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1. 发明申请

WO2005033293A3 HYPOXIA - RESPONSIVE HUMAN CNGH-0002 GENES AND POLYPEPTIDES 审中-公开
标题翻译： HYPOXIA - 响应人类CNGH-0002基因和多肽
公开(公告)号：WO2005033293A3
公开(公告)日：2007-06-07
申请号：PCT/US2004032620
申请日：2004-10-01
申请人： CENTOCOR INC , YAN LI , HUANG CHRIS , KESAVAN PRABAKARAN , LI KATHERINE , NAKADA MARIAN
发明人： YAN LI , HUANG CHRIS , KESAVAN PRABAKARAN , LI KATHERINE , NAKADA MARIAN
IPC分类号： C07H21/04 , A61K38/19 , C07K14/47 , C12N20060101 , C12N5/00 , C12N9/02 , C12Q1/68
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of nucleic acids and proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acids molecules, expression vectors containing the nucleic acids molecules of the invention, host cells into which the expression vectors have been introduced, and non- human transgenic animals in which a nucleic acids molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种核酸和蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供了反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或破坏。本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

2. 发明申请

WO2006039343A3 EMMPRIN ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译： EMMPRIN ANTAGONISTS及其用途
公开(公告)号：WO2006039343A3
公开(公告)日：2007-01-04
申请号：PCT/US2005034839
申请日：2005-09-29
申请人： CENTOCOR INC , JOHNSON & JOHNSON RES PARTY LT , ARNDT GREGORY , NAKADA MARIAN , LOMAS MEHNAAZ , RIVORY LAURENT , TANG YI , YAN LI
发明人： ARNDT GREGORY , NAKADA MARIAN , LOMAS MEHNAAZ , RIVORY LAURENT , TANG YI , YAN LI
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N5/00 , C12Q1/68
CPC分类号： C12N15/1138 , C07K16/2803 , C07K2317/76 , C12N2310/111 , C12N2310/12 , C12N2310/14
摘要： EMMPRIN (Extracellular Matrix Metalloproteinase Inducer) antagonists, such as antibodies, including specified portions or variants, siRNA, shRNA, and DNAzymes, can be used to treat pathological processes associated with proliferative diseases, such as cancer, by specifically preventing or inhibiting the ability of proliferating tissue to develop a blood supply.
摘要翻译：包括特定部分或变体的siRNA，shRNA和DNA酶的EMMPRIN（细胞外基质金属蛋白酶诱导剂）拮抗剂可用于治疗与增殖性疾病如癌症相关的病理过程，特异性地预防或抑制增殖组织发展血液供应。

3. 发明申请

WO2005044200A2 METHODS AND COMPOSITIONS FOR TREATING MCP-1 RELATED PATHOLOGIES 审中-公开
标题翻译：用于治疗MCP-1相关病理学的方法和组合物
公开(公告)号：WO2005044200A2
公开(公告)日：2005-05-19
申请号：PCT/US2004037024
申请日：2004-11-05
申请人： CENTOCOR INC , YAN LI , NAKADA MARIAN T , DAS ANUK
发明人： YAN LI , NAKADA MARIAN T , DAS ANUK
IPC分类号： A61K20060101 , A61K31/137 , A61K31/445 , A61K31/473 , A61K31/573 , A61K38/18 , A61K38/54 , A61K39/395 , A61K45/06 , C07K16/24 , A61K
CPC分类号： A61K31/573 , A61K31/137 , A61K31/445 , A61K31/473 , A61K38/00 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/73 , A61K2300/00
摘要： The present invention relates to methods for treating at least one MCP-1 related condition or pathology, including therapeutic compositions, methods and devices.
摘要翻译：本发明涉及用于治疗至少一种MCP-1相关病症或病理学的方法，包括治疗组合物，方法和装置。

4. 发明专利

BR102018004897A2 escorredor com cesto ajustável para ajustar a altura do corpo flutuante 未知
公开(公告)号：BR102018004897A2
公开(公告)日：2019-10-01
申请号：BR102018004897
申请日：2018-03-12
申请人： YAN LI
发明人： YAN LI
IPC分类号： E03C1/23 , E03C1/282
摘要： escorredor com cesto ajustável para ajustar a altura do corpo flutuante. esta invenção descreve um escorredor que usa um cesto com altura ajustável para controlar a altura do corpo flutuante; é caracterizada pelo fato de que o escorredor inclui o corpo, o cesto com altura ajustável, o corpo flutuante e o componente de economia de água; o corpo do escorredor compreende uma entrada de água, cavidade interna do corpo do escorredor, coluna de ajuste de altura e a saída de água; o cesto com altura ajustável, o corpo flutuante e o componente de economia de água são alternadamente colocados no corpo do escorredor com componente de economia de água mais próximo da saída de água.

5. 发明专利

ZA202109247B SMART IRRIGATION CONTROL SYSTEM, AND CONTROL METHOD THEREFOR 未知
公开(公告)号：ZA202109247B
公开(公告)日：2022-04-28
申请号：ZA202109247
申请日：2021-11-18
申请人： YAN LI
发明人： YAN LI , HUA CHEN
摘要： A smart irrigation control system, an irrigation apparatus, and a control method therefor. The smart irrigation control system comprises: a data acquisition module (201), a data receiving module (202), a central processing module (203), an irrigation apparatus management module (204), an irrigation apparatus terminal execution module (205), and a feedback data module (206). The data acquisition module (201) is used to acquire and send related data to the data receiving module (202). The data receiving module (202) sends the received data to the central processing module (203) to be processed and form an irrigation request. The central processing module (203) sends the irrigation request to the irrigation apparatus management module (204). The irrigation apparatus forms an irrigation instruction, and sends the irrigation instruction to the irrigation apparatus terminal execution module (205). The irrigation apparatus terminal execution module (205) controls the corresponding irrigation apparatus to execute a corresponding operation. The feedback data module (206) sends feedback of the irrigation apparatus terminal execution data to the data acquisition module (201). The invention achieves water-, fertilizer-, and pesticide-integrated automatic irrigation control, thereby eliminating the need of manually opening valves, and saving time and labor.

6. 发明申请

WO2010096289A3 COMBINATION THERAPY USING AN ANTI-EGFR AGENT(S) AND IGF-1R SPECIFIC ANTIBODIES 审中-公开
标题翻译：使用抗EGFR代谢物和IGF-1R特异性抗体的联合治疗
公开(公告)号：WO2010096289A3
公开(公告)日：2010-12-23
申请号：PCT/US2010023433
申请日：2010-02-08
申请人： MERCK SHARP & DOHME , YAN LI , CHASTAIN MICHAEL , HSU KARL
发明人： YAN LI , CHASTAIN MICHAEL , HSU KARL
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K39/39558 , A61K2039/505 , A61K2039/545 , A61K2300/00
摘要： A combination of an IGF -1 R antagonist and an antiproliferative drug is described. A preferred combination of an IGF-1r antibody and an antiproliferative drug belonging to the EGFR-inhibitor class, preferably erlotinib, useful for the treatment of tumours, including IGF -IR and lor EGFR mediated or dependent tumours, is disclosed.
摘要翻译：描述了IGF-1R拮抗剂和抗增殖药物的组合。公开了可用于治疗肿瘤（包括IGF-1R和EGFR或EGFR介导的或依赖性肿瘤）的属于EGFR抑制剂类型的优选埃洛替尼的IGF-1R抗体和抗增殖药物的优选组合。

7. 发明申请

WO2013049421A3 LIGHT EMITTING DEVICES HAVING LIGHT COUPLING LAYERS WITH RECESSED ELECTRODES 审中-公开
标题翻译：具有接触电极的光耦合层的发光器件
公开(公告)号：WO2013049421A3
公开(公告)日：2013-07-11
申请号：PCT/US2012057669
申请日：2012-09-27
申请人： BRIDGELUX INC , LIN CHAO-KUN , YAN LI , CHUANG CHIH-WEI
发明人： LIN CHAO-KUN , YAN LI , CHUANG CHIH-WEI
IPC分类号： H01L33/30 , H01L33/22
CPC分类号： H01L33/30 , H01L33/10 , H01L33/22 , H01L33/32 , H01L33/382 , H01L33/58 , H01L2924/0002 , H01L2924/00
摘要： A light emitting device comprises a first layer of an n-type semiconductor material, a second layer of a p-type semiconductor material, and an active layer between the first layer and the second layer. A light coupling structure is disposed adjacent to one of the first layer and the second layer. In some cases, the light coupling structure is disposed adjacent to the first layer. An orifice formed in the light coupling structure extends to the first layer. An electrode formed in the orifice is in electrical communication with the first layer.
摘要翻译：发光器件包括n型半导体材料的第一层，p型半导体材料的第二层和在第一层和第二层之间的有源层。光耦合结构设置成与第一层和第二层之一相邻。在一些情况下，光耦合结构邻近第一层设置。形成在光耦合结构中的孔口延伸到第一层。形成在孔中的电极与第一层电连通。

8. 发明申请

WO0231507A3 NON-INVASIVE ENZYME SCREEN FOR TISSUE REMODELLING-ASSOCIATED CONDITIONS 审中-公开
标题翻译：用于组织重组相关条件的非入侵性酶屏
公开(公告)号：WO0231507A3
公开(公告)日：2003-06-05
申请号：PCT/US0131980
申请日：2001-10-15
申请人： CHILDRENS MEDICAL CENTER , MOSES MARSHA A , YAN LI
发明人： MOSES MARSHA A , YAN LI
IPC分类号： G01N33/493 , C12Q1/00 , C12Q1/37 , G01N27/447 , G01N33/573 , G01N33/574
CPC分类号： G01N33/573 , C12Q1/37 , G01N33/574 , G01N33/57434 , G01N33/57488 , G01N2333/96486 , G01N2333/96494 , G01N2333/99 , G01N2550/00
摘要： methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular weight enzyme complexes comprising MMPs.
摘要翻译：公开了用于诊断存在并预测组织重塑相关病症的外观的方法和试剂盒，其涉及生物样品中酶复合物的存在。特别地，该方法涉及通过鉴定包含MMP的高分子量酶复合物来诊断转移性癌症的存在或预后。

9. 发明申请

WO2013049419A3 LIGHT EMITTING DEVICES HAVING LIGHT COUPLING LAYERS 审中-公开
标题翻译：具有轻型耦合层的发光装置
公开(公告)号：WO2013049419A3
公开(公告)日：2013-07-11
申请号：PCT/US2012057666
申请日：2012-09-27
申请人： BRIDGELUX INC , YAN LI , LIN CHAO-KUN , CHUANG CHIH-WEI
发明人： YAN LI , LIN CHAO-KUN , CHUANG CHIH-WEI
IPC分类号： H01L33/30 , H01L33/22
CPC分类号： H01L33/0075 , H01L33/0025 , H01L33/0079 , H01L33/10 , H01L33/22 , H01L33/32 , H01L33/38 , H01L33/405 , H01L2924/00 , H01L2924/0002 , H01L2933/0016 , H01L2933/0058
摘要： A light emitting device comprises a first layer of an n-type semiconductor material, a second layer of a p-type semiconductor material, and an active layer between the first layer and the second layer. A light coupling layer is disposed adjacent to one of the first layer and the second layer. In some cases, the light coupling layer is formed by roughening a buffer layer of the light emitting device. The light emitting device includes an electrode in electrical communication with one of the first layer and the second layer through a portion of the light coupling layer.
摘要翻译：发光器件包括n型半导体材料的第一层，p型半导体材料的第二层和在第一层和第二层之间的有源层。光耦合层设置成与第一层和第二层中的一个相邻。在一些情况下，通过使发光器件的缓冲层粗糙化来形成光耦合层。发光器件包括通过光耦合层的一部分与第一层和第二层之一电连通的电极。

10. 发明申请

WO2011144078A3 HIGH-SPEED LINK SELF-NEGOTIATION METHOD AND SINGLE BOARD 审中-公开
标题翻译：高速链路自解调方法和单板
公开(公告)号：WO2011144078A3
公开(公告)日：2012-04-19
申请号：PCT/CN2011074645
申请日：2011-05-25
申请人： HUAWEI TECH CO LTD , YAN LI , TONG YUNMIN , HUANG LIGANG , CHEN XIAOQIN
发明人： YAN LI , TONG YUNMIN , HUANG LIGANG , CHEN XIAOQIN
IPC分类号： H04L29/06
CPC分类号： H04L5/1446 , H04L12/40013 , H04L12/413 , H04L41/145 , H04L49/3054
摘要： A high-speed link self-negotiation method and single board are disclosed, which belong to the field of high-speed Ethernet. The method includes: a first single board and a second single board set the port speed to a common speed supported by both the first single board and the second single board; the first single board sends a first self-negotiation message, which carries the speed supported by the first single board, to the second single board according to the common speed, so as to make the second single board determine, according to the speed supported by the first single board and the speed supported by the second single board, the highest speed supported by both the first single board and the second single board and set the port speed to the highest speed; the first single board receives a second self-negotiation message which is sent by the second single board according to the common speed and carries the speed supported by the second single board; according to the speed supported by the first single board and the speed supported by the second single board, the first single board determines the highest speed supported by both the first single board and the second single board and sets the port speed to the highest speed. The present invention can implement the self-negotiation mechanism by messages and have no need of specific hardware support, and can support dynamic switching of speeds at the same time.
摘要翻译：公开了一种高速链路自协商法和单板，属于高速以太网领域。该方法包括：第一单板和第二单板将端口速度设置为由第一单板和第二单板支持的公共速度; 第一单板根据通用速度将第一单板支持的速度的第一自协商消息发送到第二单板，以使第二单板根据由第一单板支持的速度确定第一单板和第二单板支持的速度，由第一单板和第二单板支持的最高速度，并将端口速度设置为最高速度; 第一单板接收第二单板根据通用速度发送的第二自协商消息，并携带由第二单板支持的速率; 根据第一单板支持的速度和第二单板支持的速度，第一单板决定了第一单板和第二单板支持的最高速度，并将端口速度设置为最高速度。本发明可以通过消息实现自协商机制，并且不需要特定的硬件支持，并且可以同时支持速度的动态切换。

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