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1. 发明申请

WO2021231967A1 SYSTEMS AND METHODS FOR TUMOR SUBTYPING USING MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2021231967A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/032613
申请日：2021-05-14
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , GOMER, Heather , SAMIEI, Arash , DARR, Marlena
发明人： STEWART, Shona , GOMER, Heather , SAMIEI, Arash , DARR, Marlena
IPC分类号： G01N21/31
摘要： Systems and methods designed to determine tumor histological subtypes in order to guide a surgical procedure. The systems and methods illuminate biological tissue in order to generate a plurality of interacted photons, collect the interacted photons, detect the plurality of a interacted photons to generate at least one hyperspectral image, and analyze a hyperspectral image by extracting a spectrum from a location in the hyperspectral image. The location should correspond to an area that is of interest in the biological tissue.

2. 发明申请

WO2021262844A1 METHODS FOR DETERMINING BLOOD OXYGENATION AND TISSUE PERFUSION LEVELS AND DEVICES THEREOF 审中-公开
公开(公告)号：WO2021262844A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/038674
申请日：2021-06-23
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , GOMER, Heather, E. , STEWART, Shona , SMITH, Aaron, G.
发明人： TREADO, Patrick, J. , GOMER, Heather, E. , STEWART, Shona , SMITH, Aaron, G.
IPC分类号： H04N5/33 , A61B5/00 , G01N33/483 , A61B5/1455 , A61B5/0261
摘要： Methods for improved tissue perfusion monitoring are disclosed. A method includes collecting hyperspectral image data from an image sensor positioned to collect interacted photons from a tissue region resulting from illumination of the tissue sample at a plurality of wavelengths in the visible, near infrared, or shortwave infrared regions. Hypercubes are generated based on the collected hyperspectral image data. The hypercubes are analyzed to identify one or more of the plurality of wavelengths resulting in contrast in the hyperspectral images. One or more regions in the tissue region with altered perfusion states are identified based on the contrast in the hyperspectral images. A tissue perfusion monitoring computing device and non-transitory medium are also disclosed.

3. 发明申请

WO2009035946A1 DISTINGUISHING BETWEEN INVASIVE DUCTAL CARCINOMA AND INVASIVE LOBULAR CARCINOMA USING RAMAN MOLECULAR IMAGING 审中-公开
标题翻译：使用拉曼分子成像检测入侵性肺癌和入侵性肺癌之间的差异
公开(公告)号：WO2009035946A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075609
申请日：2008-09-08
申请人： CHEMIMAGE CORPORATION , MAIER, John , COHEN, Jeffrey , STEWART, Shona
发明人： MAIER, John , COHEN, Jeffrey , STEWART, Shona
IPC分类号： G01N33/48 , G01J3/44 , G06F19/00
CPC分类号： G01J3/02 , A61B5/0059 , A61B5/417 , G01J3/0291 , G01J3/0294 , G01J3/28 , G01J3/2823 , G01J3/36 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N33/57415 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , Y02A90/26
摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
摘要翻译：一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。用基本上单色的光照射测试乳房样品以产生散射光子，得到测试拉曼数据集。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

4. 发明申请

WO2008100582A9 SPECTROSCOPIC SYSTEM AND METHOD FOR PREDICTING OUTCOME OF DISEASE 审中-公开
公开(公告)号：WO2008100582A9
公开(公告)日：2008-08-21
申请号：PCT/US2008/001988
申请日：2008-02-14
申请人： CHEMIMAGE CORPORATION , MAIER, John , COHEN, Jeffrey , PANZA, Janice, L. , STEWART, Shona , DRAUGH, Amy, J.
发明人： MAIER, John , COHEN, Jeffrey , PANZA, Janice, L. , STEWART, Shona , DRAUGH, Amy, J.
IPC分类号： C12Q1/00
摘要： A system and method to predict the progression of disease of a test sample is provided A group of known biological samples is provided, each having an associated known outcome including a non-diseased or diseased sample. A Raman data set is obtained for each known biological sample. Each data set is analyzed to identify a diseased or non-diseased reference data set. A first database is generated which contains reference Raman data sets for all diseased samples. A second-database is generated which contains reference data sets for all non-diseased samples. A test Raman data set of a test biological sample having an unknown disease status is received. A diagnostic is provided as to whether the test sample is non-diseased or diseased The diagnostic is obtained by comparing the test data set against the reference data sets in the databases using a chemometric technique to predict the progression of disease.

5. 发明申请

WO2006091853A2 METHOD OF CHEMICAL IMAGING TO DETERMINE TISSUE MARGINS DURING SURGERY 审中-公开
标题翻译：化学成像在手术期间确定组织标记的方法
公开(公告)号：WO2006091853A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006663
申请日：2006-02-24
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , STEWART, Shona , COHEN, Jeffrey , NELSON, Matthew
发明人： MAIER, John, S. , STEWART, Shona , COHEN, Jeffrey , NELSON, Matthew
IPC分类号： A61B6/00 , A61B18/18 , G01J3/44 , G01J3/40 , A61B5/00
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/0084 , G01N2021/6484 , G01N2021/656 , G01N2201/08
摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.
摘要翻译：在各种医疗过程中区分组织边缘的方法和系统。用基本上单色的光照射含有生物组织的区域。从照射区域获得拉曼光谱数据。在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

6. 发明公开

EP2917734A1 SYSTEM AND METHOD FOR SERUM BASED CANCER DETECTION 审中-实审转让
标题翻译：系统和方法基于血清癌检测
公开(公告)号：EP2917734A1
公开(公告)日：2015-09-16
申请号：EP13853852.5
申请日：2013-11-06
申请人： ChemImage Corporation , Treado, Patrick , Stewart, Shona , Kirschner, Heather , Priore, Ryan , Wilson, Alan
发明人： TREADO, Patrick , STEWART, Shona , KIRSCHNER, Heather , PRIORE, Ryan , WILSON, Alan
IPC分类号： G01N33/574 , G01N33/48 , G01N33/53
CPC分类号： G06F19/345 , G01J3/1804 , G01J3/44 , G01J3/4406 , G01N21/65 , G01N33/49 , G01N33/57419 , G06F19/24 , G16H50/20
摘要： A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

7. 发明申请

WO2021231913A1 SYSTEMS AND METHODS FOR SIMULTANEOUS WOUND DETECTION AND THERAPY 审中-公开
公开(公告)号：WO2021231913A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/032527
申请日：2021-05-14
申请人： CHEMIMAGE CORPORATION , STEWART, Shona
发明人： STEWART, Shona
IPC分类号： A61B6/00 , A61N5/06 , G01N21/00 , G01N21/64 , A61B5/0036 , A61B5/0077 , A61B5/444 , A61B5/445 , A61N2005/0628 , A61N2005/0653 , A61N2005/0654 , A61N2005/0656 , A61N2005/0659 , A61N2005/0661 , A61N2005/0663 , A61N5/0616 , A61N5/062 , A61N5/067
摘要： Medical conditions in tissues are simultaneously imaged and treated using light within selected wavelength ranges. By treating conditions, such as wounds, lesions, and tumors, at the same time that they are imaged, the overall diagnostic and treatment time is substantially reduced.

8. 发明申请

WO2009035942A1 DISTINGUISHING BETWEEN RENAL ONCOCYTOMA AND CHROMOPHOBE RENAL CELL CARCINOMA USING RAMAN MOLECULAR IMAGING 审中-公开
标题翻译：使用拉坦分子成像技术检测肾上腺癌和染色质细胞癌细胞
公开(公告)号：WO2009035942A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075598
申请日：2008-09-08
申请人： CHEMIMAGE CORPORATION , MAIER, John , COHEN, Jeffrey , STEWART, Shona
发明人： MAIER, John , COHEN, Jeffrey , STEWART, Shona
IPC分类号： G01N33/48 , G01J3/44 , G06F19/00
CPC分类号： G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
摘要： A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state.
摘要翻译：一种用于提供测试肾脏样本的肾脏疾病状态诊断的系统和方法。提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知肾脏样本和相关联的已知肾病状态。用基本单色光照射测试肾脏样品，以产生散射光子，得到测试拉曼数据集。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。基于比较，提供了测试肾脏样本的肾脏疾病状态的诊断。肾脏疾病状态包括肾细胞瘤或发色团肾癌疾病状态。

9. 发明申请

WO2007021485A2 RAMAN SPECTRAL ANALYSIS OF PATHOGENS 审中-公开
标题翻译：拉曼光谱分析病原体
公开(公告)号：WO2007021485A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/029187
申请日：2006-07-27
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
发明人： STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.
摘要翻译：使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。该方法可用于检测使用其他方法（如原生动物）难以检测的病原体。使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。本文描述的方法具有重要的应用，例如用于在市政水系统中检测隐孢子虫生物体。

10. 发明申请

WO2006135628A2 CYTOLOGICAL METHODS FOR DETECTING A DISEASE CONDITION SUCH AS MALIGNANCY BY RAMAN SPECTROSCOPIC IMAGING 审中-公开
标题翻译：用于通过拉曼光谱成像检测疾病状态如恶性肿瘤的细胞学方法
公开(公告)号：WO2006135628A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022083
申请日：2006-06-06
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , STEWART, Shona , TREADO, Patrick, J.
发明人： MAIER, John, S. , STEWART, Shona , TREADO, Patrick, J.
IPC分类号： C12Q1/00 , C12Q1/70 , C12Q1/68 , G06F19/00 , G01J3/44
CPC分类号： G01N21/65 , G01N2021/656
摘要： Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.
摘要翻译：拉曼分子成像（RMI）用于检测特定表型的哺乳动物细胞。例如，本公开包括使用RMI来区分正常和患病细胞或组织，例如癌细胞，以及确定所述癌细胞的等级。在一个优选实施方案中，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾，乳腺和结肠以及非上皮组织，例如骨髓和脑。可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。此外，RMI技术可以与可视图像数据组合，并用其他检测方法验证，以确定RMI获得的事项。

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