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1. 发明申请

WO2004098502A3 CNGH0010 SPECIFIC POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES, COMPOSITIONS, METHODS AND USES. 审中-公开
标题翻译： CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途。
公开(公告)号：WO2004098502A3
公开(公告)日：2006-03-23
申请号：PCT/US2004013211
申请日：2004-04-30
申请人： CENTOCOR INC , SONG XIAO-YU R , HUANG CHRIS , MA KEYING , LIANG BAILIN , NASO MICHAEL
发明人： SONG XIAO-YU R , HUANG CHRIS , MA KEYING , LIANG BAILIN , NASO MICHAEL
IPC分类号： A61K20060101 , A61K38/00 , C07K14/47 , C07H21/04 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12P21/02
CPC分类号： C07K14/47 , A61K45/06
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.
摘要翻译：对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体，其制备和使用方法可用于治疗和诊断制剂，给药和装置。上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病，伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

2. 发明申请

WO2005033293A3 HYPOXIA - RESPONSIVE HUMAN CNGH-0002 GENES AND POLYPEPTIDES 审中-公开
标题翻译： HYPOXIA - 响应人类CNGH-0002基因和多肽
公开(公告)号：WO2005033293A3
公开(公告)日：2007-06-07
申请号：PCT/US2004032620
申请日：2004-10-01
申请人： CENTOCOR INC , YAN LI , HUANG CHRIS , KESAVAN PRABAKARAN , LI KATHERINE , NAKADA MARIAN
发明人： YAN LI , HUANG CHRIS , KESAVAN PRABAKARAN , LI KATHERINE , NAKADA MARIAN
IPC分类号： C07H21/04 , A61K38/19 , C07K14/47 , C12N20060101 , C12N5/00 , C12N9/02 , C12Q1/68
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of nucleic acids and proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acids molecules, expression vectors containing the nucleic acids molecules of the invention, host cells into which the expression vectors have been introduced, and non- human transgenic animals in which a nucleic acids molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种核酸和蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供了反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或破坏。本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

3. 发明申请

WO2007100933A3 ETCH SELECTIVITY ENHANCEMENT, DEPOSITION QUALITY EVALUATION, STRUCTURAL MODIFICATION AND THREE-DIMENSIONAL IMAGING USING ELECTRON BEAM ACTIVATED CHEMICAL ETCH 审中-公开
标题翻译： ETCH选择性增强，沉积质量评估，结构改性和使用电子束激活化学蚀刻的三维成像
公开(公告)号：WO2007100933A3
公开(公告)日：2008-04-10
申请号：PCT/US2007060503
申请日：2007-01-12
申请人： KLA TENCOR TECH CORP , NASSER-GHODSI MEHRAN , GOTKIS YEHIEL , LOPATIN SERGEY , PICKARD GARRETT , GARCIA RUDY F , YU MING LUN , KRZECZOWSKI KENNETH , LENT MATTHEW , HUANG CHRIS , MACDONALD NILES K , BOROWICZ STANISLAW MAREK , CHUANG TZU-CHIN
发明人： NASSER-GHODSI MEHRAN , GOTKIS YEHIEL , LOPATIN SERGEY , PICKARD GARRETT , GARCIA RUDY F , YU MING LUN , KRZECZOWSKI KENNETH , LENT MATTHEW , HUANG CHRIS , MACDONALD NILES K , BOROWICZ STANISLAW MAREK , CHUANG TZU-CHIN
IPC分类号： C23F1/00 , A61N5/00 , B44C1/22 , G21K7/00
CPC分类号： G03F7/2043 , H01J2237/31732 , H01J2237/3174 , H01J2237/31744 , H01L21/02057 , H01L21/3065 , H01L21/31116 , H01L21/32136
摘要： Etch selectivity enhancement during electron beam activated chemical etch (EBACE), methods and apparatus for evaluating the quality of structures on an integrated circuit wafer using EBACE, a method for modifying a surface of a substrate (or a portion there of), methods and apparatus for imaging a structure and an associated processor-readable medium are disclosed. A target or portion thereof may be exposed to a gas composition of a type that etches the target when the gas composition and/or target are exposed to an electron beam. By directing an electron beam toward the target in the vicinity of the gas composition, an interaction between the electron beam and the gas composition etches a portion of the target exposed to both the gas composition and the electron beam.
摘要翻译：电子束激活化学蚀刻（EBACE）中的蚀刻选择性增强，用于使用EBACE评估集成电路晶片上的结构质量的方法和装置，用于改变衬底（或其部分）的表面的方法，方法和装置用于对结构进行成像和相关联的处理器可读介质。当气体组合物和/或靶暴露于电子束时，靶或其部分可暴露于蚀刻靶的类型的气体组合物。通过在气体组合物附近引导电子束朝向靶，电子束和气体组成之间的相互作用会蚀刻暴露于气体组成和电子束两者的靶的一部分。

4. 发明申请

WO2009117547A2 MARKERS AND METHODS FOR ASSESSING AND TREATING SEVERE OR PERSISTANT ASTHMA AND TNF RELATED DISORDERS 审中-公开
标题翻译：评估和治疗严重哮喘和TNF相关疾病的标记和方法
公开(公告)号：WO2009117547A2
公开(公告)日：2009-09-24
申请号：PCT/US2009037611
申请日：2009-03-19
申请人： CENTOCOR ORTHO BIOTECH INC , HUANG CHRIS , WATT ROSEMARY , BARNATHAN ELLIOT , LO KIM HUNG
发明人： HUANG CHRIS , WATT ROSEMARY , BARNATHAN ELLIOT , LO KIM HUNG
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： A method for assessment of the suitability of and/or effectiveness of a target therapy for a TNF-mediated-related disorder, such as severe or persistent asthma, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes corresponding to contacting the sample with a panel of nucleic acid segments consisting of at least a portion of at least one member from the group consisting of the nucleotide sequences corresponding to at least one of, TNFRSF1A SNP rs4149581 (SEQ ID NO:1 ), TNFRSF1 B SNP rs3766730 (SEQ ID NO:2) or TNFRSFI B SNP rs590977 (SEQ ID NO:3) SNPs which results in a determination that one or more of said SNPs in a sample are in linkage disequilibrium (LD). The method enables identification of the effectiveness of target therapies prior to or after starting a patient on such therapies.
摘要翻译：用于评估靶标治疗对TNF介导的相关疾病（例如严重或持续性哮喘）在受试者中的适用性和/或有效性的方法评估一种或多种更多的基因对应于将样品与由至少一部分至少一个成员组成的组中的至少一个对应于TNFRSF1A SNP rs4149581（SEQ ID NO：1）中的至少一个的核苷酸序列组合的核酸片段接触，，TNFRSF1B SNP rs3766730（SEQ ID NO：2）或TNFRSFI B SNP rs590977（SEQ ID NO：3）SNP，其导致样品中的一种或多种所述SNP处于连锁不平衡（LD）的SNP。该方法能够在开始患者之前或之后鉴定目标疗法在这些疗法上的有效性。

5. 发明专利

AU2004237766A1 CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses. 未知
公开(公告)号：AU2004237766A1
公开(公告)日：2004-11-18
申请号：AU2004237766
申请日：2004-04-30
申请人： CENTOCOR INC
发明人： HUANG CHRIS , LIANG BAILIN , NASO MICHAEL , MA KEYING , SONG XIAO-YU R
IPC分类号： A61K20060101 , A61K38/00 , C07K14/47
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

6. 发明专利

AU2004237766B2 CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses. 未知
公开(公告)号：AU2004237766B2
公开(公告)日：2010-08-19
申请号：AU2004237766
申请日：2004-04-30
申请人： CENTOCOR INC
发明人： HUANG CHRIS , LIANG BAILIN , NASO MICHAEL , MA KEYING , SONG XIAO-YU R
IPC分类号： C07K14/47 , A61K20060101 , A61K38/00
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

7. 发明专利

AU2004278779A1 Hypoxia - responsive human CNGH-0002 genes and polypeptides 未知
公开(公告)号：AU2004278779A1
公开(公告)日：2005-04-14
申请号：AU2004278779
申请日：2004-10-01
申请人： CENTOCOR INC
发明人： LI KATHERINE , NAKADA MARIAN , YAN LI , KESAVAN PRABAKARAN , HUANG CHRIS
IPC分类号： C07H21/04 , C07K14/47 , C12N20060101 , C12N9/02 , C12Q1/68
摘要： The invention provides isolated nucleic acids encoding a variety of nucleic acids and proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acids molecules, expression vectors containing the nucleic acids molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acids molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

8. 发明专利

CA2490621A1 CNGH0005 POLYPEPTIDES, ANTIBODIES, COMPOSITIONS, METHODS ANDUSES 未知
公开(公告)号：CA2490621A1
公开(公告)日：2004-01-08
申请号：CA2490621
申请日：2003-06-25
申请人： CENTOCOR INC
发明人： HUANG CHRIS , NAKADA MARIAN , LU JIN
IPC分类号： A61K38/00 , C07K14/47 , C12N15/13 , C07H21/00 , A61K45/00 , A61K48/00 , C12P21/02 , C07K7/08 , C12P21/08 , C12N15/12 , A61K38/17 , C07K16/18 , C12P19/34 , A61K39/395 , A61K31/7088
摘要： The present invention relates to at least one novel CNGH0005 polypeptides, antibodies, including isolated nucleic acids that encode at least one CNGH00 05 polypeptide or antibody, CNGH0005 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

9. 发明专利

CA2541823A1 HYPOXIA - RESPONSIVE HUMAN CNGH-0002 GENES AND POLYPEPTIDES 未知
公开(公告)号：CA2541823A1
公开(公告)日：2005-04-14
申请号：CA2541823
申请日：2004-10-01
申请人： CENTOCOR INC
发明人： YAN LI , HUANG CHRIS , LI KATHERINE , KESAVAN PRABAKARAN , NAKADA MARIAN
IPC分类号： C12N15/12 , A61K38/17 , A61K39/395 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/30 , C12N20060101 , C12N5/06 , C12N9/02 , C12N15/10 , C12N15/85 , C12P21/02 , C12Q1/68 , G01N33/53
摘要： The invention provides isolated nucleic acids encoding a variety of nucleic acids and proteins having diagnostic, preventive, therapeutic, and other use s. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acids molecules, expression vectors containing th e nucleic acids molecules of the invention, host cells into which the expressi on vectors have been introduced, and non- human transgenic animals in which a nucleic acids molecule of the invention has been introduced or disrupted. Th e invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucle ic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

10. 发明专利

CA2524172A1 CNGH0010 SPECIFIC POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES,COMPOSITIONS, METHODS AND USES 未知
公开(公告)号：CA2524172A1
公开(公告)日：2004-11-18
申请号：CA2524172
申请日：2004-04-30
申请人： CENTOCOR INC
发明人： SONG XIAO-YU R , HUANG CHRIS , MA KEYING , LIANG BAILIN , NASO MICHAEL
IPC分类号： C12N15/13 , A61K20060101 , A61K31/7088 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , C07K14/47 , C07K16/18 , C07K19/00 , C12N15/12 , C12P19/34 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/48
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions o r variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptid es and antibodies, complementary nucleic acids, vectors, host cells, and method s of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/ or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodi es are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes , autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disea se and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammato ry and hyperproliferative diseases.

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