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1. 发明申请

WO2008063535A3 CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING CARDIAC ACTIVATION SEQUENCE INFORMATION 审中-公开
标题翻译：使用心脏激活序列信息的心脏再生治疗优化
公开(公告)号：WO2008063535A3
公开(公告)日：2008-07-10
申请号：PCT/US2007023988
申请日：2007-11-15
申请人： CARDIAC PACEMAKERS INC , ARCOT-KRISHNAMURTHY SHANTHA , ZHANG YI , DING JIANG , YU YINGHONG , DONG YANTING
发明人： ARCOT-KRISHNAMURTHY SHANTHA , ZHANG YI , DING JIANG , YU YINGHONG , DONG YANTING
IPC分类号： A61N1/362 , A61B5/04 , A61B5/0452 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/04011 , A61B5/0452 , A61N1/365 , A61N1/36535 , A61N1/36542
摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.
摘要翻译：系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

2. 发明申请

WO2012125273A2 HIS CAPTURE VERIFICATION USING ELECTRO-MECHANICAL DELAY 审中-公开
标题翻译：使用电子机械延迟的捕获验证
公开(公告)号：WO2012125273A2
公开(公告)日：2012-09-20
申请号：PCT/US2012026571
申请日：2012-02-24
申请人： CARDIAC PACEMAKERS INC , MASKARA BARUN , DING JIANG , ARCOT-KRISHNAMURTHY SHANTHA , SHUROS ALLAN C
发明人： MASKARA BARUN , DING JIANG , ARCOT-KRISHNAMURTHY SHANTHA , SHUROS ALLAN C
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/365 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/371
摘要： Stimulation energy can be provided to a His-bundle to activate natural cardiac contraction mechanisms. Interval information can be used to describe a cardiac response to His-bundle stimulation, and the interval information can provide cardiac stimulation diagnostic information. For example, interval information can be used to discriminate between intrinsic conduction cardiac contractions and contractions responsive to His-bundle pacing.
摘要翻译：可以向His束提供刺激能量以激活自然心脏收缩机制。间隔信息可用于描述对His束刺激的心脏反应，间隔信息可提供心脏刺激诊断信息。例如，间隔信息可用于区分内在传导性心脏收缩和响应于His束起搏的收缩。

3. 发明申请

WO2006078519A3 CONTROL OF ELECTRICAL STIMULATION USING HEART RATE VARIABILITY 审中-公开
标题翻译：使用心率变化控制电刺激
公开(公告)号：WO2006078519A3
公开(公告)日：2007-04-19
申请号：PCT/US2006000963
申请日：2006-01-12
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
发明人： PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value. In another embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode. In another embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。在另一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。在另一个实施例中，HRV参数用作安全检查以在认为其可能有害以继续治疗时停止电疗法。

4. 发明申请

WO2004069333A3 METHOD AND APPARATUS FOR SETTING PACING PARAMETERS 审中-公开
标题翻译：方法和设备的设置参数
公开(公告)号：WO2004069333A3
公开(公告)日：2005-02-10
申请号：PCT/US2004002332
申请日：2004-01-28
申请人： CARDIAC PACEMAKERS INC , DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
发明人： DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus is disclosed for automatically setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way is the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes.
摘要翻译：公开了一种用于自动设置可植入心脏装置在输送心脏再同步治疗中使用的起搏参数的方法和装置。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式中使用的心房延迟间隔。

5. 发明申请

WO2010042364A3 DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTRINSIC CONDUCTION 审中-公开
标题翻译：通过追踪内部电导进行动态心脏再生治疗
公开(公告)号：WO2010042364A3
公开(公告)日：2011-06-23
申请号：PCT/US2009059005
申请日：2009-09-30
申请人： CARDIAC PACEMAKERS INC , MASKARA BARUN , DING JIANG
发明人： MASKARA BARUN , DING JIANG
IPC分类号： A61N1/362
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36507 , A61N1/368 , A61N1/3684
摘要： Systems and methods for pacing the heart using resynchronization pacing delays that achieve improvement of cardiac function are described. An early activation pacing interval is calculated based on an optimal AV delay and an atrial to early ventricular activation interval between an atrial event and early activation of a ventricular depolarization. The early activation pacing interval for the ventricle is calculated by subtracting the measured AVEA from the calculated optimal AV delay. The early activation pacing interval is initiated responsive to sensing early activation of the ventricle and pacing is delivered relative to expiration of the early activation pacing interval.
摘要翻译：描述了实现心脏功能改善的再同步起搏延迟来起搏心脏的系统和方法。基于最佳AV延迟和心房事件与心室去极化的早期激活之间的早期心室激活间隔来计算早期激活起搏间隔。通过从计算的最佳AV延迟中减去测量的AVEA来计算心室的早期激活起搏间隔。响应于感测心室的早期激活而启动早期激活起搏间隔，并且相对于早期激活起搏间隔的期满而递送起搏。

6. 发明专利

JP2008194496A Cardiac pacing using adjustable atrio-ventricular delays 审中-公开
标题翻译：使用可调节ATRIO-VENTRICULAR延迟的心脏瓣膜
公开(公告)号：JP2008194496A
公开(公告)日：2008-08-28
申请号：JP2008121532
申请日：2008-05-07
申请人： Cardiac Pacemakers Inc , カーディアックペースメーカーズ,インコーポレイティド
发明人： DING JIANG , YU YINGHONG , KRAMER ANDREW P , SPINELLI JULIO
IPC分类号： A61N1/365 , A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682
摘要： PROBLEM TO BE SOLVED: To realize a plurality of approaches to provide a timing optimal for a ventricular pacing by judging internal electrical or mechanical events having a predictable timing relationship with the sending of the ventricular pacing with the optimal timing that allows ventricular functions to be maximized. SOLUTION: This pacing system is to provide an optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system provides an option for near optimal pacing of a plurality of hemodynamic parameters. The system uses the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal so as to induce its proper timing. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了实现多种方法以通过判断具有可预测的时间关系的内部电气或机械事件来提供对于心室起搏最佳的定时，其具有允许心室功能的最佳定时的心室起搏发送最大化。
解决方案：该起搏系统是为使用用于计算动脉粥样硬化的系统提供诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的最佳血液动力学心脏功能或行程体积（主动脉脉压）心室起搏脉搏的最佳时机的室间延迟。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用具有与最佳心室起搏定时信号具有可预测关系的电气或机械事件的正确定时，以便引起其正确的定时。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2013099601A Cardiac treatment system 审中-公开
标题翻译：心脏治疗系统
公开(公告)号：JP2013099601A
公开(公告)日：2013-05-23
申请号：JP2013027928
申请日：2013-02-15
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： YU YINGHONG , ARCOT-KRISHNAMUTHY SHANTHA , STUCKY MICHAEL JOHN , DING JIANG
IPC分类号： A61N1/368
CPC分类号： A61N1/36585 , A61N1/36514 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/36578 , A61N1/36592
摘要： PROBLEM TO BE SOLVED: To provide a cardiac treatment system where the pacing of a cardiac cavity is performed according to the hemodynamic change of a patient.SOLUTION: While a cardiac treatment system is arranged on the lead, it includes two or more electrodes which allow positioning in many positions in the heart respectively, one or more sensors which are composed to detect the hemodynamic change of a patient, a processor which is composed so that while (i) a parameter related to the systolic function of a cardiac cavity about each position of the two or more positioned electrodes in the heart is decided, (ii) the distribution of the parameter related to the systolic function of the cardiac cavity about each position of the two or more positioned electrodes in the heart is decided according to the detected hemodynamic change of the patient, a selection circuit which is composed to select one or more electrodes from among the two or more electrodes based on the determined parameter distribution, and a pulse generator which is composed to perform the pacing of the cardiac cavity using two or more electrodes which include the one or more selected electrodes.
摘要翻译：要解决的问题：提供根据患者的血液动力学变化进行心脏腔起搏的心脏治疗系统。解决方案：当心脏处理系统布置在引线上时，它包括两个或更多个电极，其允许分别定位在心脏中的许多位置，一个或多个传感器被组成以检测患者的血液动力学变化，处理器，其被构成为：（i）与心脏腔内的两个或更多个定位电极的每个位置的心脏腔的收缩功能相关的参数被决定，（ii）与收缩功能相关的参数的分布基于检测到的患者的血液动力学变化来决定心脏中两个或更多个定位电极的每个位置的心腔的选择电路，该选择电路被组合以从两个或更多个电极中选择一个或多个电极，基于所确定的参数分布以及脉冲发生器，其被组成以使用包括所述一个或多个的两个或更多个电极来执行所述心腔的起搏选定的电极。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2012071206A Control of electrical stimulation using heart rate variability 有权
标题翻译：使用心率变化控制电刺激
公开(公告)号：JP2012071206A
公开(公告)日：2012-04-12
申请号：JP2012009614
申请日：2012-01-20
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
IPC分类号： A61N1/368 , A61N1/38
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： PROBLEM TO BE SOLVED: To modulate the delivery of cardiac electrical therapies based on the changing needs and conditions of a patient.SOLUTION: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate the cardiac condition of a patient, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value. In another embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode. In another embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：要解决的问题：根据患者的不断变化的需要和状况来调节心脏电疗法的输送。解决方案：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的输送。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。在另一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。在另一个实施例中，HRV参数用作安全检查以在认为其可能有害以继续治疗时停止电疗法。版权所有（C）2012，JPO＆INPIT

9. 发明专利

AT551096T 未知
公开(公告)号：AT551096T
公开(公告)日：2012-04-15
申请号：AT07796501
申请日：2007-06-27
申请人： CARDIAC PACEMAKERS INC
发明人： YU YINGHONG , ARCOT-KRISHNAMUTHY SHANTHA , STUCKY MICHAEL JOHN , DING JIANG
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368

10. 发明专利

AT500864T 未知
公开(公告)号：AT500864T
公开(公告)日：2011-03-15
申请号：AT09170835
申请日：2006-03-16
申请人： CARDIAC PACEMAKERS INC
发明人： KWOK JONATHAN , LEE KENT , HARTLEY JESSE W , STAHMANN JEFFREY E , YU YINGHONG , DING JIANG
IPC分类号： A61N1/365 , A61B5/053
摘要： A cardiac function management device or other implantable medical device includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.

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