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1. 发明申请

WO2008143832A2 STIMULATION SYSTEM FOR BLOOD VOLUME REGULATION 审中-公开
标题翻译：血液体积调节刺激系统
公开(公告)号：WO2008143832A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/006084
申请日：2008-05-13
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , BENTSEN, James G. , DALAL, Yousufali
发明人： ZHANG, Yunlong , BENTSEN, James G. , DALAL, Yousufali
IPC分类号： A61B5/029 , A61B5/053 , A61B5/03 , A61N1/36 , A61M25/10 , A61N1/365 , A61B5/00
CPC分类号： A61N1/36114 , A61B5/4035 , A61B5/4869 , A61B7/003 , A61B7/04 , A61M25/10 , A61M25/1002 , A61N1/36521 , A61N1/36528 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36571
摘要： A system delivers stimulation to volume receptors in the cardiovascular system to induce diuresis in a patient suffering volume overload. The system senses a volume signal indicative of a level of fluid retention in the patient's body and controls the delivery of the stimulation using the volume signal. In various embodiments, the stimulation includes one or more of electrical stimulation, which delivers electrical pulses to the volume receptors, and mechanical stimulation, which physically stretches the volume receptors.
摘要翻译：系统向心血管系统中的体积受体提供刺激，以在患有体积过载的患者中诱发利尿。该系统感测指示患者体内的液体保留水平的体积信号，并使用体积信号控制刺激的传送。在各种实施例中，刺激包括将电脉冲传送到体积受体的电刺激和物理地拉伸体积受体的机械刺激中的一种或多种。

2. 发明申请

WO2009110996A1 AUTOMATED HEART FUNCTION CLASSIFICATION TO STANDARDIZED CLASSES 审中-公开
标题翻译：自动心功能分类到标准化类
公开(公告)号：WO2009110996A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/001314
申请日：2009-03-02
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , ZHANG, Yi , PATANGAY, Abhilash
发明人： ZHANG, Yunlong , ZHANG, Yi , PATANGAY, Abhilash
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/7264 , A61B5/7275 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H50/30
摘要： A non-infrared sensitized low silver photographic element with a non-light sensitive layer, preferably an antihalation layer, containing a diphenylaminocyclopentene heptacyanine benzothiazolium infrared dye where the benzothiazolium groups have electron-withdrawing substituents on the phenyl ring and solubilzed alkyl groups on the nitrogen. The infrared dye can be present as a liquid-crystalline dispersion. This class of infrared dyes form J-aggregrated species in a liquid-crystalline or a solid particle dispersion with high IR density and low visible absorbance.
摘要翻译：一种具有非光敏层的非红外敏感低银照相元件，优选为防晕层，其含有二苯基氨基环戊烯七叶酸苯并噻唑鎓红外染料，其中苯并噻唑鎓基在苯环上具有吸电子取代基并在氮上溶解烷基。红外染料可以作为液晶分散体存在。这类红外染料在具有高IR密度和低可见光吸收度的液晶或固体颗粒分散体中形成J-聚集物。

3. 发明申请

WO2008027630A1 SYSTEM TO REDUCE DEVICE THERAPY PAIN 审中-公开
标题翻译：减少器械治疗疼痛的系统
公开(公告)号：WO2008027630A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/069007
申请日：2007-05-16
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , SCHWARTZ, Mark
发明人： ZHANG, Yunlong , SCHWARTZ, Mark
IPC分类号： A61N1/34 , A61N1/36 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3601 , A61N1/36071
摘要： Systems and methods include sensing whether a shock to a heart is needed, and prior to delivering the shock, causing at least a partial contraction of a musculature in a chest, and delivering the shock while the musculature is at least partially contracted.
摘要翻译：系统和方法包括检测是否需要对心脏的休克，以及在传递休克之前，引起胸部肌肉组织的至少部分收缩，以及在肌肉组织至少部分收缩期间递送休克。

4. 发明申请

WO2005107861A1 ATP PACING WITH ENTRAINMENT MONITORING 审中-公开
标题翻译： ATP PACING WITH INTRAINMENT MONITORING
公开(公告)号：WO2005107861A1
公开(公告)日：2005-11-17
申请号：PCT/US2005/014791
申请日：2005-04-28
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong
发明人： ZHANG, Yunlong
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3622
摘要： A method and system for delivering anti-tachycardia pacing (ATP) is disclosed. During delivery of an ATP burst, an implantable cardiac rhythm management device is programmed to sense evoked responses and determine whether or not the ATP burst has entrained the heart by counting the number of successive pacing pulses achieving capture. This information may then be used by the device to adjust the manner in which the ATP therapy is delivered.
摘要翻译：公开了用于递送抗心动过速起搏（ATP）的方法和系统。在ATP突发的传送期间，将可植入的心律管理装置编程为感测诱发反应并且通过对实现捕获的连续起搏脉冲的数量进行计数来确定ATP突发是否夹带心脏。然后该装置可以使用该信息来调整ATP疗法的输送方式。

5. 发明申请

WO2011005953A2 SYSTEM AND METHOD OF PULMONARY EDEMA DETECTION 审中-公开
标题翻译：脉搏检测的系统与方法
公开(公告)号：WO2011005953A2
公开(公告)日：2011-01-13
申请号：PCT/US2010/041360
申请日：2010-07-08
申请人： CARDIAC PACEMAKERS, INC. , TRAN, Binh C. , MI, Bin , ZHANG, Yunlong
发明人： TRAN, Binh C. , MI, Bin , ZHANG, Yunlong
IPC分类号： A61B8/08
CPC分类号： A61B8/08 , A61B5/4878 , A61B8/12
摘要： A system includes means for receiving acoustic energy from a thorax region of a subject by an implantable medical device; means for transmitting the acoustic energy to the thorax region; means for trending a parameter of the received acoustic energy using the implantable medical device; and means for indicating, to a user or process, a pulmonary edema status of the subject using the trended parameter.
摘要翻译：系统包括用于通过可植入医疗装置从受试者的胸部区域接收声能的装置; 用于将声能发送到胸部区域的装置; 用于使用所述可植入医疗装置趋向于接收的声能的参数的装置; 以及用于使用趋势参数向用户或过程指示对象的肺水肿状态的装置。

6. 发明申请

WO2009075750A2 SYSTEM FOR DELIVERING NEUROSTIMULATION FROM PULMONARY ARTERY 审中-公开
标题翻译：从脉动神经递送神经系统的系统
公开(公告)号：WO2009075750A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/013306
申请日：2008-12-03
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , SACHANANDANI, Haresh G. , LI, Dan , MI, Bin
发明人： ZHANG, Yunlong , SACHANANDANI, Haresh G. , LI, Dan , MI, Bin
IPC分类号： A61N1/372
CPC分类号： A61N1/0587 , A61B5/4035 , A61B5/6862 , A61B5/6876 , A61N1/057 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/37211 , A61N1/37288
摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.
摘要翻译：各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。锚结构被配置为长期且牢固地将神经刺激器，电源和至少一个电极植入肺动脉内。锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

7. 发明申请

WO2006017381A1 ATP THERAPY FOR TACHYARRYTHMIAS 审中-公开
标题翻译： ATP治疗TACHYARRYTHMIAS
公开(公告)号：WO2006017381A1
公开(公告)日：2006-02-16
申请号：PCT/US2005/026955
申请日：2005-08-01
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong
发明人： ZHANG, Yunlong
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A method and apparatus for delivering therapy to treat ventricular tachyarrhythmias is described. A ventricular tachyarrhythmia can be classified into tachycardia or fibrillation zones using a rate criterion so that the tachyarrhythmia can be treated with either anti-tachycardia pacing or shock therapy, respectively. Rate stability and morphology criteria are employed to determine if a tachyarrhythmia in the fibrillation zone is actually monomorphic ventricular tachycardia which can be treated with ATP.
摘要翻译：描述了用于递送治疗以治疗室性快速性心律失常的方法和装置。室性快速性心律失常可以使用速率标准分类为心动过速或颤动区，以便分别用抗心动过速起搏或休克疗法治疗快速性心律失常。速率稳定性和形态学标准被用于确定原纤维化区域中的快速性心律失常是否实际上是可以用ATP治疗的单态性室性心动过速。

8. 发明申请

WO2009020571A1 LUNG FLUID STATUS MONITORING USING ACOUSTIC ENERGY 审中-公开
标题翻译：使用声学能量的肺液体状态监测
公开(公告)号：WO2009020571A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/009342
申请日：2008-08-01
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , ZHANG, Yongxing , ZAREMBO, Paul E.
发明人： ZHANG, Yunlong , ZHANG, Yongxing , ZAREMBO, Paul E.
IPC分类号： A61B5/00 , A61B8/08
CPC分类号： A61B8/12 , A61B5/0031 , A61B5/08 , A61B5/4878 , A61B8/4472
摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.
摘要翻译：描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。在一个示例中，可植入装置包括在其体内具有声窗口的心脏功能管理装置。在另一示例中，可植入装置包括一个或多个皮下引线。植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。

9. 发明申请

WO2010111349A1 SYSTEMS FOR ANEMIA DETECTION, MONITORING AND TREATMENT 审中-公开
标题翻译： ANEMIA检测，监测和治疗系统
公开(公告)号：WO2010111349A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028434
申请日：2010-03-24
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , MI, Bin , HATLESTAD, John, D.
发明人： ZHANG, Yunlong , MI, Bin , HATLESTAD, John, D.
IPC分类号： A61B5/00 , A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0031 , A61B5/02028 , A61B5/02035 , A61B5/0215 , A61B5/14535 , A61B5/417 , A61N1/36007 , A61N1/36114 , A61N1/36135 , A61N1/3627
摘要： Systems for implantably determining a patient's anemia status and treating anemia are described. Blood viscosity is compared to one or more thresholds to determine a patient's anemia status. Therapy, in the form of electrical stimulation therapy or administration of a pharmaceutical delivered to the patient's kidneys or hypothalamus is controlled based on the anemia status.
摘要翻译：描述了用于可植入地确定患者的贫血状态和治疗贫血的系统。将血液粘度与一个或多个阈值进行比较以确定患者的贫血状态。基于贫血状态来控制以电刺激治疗或递送至患者的肾脏或下丘脑的药物的给药形式的治疗。

10. 发明申请

WO2010027652A1 CARDIAC OUTPUT ESTIMATION USING PULMONARY ARTERY PRESSURE 审中-公开
标题翻译：使用脉搏压力的心脏输出估计
公开(公告)号：WO2010027652A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/054180
申请日：2009-08-18
申请人： CARDIAC PACEMAKERS, INC. , SOFFER, Leah , SACHANANDANI, Haresh, G. , MI, Bin , ZHANG, Yunlong
发明人： SOFFER, Leah , SACHANANDANI, Haresh, G. , MI, Bin , ZHANG, Yunlong
IPC分类号： A61B5/0215 , A61B5/029
CPC分类号： A61B5/029 , A61B5/0002 , A61B5/02028 , A61B5/02116 , A61B5/0215 , G06F19/00
摘要： A system and method sense a pressure signal in a pulmonary artery and compute a stroke volume and cardiac output. A pressure signal is received from an implantable pressure sensor disposed in a pulmonary artery. The pressure signal includes a systolic period and a diastolic period for determining a heart rate (HR) and a heart cycle. An iteratively-updating model can relate pressure signal and HR to a stroke volume (SV) and a cardiac output (CO). The model extracts a mean pulse pressure (MPP) from the PAP signal and receives a patient-specific vascular resistance model parameter and a patient-specific arterial compliance model parameter. CO can be calculated using the HR, the PAP signal, and the model. The vascular resistance model parameter and the arterial compliance model parameter are iteratively updated using the output of the model.
摘要翻译：系统和方法检测肺动脉中的压力信号并计算出行程体积和心输出量。从设置在肺动脉中的可植入压力传感器接收压力信号。压力信号包括用于确定心率（HR）和心脏周期的收缩期和舒张期。迭代更新模型可以将压力信号和HR相关联到行程体积（SV）和心输出量（CO）。该模型从PAP信号中提取平均脉压（MPP），并接收患者特异性血管阻力模型参数和患者特异性动脉顺应性模型参数。 CO可以使用HR，PAP信号和模型来计算。使用模型的输出迭代地更新血管阻力模型参数和动脉顺应性模型参数。

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