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1. 发明申请

WO2011038118A1 MORPHOLOGY BASED ISCHEMIA DETECTION USING INTRACARDIAC ELECTROGRAMS 审中-公开
标题翻译：基于形态学的ISCHEMIA检测使用内皮细胞电泳
公开(公告)号：WO2011038118A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/049998
申请日：2010-09-23
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , SHOME, Shibaji , GUPTA, Kritika , LI, Dan , THOMPSON, Julie A.
发明人： ZHANG, Yi , SHOME, Shibaji , GUPTA, Kritika , LI, Dan , THOMPSON, Julie A.
IPC分类号： A61B5/0452
CPC分类号： A61B5/04525 , A61B5/0464
摘要： An apparatus comprises an ambulatory cardiac signal sensing circuit configured to provide an electrical cardiac signal representative of cardiac activity of a subject and processor. The processor includes a feature module, a correlation module, and an ischemia detection module. The feature module is configured to identify a fiducial feature in the cardiac signal and locate one or more cardiac features in the cardiac signal using the fiducial feature. The correlation module is configured to calculate a measure of similarity of morphology for a segment of the cardiac signal that includes the cardiac features. The ischemia detection module is configured to detect a change in the measure of similarity and determine whether the detected change in the measure of similarity is indicative of ischemia.
摘要翻译：一种装置包括动态心脏信号感测电路，其被配置为提供代表对象和处理器的心脏活动的电心脏信号。处理器包括特征模块，相关模块和缺血检测模块。特征模块被配置为识别心脏信号中的基准特征并且使用基准特征来定位心脏信号中的一个或多个心脏特征。相关模块被配置为计算包括心脏特征的心脏信号的片段的形态的相似度的度量。缺血检测模块被配置为检测相似度测量的变化，并确定检测到的相似性测量的变化是否指示缺血。

2. 发明申请

WO2010042790A3 MULTI-SENSOR STRATEGY FOR HEART FAILURE PATIENT MANAGEMENT 审中-公开
公开(公告)号：WO2010042790A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/060118
申请日：2009-10-09
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , STAHMANN, Jeffrey E. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh , THOMPSON, Julie A. , HATLESTAD, John D. , BECK, Kenneth C.
发明人： ZHANG, Yi , STAHMANN, Jeffrey E. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh , THOMPSON, Julie A. , HATLESTAD, John D. , BECK, Kenneth C.
IPC分类号： A61B5/02 , A61B5/00 , A61N1/39 , A61B5/085 , A61B5/0452 , A61B5/12 , A61B7/04 , A61B5/029 , A61B5/0215
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

3. 发明申请

WO2010123749A3 MEASURES OF CARDIAC CONRACTILITY VARIABILITY DURING ISCHEMIA 审中-公开
公开(公告)号：WO2010123749A3
公开(公告)日：2010-10-28
申请号：PCT/US2010/031220
申请日：2010-04-15
申请人： CARDIAC PACEMAKERS, INC. , PATANGAY, Abhilash , ZHANG, Yi , LEWICKE, Aaron , THOMPSON, Julie A.
发明人： PATANGAY, Abhilash , ZHANG, Yi , LEWICKE, Aaron , THOMPSON, Julie A.
IPC分类号： A61B5/0452
摘要： Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability (CCV) is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided. In an example, the CCV can be determined using variability metrics of RR interval or Sl amplitude.

4. 发明申请

WO2015084595A1 APPARATUS FOR PREDICTING HEART FAILURE 审中-公开
标题翻译：预防心脏衰竭的装置
公开(公告)号：WO2015084595A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/066544
申请日：2014-11-20
申请人： CARDIAC PACEMAKERS, INC.
发明人： AN, Qi , THAKUR, Pramodsingh Hirasingh , AVERINA, Viktoria A. , THOMPSON, Julie A. , SWEENEY, Robert J.
IPC分类号： A61B5/00 , A61B5/053 , A61N1/362 , A61N1/37
CPC分类号： A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/0402 , A61B5/053 , A61B5/0535 , A61B5/0816 , A61B5/1116 , A61B5/1118 , A61B5/14542 , A61B5/4842 , A61B5/7239 , A61B5/7253 , A61B5/7275 , A61B5/7282 , A61B7/02 , A61N1/3627 , G06F19/00
摘要： Devices and methods for detecting heart failure (HF) events or identifying patient at elevated risk of developing future HF events, such as events indicative of HF decompensation status, are described. The devices and methods can detect an HF event or predict HF risk using signal transformations on different portions of a physiologic signal. A system can comprise a physiologic signal analyzer circuit that can generate a signal trend of a signal feature calculated using one or more physiologic signals obtained from a patient. A signal transformation circuit can dynamically generates first and second transformations, apply the transformations to respective first and second portions of the signal trend, and generate respectively a first and second transformed signal trends. A target physiologic event detector circuit can detect a target physiologic event such as an event of worsening HF using a comparison of the first and second transformed signal trends.
摘要翻译：描述了用于检测心力衰竭（HF）事件或识别发展未来HF事件（例如表示HF代偿失调状态的事件）的风险升高的患者的装置和方法。这些装置和方法可以使用在生理信号的不同部分上的信号变换来检测HF事件或预测HF风险。系统可以包括生理信号分析器电路，其可以产生使用从患者获得的一个或多个生理信号计算的信号特征的信号趋势。信号变换电路可以动态地产生第一和第二变换，将变换应用到信号趋势的相应的第一和第二部分，并分别产生第一和第二变换信号趋势。目标生理事件检测器电路可以使用第一和第二变换信号趋势的比较来检测目标生理事件，例如HF恶化的事件。

5. 发明申请

WO2015175207A1 AUTOMATIC DIFFERENTIAL DIAGNOSIS OF WORSENING HEART FAILURE 审中-公开
标题翻译：自动差异性诊断心脏衰竭
公开(公告)号：WO2015175207A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/027947
申请日：2015-04-28
申请人： CARDIAC PACEMAKERS, INC.
发明人： ZHANG, Yi , WARIAR, Ramesh , THAKUR, Pramodsingh Hirasingh , AVERINA, Viktoria A. , AN, Qi , SWEENEY, Robert J. , THOMPSON, Julie A.
IPC分类号： A61B5/00 , G06F19/00 , A61B5/08 , A61B5/0205 , A61B8/08
CPC分类号： A61B5/0205 , A61B5/0452 , A61B5/0809 , A61B5/4818 , A61B5/4842 , A61B5/7264 , A61B5/7275 , A61B5/74 , A61B7/04 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Devices and methods for differentially diagnosing between worsening heart failure (HF) and other diseases or medical conditions are described. A medical system can receive patient information including one or more physiologic signals, and detect a respective physiologic feature from each of the one or more received physiologic signals. The medical system can include a differential diagnosis circuit that generates one or more signal metrics, receive two or more candidate conditions associated with the change in patient physical or physiological status, and determine a respective diagnostic score for each of the candidate conditions. The diagnostic score can indicate likelihood the change in the patient physical or physiologic status being caused by the corresponding candidate condition. A user interface can be provided to generate a presentation of the detected physiologic features and the diagnostic scores associated with the candidate conditions.
摘要翻译：描述了恶化心力衰竭（HF）与其他疾病或医疗状况之间进行差异诊断的装置和方法。医疗系统可以接收包括一个或多个生理信号的患者信息，并从所述一个或多个所接收的生理信号中的每一个检测相应的生理特征。医疗系统可以包括产生一个或多个信号量度的差分诊断电路，接收与患者物理或生理状态的变化相关联的两个或更多候选条件，并且确定每个候选条件的相应诊断分数。诊断分数可以指示患者身体或生理状态的变化是由相应的候选条件引起的可能性。可以提供用户界面以生成检测到的生理特征和与候选条件相关联的诊断分数的呈现。

6. 发明申请

WO2015134556A1 MULTI-LEVEL HEART FAILURE EVENT DETECTION 审中-公开
标题翻译：多级心脏失败事件检测
公开(公告)号：WO2015134556A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/018565
申请日：2015-03-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： ZHANG, Yi , THAKUR, Pramodsingh Hirasingh , AN, Qi , THOMPSON, Julie A. , WARIAR, Ramesh , SWEENEY, Robert J.
IPC分类号： A61B5/00 , A61B5/0205 , G06F19/00
CPC分类号： A61B5/7275 , A61B5/0205 , A61B5/4842 , A61B5/686 , A61B7/00 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition. The categorical fusion circuit uses the categorical risk indices to generate a composite risk indicator indicating likelihood of the patient developing the target physiologic event.
摘要翻译：描述了用于检测目前或预测未来的目标生理事件（例如恶化的心力衰竭（HF））的系统和方法。系统可以包括患者信息接收器电路，至少两个分类风险分析器电路和分类融合电路。患者信息接收电路接收生理信号并产生信号趋势。分类风险分析器电路根据指示或相关于目标事件的关联生理条件接收从信号趋势中选择的类别特定输入。分类风险分析仪电路产生信号趋势指标，指示信号强度随时间的相对变化。分类风险分析器电路计算出指示患者发展或呈现关联生理状况的可能性的分类风险指数。分类融合电路使用分类风险指数来产生指示患者发展目标生理事件的可能性的综合风险指标。

7. 发明申请

WO2017096340A1 SYSTEM FOR ASTHMA EVENT DETECTION AND NOTIFICATION 审中-公开
标题翻译：用于哮喘事件检测和通知的系统
公开(公告)号：WO2017096340A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064879
申请日：2016-12-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , KANE, Michael J. , THOMPSON, Julie A.
IPC分类号： A61B5/00 , A61B5/07
CPC分类号： G16H50/30 , A61B5/0031 , A61B5/076 , A61B5/4839 , A61B5/4842 , A61B5/746 , G06F19/00 , G06F19/3418 , G06F19/3456
摘要： A system, including a sensor configured to ambulatorily sense a parameter and a status unit configured to determine a change in asthma status of a patient based on the parameter.
摘要翻译：系统，包括被配置为以非环境方式感测参数的传感器和被配置成基于参数确定患者的哮喘状态的改变的状态单元。

8. 发明申请

WO2017172755A1 MULTI-DISEASE PATIENT MANAGEMENT 审中-公开
标题翻译：多病患者管理
公开(公告)号：WO2017172755A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024521
申请日：2017-03-28
申请人： CARDIAC PACEMAKERS, INC.
发明人： AN, Qi , THAKUR, Pramodsingh Hirasingh , AVERINA, Viktoria A. , THOMPSON, Julie A.
IPC分类号： A61B5/00 , A61B5/02 , A61B5/0205 , A61B5/08 , A61B5/20
CPC分类号： A61B5/7275 , A61B5/0022 , A61B5/02 , A61B5/02028 , A61B5/0205 , A61B5/08 , A61B5/201 , A61B5/746 , A61B2505/07 , G16H20/10 , G16H40/63 , G16H50/30
摘要： Systems and methods for monitoring patients with multiple chronic diseases are described. A system may include a health status monitor that receives diagnostic data including physiological signals sensed from a patient. The system may produce at least a first risk indication of the patient developing a first disease and a second risk indication of the patient developing a different second disease. The system may detect the first and second diseases from the physiological signals, and generate a composite health status indicator using the detections of the first and second diseases and the first and second risk indications. An alert of worsening health status may be generated if the composite detection score exceeds an alert threshold.
摘要翻译：描述了用于监测患有多种慢性疾病的患者的系统和方法。系统可以包括健康状态监视器，其接收包括从患者感测的生理信号的诊断数据。该系统可以产生患者发展第一种疾病的至少第一风险指示和发展不同第二种疾病的患者的第二风险指征。系统可以从生理信号中检测第一和第二疾病，并且使用第一和第二疾病以及第一和第二风险指示的检测来生成综合健康状态指示符。如果综合检测分数超过警戒阈值，可能会产生恶化健康状况的警报。

9. 发明申请

WO2017074999A1 MULTI-SENSOR BASED CARDIAC STIMULATION 审中-公开
标题翻译：基于多传感器的心脏介入刺激
公开(公告)号：WO2017074999A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058776
申请日：2016-10-26
申请人： CARDIAC PACEMAKERS, INC.
发明人： AN, Qi , THOMPSON, Julie A. , YU, Yinghong , ZHANG, Yi , THAKUR, Pramodsingh Hirasingh
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/3655 , A61N1/36564 , A61N1/36592 , A61N1/3682 , A61N1/3684 , A61N1/36843 , A61N1/37264
摘要： Devices and methods for improving device therapy such as cardiac resynchronization therapy by determining a value for a device parameter are described. An ambulatory medical device (AMD) can include a sensor circuit to sense a physiological signal and generate two or more signal metrics, and detect an event of worsening cardiac condition using the two or more signal metrics. In response to the detection of worsening cardiac condition, the AMD can determine, for a stimulator, a value of at least one stimulation parameter based on temporal responses of two or more signal metrics. The temporal responses include near-term and long-term responses to the stimulation. The AMD can program the stimulator with the determined parameter value, and generate stimulation according to the determined parameter value to stimulate target tissue.
摘要翻译：描述了通过确定装置参数的值来改善诸如心脏再同步治疗的装置治疗的装置和方法。流动医疗设备（AMD）可以包括传感器电路以感测生理信号并且生成两个或更多个信号度量，并且使用两个或更多个信号度量来检测恶化的心脏状况的事件。响应于恶化的心脏状况的检测，AMD可以基于两个或更多个信号度量的时间响应来针对刺激器确定至少一个刺激参数的值。时间响应包括对刺激的近期和长期响应。 AMD可以用确定的参数值对刺激器进行编程，并根据确定的参数值生成刺激以刺激目标组织。

10. 发明申请

WO2017172934A1 ALERT MANAGEMENT FOR PHYSIOLOGICAL EVENT DETECTION 审中-公开
标题翻译：生理事件检测报警管理
公开(公告)号：WO2017172934A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024775
申请日：2017-03-29
申请人： CARDIAC PACEMAKERS, INC.
发明人： AVERINA, Viktoria A. , THOMPSON, Julie A. , THAKUR, Pramodsingh Hirasingh , AN, Qi , ZHANG, Yi
IPC分类号： A61B5/00
CPC分类号： A61B5/746 , A61B5/0031 , A61B5/04012 , A61B5/042 , A61B5/686 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B2505/03 , A61B2505/07 , G08B21/0453 , G08B29/22 , G16H40/20 , G16H50/30
摘要： Systems, devices, and methods for managing alerts associated with a target physiological event such as a worsening heart failure event are described. A system may detect one or more alert onsets using an onset threshold, and one or more corresponding alert terminations using a reset threshold. Alerts may be issued corresponding to the detected alert onsets and alert terminations. The system may compare the alerts to a specified alert characteristic, and iteratively adjust the onset or reset threshold until the alerts corresponding to the adjusted onset or reset threshold satisfy the specified alert characteristic. The adjusted onset and reset thresholds may be presented to a user or a process for detecting the target physiological event.
摘要翻译：描述了用于管理与目标生理事件（例如恶化的心力衰竭事件）相关联的警报的系统，设备和方法。系统可以使用发作阈值来检测一个或多个警报起始点，并且使用重置阈值来检测一个或多个对应的警报终止。警报可以与检测到的警报起始和警报终止相对应地发布。系统可以将警报与指定的警报特征进行比较，并且迭代地调整起始或重置阈值，直到对应于调整后的起始或重置阈值的警报满足指定的警报特征。调整后的开始和重置阈值可以呈现给用户或用于检测目标生理事件的过程。

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