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1. 发明专利

JP2008194496A Cardiac pacing using adjustable atrio-ventricular delays 审中-公开
标题翻译：使用可调节ATRIO-VENTRICULAR延迟的心脏瓣膜
公开(公告)号：JP2008194496A
公开(公告)日：2008-08-28
申请号：JP2008121532
申请日：2008-05-07
申请人： Cardiac Pacemakers Inc , カーディアックペースメーカーズ,インコーポレイティド
发明人： DING JIANG , YU YINGHONG , KRAMER ANDREW P , SPINELLI JULIO
IPC分类号： A61N1/365 , A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682
摘要： PROBLEM TO BE SOLVED: To realize a plurality of approaches to provide a timing optimal for a ventricular pacing by judging internal electrical or mechanical events having a predictable timing relationship with the sending of the ventricular pacing with the optimal timing that allows ventricular functions to be maximized. SOLUTION: This pacing system is to provide an optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system provides an option for near optimal pacing of a plurality of hemodynamic parameters. The system uses the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal so as to induce its proper timing. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了实现多种方法以通过判断具有可预测的时间关系的内部电气或机械事件来提供对于心室起搏最佳的定时，其具有允许心室功能的最佳定时的心室起搏发送最大化。
解决方案：该起搏系统是为使用用于计算动脉粥样硬化的系统提供诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的最佳血液动力学心脏功能或行程体积（主动脉脉压）心室起搏脉搏的最佳时机的室间延迟。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用具有与最佳心室起搏定时信号具有可预测关系的电气或机械事件的正确定时，以便引起其正确的定时。版权所有（C）2008，JPO＆INPIT

2. 发明专利

AT429951T 未知
公开(公告)号：AT429951T
公开(公告)日：2009-05-15
申请号：AT02794339
申请日：2002-12-20
申请人： CARDIAC PACEMAKERS INC
发明人： SPINELLI JULIO , ZHU QINGSHENG , STAHMANN JEFFREY , KRAMER ANDREW
IPC分类号： A61N1/362

3. 发明专利

DE69926502D1 未知
公开(公告)号：DE69926502D1
公开(公告)日：2005-09-08
申请号：DE69926502
申请日：1999-05-07
申请人： CARDIAC PACEMAKERS INC
发明人： DING JIANG , YU YINGHONG , KRAMER P , SPINELLI JULIO
IPC分类号： A61N1/368 , A61N1/362

4. 发明专利

AT437674T 未知
公开(公告)号：AT437674T
公开(公告)日：2009-08-15
申请号：AT04755060
申请日：2004-06-12
申请人： CARDIAC PACEMAKERS INC
发明人： SPINELLI JULIO , ZHU QINGSHENG , KENKNIGHT BRUCE , YU YINGHONG , DING JIANG
IPC分类号： A61N1/362
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

5. 发明专利

AT427771T 未知
公开(公告)号：AT427771T
公开(公告)日：2009-04-15
申请号：AT02790155
申请日：2002-12-19
申请人： CARDIAC PACEMAKERS INC
发明人： SPINELLI JULIO , ZHU QINGSHENG , KRAMER ANDREW , STAHMANN JEFFREY
IPC分类号： A61N1/362 , A61N1/368

6. 发明专利

AT368420T 未知
公开(公告)号：AT368420T
公开(公告)日：2007-08-15
申请号：AT99928404
申请日：1999-06-04
申请人： CARDIAC PACEMAKERS INC
发明人： CARLSON GERRARD , KADHIRESAN V , SPINELLI JULIO
IPC分类号： A61B5/22 , A61B5/352 , A61N1/362 , A61N1/365 , A61N1/37 , A61N1/372
摘要： Based upon patient studies indices a high degree of correlation was found between HRV and VO2max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient's heart with a pacemaker programmed to operate in a first mode for a predetermined time period and then collecting electrogram data from which a HRV index is derived. The mode is then changed and the steps repeated until all possible modes have been utilized. At that time, a determination is made as to which of the modes is associated with the largest HRV index and the pacemaker is then programmed to function in that mode. Alternatively, the method of the present invention can be applied to changes in drug therapy instead of or in combination with pacing therapy.

7. 发明专利

DE602004022287D1 未知
公开(公告)号：DE602004022287D1
公开(公告)日：2009-09-10
申请号：DE602004022287
申请日：2004-06-12
申请人： CARDIAC PACEMAKERS INC
发明人： SPINELLI JULIO , ZHU QINGSHENG , KENKNIGHT BRUCE H , YU YINGHONG , DING JIANG
IPC分类号： A61N1/362
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

8. 发明专利

DE69926502T2 未知
公开(公告)号：DE69926502T2
公开(公告)日：2006-06-01
申请号：DE69926502
申请日：1999-05-07
申请人： CARDIAC PACEMAKERS INC
发明人： DING JIANG , YU YINGHONG , KRAMER P , SPINELLI JULIO
IPC分类号： A61N1/368 , A61N1/362

9. 发明专利

AT300975T 未知
公开(公告)号：AT300975T
公开(公告)日：2005-08-15
申请号：AT99921811
申请日：1999-05-07
申请人： CARDIAC PACEMAKERS INC
发明人： DING JIANG , YU YINGHONG , KRAMER ANDREW P , SPINELLI JULIO
IPC分类号： A61N1/368 , A61N1/362

10. 发明专利

AU5741500A Patient identification for pacing therapy using normalized lv-rv pressure loop 未知
公开(公告)号：AU5741500A
公开(公告)日：2001-05-30
申请号：AU5741500
申请日：2000-06-15
申请人： CARDIAC PACEMAKERS INC
发明人： YU YINGHONG , DING JIANG , SPINELLI JULIO
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , G06F19/00
摘要： A method and apparatus for determining whether a patient with congestive heart failure (CHF) will benefit from pacing therapy through the use of an implantable cardiac rhythm management device. A patient's right ventricular and left ventricular pressures are measured, and the patient's PP_Area is calculated for each normal heartbeat that occurs during the testing period. Depending upon the value of the patient's mean PP_Area, it can be determined whether the patient will or will not respond well acutely to pacing therapy. A mean PP_Area value of greater than or equal to a predetermined threshold, which is about 0.3, indicates that the patient is a responder to pacing therapy, while a value of less than the predetermined threshold of about 0.3 indicates that the patient is a non-responder.

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