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1. 发明专利

AU2014351811A1 Method for detection of a reversibly photo-convertible fluorescent species 未知
公开(公告)号：AU2014351811A1
公开(公告)日：2016-06-09
申请号：AU2014351811
申请日：2014-11-21
申请人： CENTRE NAT RECH SCIENT , ECOLE NORMALE SUPERIEURE DE PARIS , INST CURIE , UNIV PARIS CURIE
发明人： JULLIEN LUDOVIC , LE SAUX THOMAS , GAUTIER ARNAUD , CROQUETTE VINCENT , SARANG NATH , WANG PENCHENG , QUERARD JEROME , ALBRIGHT SAMANTHA
IPC分类号： G01N21/64
摘要： Method for detection of at least one reversibly photo-convertible fluorescent species (P), comprising the following steps: a) illumination of a sample comprising said or at least one of said reversibly photo-convertible fluorescent species by a periodically modulated illuminating light (FEX); and b) detection of fluorescent radiation (FLU) emitted by the sample thus illuminated; characterised in that the method further comprises the following step: c) extraction of the amplitude (lF0Ut) of the intensity component of said fluorescent radiation exhibiting the same periodicity as said periodically modulated illuminating light and a phase quadrature with respect to the same; and in that the mean intensity of said illuminating light and the modulation frequency of the same are chosen in such a way as to maximise said amplitude of the intensity component of said fluorescent radiation.

2. 发明专利

CA2931185A1 METHOD FOR DETECTION OF A REVERSIBLY PHOTO-CONVERTIBLE FLUORESCENT SPECIES 未知
公开(公告)号：CA2931185A1
公开(公告)日：2015-05-28
申请号：CA2931185
申请日：2014-11-21
申请人： CENTRE NAT RECH SCIENT , INST CURIE , ECOLE NORMALE SUPERIEURE DE PARIS , UNIV PARIS CURIE
发明人： JULLIEN LUDOVIC , LE SAUX THOMAS , GAUTIER ARNAUD , CROQUETTE VINCENT , SARANG NATH , WANG PENCHENG , QUERARD JEROME , ALBRIGHT SAMANTHA
IPC分类号： G01N21/64
摘要： Method for detection of at least one reversibly photo-convertible fluorescent species (P), comprising the following steps: a) illumination of a sample comprising said or at least one of said reversibly photo-convertible fluorescent species by a periodically modulated illuminating light (FEX); and b) detection of fluorescent radiation (FLU) emitted by the sample thus illuminated; characterised in that the method further comprises the following step: c) extraction of the amplitude (lF0Ut) of the intensity component of said fluorescent radiation exhibiting the same periodicity as said periodically modulated illuminating light and a phase quadrature with respect to the same; and in that the mean intensity of said illuminating light and the modulation frequency of the same are chosen in such a way as to maximise said amplitude of the intensity component of said fluorescent radiation.

3. 发明专利

FR3013452B1 PROCEDE DE DETECTION D'UNE ESPECE FLUORESCENTE REVERSIBLEMENT PHOTOCONVERTIBLE 未知
公开(公告)号：FR3013452B1
公开(公告)日：2016-02-05
申请号：FR1361476
申请日：2013-11-21
申请人： CENTRE NAT RECH SCIENT , INST CURIE , ECOLE NORMALE SUPERIEURE DE PARIS , UNIV PARIS CURIE
发明人： JULLIEN LUDOVIC , LE SAUX THOMAS , GAUTIER ARNAUD , CROQUETTE VINCENT , NATH SARANG , WANG PENGCHENG , QUERARD JEROME
IPC分类号： G01N21/64

4. 发明专利

FR3013452A1 PROCEDE DE DETECTION D'UNE ESPECE FLUORESCENTE REVERSIBLEMENT PHOTOCONVERTIBLE 未知
公开(公告)号：FR3013452A1
公开(公告)日：2015-05-22
申请号：FR1361476
申请日：2013-11-21
申请人： CENTRE NAT RECH SCIENT , INST CURIE , ECOLE NORMALE SUPERIEURE DE PARIS , UNIV PARIS CURIE
发明人： JULLIEN LUDOVIC , LE SAUX THOMAS , GAUTIER ARNAUD , CROQUETTE VINCENT , NATH SARANG , WANG PENGCHENG , QUERARD JEROME
IPC分类号： G01N21/64
摘要： Procédé de détection d'au moins une espèce fluorescente réversiblement photoconvertible (P), comportant les étapes suivantes : a) éclairer un échantillon contenant ladite ou au moins une dite espèce fluorescente réversiblement photoconvertible avec une lumière d'éclairage (FEX) modulée périodiquement ; et b) détecter un rayonnement de fluorescence (FLU) émis par ledit échantillon ainsi éclairé ; caractérisé en ce qu'il comprend également l'étape suivante : c) extraire l'amplitude (IFout) de la composante de l'intensité dudit rayonnement de fluorescence présentant la même périodicité que ladite lumière d'éclairage modulée périodiquement et en quadrature de phase par rapport à ce dernier ; et en ce que l'intensité moyenne de ladite lumière d'éclairage et sa fréquence de modulation sont choisies de manière à maximiser ladite amplitude de la composante d'intensité dudit rayonnement de fluorescence.

5. 发明专利

AU2012356826A1 Method of DNA detection and quantification by single-molecule hybridization and manipulation 未知
公开(公告)号：AU2012356826A1
公开(公告)日：2014-07-24
申请号：AU2012356826
申请日：2012-12-21
申请人： ECOLE NORMALE SUPERIEURE , CENTRE NAT RECH SCIENT , UNIV PARIS CURIE
发明人： BENSIMON DAVID , ALLEMAND JEAN-FRANCOIS , DING FANG-YUAN , CROQUETTE VINCENT
IPC分类号： C12Q1/68
摘要： The present invention relates to a fast method for the detection and the quantification of a nucleic acid, DNA or RNA. Specifically, the invention provides a method for detecting and quantifying the presence of a specific nucleic acid molecule which is based on physical and electronic treatments. The method of the invention is particularly useful for applications as diverse as detection of chromosomal abnormal distributions or gene expression analysis.

6. 发明专利

CA2859913A1 METHOD OF DNA DETECTION AND QUANTIFICATION BY SINGLE-MOLECULE HYBRIDIZATION AND MANIPULATION 未知
公开(公告)号：CA2859913A1
公开(公告)日：2013-06-27
申请号：CA2859913
申请日：2012-12-21
申请人： CENTRE NAT RECH SCIENT , ECOLE NORMALE SUPERIEURE , UNIV PARIS CURIE
发明人： BENSIMON DAVID , ALLEMAND JEAN-FRANCOIS , DING FANG-YUAN , CROQUETTE VINCENT
IPC分类号： C12Q1/68
摘要： The present invention relates to a fast method for the detection and the quantification of a nucleic acid, DNA or RNA. Specifically, the invention provides a method for detecting and quantifying the presence of a specific nucleic acid molecule which is based on physical and electronic treatments. The method of the invention is particularly useful for applications as diverse as detection of chromosomal abnormal distributions or gene expression analysis.

7. 发明专利

CA2800637C METHOD OF DNA SEQUENCING BY POLYMERISATION 未知
公开(公告)号：CA2800637C
公开(公告)日：2018-08-28
申请号：CA2800637
申请日：2011-05-26
申请人： CENTRE NAT RECH SCIENT , ECOLE NORMALE SUPERIEURE
发明人： BENSIMON DAVID , CROQUETTE VINCENT , ALLEMAND JEAN-FRANCOIS , MANOSAS MARIA , DING FANG-YUAN
IPC分类号： C12Q1/6869
摘要： The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork. This allows the determination of the physical location of the site where a pause or a blockage of the replication occurs, and deducing therefrom information on the sequence of the nucleic acid.

8. 发明专利

SG11201505618XA PROCESS FOR DETECTION OF DNA MODIFICATIONS AND PROTEIN BINDING BY SINGLE MOLECULE MANIPULATION 未知
公开(公告)号：SG11201505618XA
公开(公告)日：2015-08-28
申请号：SG11201505618X
申请日：2014-01-22
申请人： CENTRE NAT RECH SCIENT , ECOLE NORMALE SUPERIEURE , UNIV PIERRE ET MARIE CURIE PARIS 6
发明人： BENSIMON DAVID , CROQUETTE VINCENT , GOUET HAROLD , ALLEMAND JEAN-FRANÇOIS , DING FANG-YUAN
IPC分类号： G01N33/557 , C12Q1/68
摘要： The present invention relates to a method for determining whether a protein binds to a specific DNA sequence. This method is useful in particular for identifying modifications to the DNA sequence (e.g. methylations) via the binding of proteins that specifically recognize those modifications (e.g. antibodies), but also to identify the binding sequence on DNA of a variety of proteins.

9. 发明专利

AT190357T 未知
公开(公告)号：AT190357T
公开(公告)日：2000-03-15
申请号：AT94913139
申请日：1994-04-06
申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT
发明人： BENSIMON AARON , BENSIMON DAVID , CROQUETTE VINCENT , CHIFFAUDEL ARNAUD
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , C12Q1/6869 , G01N37/00 , G01Q60/00 , G01N27/00

10. 发明专利

AU2020301577A1 Deformable device for positioning a holder 未知
公开(公告)号：AU2020301577A1
公开(公告)日：2022-02-10
申请号：AU2020301577
申请日：2020-06-26
申请人： CENTRE NAT RECH SCIENT , PARIS SCIENCES ET LETTRES , UNIV SORBONNE , UNIV PARIS CITE
发明人： RADOU GAËL , VIEILLE THIBAULT , CROQUETTE VINCENT
IPC分类号： G02B7/00
摘要： The present invention relates to a device (1) for positioning an object according to a given direction (2), comprising a frame (3), a holder (4) for holding the object, the holder (4) being movable relative to the frame (3) according to the given direction (2), a main lever (5) extending between a first point (6) and a second point (7), said main lever (5) being rotatably mounted to the frame (3) via a first pivot link (9) connecting the main lever (5) and the frame (3) at the first point (6) of the main lever (5), the main lever (5) being connected to the holder (4) at a third point (8) which is arranged between the first point (6) and the second point (7), so that a displacement of the second point (7) of the main lever (5) relative to the frame (3) according to the given direction (2) causes displacement of the holder (4) in said given direction (2), said displacement of the holder (4) having a smaller amplitude than an amplitude of the displacement of the second point (7), the device (1) comprising a secondary lever (11) connected to the holder via a third pivot link (12), the secondary lever (11) being connected to the main lever (5) via a fourth pivot link (13), and being rotatably mounted to the frame via a fifth pivot link (14), the third pivot link (12) being arranged between the fourth pivot link (13) and the fifth pivot link (14).

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