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1. 发明申请

WO2007127831A3 IMPLANTABLE THERMOELECTRIC POWER SYSTEM 审中-公开
标题翻译：可植入式热电系统
公开(公告)号：WO2007127831A3
公开(公告)日：2008-04-03
申请号：PCT/US2007067481
申请日：2007-04-26
申请人： CARDIAC PACEMAKERS INC , ERBSTOESZER BLAIR , JAMES KRISTOFER J , MORITA GLENN
发明人： ERBSTOESZER BLAIR , JAMES KRISTOFER J , MORITA GLENN
IPC分类号： A61N1/00
CPC分类号： A61N1/3785
摘要： The present subject matter includes a first housing portion which is thermally conductive and which has a first housing opening, a second housing portion which is thermally conductive and which has a second housing opening, the second housing opening being hermetically sealed to the first housing opening, with the first housing portion and the second housing portion at least partially defining an interior volume, cardiac rhythm management electronics disposed in the interior volume, and a thermoelectric energy converter disposed in the interior volume, the thermoelectric energy converter having a hot pole and a cold pole, with the hot pole thermally connected to the first housing portion, and the cold pole thermally connected to the second housing portion.
摘要翻译：本主题包括第一壳体部分，其是导热的并且具有第一壳体开口，第二壳体部分是导热的并且具有第二壳体开口，第二壳体开口被密封地密封到第一壳体开口，其中第一壳体部分和第二壳体部分至少部分地限定内部体积，设置在内部体积中的心律管理电子器件和布置在内部体积中的热电能量转换器，热电能量转换器具有热极和冷的所述热极热连接到所述第一壳体部分，并且所述冷极热连接到所述第二壳体部分。

2. 发明申请

WO2008027339A3 SYSTEM FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 审中-公开
标题翻译：呼吸反馈神经刺激系统
公开(公告)号：WO2008027339A3
公开(公告)日：2008-07-24
申请号：PCT/US2007018846
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS INC , HAEFNER PAUL A , JAMES KRISTOFER J , LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN
发明人： HAEFNER PAUL A , JAMES KRISTOFER J , LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN
IPC分类号： A61N1/36 , A61B5/08
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能中潜在的不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔使神经刺激脉冲的传递与呼吸周期同步。在另一个实施例中，神经刺激系统检测呼吸障碍，并作为响应调整神经刺激脉冲的传递和/或传递治疗检测到的呼吸障碍的呼吸治疗。

3. 发明申请

WO2008027297A2 SYSTEM FOR NEURAL STIMULATION DURING DISORDERED BREATHING 审中-公开
标题翻译：异常呼吸期神经刺激系统
公开(公告)号：WO2008027297A2
公开(公告)日：2008-03-06
申请号：PCT/US2007018697
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS INC , LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN , HAEFNER PAUL A , JAMES KRISTOFER J
发明人： LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN , HAEFNER PAUL A , JAMES KRISTOFER J
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

4. 发明专利

JP2012228575A System for neural stimulation 有权
标题翻译：神经刺激系统
公开(公告)号：JP2012228575A
公开(公告)日：2012-11-22
申请号：JP2012185580
申请日：2012-08-24
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： LIBBUS IMAD , KRAMER ANDREW P , CAPARSO ANTHONY V , JAMES KRISTOFER J , RUBLE STEPHEN , ZHAO WEIYING
IPC分类号： A61N1/368
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： PROBLEM TO BE SOLVED: To provide a system for neural stimulation.SOLUTION: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：要解决的问题：提供神经刺激系统。解决方案：各种方面提供可植入装置。在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到电极。刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适用于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。版权所有（C）2013，JPO＆INPIT

5. 发明专利

AU2012200589A1 System for neural stimulation with respiratory feedback 未知
公开(公告)号：AU2012200589A1
公开(公告)日：2012-02-23
申请号：AU2012200589
申请日：2012-02-02
申请人： CARDIAC PACEMAKERS INC
发明人： HAEFNER PAUL A , JAMES KRISTOFER J , LEE KENT , LIBBUS IMAD , CARPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN
IPC分类号： A61N1/36 , A61B5/08
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder. RESPIRATION-CONTROLLED NEURAL STlIMULATION CIRCUIT 42% CONTROLLER SENSOR RESPIRATORY PROCESSING SIGNAL INPUT CIRCUlT RESPIRATORY RESPIRATORY DISORDER DETECTOR STIMULATION ADJUSTMENT MODULE ST'IMUL.ATION STIMULATION TO ELECTRODES 1 - OUTPUT CIRCUIT DELIVERY CONTROLLER TRANSDUCER(S) SYNCHRONIZATION fiW!/

6. 发明专利

AU2007290623B2 System for neural stimulation during disordered breathing 未知
公开(公告)号：AU2007290623B2
公开(公告)日：2011-06-09
申请号：AU2007290623
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS INC
发明人： LIBBUS IMAD , HAEFNER PAUL A , CAPARSO ANTHONY V , PU YACHUAN , LEE KENT , KWOK JONATHAN , JAMES KRISTOFER J
IPC分类号： A61N1/36

7. 发明专利

AU2007290727A1 System for neural stimulation 未知
公开(公告)号：AU2007290727A1
公开(公告)日：2008-03-06
申请号：AU2007290727
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS INC
发明人： ZHAO WEIYING , CAPARSO ANTHONY V , RUBLE STEPHEN , LIBBUS IMAD , JAMES KRISTOFER J , KRAMER ANDREW P
IPC分类号： A61N1/362

8. 发明专利

AU2007290727B2 System for neural stimulation 未知
公开(公告)号：AU2007290727B2
公开(公告)日：2012-01-12
申请号：AU2007290727
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS INC
发明人： WEIYING ZHAO , CAPARSO ANTHONY V , STEPHEN RUBLE , IMAD LIBBUS , JAMES KRISTOFER J , KRAMER ANDREW P
IPC分类号： A61N1/362
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

9. 发明专利

AU2007290571B2 System for neural stimulation with respiratory feedback 未知
公开(公告)号：AU2007290571B2
公开(公告)日：2011-11-17
申请号：AU2007290571
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS INC
发明人： IMAD LIBBUS , JONATHAN KWOK , YACHUAN PU , CAPARSO ANTHONY V , HAEFNER PAUL A , KENT LEE , JAMES KRISTOFER J
IPC分类号： A61N1/36 , A61B5/08
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

10. 发明专利

AT530223T 未知
公开(公告)号：AT530223T
公开(公告)日：2011-11-15
申请号：AT07837051
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS INC
发明人： LIBBUS IMAD , KRAMER ANDREW , CAPARSO ANTHONY V , JAMES KRISTOFER J , RUBLE STEPHEN , ZHAO WEIYING
IPC分类号： A61N1/362

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