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1. 发明专利

CA3100859A1 USING ALTERNATING ELECTRIC FIELDS TO INCREASE CELL MEMBRANE PERMEABILITY 未知
公开(公告)号：CA3100859A1
公开(公告)日：2020-01-09
申请号：CA3100859
申请日：2019-07-03
申请人： CHANG EDWIN , PATEL CHIRAG B , GAMBHIR SANJIV S , VOLOSHIN SELA TALI , PORAT YAARA , GILADI MOSHE
发明人： CHANG EDWIN , PATEL CHIRAG B , GAMBHIR SANJIV S , VOLOSHIN-SELA TALI , PORAT YAARA , GILADI MOSHE
IPC分类号： A61N1/32
摘要： Certain substances (e.g. large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that the application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

2. 发明专利

IL279465D0 Using alternating electric fields to increase cell membrane permeability 未知
公开(公告)号：IL279465D0
公开(公告)日：2021-01-31
申请号：IL27946520
申请日：2020-12-15
申请人： CHANG EDWIN , PATEL CHIRAG B , GAMBHIR SANJIV S , VOLOSHIN SELA TALI , PORAT YAARA , GILADI MOSHE
发明人： CHANG EDWIN , PATEL CHIRAG B , GAMBHIR SANJIV S , VOLOSHIN-SELA TALI , PORAT YAARA , GILADI MOSHE
IPC分类号： A61K41/00 , A61N1/02 , A61N1/32 , A61N1/36 , A61P35/00
摘要： Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

3. 发明专利

SG11202012597UA USING ALTERNATING ELECTRIC FIELDS TO INCREASE CELL MEMBRANE PERMEABILITY 未知
公开(公告)号：SG11202012597UA
公开(公告)日：2021-01-28
申请号：SG11202012597U
申请日：2019-07-03
申请人： CHANG EDWIN , PATEL CHIRAG B , GAMBHIR SANJIV S , VOLOSHIN SELA TALI , PORAT YAARA , GILADI MOSHE
发明人： CHANG EDWIN , PATEL CHIRAG B , GAMBHIR SANJIV S , VOLOSHIN-SELA TALI , PORAT YAARA , GILADI MOSHE
IPC分类号： A61N1/32
摘要： Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

4. 发明申请

WO2007081716A3 SELF-ILLUMINATING QUANTUM DOT SYSTEMS AND METHODS OF USE THEREOF 审中-公开
标题翻译：自我照明量子点系统及其使用方法
公开(公告)号：WO2007081716A3
公开(公告)日：2008-08-07
申请号：PCT/US2007000096
申请日：2007-01-04
申请人： UNIV STANFORD , RAO JIANGHONG , LOENING ANDREAS M , GAMBHIR SANJIV S , SO MIN-KYUNG , XU CHENJIE
发明人： RAO JIANGHONG , LOENING ANDREAS M , GAMBHIR SANJIV S , SO MIN-KYUNG , XU CHENJIE
IPC分类号： G01N37/00
CPC分类号： G01N33/543 , B82Y15/00 , G01N21/763 , G01N33/588
摘要： Generally, aspects of the present disclosure are directed to conjugate systems, self-illuminating quantum dot conjugates, methods of detecting a target in a host, methods of treating a disease in a host, and the like.
摘要翻译：通常，本公开的方面涉及共轭系统，自发光量子点缀合物，检测宿主中靶标的方法，治疗宿主中疾病的方法等。

5. 发明申请

WO2008045252A2 ENGINEERED INTEGRIN BINDING PEPTIDES 审中-公开
标题翻译：工程整合胶粘剂
公开(公告)号：WO2008045252A2
公开(公告)日：2008-04-17
申请号：PCT/US2007021218
申请日：2007-10-03
申请人： UNIV LELAND STANFORD JUNIOR , COCHRAN JENNIFER R , KIMURA RICHARD , LEVIN ARON M , GAMBHIR SANJIV S
发明人： COCHRAN JENNIFER R , KIMURA RICHARD , LEVIN ARON M , GAMBHIR SANJIV S
IPC分类号： C07K16/28
CPC分类号： A61K38/1709 , A61K38/06 , A61K38/08 , A61K45/06 , A61K49/0056 , A61K51/082 , C07K14/47 , G01N33/57492
摘要： Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (a 5 ß 1 ) or vitronectin (a v ß 3 and a v ß 5 integrins) are disclosed. These peptides are based on a molecular scaffold into which a subsequence containing the RGD integrin-binding motif has been inserted. The subsequence (RGD mimic) comprises about 9-13 amino acids, and the RGD contained within the subsequence can be flanked by a variety of amino acids, the sequence of which was determined by sequential rounds of selection (in vitro evolution). The molecular scaffold is preferably based on a knottin, e.g., EETI (Trypsin inhibitor 2 (Trypsin inhibitor II) (EETI-II) [Ecballium elaterium (Jumping cucumber)], AgRP (Agouti-related protein), and Agatoxin IVB, which peptides have a rigidly defined three-dimensional conformation.
摘要翻译：以高亲和力（低平衡解离常数（Kd））结合到纤连蛋白（α5β1S1）的细胞表面受体或玻连蛋白（a < v3＆lt; 3＆gt;和＆lt;＆lt;＆lt;＆lt;＆lt; 5＆gt; 5＆gt; 5）整联蛋白）。这些肽基于其中插入了含有RGD整联蛋白结合基序的子序列的分子支架。子序列（RGD模拟物）包含约9-13个氨基酸，并且子序列内含有的RGD可以侧接多种氨基酸，其序列通过连续的选择轮次（体外进化）确定。分子支架优选基于knottin，例如EETI（胰蛋白酶抑制剂2（胰蛋白酶抑制剂II）（EETI-II）[Ecballium elaterium（跳跃黄瓜）]，AgRP（Agouti相关蛋白）和Agatoxin IVB，该肽具有刚性定义的三维构象。

6. 发明申请

WO2007109335A3 A METHOD FOR NONINVASIVELY AND QUANTITATIVELY MONITORING THERAPEUTIC AND DIAGNOSTIC TRANSGENE EXPRESSION INDUCED BY EX VIVO AND IN VIVO GENE TARGETING IN ORGANS, TISSUES AND CELLS 审中-公开
标题翻译：一种无创和定量监测EXVIVO和VIVO基因指导在器官，组织和细胞中诱导的诊断和诊断转移表达的方法
公开(公告)号：WO2007109335A3
公开(公告)日：2008-10-09
申请号：PCT/US2007007048
申请日：2007-03-20
申请人： UNIV CALIFORNIA , SEN LUYI , GAMBHIR SANJIV S
发明人： SEN LUYI , GAMBHIR SANJIV S
IPC分类号： C12Q1/68 , A61K49/00 , G21H5/02
CPC分类号： C12Q1/6897
摘要： An composition in a method for noninvasively monitoring the expression of therapeutic transgene delivered ex vivo and in vivo for the treatment of diseases includes the step of quantitatively imaging a reporter gene expression which is coupled to a therapeutic gene on a plasmid vector to infer levels, location, or duration of the therapeutic gene expression in the targeted tissues or organs. The reporter gene is imaged using a radiopharmaceutical for scintigraphic imaging of the gene expression interactions with the reporter gene, namely positron emission tomography, gamma camera or single-photon emission computed tomography. The genes are delivered with a liposome encapsulated reporter-therapeutic linked transgene vector with balanced reporter/therapeutic transgene expression. A transgene composition includes the reporter gene linked to the therapeutic gene or genes incorporated in and delivered by a liposome encapsulated reporter-therapeutic linked transgene vector.
摘要翻译：用于非侵入性监测离体和体内递送的用于治疗疾病的治疗性转基因表达的方法中的组合物包括定量成像与质粒载体上的治疗基因偶联的报告基因表达以推断水平，位置或靶向组织或器官中治疗性基因表达的持续时间。使用放射性药物对报告基因进行成像，用于与报告基因的基因表达相互作用的闪烁照相成像，即正电子发射断层扫描，γ照相机或单光子发射计算机断层摄影。基因与具有平衡的报告基因/治疗性转基因表达的脂质体封装的报告基因治疗连接的转基因载体递送。转基因组合物包括与治疗基因连接的报告基因或掺入脂质体封装的报告基因 - 治疗连锁的转基因载体并递送的基因。

7. 发明申请

WO2006099160A3 BIOLUMINESCENCE RESONANCE ENERGY TRANSFER (BRET) SYSTEMS AND METHODS OF USE THEREOF 审中-公开
标题翻译：生物共振能量转移（BRET）系统及其使用方法
公开(公告)号：WO2006099160A3
公开(公告)日：2007-08-02
申请号：PCT/US2006008632
申请日：2006-03-10
申请人： UNIV STANFORD , GAMBHIR SANJIV S , DE ABHIJIT
发明人： GAMBHIR SANJIV S , DE ABHIJIT
IPC分类号： G01N33/53 , C07H21/04 , C07K14/435 , C07K19/00 , C12N9/02 , C12P21/04 , C12Q1/66
CPC分类号： G01N33/542 , C12Q1/66
摘要： Briefly described, embodiments of this disclosure include bioluminescence resonance energy transfer (BRET) systems, methods of detecting a protein-protein interaction, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, methods to determine the efficacy of a test compound administered to modulate the interaction of a first protein with a second protein in a living animal, BRET vectors, kits relating to each of the above, transgenic cell or progeny thereof and/or animals relating to each of the above, and the like.
摘要翻译：简要描述，本公开的实施方案包括生物发光共振能量转移（BRET）系统，检测蛋白质 - 蛋白质相互作用的方法，用于检测活体动物中第一蛋白质与第二蛋白质的相互作用的非侵入性方法，确定功效的方法用于调节活体动物中第一蛋白质与第二蛋白质的相互作用的测试化合物，BRET载体，与上述每种相关的试剂盒，转基因细胞或其后代和/或与上述每种相关的动物，和类似。

8. 发明申请

WO2009020680A3 MOLECULAR IMAGING OF LIVING SUBJECTS USING RAMAN SPECTROSCOPY AND LABELED RAMAN NANOPARTICLES 审中-公开
标题翻译：使用拉曼光谱和标记的拉曼纳米粒子分析生命体的成像
公开(公告)号：WO2009020680A3
公开(公告)日：2009-06-11
申请号：PCT/US2008062649
申请日：2008-05-05
申请人： UNIV STANFORD , GAMBHIR SANJIV S , KEREN SHAY , WALTON IAN , GUAGLIARDO DAVID
发明人： GAMBHIR SANJIV S , KEREN SHAY , WALTON IAN , GUAGLIARDO DAVID
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B82Y30/00
摘要： Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a living host using a plurality of Raman nanoparticles; methods of generating multimodality images by combining Raman images with other functional/anatomical images; labeled Raman nanoparticles; and the like, are provided.
摘要翻译：使用拉曼纳米粒子成像活体宿主的方法; 产生已施用拉曼纳米颗粒的活体宿主的真实图像的方法; 使用多个拉曼纳米颗粒对活体宿主进行多重成像的方法; 通过组合拉曼图像与其他功能/解剖图像来生成多模态图像的方法; 标记的拉曼纳米颗粒; 提供了类似的装置。

9. 发明申请

WO2009070636A2 ENGINEERED CELLS, IMAGING REPORTER GENE/PROBE SYSTEMS, AND METHODS OF IMAGING 审中-公开
标题翻译：工程细胞，成像报告基因/检测系统和成像方法
公开(公告)号：WO2009070636A2
公开(公告)日：2009-06-04
申请号：PCT/US2008084785
申请日：2008-11-26
申请人： UNIV STANFORD , GAMBHIR SANJIV S , YAGHOUBI SHAHRIAR
发明人： GAMBHIR SANJIV S , YAGHOUBI SHAHRIAR
IPC分类号： C12N15/09 , C12N15/10
CPC分类号： A61K51/1203 , A61K49/0045 , A61K49/1896 , A61K51/0459
摘要： Embodiments of the present disclosure provide: methods of imaging the location and survival of an engineered cell in a host (e.g., human) with an imaging reporter probe, methods of imaging the location and survival of an engineered cell in a host, and, kits, engineered cells, and methods of making the engineered cells, and the like.
摘要翻译：本公开的实施例提供：使用成像报告探针对工程细胞在宿主（例如人）中的位置和存活进行成像的方法，成像宿主中工程细胞的位置和存活的方法，以及试剂盒，工程细胞，以及制造工程细胞的方法等。

10. 发明申请

WO2007030473A3 LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：润滑剂及其制备和使用方法
公开(公告)号：WO2007030473A3
公开(公告)日：2007-08-09
申请号：PCT/US2006034601
申请日：2006-09-06
申请人： UNIV STANFORD , GAMBHIR SANJIV S , LOENING ANDREAS M , WU ANNA
发明人： GAMBHIR SANJIV S , LOENING ANDREAS M , WU ANNA
IPC分类号： C12N9/02 , C07H21/04 , C07K14/485 , C12N15/52
CPC分类号： C12Q1/66
摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
摘要翻译：简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

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