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    • 2. 发明申请
    • POWDER INHALER
    • 粉末吸入器
    • WO2004012801A1
    • 2004-02-12
    • PCT/EP2003/008432
    • 2003-07-30
    • CHIESI FARMACEUTICI S.P.A.PINON, JohnSHIRGAONKAR, SameerSMITH, Christopher, JamesBURGE, SimonMIDDLETON, Max, WilliamAHERN, DavidSARKAR, Matthew, NeilARLETT, BenLYE, Emma, LesleySMITH, Simon
    • PINON, JohnSHIRGAONKAR, SameerSMITH, Christopher, JamesBURGE, SimonMIDDLETON, Max, WilliamAHERN, DavidSARKAR, Matthew, NeilARLETT, BenLYE, Emma, LesleySMITH, Simon
    • A61M15/00
    • A61M15/0065A61M15/0026A61M15/0075A61M2202/062A61M2202/064A61M2206/16G06M1/04G06M1/045G06M1/248
    • A powder inhaler comprises a container (7) for storing a powdered medicament, a metering member (15) having a dosing recess (18) to be filled with a dose of the powdered medicament, and a mouthpiece (3) being in communication with an inhalation channel (27) of the powder inhaler. Furthermore, the powder inhaler comprises a protective member (19) which is slidingly moveable on the metering member (15) between a closed position, in which it at least covers the dosing recess (18) of the metering member (15) if the metering member (15) is in an inhalation position, and an open position, in which it exposes the dosing recess (18) thereby enabling inhalation of the dose of the powdered medicament contained in the dosing recess (18). The protective member (19) is preferably coupled to an inhalation actuated mechanism (21-23) in such a manner that the inhalation actuated mechanism (21-23) moves the protective member (19) from its closed position to its open position only if there is an inhalation suction force exerted by a user which exceeds a predetermined level. This prevents the dose contained in the dosing recess (18) from falling out of the dosing recess, unless there is no inhalation process initiated by the user. Therefore, the powder inhaler can also be operated reliably upside down. Furthermore, a deagglomerator arrangement (cyclone), which may be incorporated in such a powder inhaler, is proposed which comprises a vortex chamber (73) having a diameter between 6 mm and 8 mm, preferably 8 mm.
    • 粉末吸入器包括用于储存粉末状药剂的容器(7),具有用于填充一定剂量的粉末状药物的剂量凹槽(18)的计量构件(15),以及口部件 (3)与粉末吸入器的吸入通道(27)连通。 此外,粉末吸入器包括保护性构件(19),该保护性构件在计量构件(15)上在闭合位置和在计量构件(15)的计量凹槽(18)至少覆盖计量构件 构件15处于吸入位置和打开位置,在所述打开位置,构件15暴露定量凹槽18,从而能够吸入容纳在定量凹槽18中的粉末药剂的剂量。 保护构件(19)优选地以这样的方式联接到吸入致动机构(21-23),使得吸入致动机构(21-23)仅在如下情况下将保护构件(19)从其闭合位置移动到其打开位置 存在超过预定水平的用户施加的吸入吸力。 这防止了定量凹槽(​​18)中容纳的剂量从定量凹槽脱落,除非没有用户启动吸入过程。 因此,粉末吸入器也可以可靠地上下运行。 此外,提出了一种可结合在这种粉末吸入器中的分散器装置(旋风分离器),其包括直径在6mm和8mm之间,优选8mm的涡流腔(73)。