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1. 发明申请

WO2006129828A2 TARGET SUBSTANCE CAPTURING MOLECULE 审中-公开
标题翻译：目标物质捕获分子
公开(公告)号：WO2006129828A2
公开(公告)日：2006-12-07
申请号：PCT/JP2006/311159
申请日：2006-05-29
申请人： CANON KABUSHIKI KAISHA , SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
发明人： SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
IPC分类号： C07K19/00 , G01N33/53 , C07K14/78 , C07K16/00 , C07K16/12
CPC分类号： C07K14/47 , C07K7/08 , C07K14/82 , C07K16/00 , C07K2317/22 , C07K2317/569 , C07K2319/00 , C07K2319/24 , C07K2319/73 , C12N15/62 , G01N33/6854 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S530/866 , Y10S530/867
摘要： A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a hypervariable loop structure at a binding site to the target substance, and (2) a second domain having no hypervariable loop structure at a binding site to the target substance.
摘要翻译：具有不少于两个特异性结合靶物质不同部位的结构域的捕获分子，其中所述不少于两个结构域包括（1）在靶物质的结合位点处具有高变环结构的第一结构域和（2 ）在靶物质的结合位点处没有高变环结构的第二结构域。

2. 发明申请

WO2006129843A2 TARGET-SUBSTANCE CAPTURING MOLECULE 审中-公开
标题翻译：目标物质捕获分子
公开(公告)号：WO2006129843A2
公开(公告)日：2006-12-07
申请号：PCT/JP2006/311180
申请日：2006-05-30
申请人： CANON KABUSHIKI KAISHA , SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
发明人： SHIOTSUKA, Hidenori , HATAKEYAMA, Satoru , NOMOTO, Tsuyoshi , KAIEDA, Masaru , YAMAMICHI, Junta
IPC分类号： C07K16/46
CPC分类号： C07K16/40 , C07K2317/22 , C07K2317/31 , C07K2319/73 , G01N33/531 , G01N33/566 , G01N33/6854 , Y10S435/97 , Y10S436/81
摘要： A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.
摘要翻译：具有包含特异性结合靶物质的不同位点的多个多肽链的缔合的捕获分子，其特征在于，每个多肽链具有在结合位点与目标物质具有高变环结构的结构域，以及用于形成缔合的缔合部分和多肽链通过存在于多肽链中的缔合部分相关联。

3. 发明申请

WO2008126664A1 TARGET SUBSTANCE DETECTION ELEMENT, TARGET SUBSTANCE DETECTION METHOD, AND METHOD FOR PRODUCING TARGET SUBSTANCE DETECTION ELEMENT 审中-公开
标题翻译：目标物质检测元件，目标物质检测方法及产生目标物质检测元件的方法
公开(公告)号：WO2008126664A1
公开(公告)日：2008-10-23
申请号：PCT/JP2008/055605
申请日：2008-03-17
申请人： CANON KABUSHIKI KAISHA , HATAKEYAMA, Satoru , IKEDA, Takashi
发明人： HATAKEYAMA, Satoru , IKEDA, Takashi
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , G01N33/54393 , Y10S435/97 , Y10S436/807 , Y10T156/10
摘要： It is intended to provide a target substance detection element wherein a target substance capturing body for capturing target substances is immobilized with good orientation in a desired region on the surface of the target substance detection element, a method for producing the target substance detection element, and a detection method using the target substance detection element. The present invention provides a target substance detection element for detecting the presence or absence or concentration of a target substance in a sample, characterized in that: the target substance detection element includes at least a detection substrate including plural layers and a target substance capturing body immobilized on the surface of the detection substrate; the target substance capturing body has at least a first peptide region specifically recognizing a first layer of the plural layers constituting the detection substrate and binding to the first layer and a second peptide region specifically recognizing a second layer different from the first layer of the plural layers and binding to the second layer; and the first layer and the second layer are adjacent to each other.
摘要翻译：旨在提供一种目标物质检测元件，其中用于捕获目标物质的目标物质捕获体被固定在目标物质检测元件的表面上的期望区域中具有良好取向，该目标物质检测元件的制造方法和使用目标物质检测元件的检测方法。本发明提供了一种用于检测样品中目标物质的存在或不存在或浓度的目标物质检测元件，其特征在于：所述目标物质检测元件至少包括包含多层的检测基板和固定的靶物质捕获体在检测基板的表面上; 目标物质捕捉体具有至少第一肽区域，其具体地识别构成检测基板的多层的第一层并与第一层结合，以及特异性识别与多层的第一层不同的第二层的第二肽区域并与第二层结合; 并且第一层和第二层彼此相邻。

4. 发明申请

WO2011105071A1 METHOD FOR SCREENING NUCLEIC ACID LIGAND 审中-公开
标题翻译：筛选核酸配体的方法
公开(公告)号：WO2011105071A1
公开(公告)日：2011-09-01
申请号：PCT/JP2011/001024
申请日：2011-02-23
申请人： CANON KABUSHIKI KAISHA , HATAKEYAMA, Satoru , IBII, Takahisa
发明人： HATAKEYAMA, Satoru , IBII, Takahisa
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/53
CPC分类号： C12N15/1048 , G01N33/5308
摘要： Provided is a method for screening a library of candidate for a nucleic acid ligand. The method includes the steps of: (a) preparing a library of candidate of nucleic acid ligands; (b) contacting, under the absence of a target substance, the library with a supporting member binding to at least one of conserved sequence domains included in the ligand, and then separating and removing a ligand which does not form an intermolecular duplex; and (c) dissociating the intermolecular duplex by contacting, under the presence of the target substance, the target substance with the remaining ligand forming the intermolecular duplex obtained in step (b), and then separating and collecting a ligand having a specific secondary structure formed by the binding to the target substance, wherein the method includes at least one time of step (b) and at least one time of step (c).
摘要翻译：提供了筛选核酸配体候选文库的方法。该方法包括以下步骤：（a）制备核酸配体候选文库; （b）在不存在目标物质的情况下，使文库与支配构件接触，所述支持构件与包含在配体中的保守序列结构域中的至少一个结合，然后分离和除去不形成分子间双键的配体; 和（c）通过在靶物质的存在下使靶物质与形成步骤（b）中获得的分子间双环体的剩余配体接触，然后分离和收集形成具有特定二级结构的配体，从而解离分子间双链体通过与目标物质的结合，其中所述方法包括步骤（b）的至少一个时间和步骤（c）的至少一个时间）。

5. 发明公开

EP2494080A1 METHOD FOR SCREENING NUCLEIC ACID LIGAND 审中-公开
标题翻译：一种筛选核酸配体
公开(公告)号：EP2494080A1
公开(公告)日：2012-09-05
申请号：EP11747040.1
申请日：2011-02-23
申请人： Canon Kabushiki Kaisha
发明人： HATAKEYAMA, Satoru , IBII, Takahisa
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/53
CPC分类号： C12N15/1048 , G01N33/5308
摘要： Provided is a method for screening a library of candidate for a nucleic acid ligand. The method includes the steps of: (a) preparing a library of candidate of nucleic acid ligands; (b) contacting, under the absence of a target substance, the library with a supporting member binding to at least one of conserved sequence domains included in the ligand, and then separating and removing a ligand which does not form an intermolecular duplex; and (c) dissociating the intermolecular duplex by contacting, under the presence of the target substance, the target substance with the remaining ligand forming the intermolecular duplex obtained in step (b), and then separating and collecting a ligand having a specific secondary structure formed by the binding to the target substance, wherein the method includes at least one time of step (b) and at least one time of step (c).

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