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1. 发明申请

WO2022235966A1 UV A LIGHT EXPOSURE INCREASES MITOCHONDRIAL ANTI-VIRAL PROTEIN EXPRESSION IN TRACHEAL CELLS VIA CELL-TO-CELL COMMUNICATION AND USES THEREOF 审中-公开
公开(公告)号：WO2022235966A1
公开(公告)日：2022-11-10
申请号：PCT/US2022/027915
申请日：2022-05-05
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： PIMENTEL, Mark , REZAIE, Ali , LEITE, Gabriela Guimaraes Sousa , MATHUR, Ruchi , MELMED, Gil Y.
IPC分类号： A61B18/18 , B01J19/12
摘要： Mitochondrial antiviral signaling (MAVS) protein mediates innate antiviral responses, and is an important component of the response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Herein methods are provided to increase expression of mitochondrial antiviral signaling (MAVS) protein in epithelial cells by use of a UVA therapy to expose the epithelial cells to the UVA therapy, or to contact a first set of epithelial cells with a second set of epithelial cells which have been exposed to the UVA therapy, or to contact a first set of epithelial cells with the cell lysates of the second set of epithelial cells that have been exposed to the UVA therapy.

2. 发明申请

WO2021189020A1 INTERNAL ULTRAVIOLET THERAPY 审中-公开
公开(公告)号：WO2021189020A1
公开(公告)日：2021-09-23
申请号：PCT/US2021/023354
申请日：2021-03-19
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： REZAIE, Ali , PIMENTEL, Mark , MELMED, Gil Y. , MATHUR, Ruchi , LEITE, Gabriela Guimaraes Sousa , DEGTYAREV, Konstantin , BISCHOFF, Larry , GANDHI, Kuldeep , QUINN, Michael V. , CRONENBERG, Richard
IPC分类号： A61B1/06 , A61B1/267 , A61N5/06 , A61N5/08
摘要： A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separating a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space and a cooling tube. In some examples, the UV light source is configured to emit light with wavelengths with a desired intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

3. 发明申请

WO2018140869A1 DIAGNOSIS OF SCLERODERMA 审中-公开
公开(公告)号：WO2018140869A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/015723
申请日：2018-01-29
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： PIMENTEL, Mark , FURST, Daniel
IPC分类号： A61K39/00 , G01N33/564 , G01N33/68
摘要： Described herein are methods of diagnosing systemic sclerosis (SSc) involving the detection of anti-vinculin antibodies. Also described herein are methods of selecting treatment of subjects diagnosed with systemic sclerosis (SSc), and methods of treating systemic sclerosis (SSc).

4. 发明申请

WO2021127027A1 BREATH GAS ANALYSIS 审中-公开
公开(公告)号：WO2021127027A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065382
申请日：2020-12-16
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： PIMENTEL, Mark , GUPTA, Kapil , REZAIE, Ali , ALLAN, Nicholas David , DOLBERG, Kristofor Dyck , SYROTUCK, Nigel Anthony , KELLINGHUSEN, Martin Juergen , DRLIK, Mark Sasha , MULLER, Nathan John , MACCALLUM, Kenneth
IPC分类号： A61B5/087 , A61B5/097 , A61B2560/02 , A61B2562/0271 , A61B5/082 , A61B5/0836 , A61B5/742
摘要： Systems and methods have been developed for implementation of a breath testing system for convenient sampling of intestinal gases exhaled from a patient's breath. This may include a system with a manifold that includes thermal regulation components, for instance thermistors and resistive heating elements, which maintain the temperature of the gases above the body temperature of the patient. In some examples, the system will determine an indication of whether a patient has SIBO by adjusting a change in exhaled hydrogen concentration by a methane level exhaled by a patient.

5. 发明申请

WO2017223177A1 CLINICALLY EFFICACIOUS ANTI-METHANOGENIC COMPOSITIONS AND USES 审中-公开
标题翻译：临床有效的抗甲状腺组合物和用途
公开(公告)号：WO2017223177A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038499
申请日：2017-06-21
申请人： CEDARS-SINAI MEDICAL CENTER , SYNTHETIC BIOLOGICS, INC.
发明人： WACHER, Vincent John , PIMENTEL, Mark
IPC分类号： A61K8/33 , A61K31/045 , A61K31/351 , A61K31/366 , A61K47/10 , C07D407/14
摘要： The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at least one antimethanogenic statin are provided which release the antimethanogenic statin in the intestines.
摘要翻译：本发明部分涉及用于治疗诸如例如肠易激综合征（IBS）的甲烷菌相关病症的方法和组合物。特别地，提供了包含至少一种抗甲烷产生他汀的改性释放制剂，其在肠中释放抗甲状腺素他汀。

6. 发明申请

WO2017040546A1 BREATH GAS ANALYSIS 审中-公开
标题翻译：气道气体分析
公开(公告)号：WO2017040546A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049528
申请日：2016-08-30
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GUPTA, Kapil , PIMENTEL, Mark , REZAIE, Ali
IPC分类号： G01N33/497
CPC分类号： G01N33/497
摘要： Systems and methods have been developed for implementation of a portable SIBO testing system for convenient sampling of intestinal gases exhaled from a patient's breath. These devices may be in the form of a hand held meter that would integrate with a smartphone or other device with an application that can record data relating to food consumed by a user. Various technologies may be utilized to measure the levels of gases exhaled by a user, which may include (1) sorbent based technology and (2) membrane based technology. In some examples, the system will determine an indication of whether a patient has SIBO by adjusting a change in exhaled hydrogen concentration by a methane level exhaled by a patient.
摘要翻译：已经开发了用于实施便携式SIBO测试系统的系统和方法，用于方便地从患者呼吸中呼出的肠道气体取样。这些设备可以是手持式仪表的形式，其将与智能电话或其他设备集成，其具有可以记录与用户消费的食物相关的数据的应用。可以使用各种技术来测量用户呼出的气体水平，其可以包括（1）基于吸附剂的技术和（2）基于膜的技术。在一些实例中，系统将通过调节由呼吸的氢浓度变化由患者呼出的甲烷水平来确定患者是否患有SIBO。

7. 发明申请

WO2014152754A2 METHODS OF DIAGNOSIS, SELECTION, AND TREATMENT OF DISEASES AND CONDITIONS CAUSED BY OR ASSOCIATED WITH METHANOGENS 审中-公开
标题翻译：诊断，选择和治疗由甲状腺引起或与甲状腺相关的疾病和病症的方法
公开(公告)号：WO2014152754A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/027697
申请日：2014-03-14
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： PIMENTEL, Mark , MATHUR, Ruchi , CHANG, Christopher
IPC分类号： A61K31/4164 , C12Q1/68 , A61K31/7028 , A61K31/437 , A61K31/155 , A61K35/74
CPC分类号： A61K38/10 , A61K31/137 , A61K31/155 , A61K31/22 , A61K31/337 , A61K31/352 , A61K31/357 , A61K31/366 , A61K31/40 , A61K31/4045 , A61K31/405 , A61K31/4164 , A61K31/426 , A61K31/437 , A61K31/4525 , A61K31/454 , A61K31/47 , A61K31/505 , A61K31/55 , A61K31/7028 , A61K38/14 , A61K38/26 , A61K38/28 , C12Q1/689 , C12Q2600/106 , A61K2300/00
摘要： The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
摘要翻译：本文描述的发明提供了用于确定，选择和/或治疗由受试者或由受试者中的少量产甲烷菌引起或与之相关的疾病和病症引起的或与其相关的疾病和病症的方法和系统。在各种实施方案中，选择和/或施用抑制产甲烷菌生长或促进产甲烷菌生长的治疗方法。

8. 发明申请

WO2023069904A1 DAILY FASTING METHANE TO DETECT INTESTINAL METHANOGEN OVERGROWTH AND MONITOR TREATMENT RESPONSE 审中-公开
公开(公告)号：WO2023069904A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/078220
申请日：2022-10-17
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： REZAIE, Ali , PIMENTEL, Mark
IPC分类号： A61B5/00 , A61B10/00
摘要： Described herein are methods of utilizing single fasting methane breath concentrations to monitor, select treatment for, and to treat subjects having intestinal methanogen overgrowth.

9. 发明申请

WO2017210366A1 INTERNAL ULTRAVIOLET THERAPY 审中-公开
标题翻译：内部ULTRAVIOLET治疗
公开(公告)号：WO2017210366A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035316
申请日：2017-05-31
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： REZAIE, Ali , PIMENTEL, Mark , MELMED, Gil Y.
IPC分类号： A61N5/06 , A61B1/06 , A61B18/24 , A61B5/00
摘要： The disclosed technology relates to a system for delivering UV-A/B light with a catheter to treat infectious or inflammatory disorders in a patient. While UV light in the UV-C range has traditionally been used to treat skin disorders and for focused ablation of plaques in the arteries and other targeted internal uses, it has not been developed for broader infection, inflammation or neoplasia treatment inside the human body. Here, the inventor(s) developed a system for emission of therapeutic doses of UV light via a catheter, capsule, endoscope, tube or port that can be used to manage internal infections and inflammatory conditions inside a patient
摘要翻译：所公开的技术涉及用导管传递UV-A / B光以治疗患者中的传染性或炎性病症的系统。虽然UV-C范围内的紫外线传统上一直用于治疗皮肤疾病和动脉斑块的集中消融以及其他有针对性的内部应用，但它尚未用于人体内更广泛的感染，炎症或瘤形成治疗。在此，发明人开发了一种用于通过导管，胶囊，内窥镜，管或端口发射治疗剂量的UV光的系统，该系统可用于控制患者体内的内部感染和炎症状况

10. 发明申请

WO2014042828A2 DIAGNOSIS AND TREATMENT OF MOTILITY DISORDERS OF THE GUT AND BLADDER, AND OF FIBROMYALGIA 审中-公开
标题翻译：膀胱和膀胱运动障碍的诊断和治疗以及纤维肉瘤的诊断和治疗
公开(公告)号：WO2014042828A2
公开(公告)日：2014-03-20
申请号：PCT/US2013/055626
申请日：2013-08-19
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： PIMENTEL, Mark , CHANG, Christopher
IPC分类号： G01N33/574
CPC分类号： G01N33/6887 , A61K38/1709 , G01N33/564 , G01N2333/4703 , G01N2333/705 , G01N2800/06 , G01N2800/065 , G01N2800/2842
摘要： Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.
摘要翻译：本文描述了用于检测抗纽蛋白抗体的方法和系统，用于确定胃肠动力障碍，膀胱运动障碍或纤维肌痛的存在或可能存在。还提供了基于抗纽蛋白抗体的存在或不存在来选择和/或施用治疗的方法。

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