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1. 发明申请

WO1997038713A1 DIAGNOSIS, PREVENTION AND TREATMENT OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING HISTONE H1 审中-公开
标题翻译：诊断，预防和治疗精神分裂症及其临床亚型，使用HISTONE H1
公开(公告)号：WO1997038713A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006987
申请日：1997-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： A61K39/00
CPC分类号： G01N33/564 , A61K39/0008
摘要： The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC by administering an effective dose of histone H1, or tolerogenic fragment thereof, to the pANCA-positive patient with UC. Compositions of histone H1, or fragment thereof, combined with a tolerogizing molecule also are provided.
摘要翻译：本发明提供一种通过从个体获得样品来诊断疑似患有炎症性肠病的受试者的溃疡性结肠炎（UC）的方法; 在适于形成人组蛋白H1或其pANCA反应性片段的复合物和人组蛋白H1的抗体的条件下，将样品与人组蛋白H1或其pANCA反应性片段接触; 并检测复合物的存在或不存在，其中复合物的存在表明个体具有UC。本发明还提供了在UC患者中诊断UC的核周抗中性粒细胞胞质抗体阳性（pANCA阳性）临床亚型的相关方法。此外，本发明还提供了确定个体对UC的易感性的方法。本发明进一步提供了通过向具有UC的pANCA阳性患者施用有效剂量的组蛋白H1或其耐受性片段来诱导具有UC的pANCA阳性患者的耐受性的方法。还提供组蛋白H1或其片段的组合物与耐受性分子组合。

2. 发明申请

WO1996039186A1 ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY MATERIAL ASSOCIATED WITH ULCERATIVE COLITIS AND RELATED METHODS AND KITS 审中-公开
标题翻译：与中性粒细胞抗体相关的抗体物质与相关方法和试剂盒
公开(公告)号：WO1996039186A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008756
申请日：1996-06-05
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BRAUN, Jonathan , EGGENA, Mark, P. , TARGAN, Stephan, R.
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , C07K2319/00 , G01N33/56972 , G01N33/686
摘要： For the first time, the present invention provides isolated, substantially pure, and/or recombinantly produced pANCA associated with ulcerative colitis (UCpANCA and UCpANCA material) as well as polynucleotides encoding the UCpANCA, UCpANCA material and UCpANCA polypeptides of the present invention. Using the phage display technique, immunoglobulin gene repertoires biased for the immunoglobulin genes utilized by pANCA seropositive UC patients have been isolated, amplified, randomly re-combined to generate phagemid expression vector libraries encoding DNA homologs of the gene repertoire. Methods are provided for enriching these libraries to create libraries of VH- and VL-encoding DNA homologs having immunoreactivity of UCpANCA antigen. Also provided are methods of screening the libraries of the present invention for UCpANCA and UCpANCA material. These libraries may be encapsulated in phage particles or in cells. Methods and kits are also provided for screening for UCpANCA in a sample and isolating UCpANCA antigen.
摘要翻译：本发明首次提供与溃疡性结肠炎（UCpANCA和UCpANCA材料）相关的分离的，基本上纯的和/或重组产生的pANCA，以及编码本发明的UCpANCA，UCpANCA材料和UCpANCA多肽的多核苷酸。使用噬菌体展示技术，已经分离，扩增，随机重新组合由pANCA血清阳性UC患者利用的免疫球蛋白基因偏倚的免疫球蛋白基因库，以产生编码基因库的DNA同源物的噬菌粒表达载体文库。提供用于富集这些文库以产生具有UCpANCA抗原的免疫反应性的VH-和VL编码的DNA同系物的文库的方法。还提供了筛选本发明的文库用于UCpANCA和UCpANCA材料的方法。这些文库可以封装在噬菌体颗粒中或细胞中。还提供了用于筛选样品中的UCpANCA并分离UCpANCA抗原的方法和试剂盒。

3. 发明申请

WO1998037415A1 ULCERATIVE COLITIS pANCA SECRETORY VESICLE ANTIGEN AND METHODS OF USING SAME 审中-公开
标题翻译：维生素BANA秘密VESICLE抗原及其使用方法
公开(公告)号：WO1998037415A1
公开(公告)日：1998-08-27
申请号：PCT/US1997013059
申请日：1997-08-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , GORDON, Lynn, K. , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： G01N33/53
CPC分类号： C07K14/4713 , A61K38/00 , C07K16/18 , G01N33/564 , G01N33/6893
摘要： The present invention provides a substantially pure UC pANCA secretory vesicle antigen, including a protein immunoreactive with NANUC-1 and NANUC-2 and having the characteristic of being selectively expressed in secretory vesicle membrane. Pharmaceutical compositions containing the substantially pure UC pANCA secretory vesicle antigen and a pharmaceutical carrier also are provided. The invention further provides a tolerogenic composition containing the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof, combined with a tolerogizing molecule. In addition, there are provided methods of diagnosing ulcerative colitis in a patient and methods of determining susceptibility to ulcerative colitis in an individual using the substantially pure UC pANCA secretory vesicle antigen. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC and methods of preventing ulcerative colitis in an individual by administering the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof.
摘要翻译：本发明提供了基本上纯的UC pANCA分泌囊泡抗原，其包括与NANUC-1和NANUC-2免疫反应的蛋白质，并且具有在分泌囊泡膜中选择性表达的特征。还提供了含有基本上纯的UC pANCA分泌囊泡抗原和药物载体的药物组合物。本发明进一步提供含有基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段与耐受性分子组合的耐受性组合物。此外，提供了诊断患者溃疡性结肠炎的方法以及使用基本上纯的UC pANCA分泌囊泡抗原确定个体中溃疡性结肠炎易感性的方法。本发明还提供了在具有UC的pANCA阳性患者中诱导耐受性的方法以及通过施用基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段来预防个体的溃疡性结肠炎的方法。

4. 发明申请

WO1996012189A2 METHODS OF SCREENING FOR ULCERATIVE COLITIS AND CROHN'S DISEASE BY DETECTING VH3-15 AUTOANTIBODY AND pANCA 审中-公开
标题翻译：通过检测VH3-15自身抗体和pANCA检测血清COLITIS和CROHN病变的方法
公开(公告)号：WO1996012189A2
公开(公告)日：1996-04-25
申请号：PCT/US1995013422
申请日：1995-10-05
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BRAUN, Jonathan , TARGAN, Stephan, R.
IPC分类号： G01N33/564
CPC分类号： C07K16/4258 , G01N33/56922 , G01N33/56972 , G01N33/686 , Y10S435/961 , Y10S435/965 , Y10S435/975
摘要： The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerative colitis and Crohn's disease.
摘要翻译：本发明提供筛选溃疡性结肠炎和克罗恩病的新方法，其包括检测两种不同的自身抗体：pANCA和VH3-15自身抗体。本发明还提供了用于筛选溃疡性结肠炎和克罗恩病的试剂盒。

5. 发明申请

WO1998039357A1 METHOD OF ALLEVIATING NEUROPATHIC PAIN 审中-公开
标题翻译：治疗神经痛疼痛的方法
公开(公告)号：WO1998039357A1
公开(公告)日：1998-09-11
申请号：PCT/US1997016062
申请日：1997-09-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , O'BRIEN, John, S.
IPC分类号： C07K04/00
CPC分类号： C07K14/475 , A61K38/00
摘要： The invention provides a method of alleviating neuropathic pain in a subject by administering a neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The invention also provides a method of inhibiting the onset of neuropathic pain in a subject by administering neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The present invention also provides prosaposin receptor agonists and the use of these agonists for stimulating neurite outgrowth, inhibiting neural cell death, promoting myelination and inhibiting neural demyelination. In addition, there is provided a method of inhibiting sensory or motor neuropathy by contacting neuronal cells with a composition comprising an effective inhibiting amount of prosaposin receptor agonist.
摘要翻译：本发明提供了一种减轻受试者神经性疼痛的方法，该方法是通过对受试者施用神经性疼痛缓解量的prosaposin受体激动剂。本发明还提供一种抑制受试者神经性疼痛发作的方法，该方法是向受试者施用神经性疼痛缓解量的prosaposin受体激动剂。本发明还提供了prosaposin受体激动剂和这些激动剂用于刺激神经突生长，抑制神经细胞死亡，促进髓鞘形成和抑制神经脱髓鞘的用途。此外，提供了通过使神经元细胞与包含有效抑制量的前列腺素受体激动剂的组合物接触来抑制感觉或运动神经病的方法。

6. 发明申请

WO1998030715A1 OPTICAL SENSORS OF CELL SIGNALING 审中-公开
标题翻译：细胞信号的光学传感器
公开(公告)号：WO1998030715A1
公开(公告)日：1998-07-16
申请号：PCT/US1997019453
申请日：1997-10-24
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SIEGAL, Micah, S. , ISACOFF, Ehud, Y.
发明人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12P21/04
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2267/0393 , C07K14/43595 , C07K14/705 , C07K2319/00
摘要： A chimeric protein sensor including an optically active polypeptide linked to a responsive polypeptide, or responsive fragment thereof, which undergoes a change in response to a cell signaling event, wherein an optical property of the sensor is altered in response to the change in the responsive polypeptide, or responsive fragment thereof is provided, as well as nucleic acid sequences encoding the chimeric protein sensor. The chimeric protein sensor includes an optically active polypeptide or fragment thereof, such as green fluorescent protein (GFP), for measuring cellular events in vivo.
摘要翻译：一种嵌合蛋白传感器，其包括与响应性多肽或其响应片段连接的光学活性多肽，其响应于细胞信号传导事件而发生变化，其中响应于响应性多肽的变化而改变传感器的光学性质，或其响应片段，以及编码嵌合蛋白传感器的核酸序列。嵌合蛋白质传感器包括用于测量体内细胞事件的光学活性多肽或其片段，例如绿色荧光蛋白（GFP）。

7. 发明申请

WO1998026295A1 APPARATUS FOR AUTOMATED TESTING OF BIOLOGICAL SPECIMENS 审中-公开
标题翻译：自动测试生物样本的设备
公开(公告)号：WO1998026295A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022543
申请日：1997-12-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LAYNE, Scott, P. , BEUGELSDIJK, Tony, J.
IPC分类号： G01N35/00
CPC分类号： G01N35/0092 , G01N35/0099 , G01N2035/00326 , G01N2035/0093 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/116664 , Y10T436/2575
摘要： An apparatus for performing automated testing of infectious biological specimens is disclosed. The apparatus comprises a process controller for translating user commands into test instrument suite commands, and a test instrument suite comprising a means to treat the specimen to manifest an observable result, and a detector for measuring the observable result to generate specimen test results.
摘要翻译：公开了一种用于执行感染性生物样本的自动化测试的装置。该装置包括用于将用户命令转换为测试仪器套件命令的过程控制器，以及包括用于处理样本以显示可观察结果的装置的测试仪器套件，以及用于测量可观察结果以产生样本测试结果的检测器。

8. 发明申请

WO1998026290A1 APPARATUS FOR TESTING FOR INFECTION BY A RETROVIRUS 审中-公开
标题翻译：用于检测由RETROVIRUS感染的装置
公开(公告)号：WO1998026290A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022545
申请日：1997-12-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LAYNE, Scott, P. , BEUGELSDIJK, Tony, J.
IPC分类号： G01N33/569
CPC分类号： G01N33/56988 , G01N35/0092 , G01N35/0099 , G01N2035/00326 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/116664 , Y10T436/2575
摘要： An apparatus for testing specimens for infection by a retrovirus is described. The apparatus comprises a process controller including a communications module for translating user commands into test instrument suite commands and a means for communicating specimen test results to a user. The apparatus further comprises a test instrument suite including a means for treating the specimen to manifest an observable result and a detector for measuring the observable result.
摘要翻译：描述了用于测试由逆转录病毒感染的样品的装置。该装置包括一个过程控制器，该过程控制器包括用于将用户命令转换成测试仪器套件命令的通信模块和用于将样本测试结果传送给用户的装置。该装置还包括测试仪器套件，其包括用于处理样本以显示可观察结果的装置和用于测量可观察结果的检测器。

9. 发明申请

WO1998026044A1 IN CULTURE PROLIFERATION OF HUMAN PANCREATIC ENDOCRINE CELLS 审中-公开
标题翻译：文化增殖人胰腺内皮细胞
公开(公告)号：WO1998026044A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022827
申请日：1997-12-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BEATTIE, Gillian, M. , HAYEK, Alberto
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12N05/00
CPC分类号： C12N5/0676 , C12N2502/30
摘要： Islets and islet-like cell clusters are proliferated in culture without loss of insulin-secreting function by incubation in a medium containing extracellular matrix of human bladder carcinoma cells, preferably the human bladder carcinoma cell line HTB-9.
摘要翻译：在含有人膀胱癌细胞，优选人膀胱癌细胞系HTB-9细胞外基质的培养基中孵育，胰岛和胰岛样细胞簇在培养物中增殖而不损失胰岛素分泌功能。

10. 发明申请

WO1998025701A1 MICROFABRICATED SLEEVE DEVICES FOR CHEMICAL REACTIONS 审中-公开
标题翻译：用于化学反应的微波清洗装置
公开(公告)号：WO1998025701A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023180
申请日：1997-12-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NORTHRUP, M., Allen
IPC分类号： B01L03/00
CPC分类号： B01L7/52 , B01J19/0046 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00936 , B01J2219/00945 , B01J2219/00952 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0654 , B01L2300/0867 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0421 , B01L2400/0439 , B01L2400/0487 , B81C3/00 , G01N21/0332 , G01N21/05 , G01N21/69 , G01N21/76 , G01N2021/0346
摘要： A silicon-based sleeve type chemical reaction chamber (50) that combines doped silicon heating elements (57) and bulk silicon convective cooling elements (51, 52). A critical ratio of silicon and non-silicon based materials provides the thermal properties desired. The reaction chamber may be used for any chemical reaction, especially synthetic, thermal-cycling-based reactions such as the polymerase chain reaction (PCR) or ligase chain reaction.
摘要翻译：组合掺杂硅加热元件（57）和体硅对流冷却元件（51,52）的硅基套管型化学反应室（50）。硅和非硅基材料的临界比提供了所需的热性质。反应室可用于任何化学反应，特别是合成的基于热循环的反应，如聚合酶链式反应（PCR）或连接酶链式反应。

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