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1. 发明申请

WO2004041339A2 PRESSURISED INHALERS 审中-公开
标题翻译：加压吸入器
公开(公告)号：WO2004041339A2
公开(公告)日：2004-05-21
申请号：PCT/GB2003/004751
申请日：2003-11-04
申请人： CAMBRIDGE CONSULTANTS LIMITED , BURGE, Simon , ISAACS, Warren, Paul , SMITH, Simon, James , TUCKWELL, Jonathan, David
发明人： BURGE, Simon , ISAACS, Warren, Paul , SMITH, Simon, James , TUCKWELL, Jonathan, David
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0068 , A61M15/0073 , A61M15/009 , A61M15/0096
摘要： A pressurised medicament canister (4) has a valve (2) which dispenses a metered dose upon being released from a depressed condition. An inhaler device adapted for use with the canister has a breath-actuated latch mechanism (60, 62; 208, 216) arranged in use to latch the canister (4) in a depressed condition and further to release the latch (60, 62; 208, 216) in response to inhalation through the inhaler by a user. Also disclosed is a dose counter for counting the number of doses dispensed from the canister comprising a counter member (240) having a helical toothed track (238) which is incrementally advanced each time a dose is dispensed from the canister (4). Also disclosed is a valve for the canister comprising a sliding seal delimiting the metering chamber and slidable relative to a nozzle member, said sliding seal being biased in (136) use to reduce the volume of the metering chamber (146) substantially to zero once the metering chamber (146) has been vented to the atmosphere.
摘要翻译：加压药剂罐（4）具有阀（2），其在从沮丧状态释放时分配计量剂量。适于与该罐一起使用的吸入器装置具有一个呼吸致动的锁定机构（60,62; 208,216），该闩锁机构设置在使用中以将凹陷（4）锁定在凹陷状态，并进一步释放闩锁（60,62; 208,216）。 208,116），以响应于使用者通过吸入器的吸入。还公开了一种用于计数从罐分配的剂量数量的剂量计数器，其包括具有螺旋齿状轨迹（238）的计数器构件（240），每当从罐（4）分配剂量时，其逐渐前进。还公开了一种用于罐的阀，包括限定计量室并可相对于喷嘴构件滑动的滑动密封件，所述滑动密封件用于将计量腔室（146）的体积基本上减小到零（136），一旦计量室（146）已经排放到大气中。

2. 发明申请

WO2007140238A2 RECONSTITUTION DEVICE 审中-公开
标题翻译：重新配置设备
公开(公告)号：WO2007140238A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/069639
申请日：2007-05-24
申请人： BAYER HEALTHCARE LLC , TUCKWELL, Jonathan David , DYER, Robert , KIVLIN, Robert Owen , PALMER-FELGATE, John Paul , AVERY, Matthew Burgess , SKINNER, Kevin, George , KADAMUS, Chris , WOOD, Lee , SCHWAN, Peter , ARLETT, Ben
发明人： TUCKWELL, Jonathan David , DYER, Robert , KIVLIN, Robert Owen , PALMER-FELGATE, John Paul , AVERY, Matthew Burgess , SKINNER, Kevin, George , KADAMUS, Chris , WOOD, Lee , SCHWAN, Peter , ARLETT, Ben
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2051 , A61J1/2055 , A61J1/2075 , A61J1/2082 , A61J1/2086 , Y10T29/49826
摘要： A reconstitution device for storing a first component of a pharmaceutical preparation includes a receptacle, a cap having a first end secured to the receptacle, a second end, and an inner bore having a central aperture. The device further includes a stopper located between the receptacle and the cap, the stopper including a portion capable of being perforated. The device also includes a plunger secured to the second end of the cap, a locking mechanism located in the cap, and an actuating mechanism. The actuating mechanism may prevent the device from inadvertent activation.
摘要翻译：用于储存药物制剂的第一组分的重建装置包括容器，具有固定到容器的第一端的帽，第二端和具有中心孔的内孔。该装置还包括位于容器和盖之间的止动件，止动件包括能够穿孔的部分。该装置还包括固定到盖的第二端的柱塞，位于盖中的锁定机构和致动机构。致动机构可以防止装置意外激活。

3. 发明申请

WO2004091707A3 AEROSOLIZATION APPARATUS WITH CAPSULE PUNCTURE ALIGNMENT GUIDE 审中-公开
标题翻译：胶囊矫正装置与胶囊针刺对准指南
公开(公告)号：WO2004091707A3
公开(公告)日：2005-03-31
申请号：PCT/US2004011234
申请日：2004-04-09
申请人： NEKTAR THERAPEUTICS , DUNKLEY MICHAEL JOHN , TUCKWELL JONATHAN DAVID , VERNON-HARCOURT EDWARD WILLIAM , GLUSKER MARK J , PABOOJIAN STEVE
发明人： DUNKLEY MICHAEL JOHN , TUCKWELL JONATHAN DAVID , VERNON-HARCOURT EDWARD WILLIAM , GLUSKER MARK J , PABOOJIAN STEVE
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0033 , A61M2202/064
摘要： An aerosolization apparatus (100) comprises a housing (105) defining a chamber (110) having one or more air inlets (115) . The chamber is sized to receive a capsule (125) which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism (130) within the housing. The puncturing mechanism comprises an alignment guide (132) and a puncture member (135), wherein the alignment guide comprises a surface (133) adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions (300). An end section (140) is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.
摘要翻译：雾化装置（100）包括限定具有一个或多个空气入口（115）的腔室（110）的壳体（105）。该腔室的大小适于接收含有可雾化药物制剂的胶囊（125）。雾化装置还包括在壳体内的穿刺机构（130）。穿刺机构包括对准引导件（132）和穿刺构件（135），其中对准引导件包括适于在穿刺构件前进到胶囊中以接触胶囊的表面（133），以在胶囊中形成开口。表面的至少一部分相对于胶囊的纵向轴线倾斜。或者或另外，表面可以包括一个或多个突起（300）。端部（140）与壳体相关联。端部的尺寸和形状被容纳在使用者的嘴或鼻中，使得使用者可以通过端部部分吸入，以吸入通过在胶囊中形成的开口离开胶囊的雾化药物制剂。对准引导件允许胶囊的更一致的穿刺和装置的更长的使用寿命。

4. 发明申请

WO2007140238A3 RECONSTITUTION DEVICE 审中-公开
标题翻译：重新配置设备
公开(公告)号：WO2007140238A3
公开(公告)日：2008-04-24
申请号：PCT/US2007069639
申请日：2007-05-24
申请人： BAYER HEALTHCARE LLC , TUCKWELL JONATHAN DAVID , DYER ROBERT , KIVLIN ROBERT OWEN , PALMER-FELGATE JOHN PAUL , AVERY MATTHEW BURGESS , SKINNER KEVIN GEORGE , KADAMUS CHRIS , WOOD LEE , SCHWAN PETER , ARLETT BEN
发明人： TUCKWELL JONATHAN DAVID , DYER ROBERT , KIVLIN ROBERT OWEN , PALMER-FELGATE JOHN PAUL , AVERY MATTHEW BURGESS , SKINNER KEVIN GEORGE , KADAMUS CHRIS , WOOD LEE , SCHWAN PETER , ARLETT BEN
IPC分类号： A61J1/20
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2051 , A61J1/2055 , A61J1/2075 , A61J1/2082 , A61J1/2086 , Y10T29/49826
摘要： A reconstitution device for storing a first component of a pharmaceutical preparation includes a receptacle, a cap having a first end secured to the receptacle, a second end, and an inner bore having a central aperture. The device further includes a stopper located between the receptacle and the cap, the stopper including a portion capable of being perforated. The device also includes a plunger secured to the second end of the cap, a locking mechanism located in the cap, and an actuating mechanism. The actuating mechanism may prevent the device from inadvertent activation.
摘要翻译：用于储存药物制剂的第一组分的重建装置包括容器，具有固定到容器的第一端的帽，第二端和具有中心孔的内孔。该装置还包括位于容器和盖之间的止动件，止动件包括能够穿孔的部分。该装置还包括固定到盖的第二端的柱塞，位于盖中的锁定机构和致动机构。致动机构可以防止装置意外激活。

5. 发明申请

WO2004091707A2 AEROSOLIZATION APPARATUS WITH CAPSULE PUNCTURE ALIGNMENT GUIDE 审中-公开
标题翻译：胶囊矫正装置与胶囊针刺对准指南
公开(公告)号：WO2004091707A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011234
申请日：2004-04-09
申请人： NEKTAR THERAPEUTICS , DUNKLEY, Michael, John , TUCKWELL, Jonathan, David , VERNON-HARCOURT, Edward, William , GLUSKER, Mark, J. , PABOOJIAN, Steve
发明人： DUNKLEY, Michael, John , TUCKWELL, Jonathan, David , VERNON-HARCOURT, Edward, William , GLUSKER, Mark, J. , PABOOJIAN, Steve
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0033 , A61M2202/064
摘要： An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user’s mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.
摘要翻译：雾化装置包括限定具有一个或多个空气入口的室的壳体。该腔室的大小适于接收含有可雾化药物制剂的胶囊。雾化装置还包括在壳体内的穿刺机构。穿刺机构包括对准引导件和穿刺构件，其中对齐引导件包括适于在穿刺构件前进到胶囊中以接触胶囊的表面以在胶囊中形成开口。表面的至少一部分相对于胶囊的纵向轴线倾斜。或者或另外，表面可以包括一个或多个突起。端部与壳体相关联。端部的尺寸和形状被容纳在使用者的嘴或鼻中，使得使用者可以通过端部部分吸入，以吸入通过在胶囊中形成的开口离开胶囊的雾化药物制剂。对准引导件允许胶囊的更一致的穿刺和装置的更长的使用寿命。

6. 发明申请

WO2004041339A3 PRESSURISED INHALERS 审中-公开
标题翻译：加压吸入器
公开(公告)号：WO2004041339A3
公开(公告)日：2004-07-29
申请号：PCT/GB0304751
申请日：2003-11-04
申请人： CAMBRIDGE CONSULTANTS , BURGE SIMON , ISAACS WARREN PAUL , SMITH SIMON JAMES , TUCKWELL JONATHAN DAVID
发明人： BURGE SIMON , ISAACS WARREN PAUL , SMITH SIMON JAMES , TUCKWELL JONATHAN DAVID
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0068 , A61M15/0073 , A61M15/009 , A61M15/0096
摘要： A pressurised medicament canister (4) has a valve (2) which dispenses a metered dose upon being released from a depressed condition. An inhaler device adapted for use with the canister has a breath-actuated latch mechanism (60, 62; 208, 216) arranged in use to latch the canister (4) in a depressed condition and further to release the latch (60, 62; 208, 216) in response to inhalation through the inhaler by a user. Also disclosed is a dose counter for counting the number of doses dispensed from the canister comprising a counter member (240) having a helical toothed track (238) which is incrementally advanced each time a dose is dispensed from the canister (4). Also disclosed is a valve for the canister comprising a sliding seal (136) delimiting the metering chamber and slidable relative to a nozzle member, said sliding seal (136) being biased in use to reduce the volume of the metering chamber (146) substantially to zero once the metering chamber (146) has been vented to the atmosphere.
摘要翻译：加压药剂罐（4）具有阀（2），其在从沮丧状态释放时分配计量剂量。适于与该罐一起使用的吸入器装置具有一个呼吸致动的锁定机构（60,62; 208,216），该锁定机构设置在使用中以将凹槽（4）锁定在凹陷状态，并进一步释放闩锁（60,62; 208,216）。 208,116），以响应于使用者通过吸入器的吸入。还公开了一种用于计数从罐分配的剂量数量的剂量计数器，其包括具有螺旋齿状轨迹（238）的计数器构件（240），每当从罐（4）分配剂量时，其逐渐前进。还公开了一种用于罐的阀，其包括限定计量室并相对于喷嘴构件可滑动的滑动密封件（136），所述滑动密封件（136）在使用中被偏压以将计量腔室（146）的体积基本上减小到一旦计量室（146）已经排放到大气中，则为零。

7. 发明申请

WO2004041338A1 INHALERS 审中-公开
标题翻译：吸入器
公开(公告)号：WO2004041338A1
公开(公告)日：2004-05-21
申请号：PCT/GB2003/004748
申请日：2003-11-04
申请人： CAMBRIDGE CONSULTANTS LIMITED , CLAY, Edward, John , PINON, John , TUCKWELL, Jonathan, David , WILKINSON, Eric
发明人： CLAY, Edward, John , PINON, John , TUCKWELL, Jonathan, David , WILKINSON, Eric
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M11/002 , A61M15/009 , A61M2206/14 , A61M2206/16
摘要： A metered dose inhaler for receiving a pressurised medicament canister (8) comprises a mouthpiece (2) and a cyclonic flow chamber (4) disposed between the canister and the mouthpiece (2). The flow chamber (4) is arranged so that upon inhalation by a user through the mouthpiece (2), a substantially planar cyclonic flow is generated in the flow chamber (4). The mouthpiece (2) is disposed generally centrally of this planar cyclonic flow.
摘要翻译：用于接收加压药剂罐（8）的计量剂量吸入器包括设置在所述罐和所述接口管（2）之间的接口（2）和旋流器室（4）。流动室（4）被布置成使得在用户通过接口（2）吸入时，在流动室（4）中产生基本上平面的旋流。接口（2）通常设置在该平面气旋流的中心。

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