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    • 7. 发明申请
    • DETERMINATION OF THE HYDRODYNAMIC RANGES OF THE CONSTITUENTS OF A MIXTURE BY ANALYSING A TAYLOR DISPERSION PRODUCED AFTER A CAPILLARY ELECTROPHORESIS SEPARATION
    • 通过分析毛细管电泳分离后产生的TAYLOR分散液来确定混合物组分的水动力学范围
    • WO2008031958A3
    • 2008-05-15
    • PCT/FR2007001499
    • 2007-09-14
    • CENTRE NAT RECH SCIENTCOTTET HERVELE SAUX THOMAS
    • COTTET HERVELE SAUX THOMAS
    • G01N15/02B01F13/00
    • G01N27/447G01N27/44726
    • The subject of the present invention is a method for determining the hydrodynamic range of the constituents of a mixture, in which: (A) by capillary electrophoresis, the constituents of the mixture M are separated, leaving them within the capillary; (B) at one of the ends of the capillary thus obtained, containing, in various zones, the constituents separated in step (A), a marker is injected that can be detected by a detection device placed on the side facing the other end of the capillary; (C) a pressure difference is induced between the ends of the capillary so as to make the various constituents separated during step (A) and, finally, the marker migrate towards the outlet of the capillary; and (D) the hydrodynamic range of each of said constituents is determined, by analysing the Taylor dispersion produced in step (C), from the time at which the marker is detected and from the elution profile of each of the constituents.
    • 本发明的主题是确定混合物组分的流体动力学范围的方法,其中:(A)通过毛细管电泳,混合物M的组分被分离,留在毛细管内; (B)在如此获得的毛细管的一端上,在各个区域中包含在步骤(A)中分离的成分,注射标记物,其可以通过放置在面向另一端的一侧的检测装置 毛细管; (C)在毛细管的端部之间产生压力差,以使步骤(A)中各种成分分离,最后标记物向毛细管出口移动; 和(D)通过分析步骤(C)中产生的泰勒分散度,从检测标记的时间和每种成分的洗脱曲线确定每个所述成分的流体动力学范围。
    • 10. 发明专利
    • FR2906032B1
    • 2008-12-12
    • FR0608112
    • 2006-09-15
    • CENTRE NAT RECH SCIENT
    • COTTET HERVELE SAUX THOMAS
    • G01N27/447G01N15/02
    • A method for determining the hydrodynamic radius for the constituents of an admixture, includes: (A) by separating capillary electrophoresis, the constituents of the admixture, leaving them within the capillary; (B) at one of the ends of the capillary obtained in this manner, containing, in different zones, the separated constituents, a detectable marker is injected in the region of a detection device which is placed at the side of the other end of the capillary; (C) a pressure difference is induced between the ends of the capillary in order to cause the various constituents separated in step (A) and finally the marker to migrate towards the outlet of the capillary; and (D) by analyzing the Taylor dispersion produced in step (C), the hydrodynamic radius is determined for each of the constituents, based on the detection time of the marker and the elution profile of each of the constituents.