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1. 发明申请

WO2021231967A1 SYSTEMS AND METHODS FOR TUMOR SUBTYPING USING MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2021231967A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/032613
申请日：2021-05-14
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , GOMER, Heather , SAMIEI, Arash , DARR, Marlena
发明人： STEWART, Shona , GOMER, Heather , SAMIEI, Arash , DARR, Marlena
IPC分类号： G01N21/31
摘要： Systems and methods designed to determine tumor histological subtypes in order to guide a surgical procedure. The systems and methods illuminate biological tissue in order to generate a plurality of interacted photons, collect the interacted photons, detect the plurality of a interacted photons to generate at least one hyperspectral image, and analyze a hyperspectral image by extracting a spectrum from a location in the hyperspectral image. The location should correspond to an area that is of interest in the biological tissue.

2. 发明申请

WO2021113660A1 SYSTEMS AND METHODS FOR IN SITU OPTIMIZATION OF TUNABLE LIGHT EMITTING DIODE SOURCES 审中-公开
公开(公告)号：WO2021113660A1
公开(公告)日：2021-06-10
申请号：PCT/US2020/063345
申请日：2020-12-04
申请人： CHEMIMAGE CORPORATION
发明人： TAZIK, Shawna , ZRIMSEK, Alyssa , GOMER, Heather , WANG, Jihang , TREADO, Patrick J.
IPC分类号： G01J3/51
摘要： Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

3. 发明申请

WO2021119604A1 SYSTEMS AND METHODS FOR DISCRIMINATION OF TISSUE TARGETS 审中-公开
公开(公告)号：WO2021119604A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/064894
申请日：2020-12-14
申请人： CHEMIMAGE CORPORATION
发明人： ZRIMSEK, Alyssa , NELSON, Matthew , SHI, Lei , GOMER, Heather , TAZIK, Shawna
IPC分类号： A61B5/00 , A61B1/04 , A61B6/00 , G02B21/36
摘要： Systems for and methods for detecting samples and other compounds of interest are disclosed herein. The system can include an illumination source that is configured to emit light in a variety of different wavelength bands, an optical filter, a camera chip, and an optical path configured to direct the light emitted by the first illumination source at a target and direct the light reflected from the target to the at least one camera chip. The illumination source and the optical filter are transitionable between a first tuning state corresponding to a target tissue and a second tuning state corresponding to a background tissue. The system can be configured to record images at the different tuning states and generate a score image corresponding to the target tissue based on the recorded images.

4. 发明申请

WO2021067677A1 FUSION OF MOLECULAR CHEMICAL IMAGING WITH RGB IMAGING 审中-公开
公开(公告)号：WO2021067677A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/053914
申请日：2020-10-02
申请人： CHEMIMAGE CORPORATION
发明人： GOMER, Heather , TREADO, Patrick , WANG, Jihang
IPC分类号： G02B13/14 , G02B27/10 , G03B13/18 , H04N5/33 , H04N9/04
摘要： Methods, systems, and computer program products of fusing Molecular Chemical Imaging (MCI) and Red Green Blue (RGB) images are disclosed herein. A sample is illuminated with illuminating photons which interact with the sample and are used to form MCI and RGB images. The MCI and RGB images are fused by way of mathematical operations to generate a RGB image with a detection overlay.

5. 发明申请

WO2020037315A1 DISCRIMINATION OF CALCULI AND TISSUES WITH MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2020037315A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/047064
申请日：2019-08-19
申请人： CHEMIMAGE CORPORATION
发明人： COHEN, Jeffrey , TREADO, Patrick , STEWART, Shona , GOMER, Heather , SAMIEI, Arash , ZRIMSEK, Alyssa , WANG, Jihang
IPC分类号： A61B1/07 , A61B90/30
摘要： Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.

6. 发明申请

WO2021127512A1 SYSTEM AND METHOD FOR SPECTRAL LIBRARY TRAINING 审中-公开
公开(公告)号：WO2021127512A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/066132
申请日：2020-12-18
申请人： CHEMIMAGE CORPORATION
发明人： ZRIMSEK, Alyssa , GOMER, Heather , TAZIK, Shawna
IPC分类号： A61B1/04 , A61B1/06 , G01J3/0218 , G01J3/0224 , G01J3/0227 , G01J3/0245 , G01J3/447 , G01J3/457
摘要： Techniques, devices and methods for discriminating a target from a background material without optimizing directly on the target are provided. The devices and methods can generate pass bands of single or multiple wavelengths of variable shape and intensity, and can also select and control the shape of the pass band profiles to improve the detection of targets of interest.

7. 发明申请

WO2020163338A1 QUANTIFICATION OF HEART FAILURE USING MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2020163338A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/016589
申请日：2020-02-04
申请人： CHEMIMAGE CORPORATION
发明人： COHEN, Jeffrey, K. , POST, J. Christopher , STEWART, Shona , TREADO, Patrick, J. , GOMER, Heather , SMITH, Aaron
IPC分类号： A61B5/1455 , G01N21/17 , G02F1/1335 , A61B5/05 , A61B5/00 , G01J3/28
摘要： Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.

8. 发明申请

WO2017087574A1 RAMAN-BASED IMMUNOASSAY SYSTEMS AND METHODS 审中-公开
标题翻译：基于拉曼的免疫系统和方法
公开(公告)号：WO2017087574A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062361
申请日：2016-11-16
申请人： CHEMIMAGE CORPORATION
发明人： TREADO, Patrick , STEWART, Shona , SMITH, Aaron , GOMER, Heather
IPC分类号： G01J3/44 , A61B6/00 , G01N21/17 , G01N21/65 , G01N33/53
CPC分类号： G01N21/65 , G01J3/44 , G01N2201/0833
摘要： This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.
摘要翻译：本公开涉及用于将拉曼数据与生物标志数据融合以鉴定疾病和/或疾病进展的系统和方法。本文公开的系统可以包括用于生成来自生物样本的相互作用的光子的照射源和用于检测相互作用的光子以生成拉曼数据集的检测器。包括处理器以将拉曼数据组与生物标志物数据组融合以识别疾病和/或疾病进展。本公开还包括一种方法，该方法包括照射生物样本以生成相互作用的光子，并且检测相互作用的光子以生成拉曼数据集。从生物样品获得生物标记数据集，并将拉曼数据集与生物标记数据集融合以产生指数分数。指数评分与一种或多种疾病和疾病进展相关。

9. 发明公开

EP4070055A1 SYSTEMS AND METHODS FOR IN SITU OPTIMIZATION OF TUNABLE LIGHT EMITTING DIODE SOURCES 审中-实审
公开(公告)号：EP4070055A1
公开(公告)日：2022-10-12
申请号：EP20895627.6
申请日：2020-12-04
申请人： ChemImage Corporation
发明人： TAZIK, Shawna , ZRIMSEK, Alyssa , GOMER, Heather , WANG, Jihang , TREADO, Patrick J.
IPC分类号： G01J3/51

10. 发明公开

EP3920800A1 QUANTIFICATION OF HEART FAILURE USING MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：EP3920800A1
公开(公告)日：2021-12-15
申请号：EP20751965.3
申请日：2020-02-04
申请人： ChemImage Corporation
发明人： COHEN, Jeffrey, K. , POST, J. Christopher , STEWART, Shona , TREADO, Patrick, J. , GOMER, Heather , SMITH, Aaron
IPC分类号： A61B5/1455 , G01N21/17 , G02F1/1335 , A61B5/05 , A61B5/00 , G01J3/28

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