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1. 发明申请

WO2010042790A3 MULTI-SENSOR STRATEGY FOR HEART FAILURE PATIENT MANAGEMENT 审中-公开
公开(公告)号：WO2010042790A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/060118
申请日：2009-10-09
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , STAHMANN, Jeffrey E. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh , THOMPSON, Julie A. , HATLESTAD, John D. , BECK, Kenneth C.
发明人： ZHANG, Yi , STAHMANN, Jeffrey E. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh , THOMPSON, Julie A. , HATLESTAD, John D. , BECK, Kenneth C.
IPC分类号： A61B5/02 , A61B5/00 , A61N1/39 , A61B5/085 , A61B5/0452 , A61B5/12 , A61B7/04 , A61B5/029 , A61B5/0215
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

2. 发明申请

WO2008130549A1 HEART FAILURE DETECTION USING RESPIRATION DISTRESS MANIFESTATIONS 审中-公开
标题翻译：心脏失效检测使用呼吸分支清除
公开(公告)号：WO2008130549A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004858
申请日：2008-04-15
申请人： CARDIAC PACEMAKERS, INC. , DALAL, Yousufali , HATLESTAD, John D. , ZHANG, Yi , LEWICKE, Aaron , STAHMANN, Jeffrey E.
发明人： DALAL, Yousufali , HATLESTAD, John D. , ZHANG, Yi , LEWICKE, Aaron , STAHMANN, Jeffrey E.
IPC分类号： A61B5/08 , A61B5/113 , A61N1/362
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译：讨论了通过可植入地识别其发生和评估关于其的信息来诊断一种或多种呼吸窘迫表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿态传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。

3. 发明申请

WO2012087696A3 PHYSIOLOGIC RESPONSE TO POSTURE 审中-公开
公开(公告)号：WO2012087696A3
公开(公告)日：2012-06-28
申请号：PCT/US2011/064811
申请日：2011-12-14
申请人： CARDIAC PACEMAKERS, INC. , AVERINA, Viktoria A. , HATLESTAD, John D. , PATANGAY, Abhilash , THAKUR, Pramodsingh Hirasingh , ZHANG, Yi , BECK, Kenneth C.
发明人： AVERINA, Viktoria A. , HATLESTAD, John D. , PATANGAY, Abhilash , THAKUR, Pramodsingh Hirasingh , ZHANG, Yi , BECK, Kenneth C.
IPC分类号： A61N1/365 , A61B5/11
摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

4. 发明申请

WO2012091848A3 NEURO CARDIAC THERAPY USING ELECTRICAL IMPEDANCE 审中-公开
公开(公告)号：WO2012091848A3
公开(公告)日：2012-07-05
申请号：PCT/US2011/062917
申请日：2011-12-01
申请人： CARDIAC PACEMAKERS, INC. , ARCOT-KRISHNAMURTHY, Shantha , ZHANG, Yi , HATLESTAD, John D.
发明人： ARCOT-KRISHNAMURTHY, Shantha , ZHANG, Yi , HATLESTAD, John D.
IPC分类号： A61N1/36 , A61B5/053
摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

5. 发明申请

WO2009011886A1 APPARATUS FOR DETERMINING WELLNESS BASED ON POSTURE 审中-公开
标题翻译：用于确定基于姿势的健康的装置
公开(公告)号：WO2009011886A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/008738
申请日：2008-07-17
申请人： CARDIAC PACEMAKERS, INC. , LEWICKE, Aaron , HATLESTAD, John D. , PATANGAY, Abhilash
发明人： LEWICKE, Aaron , HATLESTAD, John D. , PATANGAY, Abhilash
IPC分类号： A61B5/11
CPC分类号： A61B5/1112 , A61B5/1116 , A61B5/686
摘要： An example method includes monitoring a first posture including a first lateral decubitus posture (LDP), recording a first LDP record based on the first LDP, computing a first posture trend based on the first LDP record and determining and providing a wellness indication based on the first posture trend.
摘要翻译：一种示例性方法包括监视包括第一侧卧位姿势（LDP）的第一姿势，基于第一LDP记录第一LDP记录，基于第一LDP记录计算第一姿态趋势，并基于该第一LDP记录确定并提供健康指示第一姿势趋势。

6. 发明申请

WO2010030454A1 CHRONICALLY IMPLANTED ABDOMINAL PRESSURE SENSOR FOR CONTINUOUS AMBULATORY ASSESSMENT OF RENAL FUNCTIONS 审中-公开
标题翻译：用于连续评估肾功能的CHRONICALLAL IMPADAL ABDOMINAL PRESSURE传感器
公开(公告)号：WO2010030454A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/053087
申请日：2009-08-07
申请人： Cardiac Pacemakers, Inc. , HATLESTAD, John D. , TRAN, Binh C. , MI, Bin , HEIL, Ronald W.
发明人： HATLESTAD, John D. , TRAN, Binh C. , MI, Bin , HEIL, Ronald W.
IPC分类号： A61B5/03
CPC分类号： A61B5/0205 , A61B5/0028 , A61B5/0031 , A61B5/03 , A61B5/036 , A61B5/201 , A61B5/416 , A61B5/6846
摘要： An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor (12) implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor (18) is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device (14) or in an external device/system (16).
摘要翻译：用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器（12），用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期以周期性间隔感测和产生代表患者的腹内压力值的输出。提供至少一个第二可植入传感器（18），用于感测和产生代表患者的第二生理参数的输出。另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。处理器可以驻留在另一可植入装置（14）中或在外部装置/系统（16）中。

7. 发明申请

WO2011100422A1 METHODS FOR CONSTRUCTING POSTURE CALIBRATION MATRICES 审中-公开
标题翻译：建立姿势校准矩阵的方法
公开(公告)号：WO2011100422A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024339
申请日：2011-02-10
申请人： CARDIAC PACEMAKERS, INC. , HATLESTAD, John D. , CHAN, Tsz Ping
发明人： HATLESTAD, John D. , CHAN, Tsz Ping
IPC分类号： A61B5/103 , A61B5/11 , A61N1/365 , G01P15/18
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1117 , A61B5/1118 , A61B5/686 , A61B2560/0223 , A61B2562/0219 , A61N1/3925 , G01P15/18
摘要： A device can include a multi-dimensional posture sensor that provides an electrical sensor output representative of alignment of first, second, and third non-parallel axes of the device with the gravitational field of the earth, and a processor that includes a calibration circuit and a posture circuit. The calibration circuit measures a first sensor output for the first device axis and a second sensor output for one of a second device axis while the subject is in a first specified posture, measures sensor outputs for the first, second, and third device axes while the subject is in a second specified posture, calculates one or more coordinate transformations, generates transformed sensor outputs using the coordinate transformations, and calibrates the posture sensor by calculating a calibration transformation using the first and second sensor outputs and the transformed sensor outputs. The posture circuit determines a subsequent posture of the subject using the posture sensor.
摘要翻译：设备可以包括多维姿态传感器，其提供表示设备的第一，第二和第三非平行轴线与地球的重力场的对准的电传感器输出，以及包括校准电路和姿势电路。校准电路测量第一设备轴的第一传感器输出和第二设备轴的第二传感器输出，同时对象处于第一指定姿势，测量第一，第二和第三设备轴的传感器输出，同时受试者处于第二指定姿势，计算一个或多个坐标变换，使用坐标变换生成变换的传感器输出，并且通过使用第一和第二传感器输出和变换的传感器输出计算校准变换来校准姿态传感器。姿势电路使用姿态传感器来确定对象的后续姿势。

8. 发明申请

WO2014018592A1 ELECTRODE DISPLACEMENT DETECTION 审中-公开
标题翻译：电极位移检测
公开(公告)号：WO2014018592A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051772
申请日：2013-07-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： THAKUR, Pramodsingh Hirasingh , AVERINA, Viktoria A. , AN, Qi , HATLESTAD, John D. , LIU, Lili
IPC分类号： A61N1/37
CPC分类号： A61N1/37 , A61N2001/083
摘要： Electrode displacement can be detected using a thoracic impedance or conductivity signal. The thoracic impedance or conductivity signal can be filtered to attenuate cardiac contraction (stroke) and respiration components. A fluid status component of the thoracic impedance or conductivity signal can be used to detect a posture-shift related electrode displacement, such as can result from left ventricular/coronary sinus (LV/CS) lead pullback upon a recumbent to upright posture shift.
摘要翻译：可以使用胸部阻抗或电导率信号检测电极位移。可以过滤胸部阻抗或电导率信号以减轻心脏收缩（中风）和呼吸成分。可以使用胸部阻抗或电导率信号的流体状态分量来检测姿势移位相关的电极位移，例如可以由卧式至立式姿势偏移引起的左心室/冠状窦（LV / CS）引线回拉。

9. 发明申请

WO2019023093A1 SYSTEMS AND METHODS FOR DISAMBIGUATION OF POSTURE 审中-公开
公开(公告)号：WO2019023093A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/043225
申请日：2018-07-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , HATLESTAD, John D.
IPC分类号： A61B5/11 , A61B5/145 , A61N1/365 , A61N1/368 , A61N1/37 , A61N1/05
CPC分类号： A61B5/1116 , A61B5/1118 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B2562/0219 , A61N1/056 , A61N1/365 , A61N1/368 , A61N1/3702
摘要： Embodiments include medical device systems, medical devices, including accelerometers and chemical sensors, and methods of using the same to determine the posture of a patient. In an embodiment, a medical device system herein includes an accelerometer configured to generate a signal reflecting a position of a patient, a chemical sensor configured to generate a signal reflecting physiological analyte data of the patient and a controller in electrical communication with the accelerometer and the chemical sensor. The controller can be configured to determine a posture of the patient using the position signal generated by the accelerometer and the signal generated by the chemical sensor. Other embodiments are also included herein.

10. 发明申请

WO2017075160A1 DETECTING ATRIAL TACHYARRHYTHMIA USING HEART SOUNDS 审中-公开
标题翻译：用心音检测心房心律失常
公开(公告)号：WO2017075160A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059031
申请日：2016-10-27
申请人： CARDIAC PACEMAKERS, INC.
发明人： THAKUR, Pramodsingh Hirasingh , MI, Bin , SIMMS JR., Howard D. , AN, Qi , HATLESTAD, John D. , MAILE, Keith R.
IPC分类号： A61B5/024 , A61B7/04 , A61B5/0245 , A61B5/046
CPC分类号： A61B5/0464 , A61B5/0205 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/046 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/686 , A61B5/7275 , A61B7/02
摘要： Systems and methods for detecting atrial tachyarrhythmias (AT) such as atrial fibrillation (AF) are disclosed. A medical system can include a cardiac signal sensor circuit to sense a cardiac electrical signal and a heart sound (HS) sensor to sense heart a HS signal. A cardiac electrical signal metric, including a cycle length variability or a detection of atrial electrical activity, can be generated from the cardiac electrical signal. A HS metric can be generated from the HS signal, including a status of detection of S4 heart sound or a S4 heart sound intensity indicator. The system can include an AT detector circuit that can detect an AT event, such as an AF event, using the cardiac electrical signal metric and the HS metric. The system can additionally classify the detected AT event as an AF or an atrial flutter event.
摘要翻译：公开了用于检测心房颤动（AF）等心房快速性心律失常（AT）的系统和方法。医疗系统可以包括感测心脏电信号的心脏信号传感器电路和感测心脏HS信号的心音（HS）传感器。可以从心脏电信号生成包括周期长度变化性或心房电活动检测的心电信号度量。可以从HS信号生成HS度量，包括检测S4心音或S4心音强度指示的状态。该系统可以包括AT检测器电路，其可以使用心电信号度量和HS度量来检测诸如AF事件的AT事件。系统还可以将检测到的AT事件分类为AF或心房扑动事件。

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