOIS LUCIEN , TATE ANDREA MARIA
发明人： MALLEY RICHARD , ANDERSON PORTER , LU YINGJIE , ALDERSON MARK , ROBERTSON GEORGE A , MAISONNEUVE JEAN-FRANCOIS LUCIEN , TATE ANDREA MARIA
IPC分类号： A61K39/395 , A61K39/02 , A61K39/09 , A61P31/00
CPC分类号： A61K39/092 , A61K2039/521 , A61K2039/543 , A61K2039/55505 , A61K2039/55544
摘要： The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
摘要翻译：本发明提供了免疫原性组合物和通过选择性破坏全细胞细菌制备物来产生具有多种免疫诱导级分的杀死的全细胞肺炎链球菌的免疫原性组合物，使得诱导主要抗体应答的可溶性级分，诱导主要抗体非依赖性应答的细胞级分保留在免疫原性组合物中。

7. 发明申请

WO2011044576A2 SELECTIVELY DISRUPTED WHOLE-CELL VACCINE 审中-公开
标题翻译：选择性破坏全细胞疫苗
公开(公告)号：WO2011044576A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/052298
申请日：2010-10-12
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MALLEY, Richard , ANDERSON, Porter , LU, Yingjie , PATH VACCINE SOLUTIONS , ALDERSON, Mark , ROBERTSON, George A. , MAISONNEUVE, Jean-Francois Lucien , TATE, Andrea Maria
发明人： MALLEY, Richard , ANDERSON, Porter , LU, Yingjie , ALDERSON, Mark , ROBERTSON, George A. , MAISONNEUVE, Jean-Francois Lucien , TATE, Andrea Maria
IPC分类号： A61K39/395 , A61K39/09 , A61K39/02 , A61P31/00
CPC分类号： A61K39/092 , A61K2039/521 , A61K2039/543 , A61K2039/55505 , A61K2039/55544
摘要： The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
摘要翻译：本发明提供免疫原性组合物和方法，用于通过以诱导主要抗体应答的可溶性级分的方式选择性地破坏全细胞细菌制剂来产生具有杀死的全细胞肺炎链球菌的多种免疫诱导级分的免疫原性组合物，并且诱导主要抗体非依赖性应答的细胞部分保留在免疫原性组合物中。

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