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1. 发明申请

WO2006020791A8 PACER WITH COMBINED DEFIBRILLATOR TAILORED FOR BRADYCARDIA PATIENTS 审中-公开
标题翻译： PACER与针对BRADYCARDIA患者定制的组合式除颤器
公开(公告)号：WO2006020791A8
公开(公告)日：2006-11-16
申请号：PCT/US2005028592
申请日：2005-08-10
申请人： CARDIAC PACEMAKERS INC , BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
发明人： BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
IPC分类号： A61B17/56
CPC分类号： A61N1/3956 , A61N1/3962
摘要： A combination pacer/defibrillator is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as "avoiding at all costs" delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：结合起搏器/除颤器专为心动过缓患者量身定制。在一个例子中，其休克输送特异性超过了其对休克性室性快速心律失常的敏感性。在另一个例子中，其特异性超过95％，或99％，或甚至99.5％。如果可以在不降低特异性低于期望的特异性阈值的情况下完成灵敏度，则将灵敏度编程为高期望的灵敏度值。这可以概念化为“避免不惜代价”提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常产生冲击为代价。除其他外，特异性增强包括使用多通道或高速率VT / VF检测阈值来抑制患者呼吸或不仰卧时的电击输送。目前的起搏器/除颤器装置可以潜在地挽救现在临床上不指定用于除颤器/起搏器但因一个或多个风险因素而具有增加的心脏猝死风险的缓慢心律失常患者的生命。

2. 发明申请

WO2006020791A9 PACER WITH COMBINED DEFIBRILLATOR TAILORED FOR BRADYCARDIA PATIENTS 审中-公开
标题翻译：具有组合的定位器的PACER为BRADYCARDIA患者定制
公开(公告)号：WO2006020791A9
公开(公告)日：2007-04-05
申请号：PCT/US2005028592
申请日：2005-08-10
申请人： CARDIAC PACEMAKERS INC , BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
发明人： BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3962
摘要： A combination pacer/defibrillator is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as "avoiding at all costs" delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：联合起搏器/去纤颤器是为心动过缓患者量身打造的。在一个例子中，其冲击传递特异性超过其对可震荡室性快速性心律失常的敏感性。在另一个实例中，其特异性超过95％，或99％，甚至99.5％。如果可以在不降低所需特异性阈值以下的特异性的情况下将灵敏度编程为高期望的灵敏度值。这可以被概念化为“不惜一切代价”，提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常发生冲击为代价。特异性增强包括当患者呼吸或不仰卧时，使用多个通道或高速率VT / VF检测阈值来抑制冲击输送。本发明的除颤器装置可潜在地节省目前临床指示除颤器/起搏器但由于一个或多个危险因素引起的心脏猝死风险增加的缓慢性心律失常患者的生命。

3. 发明专利

JP2012245402A Cardiac system and method for performing retrograde management 有权
标题翻译： CARDIAC系统和执行退火管理的方法
公开(公告)号：JP2012245402A
公开(公告)日：2012-12-13
申请号：JP2012206329
申请日：2012-09-19
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： ZHANG GENG , GARG ANKUR , DAUM DOUGLAS R
IPC分类号： A61N1/368
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61B5/7264 , A61N1/368 , A61N1/3714
摘要： PROBLEM TO BE SOLVED: To provide a method and a system for classifying cardiac response to a pacing pulse and avoiding retrograde cardiac conduction.SOLUTION: This cardiac system includes a controller that performs retrograde management. The retrograde management includes the steps of: sending out a first atrium pacing pulse to an atrium during a cardiac cycle; detecting a P wave during a post-ventricular atrial refractory period of the cardiac cycle; determining whether or not an interval between the detected P wave and a scheduled time of a second atrium pacing pulse exceeds an effective refractory period of the atrium; delaying the second atrium pacing pulse when the interval exceeds the effective refractory period of the atrium; sending out the second atrium pacing pulse after the effective refractory period of the atrium; determining whether or not the second atrium pacing pulse captures the atrium; and increasing the length of the effective refractory period of the atrium when the second atrium pacing pulse does not capture the atrium.
摘要翻译：要解决的问题：提供一种用于将心脏反应分类到起搏脉冲并避免逆行心脏传导的方法和系统。
解决方案：该心脏系统包括执行逆行管理的控制器。逆行管理包括以下步骤：在心动周期期间向心房发出第一心房起搏脉冲; 在心脏周期的心室心房不应期中检测P波; 确定检测到的P波与第二心房起搏脉冲的预定时间之间的间隔是否超过心房的有效不应期; 当间隔超过心房的有效不应期时，延迟第二心房起搏脉搏; 在心房的有效不应期后发出第二次心房起搏脉搏; 确定第二心房起搏脉冲是否捕获心房; 并且当第二心房起搏脉冲未捕获心房时，增加心房的有效不应期的长度。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2013027715A Medical system for classifying cardiac pacing response to pacing pulse 有权
标题翻译：用于分类过敏的药物系统对皮肤刺激的反应
公开(公告)号：JP2013027715A
公开(公告)日：2013-02-07
申请号：JP2012206328
申请日：2012-09-19
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： ZHANG GENG , GARG ANKUR , DAUM DOUGLAS R
IPC分类号： A61B5/0402 , A61B5/0452 , A61N1/368
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61B5/7264 , A61N1/368 , A61N1/3714
摘要： PROBLEM TO BE SOLVED: To provide a medical system for classifying cardiac pacing responses to pacing pulses while avoiding retrograde cardiac conduction.SOLUTION: The medical system includes: a pacing circuit for sending pulse pacing to a cardiac cavity; a detecting circuit configured to detect cardiac signals corresponding to pacing pulses; a template processor configured to generate at least one cardiac response template by measuring values of the cardiac signal characteristics corresponding to a plurality of cardiac signals of the respective pacing pulses and the median values of the cardiac signal characteristics to generate cardiac response templates using the median values; and a cardiac response classification processor for determining whether the cardiac signals detected after pacing pulses are traversed one or more cardiac response templates or not and classifying the cardiac responses to the pacing pulses based on the fact whether the cardiac signals are traversed one or more cardiac responses or not.
摘要翻译：要解决的问题：提供用于将心脏起搏响应分类到起搏脉冲同时避免逆行心脏传导的医疗系统。解决方案：医疗系统包括：起搏电路，用于向心腔发送脉搏起搏; 检测电路，被配置为检测与起搏脉冲相对应的心脏信号; 模板处理器，被配置为通过测量对应于各个起搏脉冲的多个心脏信号的心脏信号特征的值和心脏信号特征的中值来产生至少一个心脏反应模板，以使用中值 ; 以及心脏响应分类处理器，用于基于心脏信号是否穿过一个或多个心脏反应的事实来确定在起搏脉冲之后检测到的心脏信号是否穿过一个或多个心脏反应模板，并将心脏反应分类到起搏脉冲或不。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2012245403A System and method for cardiac rhythm management 有权
标题翻译： CARDIAC RHYTHM管理系统与方法
公开(公告)号：JP2012245403A
公开(公告)日：2012-12-13
申请号：JP2012206330
申请日：2012-09-19
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： ZHANG GENG , GARG ANKUR , DAUM DOUGLAS R
IPC分类号： A61N1/368
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61B5/7264 , A61N1/368 , A61N1/3714
摘要： PROBLEM TO BE SOLVED: To provide a method and a system for classifying cardiac response to a pacing pulse and avoiding retrograde cardiac conduction.SOLUTION: A medical care system includes: a pacing circuit which is constituted to send out the pacing pulse to a patient; a detection circuit which is constituted to detect a cardiac signal associated with the pacing pulse; and a cardiac response processor which is connected to the detection circuit and which is constituted to set baseline amplitude of the cardiac signal by using data acquired in a certain period in advance of transmission of the pacing pulse and to determine the cardiac response to the pacing pulse by using the baseline amplitude.
摘要翻译：要解决的问题：提供一种用于将心脏反应分类到起搏脉冲并避免逆行心脏传导的方法和系统。解决方案：医疗保健系统包括：起搏电路，其被构造成将起搏脉冲发送给患者; 检测电路，其被构造成检测与所述起搏脉冲相关联的心脏信号; 以及心脏响应处理器，其连接到所述检测电路，并且被构造成通过使用在所述起搏脉冲的发送之前的特定时段中获取的数据来设置所述心脏信号的基线幅度，并且确定对所述起搏脉冲的心脏响应通过使用基线振幅。版权所有（C）2013，JPO＆INPIT

6. 发明专利

AU2003249174A1 MINUTE VENTILATION SENSOR WITH DYNAMICALLY ADJUSTED EXCITATION CURRENT 未知
公开(公告)号：AU2003249174A1
公开(公告)日：2004-02-02
申请号：AU2003249174
申请日：2003-07-10
申请人： CARDIAC PACEMAKERS INC
发明人： LARSON DENNIS E , DAUM DOUGLAS R
IPC分类号： A61B5/08 , A61B5/296 , A61N1/365 , A61N1/37 , A61B5/053
摘要： A minute ventilation sensing device in which transthoracic impedance is measured with a excitation current waveform at a specified amplitude and frequency. In order reduce interference with the impedance measurement from external noise sources, a noise detection operation may be performed with the amplitude and/or frequency of the excitation current waveform adjusted accordingly.

7. 发明专利

DE60319419D1 未知
公开(公告)号：DE60319419D1
公开(公告)日：2008-04-10
申请号：DE60319419
申请日：2003-12-04
申请人： CARDIAC PACEMAKERS INC
发明人： NI QUAN , HAJENGA ZOE , DAUM DOUGLAS R , STAHMANN JEFFREY E , HATLESTAD JOHN D , LEE KENT
IPC分类号： A61B5/0205

8. 发明专利

AU1967701A Implantable medical device with voice responding and recording capacity 未知
公开(公告)号：AU1967701A
公开(公告)日：2001-04-30
申请号：AU1967701
申请日：2000-10-18
申请人： CARDIAC PACEMAKERS INC
发明人： DAUM DOUGLAS R , ZHU QINGSHENG , KENKNIGHT BRUCE H
IPC分类号： A61N1/362 , A61N1/372
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.

9. 发明专利

DE60319419T2 未知
公开(公告)号：DE60319419T2
公开(公告)日：2009-07-02
申请号：DE60319419
申请日：2003-12-04
申请人： CARDIAC PACEMAKERS INC
发明人： NI QUAN , HAJENGA ZOE , DAUM DOUGLAS R , STAHMANN JEFFREY E , HATLESTAD JOHN D , LEE KENT
IPC分类号： A61B5/0205

10. 发明专利

AU2003293358A1 SLEEP DETECTION USING AN ADJUSTABLE THRESHOLD 未知
公开(公告)号：AU2003293358A1
公开(公告)日：2004-06-23
申请号：AU2003293358
申请日：2003-12-04
申请人： CARDIAC PACEMAKERS INC
发明人： HAJENGA ZOE , DAUM DOUGLAS R , STAHMANN JEFFREY E , HATLESTAD JOHN D , LEE KENT , NI QUAN
IPC分类号： A61B5/0205

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