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1. 发明申请

WO9915227B1 MAIN STAGE CATHETERIZATION INSTRUMENT 审中-公开
标题翻译：主要阶段通气仪器
公开(公告)号：WO9915227B1
公开(公告)日：1999-05-14
申请号：PCT/US9820165
申请日：1998-09-24
申请人： CARDEON CORP , MACOVIAK JOHN A , SAMSON WILFRED J
发明人： MACOVIAK JOHN A , SAMSON WILFRED J
IPC分类号： A61B17/00 , A61M29/02
CPC分类号： A61M25/104 , A61B17/00234
摘要： The present invention discloses a main stage catheter instrument which serves as the primary catheterization access and arterial perfusion cannula for establishing cardiopulmonary bypass with selective perfusion and differential flow management of the cardiovascular, cardioneural and corporeal sub-circulations of a patient. The main stage catheter has a catheter shaft with a first occlusion member for occluding the thoracic descending aorta and an optional second occlusion member for occluding the abdominal descending aorta. A perfusion lumen in the main stage catheter supplies oxygenated blood to the aorta through distal, medial and proximal perfusion ports. Optionally, a second stage catheter inserted through the main stage catheter may be used to occlude the ascending aorta and to deliver a cardioplegic agent to the coronary arteries. The main stage catheter is coupled to a cardiopulmonary bypass system and a venous drainage catheter to establish partial or full cardiopulmonary bypass with elective cardioplegic arrest.
摘要翻译：本发明公开了一种主级导管仪器，其用作主要导管插入和动脉灌注插管，用于建立具有患者的心血管，心脏和体液亚循环的选择性灌注和不同流量管理的体外循环。主级导管具有导管轴，该导管杆具有用于阻塞胸降主动脉的第一阻塞构件和用于阻塞腹降主动脉的可选的第二阻塞构件。主级导管中的灌注腔通过远端，中间和近端灌注端口向主动脉供应含氧血液。任选地，插入穿过主级导管的第二级导管可用于阻塞升主动脉并将心脏停搏药递送至冠状动脉。主级导管连接到体外循环系统和静脉引流导管，以建立具有选择性心脏停搏的部分或全部体外循环。

2. 发明申请

WO9916382A3 PERFUSION FILTER CATHETER 审中-公开
标题翻译：灌注过滤器导管
公开(公告)号：WO9916382A3
公开(公告)日：1999-08-05
申请号：PCT/US9819777
申请日：1998-09-23
申请人： CARDEON CORP , MACOVIAK JOHN A , LEARY JAMES J , SAMSON WILFRED J
发明人： MACOVIAK JOHN A , LEARY JAMES J , SAMSON WILFRED J
IPC分类号： A61B17/12 , A61B17/22 , A61F2/00 , A61F2/01 , A61F2/02
CPC分类号： A61F2/013 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/221 , A61B2017/22067 , A61F2002/011 , A61F2002/018 , A61F2002/3008 , A61F2002/30093 , A61F2002/30098 , A61F2210/0019 , A61F2210/0033 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2250/0003 , A61F2250/0023 , A61F2250/0098
摘要： A perfusion filter catheter is used to capture potential emboli within the aorta during heart surgery and cardiopulmonary bypass. An expandable embolic filter assembly having fine filter mesh for capturing macroemboli and microemboli is mounted on a catheter shaft having a perfusion lumen with perfusion ports located upstream of the filter. The embolic filter assembly can be actively or passively deployed within the ascending aortic. An optional outer tube covers the embolic filter assembly to prevent premature deployment. Radiopaque markers, sonoreflective markers and/or an aortic transillumination system are provided to monitor the position of the catheter and the deployment state of the embolic filter assembly. The embolic filter assembly is configured to maximize the effective filter surface area when deployed. Embolic filter assembly configurations described include an elongated cone, a frustum of a cone, a trumpet-shape, a modified trumpet-shape, and helically, circumferentially and longitudinally convoluted shapes, as well as configurations having standoff members for centering the filter and holding the filter mesh away from the aortic walls when deployed. Oxygenated blood is perfused through the perfusion lumen and any embolic materials that might be dislodged are captured in the deployed embolic filter assembly. Embodiments are also described that combine the perfusion filter catheter with an aortic occlusion device, which may be a toroidal balloon, an expandable balloon or a selectively deployable external catheter flow control valve. The combined device allows percutaneous transluminal administration of cardiopulmonary bypass and cardioplegic arrest with protection from undesirable embolic events.
摘要翻译：灌注过滤器导管用于在心脏手术和体外循环期间捕获主动脉内的潜在栓塞。具有用于捕获大血管栓和微栓子的精细过滤网的可膨胀栓塞过滤器组件安装在具有灌注腔的导管轴上，灌注腔位于过滤器的上游。栓塞过滤器组件可主动地或被动地部署在升主动脉内。可选的外管覆盖栓塞过滤器组件以防止过早部署。提供不透射线标记物，超声反射标记物和/或主动脉透射照射系统以监测导管的位置和栓塞过滤器组件的展开状态。栓子过滤器组件被构造成当部署时使有效过滤器表面面积最大化。描述的栓塞过滤器组件配置包括细长锥体，锥体，喇叭形状，修改的喇叭形状，以及螺旋形，圆周和纵向回旋形状，以及具有用于对中过滤器并保持当展开时从主动脉壁远离过滤网。含氧血液通过灌注腔灌注，任何可能脱落的栓塞材料都被捕获在部署的栓塞过滤器组件中。还描述了将灌注过滤器导管与主动脉闭塞装置组合的实施例，所述主动脉闭塞装置可以是环形球囊，可膨胀球囊或可选择性部署的外部导管流量控制阀。联合装置允许经皮腔内管理体外循环和心脏停搏，防止不良栓塞事件。

3. 发明申请

WO0113983A3 METHOD AND APPARATUS FOR DIFFERENTIALLY PERFUSING A PATIENT DURING CARDIOPULMONARY BYPASS 审中-公开
标题翻译：方法和装置，用于在心脏旁路旁通过患者的不同程度的灌注
公开(公告)号：WO0113983A3
公开(公告)日：2001-07-19
申请号：PCT/US0021088
申请日：2000-08-02
申请人： CARDEON CORP
发明人： ROBINSON JANINE , SAMSON WILFRED J , MACOVIAK A JOHN , YOUNG LISA M , ESCH BRADY , LEE MIKE , OLSEN ERIC
IPC分类号： A61B17/00 , A61B17/12 , A61F2/958 , A61M1/36 , A61M25/10
CPC分类号： A61B17/12109 , A61B17/12045 , A61B17/12136 , A61B2017/00243 , A61B2017/12127 , A61M1/3613 , A61M25/1011 , A61M2025/1015 , A61M2210/127
摘要： The present invention provides methods, systems and devices for performing cardiopulmonary bypass (CPB), cardioplegic arrest, suction of fluid from the aorta to remove embolic or other fluid from the general circulation and the selective segmentation of the arterial system to perform differential perfusion eliminating hypoperfusion. An aortic catheter having an arch lumen which extends at least in part along the length of the catheter shaft has a proximal opening coupled to a CPB machine and a distal arch opening. A corporeal lumen extends at least in part along the length of the catheter shaft and has a proximal opening coupled to a CPB machine and a distal corporeal opening. A suction lumen extends at least in part along the length of the catheter shaft and has a proximal suction opening coupled to a suction source and a distal suction opening residing in the aortic lumen of a patient.
摘要翻译：本发明提供了用于执行心肺分流术（CPB），心脏停搏，从主动脉抽吸流体以从一般循环中除去栓塞或其它流体的方法，系统和装置以及动脉系统的选择性分割，以执行差异灌注消除低灌注。具有弓形管腔的主动脉导管至少部分地沿着导管轴的长度延伸，具有联接到CPB机器和远侧弓形开口的近侧开口。体腔内沿着导管轴的长度至少部分地延伸，并且具有与CPB机器和远端体孔开口相连的近端开口。抽吸腔沿着导管轴的长度至少部分地延伸，并且具有联接到吸入源的近侧吸入口和位于患者的主动脉腔内的远侧吸入口。

4. 发明申请

WO9958174A3 CIRCULATORY SUPPORT SYSTEM AND METHOD OF USE FOR ISOLATED SEGMENTAL PERFUSION 审中-公开
标题翻译：循环支持系统和分离分离灌注的使用方法
公开(公告)号：WO9958174A3
公开(公告)日：2000-01-27
申请号：PCT/US9909979
申请日：1999-05-07
申请人： CARDEON CORP
发明人： MACOVIAK JOHN A , SAMSON WILFRED J , BAKER STEVE G , LEARY JAMES J
IPC分类号： A61F2/958 , A61M1/36 , A61M25/00 , A61M25/10
CPC分类号： A61M25/1011 , A61M1/3653 , A61M1/3659 , A61M25/0032 , A61M2025/0034 , A61M2025/0036
摘要： A circulatory support system and method for circulatory support are described for performing cardiopulmonary bypass using differential perfusion and/or isolated segmental perfusion of the circulatory system. The circulatory support system includes one or more venous cannulae for draining blood from the venous side of the patient's circulatory system, one or more arterial cannulae for perfusing the arterial side of the patient's circulatory system, and one or more blood circulation pumps connected between the venous cannulae and the arterial cannulae. The arterial cannulae and the venous cannulae of the circulatory support system may take one of several possible configurations. The circulatory support system is configured to segment a patient's circulatory system into one or more isolated circulatory loops. The circulatory loops may be isolated from one another and/or from the remainder of the patient's circulatory system on the venous side, as well as on the arterial side, for isolated closed loop circulatory support of separate organ systems. The circulatory support system is suitable for use in minimally-invasive cardiac surgery, using thoracoscopic, port-access or minithoracotomy techniques, or for standard open-chest cardiac surgery.
摘要翻译：描述了用于循环支持的循环支持系统和方法，用于使用差异灌注和/或循环系统的分离的分段灌注进行心肺分流术。循环支持系统包括用于从患者循环系统的静脉侧排出血液的一个或多个静脉插管，用于灌注患者循环系统的动脉侧的一个或多个动脉插管和连接在患者循环系统的动脉侧的一个或多个血液循环泵插管和动脉插管。循环支持系统的动脉插管和静脉插管可以采取几种可能的构型之一。循环支持系统被配置为将患者的循环系统分成一个或多个隔离的循环循环。循环循环可以彼此隔离和/或从静脉侧以及动脉侧的患者循环系统的其余部分分离，用于分离的器官系统的闭环循环支持。循环支持系统适用于微创心脏手术，使用胸腔镜，入口口或小切开术技术，或适用于标准开胸心脏手术。

5. 发明专利

AU749573B2 Perfusion filter catheter 未知
公开(公告)号：AU749573B2
公开(公告)日：2002-06-27
申请号：AU9321498
申请日：1998-09-23
申请人： CARDEON CORP
发明人： MACOVIAK JOHN A , LEARY JAMES J , SAMSON WILFRED J
IPC分类号： A61B17/12 , A61B17/22 , A61F2/00 , A61F2/01 , A61F2/02
摘要： A aortic filter catheter is used to capture potential emboli within the aorta during heart surgery and cardiopulmonary bypass. An expandable embolic filter assembly having fine filter mesh for capturing macroemboli and microemboli is mounted on a catheter shaft having a perfusion lumen with perfusion ports located upstream of the filter. The embolic filter assembly can be actively or passively deployed within the ascending aortic. The embolic filter assembly includes an aortic occlusion device, which may be a toroidal balloon, an expandable balloon or a selectively deployable external catheter flow control valve. The combined device allows percutaneous transluminal administration of cardiopulmonary bypass and cardioplegic arrest with protection from undesirable embolic events.

6. 发明专利

CA2334978A1 CARDIOVASCULAR CATHETER APPARATUS AND CATHETER POSITIONING METHOD USING TISSUE TRANSILLUMINATION 未知
公开(公告)号：CA2334978A1
公开(公告)日：1999-12-16
申请号：CA2334978
申请日：1999-06-08
申请人： CARDEON CORP
发明人： BAKER STEVE , MACOVIAK JOHN A , SAMSON WILFRED J , LEARY JAMES J , VAN DYK KARL , ROBINSON JANINE
IPC分类号： A61B5/00 , A61B17/00 , A61B19/00 , A61M25/01 , A61M29/02
摘要： Arterial and venous cannulas or catheters are described incorporating means for tissue transillumination for positioning and for monitoring of the devic e within a blood vessel throughout a surgical procedure without expensive imaging equipment or ionizing radiation and without inconveniencing or complicating the procedure. Detailed descriptions of particular embodiments include: a single balloon catheter or cannula configured with optical fibers for tissue transillumination, a single balloon catheter or cannula configure d with light emitting diodes or laser diodes for tissue transillumination, a single balloon catheter or cannula configured with battery powered light emitting diodes or laser diodes for tissue transillumination, a catheter or cannula with two selectively expandable external catheter valves configured for tissue transillumination, a single-balloon aortic catheter deployed with in a patient's aorta via peripheral arterial access, a double-balloon aortic catheter for selective aortic perfusion of a patient's circulatory system, a two-valve aortic catheter for selective aortic perfusion, a two-lumen, doubl e- balloon venous drainage cannula for isolated venous drainage of a patient's inferior and superior vena cava and a single-lumen, two-stage venous drainag e cannula for simultaneous drainage of a patient's inferior and superior vena cava. Additional illumination means are described that can be used with any of the embodiments of catheters and cannulas. Included among these is a separat e transillumination device in the form of a stylet or guidewire that is insertable into or through a lumen of the catheter or cannula.

7. 发明专利

AU3973899A Circulatory support system and method of use for isolated segmental perfusion 未知
公开(公告)号：AU3973899A
公开(公告)日：1999-11-29
申请号：AU3973899
申请日：1999-05-07
申请人： CARDEON CORP
发明人： MACOVIAK JOHN A , SAMSON WILFRED J , BAKER STEVE G , LEARY JAMES J
IPC分类号： A61F2/958 , A61M1/36 , A61M25/00 , A61M25/10

8. 发明专利

AU9321598A Introducer and perfusion cannula 未知
公开(公告)号：AU9321598A
公开(公告)日：1999-04-23
申请号：AU9321598
申请日：1998-09-23
申请人： CARDEON CORP
发明人： MACOVIAK JOHN A , SAMSON WILFRED J , THOMPSON LYNN M , LEARY JAMES J
IPC分类号： A61B17/22 , A61B17/34 , A61M5/00 , A61M25/00 , A61M25/04 , A61M25/06
摘要： The present invention discloses a multi-access cannula for use in a variety of surgical procedures, particularly for use in the course of performing conventional open-chest and peripheral access cardiopulmonary bypass (CPB). The multi-access cannula is capable of being inserted through a single puncture site with a percutaneous tip. At the appropriate depth of insertion, a closure seal may be engaged at the point of entry to secure the positioning of the cannula and prevent leakage of blood from the incision. Once the cannula is at the appropriate position the cannula provides a multiplicity of procedural options for the surgeon. For example, when approaching through the ascending aorta, the multi-access cannula enables the simultaneous passage of various fluids and multiple catheters or instruments in opposing directions within the lumen of the aortic arch through a single insertion site.

9. 发明专利

CA2304463A1 PERFUSION FILTER CATHETER 未知
公开(公告)号：CA2304463A1
公开(公告)日：1999-04-08
申请号：CA2304463
申请日：1998-09-23
申请人： CARDEON CORP
发明人： MACOVIAK JOHN A , SAMSON WILFRED J , LEARY JAMES J
IPC分类号： A61B17/12 , A61B17/22 , A61F2/00 , A61F2/01 , A61F2/02
摘要： A perfusion filter catheter is used to capture potential emboli within the aorta during heart surgery and cardiopulmonary bypass. An expandable embolic filter assembly having fine filter mesh for capturing macroemboli and microemboli is mounted on a catheter shaft having a perfusion lumen with perfusion ports located upstream of the filter. The embolic filter assembly can be actively or passively deployed within the ascending aortic. An optional outer tube covers the embolic filter assembly to prevent premature deployment. Radiopaque markers, sonoreflective markers and/or an aortic transillumination system are provided to monitor the position of the catheter and the deployment state of the embolic filter assembly. The embolic filter assembly is configured to maximize the effective filter surface area when deployed. Embolic filter assembly configurations described include an elongated cone, a frustum of a cone, a trumpet-shape, a modified trumpet-shape, and helically, circumferentially and longitudinally convoluted shapes, as well as configurations having standoff members for centering the filter and holding the filter mesh away from the aortic walls when deployed. Oxygenated blood is perfused through the perfusion lumen and any embolic materials that might be dislodged are captured in the deployed embolic filter assembly. Embodiments are also described that combine the perfusion filter catheter with an aortic occlusion device, which may be a toroidal balloon, an expandable balloon or a selectively deployable external catheter flow control valve. The combined device allows percutaneous transluminal administration of cardiopulmonary bypass and cardioplegic arrest with protection from undesirable embolic events.

10. 发明专利

AU1781901A Expandable venous cannula and method of use 未知
公开(公告)号：AU1781901A
公开(公告)日：2001-06-04
申请号：AU1781901
申请日：2000-11-20
申请人： CARDEON CORP
发明人： SAMSON WILFRED J , ESCH BRADY , LEE MICHAEL J , ROBINSON JANINE
IPC分类号： A61M29/00

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