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1. 发明申请

WO2010151376A1 MEDICAL DEVICE LEAD INCLUDING A UNIFILAR COIL WITH IMPROVED TORQUE TRANSMISSION CAPACITY AND REDUCED MRI HEATING 审中-公开
标题翻译：医疗设备领导包括具有改进的扭矩传递能力和减少MRI加热的联合线圈
公开(公告)号：WO2010151376A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/033686
申请日：2010-05-05
申请人： CARDIAC PACEMAKERS, INC. , PERREY, Christopher , CLARK, Bryan, A. , FOSTER, Arthur, J.
发明人： PERREY, Christopher , CLARK, Bryan, A. , FOSTER, Arthur, J.
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/086
摘要： A conductor assembly for a medical device lead includes a helically coiled conductor including a plurality of turns having a coil pitch and an outer diameter and consisting of one filar having a filar diameter. The coil pitch and outer diameter are selected based on the filar diameter to minimize heating of the helically coiled conductor in the presence of an MRI field. A polymer sheath is formed about the helically coiled conductor such that the coil pitch of the unifilar helically coiled conductor is maintained. The polymer sheath is configured to increase a torque transmitting capacity of the helically coiled conductor.
摘要翻译：用于医疗装置引线的导体组件包括螺旋线圈导体，其包括具有线圈间距和外径的多个匝，并且由具有丝直径的一个丝状体组成。线圈间距和外径根据丝直径选择，以在存在MRI场的情况下最小化螺旋线圈导体的加热。围绕螺旋线圈导体形成聚合物护套，使得维持单丝螺旋线圈导体的线圈节距。聚合物护套被配置为增加螺旋线圈导体的扭矩传递能力。

2. 发明申请

WO2011081713A1 MRI CONDITIONALLY SAFE LEAD WITH MULTI-LAYER CONDUCTOR 审中-公开
标题翻译： MRI具有多层导体的安全引导
公开(公告)号：WO2011081713A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/055653
申请日：2010-11-05
申请人： CARDIAC PACEMAKERS, INC. , FOSTER, Arthur, J. , PERREY, Christopher , DEROCHE, Stephen, Earl
发明人： FOSTER, Arthur, J. , PERREY, Christopher , DEROCHE, Stephen, Earl
IPC分类号： A61N1/05 , H01B7/04 , A61N1/08
CPC分类号： A61N1/08 , A61N1/05 , A61N1/056 , A61N1/086
摘要： An implantable medical lead exhibits reduced heating under MRI conditions. The lead includes a multi-layer coil conductor including an inner coil layer, a middle coil layer disposed around the inner coil layer, and an outer coil layer disposed around the middle coil layer. Each of the coil layers is characterized by one or more of a filar thickness, a coil pitch, or a coil diameter configured such that the coil conductor exhibits a high inductance when exposed to MRI radiation. Each of the coil layers is electrically connected to the other coil layers to provide parallel conductive paths resulting in a coil conductor resistance suitable for defibrillation lead applications.
摘要翻译：可植入医疗导线在MRI条件下表现出减少的加热。引线包括多层线圈导体，其包括内线圈层，围绕内线圈层设置的中间线圈层和围绕中间线圈层设置的外线圈层。每个线圈层的特征在于丝网厚度，线圈节距或线圈直径中的一个或多个，其被配置为使得当暴露于MRI辐射时线圈导体表现出高电感。每个线圈层电连接到其它线圈层，以提供平行的导电路径，从而产生适合于除颤引线应用的线圈导体电阻。

3. 发明申请

WO2010002633A1 HELICAL FIXATION MEMBER WITH CHEMICAL ELUTION CAPABILITIES 审中-公开
标题翻译：具有化学溶解能力的螺旋固定构件
公开(公告)号：WO2010002633A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/048266
申请日：2009-06-23
申请人： CARDIAC PACEMAKERS, INC. , FOSTER, Arthur, J. , MILLER, Matthew, J.
发明人： FOSTER, Arthur, J. , MILLER, Matthew, J.
IPC分类号： A61N1/05
CPC分类号： A61N1/0575
摘要： In one embodiment, the present invention provides a lead for use in a cardiac rhythm management system. The lead includes a lead body with a proximal and a distal end and a conductive member extending between the proximal and the distal ends. The lead includes a helical fixation mechanism coupled to the distal end of the lead body. The helical fixation mechanism has an internal reservoir and at least one elution port in fluid communication with the internal reservoir. The lead may include a therapeutic agent disposed in the internal reservoir.
摘要翻译：在一个实施例中，本发明提供了一种用于心律管理系统的导联。引线包括具有近端和远端的引线体和在近端和远端之间延伸的导电构件。引线包括联接到引线主体的远端的螺旋固定机构。螺旋固定机构具有内部储存器和与内部储存器流体连通的至少一个洗脱端口。铅可以包括设置在内部储存器中的治疗剂。

4. 发明申请

WO2009137186A1 MEDICAL LEAD COIL CONDUCTOR WITH SPACER ELEMENT 审中-公开
标题翻译：带有间隔元件的医用引线线圈导体
公开(公告)号：WO2009137186A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/038629
申请日：2009-03-27
申请人： CARDIAC PACEMAKERS, INC. , FOSTER, Arthur, J.
发明人： FOSTER, Arthur, J.
IPC分类号： A61N1/05 , A61N1/08
CPC分类号： A61N1/05 , A61B5/0422 , A61B2562/222 , A61N1/056 , A61N1/086
摘要： Medical electrical leads equipped with spacer elements and configured for use during medical procedures such as magnetic resonance imaging (MRI) are disclosed. An illustrative medical electrical lead includes a proximal connector, an insulated lead body including at least one electrode, a helically coiled conductor wire, and a helically coiled spacer element interstitially disposed between adjacent turns of the conductor wire.
摘要翻译：公开了配备有间隔元件并配置用于诸如磁共振成像（MRI）的医疗过程期间使用的医用电气引线。示例性的医用电线包括近端连接器，绝缘引线主体，其包括至少一个电极，螺旋线圈导体线，以及间隙地设置在导线的相邻匝之间的螺旋线圈间隔元件。

5. 发明申请

WO2009079037A1 FIXATION HELIX AND MULTIPOLAR MEDICAL ELECTRODE 审中-公开
标题翻译：固定螺旋和多重医用电极
公开(公告)号：WO2009079037A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/072789
申请日：2008-08-11
申请人： CARDIAC PACEMAKERS, INC. , FOSTER, Arthur, J.
发明人： FOSTER, Arthur, J.
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： A cardiac rhythm management device that includes a lead and a pulse generator. The lead can comprise a lead body, a helical composite electrode, a composite conductor and a proximal connector. The helical composite electrode can have first and second electrodes in a co-axial configuration. The composite connector can electrically connect the first and second electrodes to the proximal connector. The proximal connector can be configured to couple to the pulse generator.
摘要翻译：包括引线和脉冲发生器的心律管理装置。引线可以包括引线体，螺旋复合电极，复合导体和近端连接器。螺旋复合电极可以具有同轴构型的第一和第二电极。复合连接器可以将第一和第二电极电连接到近端连接器。近端连接器可被配置为耦合到脉冲发生器。

6. 发明申请

WO2019209651A1 MULTIPOLAR LEAD FOR HIS BUNDLE PACING 审中-公开
公开(公告)号：WO2019209651A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/028302
申请日：2019-04-19
申请人： CARDIAC PACEMAKERS, INC.
发明人： SHUROS, Allan, C. , FOSTER, Arthur, J. , HERRMANN, Kaith, L. , MAHAJAN, Deepa , HAHN, Stephen, J.
IPC分类号： A61N1/05 , A61N1/36 , A61N1/368
摘要： A device for the active fixation of an implantable medical lead includes a housing, a tine assembly, an electrode, and a rotatable shaft. The housing includes a proximal end for connecting to the lead and a distal end opposite the proximal end. The housing defines a housing lumen extending between the proximal end and a recess adjacent to the distal end. The tine assembly is disposed within the housing lumen and includes at least one tine configured to self-bias from a linear configuration within the housing to a curved configuration outside of the housing. The electrode assembly is disposed at the distal end of the housing and includes a plurality of electrodes. The rotatable shaft extends through the housing lumen and is configured to engage the tine assembly such that rotation of the shaft transitions the at least one tine between the linear configuration and the curved configuration.

7. 发明申请

WO2007021535A1 NEURAL ELECTRODE 审中-公开
标题翻译：神经电极
公开(公告)号：WO2007021535A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/029927
申请日：2006-08-01
申请人： ENTEROMEDICS INC. , FOSTER, Arthur, J. , ERICKSON, Brian, J. , BIERK, Michael, D.
发明人： FOSTER, Arthur, J. , ERICKSON, Brian, J. , BIERK, Michael, D.
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0556
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a main electrode body of biocompatible dielectric material and having a concave upper surface and an opposite lower surface. The concave upper surface curves about an axis and has a curvature sized to receive a nerve within the concave surface with an axis of the nerve substantially parallel to an axis of the concave surface. An electrode contact of electrically conductive material is secured to the main electrode body and has an electrode contact surface exposed on the concave surface. The concave surface terminates at opposite first and second upper ends. The electrode contact has a first end near the first end of the concave surface. A secondary electrode body of biocompatible dielectric material is attached to the first upper end of the concave surface. An electrode lead has an electrical conductor surrounded by a biocompatible insulative coating with both the conductor and the coating flexible relative to a longitudinal axis of the lead. A first end of the lead is secured to the secondary electrode body and with a first end of said conductor electrically connected to said first end of said electrode contact.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括生物相容性电介质材料的主电极体，并且具有凹的上表面和相对的下表面。凹面上表面围绕一个轴线弯曲并且具有一个曲率，该曲率被设计成在凹面内容纳神经，其神经轴线基本上平行于凹面的轴线。导电材料的电极接触固定在主电极主体上，并具有暴露在凹面上的电极接触表面。凹面终止于相对的第一和第二上端。电极接触件具有靠近凹面第一端的第一端。生物相容介电材料的次级电极体附着到凹面的第一上端。电极引线具有由生物相容的绝缘涂层围绕的电导体，导体和涂层相对于引线的纵向轴线可挠曲。引线的第一端固定到次级电极体，并且所述导体的第一端电连接到所述电极接触件的所述第一端。

8. 发明申请

WO2014035487A1 COMPOUND-SHAPED STYLET FOR TORQUE TRANSMISSION 审中-公开
标题翻译：用于扭矩变速器的复合模型
公开(公告)号：WO2014035487A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/032842
申请日：2013-03-18
申请人： CARDIAC PACEMAKERS, INC.
发明人： FOSTER, Arthur, J.
IPC分类号： A61M25/09 , A61M25/01 , A61N1/05
CPC分类号： A61N1/0592 , A61N1/0551 , A61N1/056 , A61N1/3605 , A61N1/362 , A61N2001/058
摘要： A medical stylet for guiding a lead includes a first elongate member for attachment of the lead to target tissue and a second elongate member for reshaping the lead. The first elongate member of the medical stylet includes a proximal end portion and a distal end portion, wherein the distal end portion of the first elongate member includes a tip feature configured to engage the lead on application of torque externally. The second elongate member defines a lumen along its length. The lumen of the second elongate member can be configured to enclose at least a portion of the first elongate member. The second elongate member can have a predetermined shape. The predetermined shape of the second elongate member allows the lead to be reshaped when the second elongate member is inserted into the lead. This reshaped lead now can be guided along an anatomical passageway to an anatomical location.
摘要翻译：用于引导引线的医用探针包括用于将引线附接到靶组织的第一细长构件和用于重新形成引线的第二细长构件。医疗探针的第一细长构件包括近端部分和远端部分，其中第一细长构件的远端部分包括构造成在外部施加扭矩的情况下接合引线的尖端特征。第二细长构件沿其长度限定内腔。第二细长构件的内腔可以构造成包围第一细长构件的至少一部分。第二细长构件可以具有预定的形状。当第二细长构件插入导线时，第二细长构件的预定形状允许引线重新成形。这个重塑的导线现在可以沿着解剖通道引导到解剖学位置。

9. 发明申请

WO2005104779A2 IMPLANTABLE MEDICAL DEVICES AND RELATED METHODS 审中-公开
标题翻译：可植入医疗器械及相关方法
公开(公告)号：WO2005104779A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/014625
申请日：2005-04-27
申请人： TRANSOMA MEDICAL, INC. , BROCKWAY, Brian, P. , MILLS, Perry, A. , FOSTER, Arthur, J. , LAMBERT, Scott , SHERWOOD, Kathy, Lynn
发明人： BROCKWAY, Brian, P. , MILLS, Perry, A. , FOSTER, Arthur, J. , LAMBERT, Scott , SHERWOOD, Kathy, Lynn
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/0402 , A61N1/00 , A61N1/05 , A61N1/372 , A61N1/375 , A61N1/378
CPC分类号： A61N1/3727 , A61B5/0006 , A61B5/0031 , A61B5/0215 , A61B5/0402 , A61B5/413 , A61N1/05 , A61N1/37276 , A61N1/375 , A61N1/3752 , A61N1/3756 , A61N1/3785 , A61N1/3787
摘要： Implantable medical devices and associated methods are disclosed. In one implementation, the implantable medical device comprises a conductive housing and a remote electrode that is mechanically coupled to the conductive housing by a lead body. An amplifier is electrically connected to the remote electrode and the conductive housing for providing a signal representative of a voltage difference between the remote electrode and the conductive housing. In some methods in accordance with the present invention, the implantable medical device is implanted in an implant site overlaying one half of a rib cage of a human body. The implantable medical device produces a signal representative of the voltage difference between the remote electrode and the conductive housing and the signal is transmitted to a receiver located outside the human body.
摘要翻译：公开了可植入医疗装置和相关方法。在一个实施方案中，可植入医疗装置包括导电壳体和远程电极，其通过引线体机械耦合到导电壳体。放大器电连接到远程电极和导电壳体，用于提供表示远程电极和导电壳体之间的电压差的信号。在根据本发明的一些方法中，将植入式医疗装置植入覆盖人体肋骨的一半的植入部位。可植入医疗装置产生表示远程电极和导电外壳之间的电压差的信号，并且信号被传送到位于人体外部的接收器。

10. 发明申请

WO2014133998A1 IMPLANTABLE MEDICAL DEVICE INCLUDING ASSEMBLY INCORPORATING RADIOPAQUE AGENT AND ELUTABLE DRUG INTO A POLYMERIC LEAD TIP 审中-公开
标题翻译：可植入医疗器械，包括将放射性药剂和可药用药物纳入聚合物引导提示
公开(公告)号：WO2014133998A1
公开(公告)日：2014-09-04
申请号：PCT/US2014/018195
申请日：2014-02-25
申请人： CARDIAC PACEMAKERS, INC.
发明人： ZHANG, Steve, H. , CLEM, Bryan , CODNER, Daniel, I. , FOSTER, Arthur, J. , WOLF, Peter, J.
IPC分类号： A61N1/05 , A61L29/18 , A61L31/16 , A61L31/18
CPC分类号： A61N1/0568 , A61N1/0573
摘要： An assembly for an implantable device can be made from PEEK and can incorporate one or more radiopaque agents and one or more elutable drug components into a polymeric lead tip. The assembly can be machined or injection molded and can be configured, for example, as a housing for an active fixation lead or as an electrode base supporting a foil electrode.
摘要翻译：用于可植入装置的组件可以由PEEK制成，并且可以将一种或多种不透射线剂和一种或多种可洗脱药物组分并入聚合物引线头中。该组件可以被加工或注射模制，并且可以被配置为例如用作主动固定引线的壳体或者作为支撑箔电极的电极基座。

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