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1. 发明申请

WO2010074326A1 PROBE FOR A BIOLOGICAL SPECIMEN AND LABELLING METHOD AND SCREENING METHOD USING THE PROBE 审中-公开
标题翻译：探索生物样本和标记方法和使用探针的筛选方法
公开(公告)号：WO2010074326A1
公开(公告)日：2010-07-01
申请号：PCT/JP2009/071866
申请日：2009-12-24
申请人： CANON KABUSHIKI KAISHA , SHINTO, Taichi , MIYAZAKI, Takeshi , HIROSE, Masashi , OOKUBO, Taketoshi , WATANABE, Kohei , NOMOTO, Tsuyoshi , TANAKA, Toshio , NISHIMURA, Yuhei , SHIMADA, Yasuhito , NISHIMURA, Norihiro
发明人： SHINTO, Taichi , MIYAZAKI, Takeshi , HIROSE, Masashi , OOKUBO, Taketoshi , WATANABE, Kohei , NOMOTO, Tsuyoshi , TANAKA, Toshio , NISHIMURA, Yuhei , SHIMADA, Yasuhito , NISHIMURA, Norihiro
IPC分类号： A61K49/00 , A61K51/00 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/14 , C09B57/00 , G01N33/15 , G01N33/50 , C07D209/08 , C07D209/94
CPC分类号： A61K51/0453 , A61K49/0002 , A61K49/0008 , A61K49/0021 , A61K49/006 , A61K49/10 , C07D209/08 , C07D209/86 , C07D209/94 , C07D401/08 , C07D403/06 , C07D403/08 , C07D413/08 , C07D417/06 , C07D417/14 , C09B23/0091 , C09B23/04 , C09B23/105 , G01N33/582 , G01N2333/4603 , G01N2500/10
摘要： Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I).
摘要翻译：本发明提供了一种用于生物标本的新型探针，其自身进行标记，并清楚地观察生物体中的特定细胞和特定细胞器官中的一种，该探针具有优异的光谱特性并且显示优异的储存稳定性。生物样本的探针作为活性剂含有由通式（I）表示的至少一种化合物。

2. 发明申请

WO2010074325A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD 审中-公开
标题翻译：内标组织的标签组合物，标记物的标记方法和筛选方法
公开(公告)号：WO2010074325A1
公开(公告)日：2010-07-01
申请号：PCT/JP2009/071865
申请日：2009-12-24
申请人： CANON KABUSHIKI KAISHA , WATANABE, Kohei , SHINTO, Taichi , NOMOTO, Tsuyoshi , MIYAZAKI, Takeshi , TANAKA, Toshio , NISHIMURA, Yuhei , SHIMADA, Yasuhito , NISHIMURA, Norihiro
发明人： WATANABE, Kohei , SHINTO, Taichi , NOMOTO, Tsuyoshi , MIYAZAKI, Takeshi , TANAKA, Toshio , NISHIMURA, Yuhei , SHIMADA, Yasuhito , NISHIMURA, Norihiro
IPC分类号： A61K49/00 , C07D403/04 , C07D403/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , G01N33/15 , G01N33/50
CPC分类号： A61K49/0021 , A61K49/0002 , A61K49/0039 , A61K49/0041 , A61K49/006 , C07D209/70 , C07D209/96 , C07D215/00 , C07D221/14 , C07D221/18 , C07D263/54 , C07D277/34 , C07D277/36 , C07D277/64 , C07D311/82 , C07D311/86 , C07D405/04 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14 , C07D491/052 , C07D491/12 , C07D497/10 , G01N33/5088 , G01N33/582 , G01N2333/4603
摘要： The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as exposure of an ocular tissue or injection of a staining agent into the ocular tissue or a nerve tissue linking to the ocular tissue, a method of noninvasively labeling an intraocular tissue of a living individual, and a screening method using the labeling composition for the intraocular tissues. The composition contains a compound capable of labeling at least a photoreceptor cell layer of a retina, wherein the compound is a staining compound having a particular structure as a partial structure thereof.
摘要翻译：本发明提供了一种用于生物个体的眼内组织的标记组合物，其特异性地标记眼内组织，而不需要诸如眼组织的暴露或注射染色剂的侵入性手术或连接到眼组织的神经组织眼组织，生物体眼内组织非侵入性标记方法，以及使用眼内组织用标记组合物的筛选方法。该组合物含有能够至少标记视网膜感光细胞层的化合物，其中该化合物是具有特定结构的染色化合物作为其部分结构。

3. 发明申请

WO2006009328A1 ENZYME ELECTRODE, SENSOR, FUEL CELL, AND ELECTROCHEMICAL REACTOR 审中-公开
标题翻译： ENZYME电极，传感器，燃料电池和电化学反应器
公开(公告)号：WO2006009328A1
公开(公告)日：2006-01-26
申请号：PCT/JP2005/013907
申请日：2005-07-22
申请人： CANON KABUSHIKI KAISHA , KUBO, Wataru , YANO, Tetsuya , NOMOTO, Tsuyoshi
发明人： KUBO, Wataru , YANO, Tetsuya , NOMOTO, Tsuyoshi
IPC分类号： C12Q1/00
CPC分类号： C12Q1/004
摘要： An enzyme electrode comprises a conductive member and an enzyme, wherein a first mediator and a second mediator are immobilized by a carrier onto the conductive member, the first mediator and the second mediator having different redox potentials (reduction-oxidation potentials). A sensor employs the enzyme electrode as a detection portion for detecting a substance. A fuel cell employs the enzyme electrode as at least one of anode and a cathode. An electrochemical reactor employs the enzyme electrode as a reaction electrode.
摘要翻译：酶电极包括导电构件和酶，其中第一介体和第二介体通过载体固定在导电构件上，第一介体和第二介体具有不同的氧化还原电位（还原氧化电位）。传感器使用酶电极作为检测物质的检测部。燃料电池使用酶电极作为阳极和阴极中的至少一个。电化学反应器采用酶电极作为反应电极。

4. 发明申请

WO2004097530A1 STRUCTURE AND METHOD FOR PRODUCING STRUCTURE, TONER CONTAINING STRUCTURE, IMAGE FORMING METHOD AND DEVICE USING TONER 审中-公开
标题翻译：用于生成结构的结构和方法，包含结构的图像，图像形成方法和使用调色剂的设备
公开(公告)号：WO2004097530A1
公开(公告)日：2004-11-11
申请号：PCT/JP2004/006349
申请日：2004-04-30
申请人： CANON KABUSHIKI KAISHA , YANO, Tetsuya , NOMOTO, Tsuyoshi , KOZAKI, Shinya , IMAMURA, Takeshi , HONMA, Tsutomu
发明人： YANO, Tetsuya , NOMOTO, Tsuyoshi , KOZAKI, Shinya , IMAMURA, Takeshi , HONMA, Tsutomu
IPC分类号： G03G9/093
CPC分类号： C12N9/93 , C07K2319/23 , C09D167/04 , C12N11/08 , C12P7/625 , G01N33/54326 , G01N33/54393 , G01N2333/21 , G01N2333/245
摘要： A structure, comprising a base material, coated with polymer which can be compatible with reduced load against environment and living organisms and various functionalities is provided. The base material is covered with polyhydroxyalkanoate (PHA). The invention also relates to a method for production of the structure comprising immobilizing the enzyme which synthesize PHA on the surface of the base material, biosynthesizing the PHA and coating the base material. The invention also provides toner containing such the structure and production thereof. Further, the invention relates to an image forming method comprising forming the image by providing such toner to the medium to be recorded.
摘要翻译：提供一种结构，其包括涂覆有聚合物的基材，该聚合物可以与降低的环境负荷和生物体相容并具有各种功能。基材用聚羟基链烷酸酯（PHA）覆盖。本发明还涉及一种用于生产该结构的方法，包括将在基材表面上合成PHA的酶固定化，生物合成PHA并涂覆该基材。本发明还提供含有这种结构和其制备的调色剂。此外，本发明涉及一种图像形成方法，包括通过向要记录的介质提供这种调色剂来形成图像。

5. 发明申请

WO2007077952A1 METHOD AND DEVICE FOR DETERMINING A NUCLEIC ACID ALLELE OR BASE SEQUENCE 审中-公开
标题翻译：用于确定核酸酸碱基序列的方法和装置
公开(公告)号：WO2007077952A1
公开(公告)日：2007-07-12
申请号：PCT/JP2006/326349
申请日：2006-12-26
申请人： CANON KABUSHIKI KAISHA , NOMOTO, Tsuyoshi , KUBO, Wataru
发明人： NOMOTO, Tsuyoshi , KUBO, Wataru
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B82Y30/00 , C12Q2563/113 , C12Q2537/149 , C12Q2533/101 , C12Q2535/125 , C12Q2525/186
摘要： Information regarding a base sequence of a target nucleic acid is acquired by preparing a sample comprising the target nucleic acid hybridized with a primer or a sample comprising the target nucleic acid containing a promoter sequence, a polymerase, a nucleotide derivative having an electrochemically convertible moiety; allowing the three components to coexist in a solvent; and detecting whether the nucleotide derivative is introduced into the primer or a transcription product of the target nucleic acid or not using an electrochemical reaction.
摘要翻译：通过制备包含与引物或包含含有启动子序列的靶核酸的样品，聚合酶，具有电化学可转换部分的核苷酸衍生物杂交的靶核酸的样品获得关于靶核酸的碱基序列的信息; 使三种成分共存于溶剂中; 以及使用电化学反应来检测是否将核苷酸衍生物引入引物或靶核酸的转录产物。

6. 发明申请

WO2004097416A1 MAGNETIC SUBSTANCE-BIOSUBSTANCE COMPLEX STRUCTURE, PEPTIDE FRAGMENT CAPABLE OF LINKING TO MAGNETIC SUBSTANCE AND GENE THEREFOR, AND PROCESS FOR STRUCTURE 审中-公开
标题翻译：磁性物质 - 生物传感器复合结构，能够连接到磁性物质及其基因的肽片段和结构过程
公开(公告)号：WO2004097416A1
公开(公告)日：2004-11-11
申请号：PCT/JP2004/006350
申请日：2004-04-30
申请人： CANON KABUSHIKI KAISHA , IMAMURA, Takeshi , YANO, Tetsuya , NOMOTO, Tsuyoshi , KOZAKI, Shinya , HONMA, Tsutomu , TSUCHITANI, Akiko
发明人： IMAMURA, Takeshi , YANO, Tetsuya , NOMOTO, Tsuyoshi , KOZAKI, Shinya , HONMA, Tsutomu , TSUCHITANI, Akiko
IPC分类号： G01N33/543
CPC分类号： C12N9/1025 , C07K2319/00 , C12N11/06 , C12N11/14 , C12N15/1013 , G01N33/54326 , G01N33/54353 , Y10S530/811
摘要： A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a biosubstance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.
摘要翻译：磁性物质 - 生物物质复合物结构包括含磁性物质的载体和固定在载体上的生物体，生物质通过包含载体表面上的氨基酸序列的间隔物固定化。

7. 发明申请

WO2006129843A2 TARGET-SUBSTANCE CAPTURING MOLECULE 审中-公开
标题翻译：目标物质捕获分子
公开(公告)号：WO2006129843A2
公开(公告)日：2006-12-07
申请号：PCT/JP2006/311180
申请日：2006-05-30
申请人： CANON KABUSHIKI KAISHA , SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
发明人： SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
IPC分类号： C07K16/46
CPC分类号： C07K16/40 , C07K2317/22 , C07K2317/31 , C07K2319/73 , G01N33/531 , G01N33/566 , G01N33/6854 , Y10S435/97 , Y10S436/81
摘要： A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.
摘要翻译：具有包含特异性结合靶物质的不同位点的多个多肽链的缔合的捕获分子，其特征在于，每个多肽链具有在结合位点与目标物质具有高变环结构的结构域，以及用于形成缔合的缔合部分和多肽链通过存在于多肽链中的缔合部分相关联。

8. 发明申请

WO2007148809A1 POLYMERASE-IMMOBILIZED ELECTRODE 审中-公开
标题翻译：聚合物固定电极
公开(公告)号：WO2007148809A1
公开(公告)日：2007-12-27
申请号：PCT/JP2007/062646
申请日：2007-06-18
申请人： CANON KABUSHIKI KAISHA , NOMOTO, Tsuyoshi , KUBO, Wataru
发明人： NOMOTO, Tsuyoshi , KUBO, Wataru
IPC分类号： G01N27/416 , G01N27/327 , C12N15/09
CPC分类号： G01N27/447 , C12Q1/6869 , C12Q2565/607
摘要： The present invention is to reduce a false signal in an apparatus for electrochemically decoding a base sequence of DNA, which false signal is caused by a phenomenon that even unreacted nucleotide 51- triphosphate derivatives remaining in the solution are electrochemically converted on an electrode. The present invention provides a polymerase-immobilized electrode that comprises an electroconductive substrate and a polymerase unit immobilized on the surface of the electroconductive substrate, wherein the polymerase unit comprises a polymerase part, an anchor part and an electroconductive part, which are linked in an order of the polymerase part, the anchor part and the electroconductive part, or in an order of the polymerase part, the electroconductive part and the anchor part; and the polymerase unit is immobilized on the electroconductive substrate by the anchor part; wherein a free end of the electroconductive part, not immobilized on the electroconductive substrate, is located in the vicinity of an active site of the polymerase part.
摘要翻译：本发明是为了减少用于对DNA的碱基序列进行电化学解码的装置中的假信号，该假信号是由残留在溶液中的未反应的核苷酸51-三磷酸衍生物在电极上进行电化学转化的现象引起的。本发明提供了一种聚合酶固定化电极，其包含导电性基质和固定在导电性基质表面的聚合酶单元，其中聚合酶单元包含聚合酶部分，锚定部分和导电部分，其以顺序连接聚合酶部分，锚定部分和导电部分，或按照聚合酶部分，导电部分和锚固部分的顺序; 并且聚合酶单元通过锚定部分固定在导电基底上; 其中未固定在导电性基材上的导电性部分的自由端位于聚合酶部分的活性部位附近。

9. 发明申请

WO2006129828A2 TARGET SUBSTANCE CAPTURING MOLECULE 审中-公开
标题翻译：目标物质捕获分子
公开(公告)号：WO2006129828A2
公开(公告)日：2006-12-07
申请号：PCT/JP2006/311159
申请日：2006-05-29
申请人： CANON KABUSHIKI KAISHA , SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
发明人： SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
IPC分类号： C07K19/00 , G01N33/53 , C07K14/78 , C07K16/00 , C07K16/12
CPC分类号： C07K14/47 , C07K7/08 , C07K14/82 , C07K16/00 , C07K2317/22 , C07K2317/569 , C07K2319/00 , C07K2319/24 , C07K2319/73 , C12N15/62 , G01N33/6854 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S530/866 , Y10S530/867
摘要： A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a hypervariable loop structure at a binding site to the target substance, and (2) a second domain having no hypervariable loop structure at a binding site to the target substance.
摘要翻译：具有不少于两个特异性结合靶物质不同部位的结构域的捕获分子，其中所述不少于两个结构域包括（1）在靶物质的结合位点处具有高变环结构的第一结构域和（2 ）在靶物质的结合位点处没有高变环结构的第二结构域。

10. 发明申请

WO2006009324A1 ENZYME ELECTRODE, AND DEVICE, SENSOR, FUEL CELL AND ELECTROCHEMICAL REACTOR EMPLOYING THE ENZYME ELECTRODE 审中-公开
标题翻译：酶电极和装置，传感器，燃料电池和电化学反应器使用酶电极
公开(公告)号：WO2006009324A1
公开(公告)日：2006-01-26
申请号：PCT/JP2005/013896
申请日：2005-07-22
申请人： CANON KABUSHIKI KAISHA , KUBO, Wataru , NOMOTO, Tsuyoshi , YANO, Tetsuya
发明人： KUBO, Wataru , NOMOTO, Tsuyoshi , YANO, Tetsuya
IPC分类号： G01N27/327
CPC分类号： C12Q1/004 , H01M8/16 , Y02E60/527 , Y02P70/56
摘要： An enzyme electrode has a conductive member and an enzyme, wherein the conductive member has a porous structure, and the enzyme is immobilized through a carrier in pores constituting the porous structure. An enzyme electrode device, comprises the enzyme electrode, and wiring connected to the conductive member of the enzyme electrode.
摘要翻译：酶电极具有导电构件和酶，其中导电构件具有多孔结构，并且酶通过载体固定在构成多孔结构的孔中。酶电极装置，包括酶电极和连接到酶电极的导电构件的配线。

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