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1. 发明申请

WO2009095681A3 SUSPENSION FORMULATIONS 审中-公开
标题翻译：暂停制度
公开(公告)号：WO2009095681A3
公开(公告)日：2010-05-14
申请号：PCT/GB2009000261
申请日：2009-02-02
申请人： VECTURA LTD , INNOVATA BIOMED LTD , LEWIS DAVID ANDREW , KEEBLE CHRISTINA ALEXANDRA , WHITFIELD NICOLA KIM , CHURCH TANYA
发明人： LEWIS DAVID ANDREW , KEEBLE CHRISTINA ALEXANDRA , WHITFIELD NICOLA KIM , CHURCH TANYA
IPC分类号： A61K9/12 , A61K9/72
CPC分类号： A61K9/50 , A61K9/0078 , A61K9/008 , A61K31/00 , A61K31/167 , A61K31/58 , A61K2300/00
摘要： The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurised metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation. The suspension fomulation comprises particles of active agent, a propellant one or more suspension stabiliser (amino acid, leucine, saccharide, disaccharide, trehalose) and/or a co-solvent (alcohol, ethanol).
摘要翻译：本发明涉及悬浮液制剂，尤其涉及使用喷雾或气溶胶装置（例如加压计量剂量吸入器（pMDI））以气雾剂形式递送药物活性剂的制剂。制剂可以用于肺，鼻，颊或局部给药，但优选用于肺部吸入。悬浮液制剂包括活性剂颗粒，推进剂一种或多种悬浮稳定剂（氨基酸，亮氨酸，糖，二糖，海藻糖）和/或助溶剂（醇，乙醇）。

2. 发明申请

WO2009003657A1 METERED DOSE INHALER ACTUATOR 审中-公开
标题翻译：计量剂量吸入器执行器
公开(公告)号：WO2009003657A1
公开(公告)日：2009-01-08
申请号：PCT/EP2008/005291
申请日：2008-06-27
申请人： CHIESI FARMACEUTICI S.P.A. , BRAMBILLA, Gaetano , CHURCH, Tanya, Cathleen , LEWIS, David, Andrew , MEAKIN, Brian, John
发明人： BRAMBILLA, Gaetano , CHURCH, Tanya, Cathleen , LEWIS, David, Andrew , MEAKIN, Brian, John
IPC分类号： A61M15/00 , B05B1/00
CPC分类号： A61M15/009
摘要： A metered dose inhaler actuator for pressurised aerosol containing a formulation of at least one medicament in a liquefied propellant gas. The actuator (2) comprises - a nozzle block (5) having a bore (11) to receive a valve stem (7) - a sump (8) in connection with a bore (11), wherein the propellant formulation expands upon actuation of the inhaler, - a nozzle channel (6), exiting from the sump (8) and aligned with a mouthpiece (4) wherein the sump (8) is characterised for having an internal volume comprised between (12 and 2 mm 3) to avoid deposits of the medicament during the delivery into the chamber and/or into the nozzle channel which could cause a reduction in the delivered dose and an increase in the occurrence of the clogging of the inhaler. The actuator of the invention is particularly useful in the administration of pressurised metered dose inhaler formulations, in solution and/or in suspension, wherein the concentration of the active ingredient/s of the formulation is/are particularly high and in particular suitable to administer at least 100 μg/dose, preferably at least 200 μg/dose, even more preferably at least 400 μg/dose.
摘要翻译：一种用于加压气雾剂的计量剂量吸入器致动器，其含有在液化推进剂气体中的至少一种药物的制剂。致动器（2）包括 - 喷嘴块（5），其具有用于接收阀杆（7）的孔（11） - 与孔（11）连接的贮槽（8），其中推进剂制剂在致动所述吸入器是从所述贮槽（8）离开并与接口管（4）对准的喷嘴通道（6），其中所述贮槽（8）的特征在于具有包括在（12和2mm 3）之间的内部容积以避免沉积物的药物在输送到腔室和/或进入喷嘴通道期间，这可能导致递送剂量的减少和吸入器堵塞发生的增加。本发明的致动器特别可用于在溶液和/或悬浮液中施用加压计量吸入器制剂，其中制剂的活性成分的浓度特别高，特别适合于在至少100μg/剂量，优选至少200μg/剂量，甚至更优选至少400μg/剂量。

3. 发明申请

WO2007121913A3 PHARMACEUTICAL SOLUTION FORMULATIONS FOR PRESSURISED METERED DOSE INHALERS 审中-公开
标题翻译：用于加压计量剂量吸入剂的药物溶液制剂
公开(公告)号：WO2007121913A3
公开(公告)日：2008-03-06
申请号：PCT/EP2007003420
申请日：2007-04-19
申请人： CHIESI FARMA SPA , LEWIS DAVID ANDREW , MEAKIN BRIAN JOHN , BRAMBILLA GAETANO
发明人： LEWIS DAVID ANDREW , MEAKIN BRIAN JOHN , BRAMBILLA GAETANO
IPC分类号： A61K31/57 , A61K9/00 , A61K31/58
CPC分类号： A61K9/008 , A61K9/124 , A61K31/138 , A61K31/167 , A61K31/4704 , A61K31/4745 , A61K31/57 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： The invention relates to the use a solution formulation for pressurized metered dose inhalers able of providing therapeutical doses of two or more active drug substances to the lung for the manufacture of a medicament for the prevention or treatment of a severe broncho-pulmonary disease, wherein all the active drug substances are fully dissolved in the formulation as well as the two or more active drug substances are delivered with substantially the same particle size distribution.
摘要翻译：本发明涉及使用用于加压计量吸入器的溶液制剂，其能够向肺提供治疗剂量的两种或更多种活性药物物质用于制备用于预防或治疗严重支气管肺疾病的药物，其中全部活性药物物质完全溶解在制剂中，并且两种或更多种活性药物以大致相同的粒度分布递送。

4. 发明申请

WO2004041961A1 PHOTOCHROMIC COMPOSITIONS AND LIGHT TRANSMISSIBLE ARTICLES 审中-公开
标题翻译：光致变色组合物和光可透射性物品
公开(公告)号：WO2004041961A1
公开(公告)日：2004-05-21
申请号：PCT/AU2003/001453
申请日：2003-11-03
申请人： POLYMERS AUSTRALIA PTY LIMITED , EVANS, Richard, Alexander , SKIDMORE, Melissa, Ann , YEE, Lachlan, Hartley , HANLEY, Tracey, Lee , LEWIS, David, Andrew
发明人： EVANS, Richard, Alexander , SKIDMORE, Melissa, Ann , YEE, Lachlan, Hartley , HANLEY, Tracey, Lee , LEWIS, David, Andrew
IPC分类号： C09K9/02
CPC分类号： C09D11/50 , C07D311/92 , C07F7/21 , C09K9/02 , C09K2211/1033 , C09K2211/1048
摘要： The invention relates to a photochromic polymeric composition comprising a polymer matrix and a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendant oligomer group to provide a rate of fade of the photochromic polymeric composition which is significantly changed when compared with the corresponding composition comprising the photochromic compound without said pendent oligomer. The invention also relates to a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendent oligomer.
摘要翻译：本发明涉及一种光致变色聚合物组合物，其包含聚合物基质和光致变色化合物，其是包含光致变色部分和至少一个侧链低聚物基团的加合物，以提供光致变色聚合物组合物的褪色速率，其与相应的组合物包含不含所述侧链低聚物的光致变色化合物。本发明还涉及光致变色化合物，其是包含光致变色部分和至少一种侧挂低聚物的加合物。

5. 发明申请

WO2003103642A1 SOLUBILISATION OF DRUGS IN HFA PROPELLANT BY MEANS OF EMULSIONS 审中-公开
标题翻译：通过乳化剂在HFA推进剂中溶解药物
公开(公告)号：WO2003103642A1
公开(公告)日：2003-12-18
申请号：PCT/EP2003/005800
申请日：2003-06-03
申请人： CHIESI FARMACEUTICI S.P.A. , MEAKIN, Brian, John , LEWIS, David, Andrew , BERRILL, Susan, Ann , DAVIES, Rebecca, Jayne
发明人： MEAKIN, Brian, John , LEWIS, David, Andrew , BERRILL, Susan, Ann , DAVIES, Rebecca, Jayne
IPC分类号： A61K9/72
CPC分类号： A61K9/008 , A61K9/1075
摘要： Emulsion and microemulsion aerosol formulations in a HFA propellant system include a medicament, one or more surfactant, optionally a cosolvent and water. Emulsion formulations are based on 0.1-% w/w surfactant and 1-10% w/w water. Microemulsion formulations are based on 1-20% w/w surfactant, 1-30% w/w cosolvent and 1-10% w/w water. Preferred surfactant are Span 85, AOT and their blends, synperonics and alkylpolyglucosides (APGs) The preferred cosolvent is ethanol.
摘要翻译： HFA推进剂系统中的乳液和微乳液气溶胶制剂包括药物，一种或多种表面活性剂，任选的助溶剂和水。乳液制剂基于0.1-％w / w表面活性剂和1-10％w / w水。微乳液制剂基于1-20％w / w表面活性剂，1-30％w / w共溶剂和1-10％w / w水。优选的表面活性剂是Span 85，AOT及其共混物，异构体和烷基聚葡萄糖苷（APG）。优选的助溶剂是乙醇。

6. 发明申请

WO2003074025A2 PRESSURISED METERED DOSE INHALERS CONTAINING SOLUTIONS OF BETA-2 AGONISTS 审中-公开
标题翻译：含有BETA-2激动剂解决方案的压力计量剂吸入剂
公开(公告)号：WO2003074025A2
公开(公告)日：2003-09-12
申请号：PCT/EP2003/002004
申请日：2003-02-27
申请人： CHIESI FARMACEUTICI S.P.A. , DAVIES, Rebecca, Jaine , GANDERTON, David , LEWIS, David, Andrew , MEAKIN, Brian, John , CHURCH, Tanya, Kathleen , BRAMBILLA, Gaetano , FERRARIS, Alessandra
发明人： DAVIES, Rebecca, Jaine , GANDERTON, David , LEWIS, David, Andrew , MEAKIN, Brian, John , CHURCH, Tanya, Kathleen , BRAMBILLA, Gaetano , FERRARIS, Alessandra
IPC分类号： A61K9/00
CPC分类号： A61K9/008 , A61K31/4704 , A61K31/485 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： The present invention relates to a pharmaceutical formulation for use in the administration of 2(1H)-quinolinone derivatives long-acting β 2 -agonists by inhalation. In particular this invention relates to a chemically stable highly efficient TA 2005 HFA solution formulation to be administered by pressurised metered dose inhalers (pMDIs) characterized by a deep lung penetration. The invention also relates to methods for the preparation of said formulation and to its use in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
摘要翻译：本发明涉及用于通过吸入给药2（1H） - 喹啉酮衍生物长效β2-激动剂的药物制剂。特别地，本发明涉及一种化学稳定高效的TA 2005 HFA溶液制剂，其通过深层肺穿透特征的加压计量剂量吸入器（pMDI）来施用。本发明还涉及制备所述制剂及其在呼吸系统疾病如哮喘和慢性阻塞性肺疾病（COPD）中的应用的方法。

7. 发明申请

WO2003074023A1 AEROSOL FORMULATIONS FOR PULMONARY ADMINISTRATION OF MEDICAMENTS TO PRODUCE A SYSTEMIC EFFECT 审中-公开
标题翻译：用于产生药物作用的药物的脉管制剂的气雾剂制剂
公开(公告)号：WO2003074023A1
公开(公告)日：2003-09-12
申请号：PCT/EP2003/001962
申请日：2003-02-26
申请人： CHIESI FARMACEUTICI S.p.A. , DAVIES, Rebecca, Jaine , GANDERTON, David , LEWIS, David, Andrew , MEAKIN, Brian, John , BRAMBILLA, Gaetano , FERRARIS, Alessandra
发明人： DAVIES, Rebecca, Jaine , GANDERTON, David , LEWIS, David, Andrew , MEAKIN, Brian, John , BRAMBILLA, Gaetano , FERRARIS, Alessandra
IPC分类号： A61K9/00
CPC分类号： A61K9/008 , A61K31/00 , A61K31/4704 , A61K31/485 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： The invention discloses an aerosol pharmaceutical composition comprising a medicament in solution in a mixture of a hydrofluoroalkane propellant and one or more co-solvents wherein the aerosol liquid droplets delivered on actuation of the inhaler have a particle size comprised between 0,5 µm and 2.5 µm, with a mass median aerodynamic diameter of about 1-2 µm and wherein the fine particle fraction is at least 30%.
摘要翻译：本发明公开了一种气溶胶药物组合物，其包含在氢氟烷烃推进剂和一种或多种助溶剂的混合物中的溶液中的药物，其中在致动吸入器时输送的气溶胶液滴的粒径为0.5微米至2.5微米，质量中值空气动力学直径为约1-2微米，其中细颗粒分数为至少30％。

8. 发明申请

WO2006089656A3 PHARMACEUTICAL AEROSOL FORMULATIONS FOR PRESSURIZED METERED DOSE INHALERS COMPRISING A SEQUESTERING AGENT 审中-公开
公开(公告)号：WO2006089656A3
公开(公告)日：2006-08-31
申请号：PCT/EP2006/001287
申请日：2006-02-13
申请人： CHIESI FARMACEUTICI S.P.A. , LEWIS, David Andrew , MEAKIN, Brian John , DELCANALE, Maurizio , PIVETTI, Fausto
发明人： LEWIS, David Andrew , MEAKIN, Brian John , DELCANALE, Maurizio , PIVETTI, Fausto
IPC分类号： A61K9/12 , A61K9/72 , A61K47/02 , A61K31/573 , A61K31/58 , A61K31/4704
摘要： Aerosol solution formulation for use in an aerosol inhaler which comprises at least one active ingredient selected from a group consisting of 20-ketosteroids and quinolinone derivatives, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific amount of a sequestering agent.

9. 发明申请

WO2006024099A1 PHOTOCHROMIC COMPOUNDS COMPRISING POLYMERIC SUBSTITUENTS AND METHODS FOR PREPARATION AND USE THEREOF 审中-公开
标题翻译：包含聚合物替代物的光致变色化合物及其制备和使用方法
公开(公告)号：WO2006024099A1
公开(公告)日：2006-03-09
申请号：PCT/AU2005/001327
申请日：2005-09-02
申请人： POLYMERS AUSTRALIA PTY LIMITED , EVANS, Richard, Alexander , SUCH, Georgina, Kate , DAVIS, Thomas, Paul , MALIC, Nino , LEWIS, David, Andrew , CAMPBELL, Jonathan, Andrew
发明人： EVANS, Richard, Alexander , SUCH, Georgina, Kate , DAVIS, Thomas, Paul , MALIC, Nino , LEWIS, David, Andrew , CAMPBELL, Jonathan, Andrew
IPC分类号： C09K9/02
CPC分类号： C08F220/14 , C08F220/18 , C08F220/56 , C08F230/08 , C08F2438/01 , C08F2438/03 , C09K9/02 , G02B5/23 , G03C1/733
摘要： The present invention relates to a compound comprising a photochromic moiety and at least one substituent comprising a polymer chain having a carbon backbone and a plurality of functional moieties appended to the carbon backbone.
摘要翻译：本发明涉及包含光致变色部分和至少一个取代基的化合物，所述取代基包含具有碳骨架的聚合物链和附着在碳骨架上的多个官能部分。

10. 发明申请

WO2005105875A1 PHOTOCHROMIC COMPOSITIONS AND ARTICLES COMPRISING SILOXANE, ALKYLENE OR SUBSTITUTED ALKYLENE OLIGOMERS 审中-公开
标题翻译：包含硅氧烷，亚烷基或取代的亚烷基低聚物的光致变色组合物和文章
公开(公告)号：WO2005105875A1
公开(公告)日：2005-11-10
申请号：PCT/AU2005/000619
申请日：2005-04-29
申请人： POLYMERS AUSTRALIA PTY LIMITED , EVANS, Richard, Alexander , SUCH, Georgina, Kate , MALICK, Nino , DAVIS, Thomas, Paul , LEWIS, David, Andrew
发明人： EVANS, Richard, Alexander , SUCH, Georgina, Kate , MALICK, Nino , DAVIS, Thomas, Paul , LEWIS, David, Andrew
IPC分类号： C08F220/30
CPC分类号： C08G69/40 , C08F220/18 , C08G63/66 , C08G63/695 , C08G64/183 , C08G64/186 , G02B5/23
摘要： This invention relations to a polymerizable composition for forming a photochromic article of glass transition temperature of at least 50 °C on curing, the composition comprising: (a) a polymerizable composition comprising a monomer component or resin formed therefrom; and (b) a photochromic dye monomer comprising a photochromic moiety and at least one oligomeric group having at least one group reactive with the monomer component during or following curing wherein the oligomer group comprises a multiplicity of monomer units selected from siloxane, alkylene and substituted alkylene.
摘要翻译：本发明涉及一种用于在固化时形成玻璃化转变温度至少为50℃的光致变色制品的聚合性组合物，该组合物包含：（a）包含由其形成的单体组分或树脂的可聚合组合物; 和（b）包含光致变色部分的光致变色染料单体和至少一个具有至少一个在固化期间或之后与单体组分反应的基团的低聚物基团，其中低聚物基团包含多个选自硅氧烷，亚烷基和取代的亚烷基的单体单元。

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