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1. 发明申请

WO2011103444A1 LEAD INCLUDING CONDUCTORS CONFIGURED FOR REDUCED MRI-INDUCED CURRENTS 审中-公开
标题翻译：引导包括用于减少MRI诱导电流配置的导体
公开(公告)号：WO2011103444A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025457
申请日：2011-02-18
申请人： CARDIAC PACEMAKERS, INC. , LI, Yingbo , AMERI, Masoud , REDDY, G. Shantanu , FOSTER, Arthur J. , BENTSEN, James G.
发明人： LI, Yingbo , AMERI, Masoud , REDDY, G. Shantanu , FOSTER, Arthur J. , BENTSEN, James G.
IPC分类号： A61N1/08
CPC分类号： A61N1/05 , A61N1/0563 , A61N1/086
摘要： Systems and methods for improving response of implantable leads to magnetic fields during medical procedures such as magnetic resonance imaging (MRI) are described. In various embodiments, the lead includes an inner conductor that is helically shaped and radially surrounded, at least in part, by one or more high-voltage conductors. The high-voltage conductor can be mechanically and/or electrically coupled, via a coupler, to the shocking coil. The pitch of the inner and/or outer conductor can be varied (e.g., continuously or at certain points) along the length of the lead. In some embodiments, the filar thickness, the pitch, and the mean coil diameter of the inner coil, the high voltage conductor coil, and the shock coil can be configured such that these coils have a desired inductance value when subjected to externally applied electromagnetic energy at radio frequencies commonly generated by MRI scanners (e.g., 40 MHz to 300MHz).
摘要翻译：描述了在诸如磁共振成像（MRI）的医疗过程期间改善可植入引线对磁场的响应的系统和方法。在各种实施例中，引线包括内部导体，该内部导体至少部分由螺旋形状并且被一个或多个高压导体径向包围。高压导体可以通过耦合器机械地和/或电耦合到震动线圈。内导体和/或外导体的间距可以沿引线的长度变化（例如，连续地或在某些点处）。在一些实施例中，内部线圈，高压导体线圈和冲击线圈的丝状体厚度，间距和平均线圈直径可以被配置为使得当经受外部施加的电磁能量时，这些线圈具有期望的电感值在MRI扫描仪通常产生的射频（例如，40 MHz至300MHz）。

2. 发明申请

WO2011081700A1 MRI SAFE, MULTIPOLAR ACTIVE FIXATION STIMULATION LEAD WITH CO-RADIAL CONSTRUCTION 审中-公开
标题翻译： MRI安全，多用途有源固定刺激引线与径向结构
公开(公告)号：WO2011081700A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/053179
申请日：2010-10-19
申请人： CARDIAC PACEMAKERS, INC. , FOSTER, Arthur J. , BENTSEN, James G.
发明人： FOSTER, Arthur J. , BENTSEN, James G.
IPC分类号： A61N1/05 , A61N1/375 , A61N1/37
CPC分类号： A61N1/056 , A61N1/086
摘要： Various embodiments relating to MRI safe, multi-polar active fixation stimulation leads with co-radial construction are disclosed. Some embodiments, allow the use of the generally smaller diameter co-radially constructed body (coated wires) to construct an active fixation lead, with an extendable/retractable fixation mechanism. Some embodiments use a connector assembly with an inner terminal ring, a terminal pin partially rotatably positioned within the annular inner terminal ring, and one or more resilient C-clips disposed within circumferential recesses. The resilient C-clips mechanically and electrically couple the inner terminal ring and the terminal ring while substantially limiting relative longitudinal translation of the terminal pin. In some embodiments, the connector assembly can be connected to an electrically inactive torque tube disposed longitudinally within the flexible body of the lead such that rotation of the terminal pin relative to the lead body causes rotation and longitudinal translation of a fixation helix relative to the body.
摘要翻译：公开了涉及具有同向径向结构的MRI安全，多极活动固定刺激引线的各种实施例。一些实施例允许使用通常较小直径的共同径向构造的主体（涂覆线）来构造具有可伸缩/固定机构的主动固定引线。一些实施例使用具有内部端子环的连接器组件，部分地可旋转地定位在环形内部端子环内的端子销以及设置在周向凹部内的一个或多个弹性C形夹。弹性C形夹将机械和电耦合内端子环和端子环，同时基本上限制端子销的相对纵向平移。在一些实施例中，连接器组件可以连接到纵向设置在引线的柔性体内的电惰性转矩管，使得端子销相对于引线体的旋转导致固定螺旋相对于主体的旋转和纵向平移。

3. 发明申请

WO2008143832A3 STIMULATION SYSTEM FOR BLOOD VOLUME REGULATION 审中-公开
标题翻译：血液体积调节刺激系统
公开(公告)号：WO2008143832A3
公开(公告)日：2009-01-15
申请号：PCT/US2008006084
申请日：2008-05-13
申请人： CARDIAC PACEMAKERS INC , ZHANG YUNLONG , BENTSEN JAMES G , DALAL YOUSUFALI
发明人： ZHANG YUNLONG , BENTSEN JAMES G , DALAL YOUSUFALI
IPC分类号： A61B5/029 , A61B5/00 , A61B5/03 , A61B5/053 , A61M25/10 , A61N1/36 , A61N1/365
CPC分类号： A61N1/36114 , A61B5/4035 , A61B5/4869 , A61B7/003 , A61B7/04 , A61M25/10 , A61M25/1002 , A61N1/36521 , A61N1/36528 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36571
摘要： A system delivers stimulation to volume receptors in the cardiovascular system to induce diuresis in a patient suffering volume overload. The system senses a volume signal indicative of a level of fluid retention in the patient's body and controls the delivery of the stimulation using the volume signal. In various embodiments, the stimulation includes one or more of electrical stimulation, which delivers electrical pulses to the volume receptors, and mechanical stimulation, which physically stretches the volume receptors.
摘要翻译：系统向心血管系统中的体积受体提供刺激，以在患有体积过载的患者中诱发利尿。该系统感测指示患者体内的液体保留水平的体积信号，并使用体积信号控制刺激的传送。在各种实施例中，刺激包括将电脉冲传送到体积受体的电刺激和物理地拉伸体积受体的机械刺激中的一种或多种。

4. 发明申请

WO2008143832A2 STIMULATION SYSTEM FOR BLOOD VOLUME REGULATION 审中-公开
标题翻译：血液体积调节刺激系统
公开(公告)号：WO2008143832A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/006084
申请日：2008-05-13
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , BENTSEN, James G. , DALAL, Yousufali
发明人： ZHANG, Yunlong , BENTSEN, James G. , DALAL, Yousufali
IPC分类号： A61B5/029 , A61B5/053 , A61B5/03 , A61N1/36 , A61M25/10 , A61N1/365 , A61B5/00
CPC分类号： A61N1/36114 , A61B5/4035 , A61B5/4869 , A61B7/003 , A61B7/04 , A61M25/10 , A61M25/1002 , A61N1/36521 , A61N1/36528 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36571
摘要： A system delivers stimulation to volume receptors in the cardiovascular system to induce diuresis in a patient suffering volume overload. The system senses a volume signal indicative of a level of fluid retention in the patient's body and controls the delivery of the stimulation using the volume signal. In various embodiments, the stimulation includes one or more of electrical stimulation, which delivers electrical pulses to the volume receptors, and mechanical stimulation, which physically stretches the volume receptors.
摘要翻译：系统向心血管系统中的体积受体提供刺激，以在患有体积过载的患者中诱发利尿。该系统感测指示患者体内的液体保留水平的体积信号，并使用体积信号控制刺激的传送。在各种实施例中，刺激包括将电脉冲传送到体积受体的电刺激和物理地拉伸体积受体的机械刺激中的一种或多种。

5. 发明申请

WO0196958A3 PROCESS FOR PRODUCING MICROFLUIDIC ARTICLES 审中-公开
标题翻译：生产微流感制品的方法
公开(公告)号：WO0196958A3
公开(公告)日：2002-05-02
申请号：PCT/US0119180
申请日：2001-06-14
申请人： 3M INNOVATIVE PROPERTIES CO , BENTSEN JAMES G , DEVOE ROBERT J , WILLIAMS TODD R
发明人： BENTSEN JAMES G , DEVOE ROBERT J , WILLIAMS TODD R
IPC分类号： G03F7/004 , B01J19/00 , B01L3/00 , B81B1/00 , B81C1/00 , C08F2/46 , G03F7/028 , G03F7/031 , G03F7/038 , G03F7/20
CPC分类号： B29C35/08 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01L3/502707 , B01L2200/12 , B01L2300/0887 , G03F7/031 , G03F7/038 , G03F7/2053
摘要： A process for producing microfluidic articles comprises (a) preparing a photoreactive composition comprising (1) at least one reactive species that is a polymer or a polymer precursor and that is capable of undergoing an acid- or radical-initiated chemical reaction and (2) at least one multiphoton photoinitiator system; (b) exposing a portion of the composition to light sufficient to cause simultaneous absorption of at least two photons, thereby forming exposed and unexposed portions of the composition, and thereby inducing at least one acid- or radical-initiated chemical reaction in the exposed portion; and (c) removing either the exposed or the unexposed portion of the composition, so as to form a microfluidic article comprising a seamless polymer matrix that defines at least one inlet, at least one outlet, and a microfluid processing architecture that is capable of fluidic communication with the inlet and the outlet and that is otherwise fully enclosed within the polymer matrix.
摘要翻译：一种制备微流体制品的方法包括（a）制备光反应性组合物，其包含（1）至少一种作为聚合物或聚合物前体的反应性物质，并且能够经历酸或自由基引发的化学反应，和（2）至少一种多光子光引发剂体系; （b）将组合物的一部分暴露于足以引起同时吸收至少两个光子的光，从而形成组合物的暴露部分和未曝光部分，从而在暴露部分中诱导至少一种酸或自由基引发的化学反应 ; 和（c）去除组合物的暴露部分或未曝光部分，以形成包含无定形聚合物基质的微流体制品，所述无缝聚合物基质限定至少一个入口，至少一个出口以及能够流动的微流体加工结构与入口和出口的通信，否则完全封闭在聚合物基质内。

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