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1. 发明申请

WO2009003657A1 METERED DOSE INHALER ACTUATOR 审中-公开
标题翻译：计量剂量吸入器执行器
公开(公告)号：WO2009003657A1
公开(公告)日：2009-01-08
申请号：PCT/EP2008/005291
申请日：2008-06-27
申请人： CHIESI FARMACEUTICI S.P.A. , BRAMBILLA, Gaetano , CHURCH, Tanya, Cathleen , LEWIS, David, Andrew , MEAKIN, Brian, John
发明人： BRAMBILLA, Gaetano , CHURCH, Tanya, Cathleen , LEWIS, David, Andrew , MEAKIN, Brian, John
IPC分类号： A61M15/00 , B05B1/00
CPC分类号： A61M15/009
摘要： A metered dose inhaler actuator for pressurised aerosol containing a formulation of at least one medicament in a liquefied propellant gas. The actuator (2) comprises - a nozzle block (5) having a bore (11) to receive a valve stem (7) - a sump (8) in connection with a bore (11), wherein the propellant formulation expands upon actuation of the inhaler, - a nozzle channel (6), exiting from the sump (8) and aligned with a mouthpiece (4) wherein the sump (8) is characterised for having an internal volume comprised between (12 and 2 mm 3) to avoid deposits of the medicament during the delivery into the chamber and/or into the nozzle channel which could cause a reduction in the delivered dose and an increase in the occurrence of the clogging of the inhaler. The actuator of the invention is particularly useful in the administration of pressurised metered dose inhaler formulations, in solution and/or in suspension, wherein the concentration of the active ingredient/s of the formulation is/are particularly high and in particular suitable to administer at least 100 μg/dose, preferably at least 200 μg/dose, even more preferably at least 400 μg/dose.
摘要翻译：一种用于加压气雾剂的计量剂量吸入器致动器，其含有在液化推进剂气体中的至少一种药物的制剂。致动器（2）包括 - 喷嘴块（5），其具有用于接收阀杆（7）的孔（11） - 与孔（11）连接的贮槽（8），其中推进剂制剂在致动所述吸入器是从所述贮槽（8）离开并与接口管（4）对准的喷嘴通道（6），其中所述贮槽（8）的特征在于具有包括在（12和2mm 3）之间的内部容积以避免沉积物的药物在输送到腔室和/或进入喷嘴通道期间，这可能导致递送剂量的减少和吸入器堵塞发生的增加。本发明的致动器特别可用于在溶液和/或悬浮液中施用加压计量吸入器制剂，其中制剂的活性成分的浓度特别高，特别适合于在至少100μg/剂量，优选至少200μg/剂量，甚至更优选至少400μg/剂量。

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