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    • 2. 发明授权
    • System for cell growth
    • 细胞生长系统
    • US06340360B1
    • 2002-01-22
    • US09170574
    • 1998-10-13
    • Mark B. LylesCharles A. McLaughlinGlenn A. HalffWilliam A. Mallow
    • Mark B. LylesCharles A. McLaughlinGlenn A. HalffWilliam A. Mallow
    • A61K922
    • A61L27/105A61F2/06A61F2002/30062A61F2002/30677A61F2210/0004A61K9/0024A61L27/54A61L27/56A61L31/028A61L31/146A61L31/148A61L31/16A61L2300/222A61L2300/406A61L2300/43A61L2300/604A61L2300/64A61M31/002
    • An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and angiogenesis from adjacent vascular tissue into the implant. Infection shield embodiments stimulate cell growth and angiogenesis from adjacent vascular tissue which effectively blocks passage of pathogenic microorganisms along percutaneously implanted objects. In embodiments for drug delivery, a reservoir of the same biomaterial may contain either (1) a cell culture system enclosed within a porous sealable interior chamber or (2) a biodegradable matrix in which one or more drugs are dispersed. After implantation of a reservoir of the first embodiment in an organism, cultured cells obtain food and oxygen via diffusion in tissue fluid through the porous walls of the interior chamber, while metabolic products, including drugs, diffuse away from the cell culture in an analogous manner. In a reservoir of the second embodiment, a biodegradable matrix substantially fills the pores (voids), and progressive dissolution of the matrix releases one or more drugs into surrounding tissue fluid. Reservoirs of either embodiment comprise a plurality of voids of a predetermined size effective for stimulating angiogenesis from the surrounding vascular tissue into at least a portion of the reservoir. The reservoir thus acts to couple a source of drugs to the circulatory system of the organism.
    • 用于在血管组织中药物递送的可植入感染屏蔽和系统包括相对不可生物降解的多孔连接的纤维生物材料,其控制并引导细胞生长和血管生成从相邻血管组织进入植入物。 感染屏障实施例刺激来自相邻血管组织的细胞生长和血管生成,其有效地阻止病原微生物沿着经皮植入物体的通过。 在用于药物递送的实施方案中,相同生物材料的储库可以包含(1)包封在多孔可密封的内部室内的细胞培养系统或(2)其中分散有一种或多种药物的生物可降解基质。 在将第一实施方案的储存器植入生物体之后,培养的细胞通过内部室的多孔壁在组织液中的扩散而获得食物和氧气,而代谢产物(包括药物)以类似的方式从细胞培养物扩散 。 在第二实施方案的储存器中,生物降解基质基本上填充孔(空隙),并且基质的逐渐溶解将一种或多种药物释放到周围的组织液中。 任一实施方案的储库包括多个预定尺寸的空隙,其有效刺激来自周围血管组织的血管发生至储存器的至少一部分。 因此,储存器用于将药物源与生物体的循环系统结合。
    • 4. 发明授权
    • Fire pouch
    • 消防袋
    • US4992310A
    • 1991-02-12
    • US371609
    • 1989-06-26
    • Gabriel M. GelbWilliam A. MallowScott Stropkay
    • Gabriel M. GelbWilliam A. MallowScott Stropkay
    • A62C3/00
    • A62C3/00Y10S428/92Y10T428/232Y10T428/233Y10T428/238Y10T428/239Y10T428/2809Y10T428/2839
    • A fire pouch is provided for protecting flammable documents from both fire and water damage. The fire pouch includes a thin pliable water-type exterior container which houses a gelled water material to absorb thermal energy during the fire. The fire pouch further comprises a hydrated intumescent material layer which is secured to the exterior container, and both absorbs thermal energy and intumesce during a fire to produce a foam layer which provides substantially increased fire protection. The gelled water layer and the hydrated intumescent material layer form a relatively thin pliable rectangular-shaped blanket having a seam which divides the blanket into a base portion and a cover portion. The blanket unfolds by bending substantially along the seams to receive the flammable documents, and folds into its protective position such that the documents are sandwiched between the based portion and the covered portion to protect the docments during a fire.
    • 提供一个防火袋,用于保护易燃物品免遭火灾和水灾。 消防袋包括一个薄柔软的水型外部容器,其容纳凝胶水材料以在火中吸收热能。 消防袋还包括水合膨胀材料层,其固定到外部容器,并且在火中吸收热能和膨胀以产生提供显着增加的防火的泡沫层。 凝胶化水层和水合膨胀材料层形成相对薄的柔软矩形毯,其具有将毯子分成基部和覆盖部分的接缝。 通过基本沿着接缝弯曲以接收可燃性文件,并且折叠成其保护位置,使得文件夹在基部和被覆盖部分之间以在火灾期间保护文件,毯子展开。
    • 8. 发明授权
    • Porous drug delivery system
    • 多药物输送系统
    • US07001371B1
    • 2006-02-21
    • US09677962
    • 2000-10-03
    • Charles A. McLaughlinMark B. LylesGlenn A. HalffWilliam A. Mallow
    • Charles A. McLaughlinMark B. LylesGlenn A. HalffWilliam A. Mallow
    • A61K9/22
    • A61K9/0024A61L31/146A61L31/16A61L2300/222A61L2300/406A61L2300/43A61L2300/64
    • An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and angiogenesis from adjacent vascular tissue into the implant. Infection shield embodiments stimulate cell growth and angiogenesis from adjacent vascular tissue which effectively blocks passage of pathogenic microorganisms along percutaneously implanted objects. In embodiments for drug delivery, a reservoir of the same biomaterial may contain either (1) a cell culture system enclosed within a porous sealable interior chamber or (2) a biodegradable matrix in which one or more drugs are dispersed. After implantation of a reservoir of the first embodiment in an organism, cultured cells obtain food and oxygen via diffusion in tissue fluid through the porous walls of the interior chamber, while metabolic products, including drugs, diffuse away from the cell culture in an analogous manner. In a reservoir of the second embodiment, a biodegradable matrix substantially fills the pores (voids), and progressive dissolution of the matrix releases one or more drugs into surrounding tissue fluid. Reservoirs of either embodiment comprise a plurality of voids of a predetermined size effective for stimulating angiogenesis from the surrounding vascular tissue into at least a portion of the reservoir. The reservoir thus acts to couple a source of drugs to the circulatory system of the organism.
    • 用于在血管组织中药物递送的可植入感染屏蔽和系统包括相对不可生物降解的多孔连接的纤维生物材料,其控制并引导细胞生长和血管生成从相邻血管组织进入植入物。 感染屏障实施例刺激来自相邻血管组织的细胞生长和血管生成,其有效地阻止病原微生物沿着经皮植入物体的通过。 在用于药物递送的实施方案中,相同生物材料的储库可以包含(1)包封在多孔可密封的内部室内的细胞培养系统或(2)其中分散有一种或多种药物的生物可降解基质。 在将第一实施方案的储存器植入生物体之后,培养的细胞通过内部室的多孔壁在组织液中的扩散而获得食物和氧气,而代谢产物(包括药物)以类似的方式从细胞培养物扩散 。 在第二实施方案的储存器中,生物降解基质基本上填充孔(空隙),并且基质的逐渐溶解将一种或多种药物释放到周围的组织液中。 任一实施方案的储库包括多个预定尺寸的空隙,其有效刺激来自周围血管组织的血管发生至储存器的至少一部分。 因此,储存器用于将药物源与生物体的循环系统结合。
    • 9. 发明授权
    • Thermoplastic material for production and repair of polymeric products
and coating of metals
    • 用于生产和修复聚合物产品和金属涂层的热塑性材料
    • US5358994A
    • 1994-10-25
    • US938453
    • 1992-08-31
    • William A. Mallow
    • William A. Mallow
    • C08K5/00C08L23/04C08L23/06C08L23/08C08L23/12C08L23/16C08K3/04
    • C08K5/005C08L23/06C08L2205/03C08L23/0853C08L23/12C08L23/16Y10S524/906
    • A composition of matter comprises 100-800 parts by weight polyethylenes and copolymers thereof having a melt index of 1-4 g/10 min., a density of 0.93-0.95 g/cc and a weight average molecular weight of 5-1.0.times.10.sup.5 ; 100-400 parts by weight polyethylenes having a melt index of 2-4 g/10 min., a density of 0.93-0.95 g/cc and a molecular weight of 6-20.times.10.sup.4 ; 0-100 parts by weight polypropylene having a melt index of 5-9 g/10 min. and a density of 0.8-1.2 g/cc; 0-150 parts by weight copolymer such as ethylene-propylene or ethylene-vinyl acetate; 0-100 parts by weight graphite or carbon black; 0.04-0.2 parts by weight antioxidant; and 0.1-2.0 parts by weight light stabilizer. A sealant is obtained by compression, extrusion or injection molding the composition described above. A polyethylene surface repair or reinforcing kit comprises the sealant or thermoplastic repair material of the invention, a thin, heat-resistant, adhesion-resistant barrier, and a polyethylene surface enzyme cleaner. A method of repairing or reinforcing a polyethylene surface comprises applying over an area of the surface in need of repair or reinforcement the sealant or thermoplastic repair material of the invention, heating the area of contact between the sealant and the surface to produce thermal fusion therebetween, and cooling the fused surface. A method of preparing a thermoplastic polyethylene surface sealant or thermoplastic repair product comprises blending the composition of the invention, and compression, injection or extrusion molding the blend to form a product of a desired shape.
    • 物质组合物包含100-800重量份的聚乙烯及其共聚物,其熔体指数为1-4g / 10min,密度为0.93-0.95g / cc,重均分子量为5-1.0×10 5; 100-400重量份熔体指数为2-4g / 10分钟的聚乙烯,密度为0.93-0.95g / cc,分子量为6-20×10 4; 0-100重量份熔体指数为5-9克/ 10分钟的聚丙烯。 密度为0.8-1.2g / cc; 0-150重量份共聚物如乙烯 - 丙烯或乙烯 - 乙酸乙烯酯; 0-100重量份石墨或炭黑; 0.04-0.2重量份抗氧化剂; 和0.1-2.0重量份的光稳定剂。 通过压缩,挤出或注射成型上述组合物获得密封剂。 聚乙烯表面修复或增强套件包括本发明的密封剂或热塑性修补材料,薄的,耐热的,耐粘合的屏障和聚乙烯表面酶清洁剂。 一种修复或加固聚乙烯表面的方法包括在需要修复或加强本发明的密封剂或热塑性修复材料的表面的一个区域上施加,加热密封剂和表面之间的接触区域以在其间产生热熔融, 并冷却熔融表面。 制备热塑性聚乙烯表面密封剂或热塑性修补产品的方法包括将本发明的组合物和压缩,注射或挤出成型共混物混合以形成所需形状的产品。
    • 10. 发明授权
    • Heat hardening sealant-gel for flexible couplings
    • 用于柔性联轴器的热硬化密封胶
    • US4424867A
    • 1984-01-10
    • US249629
    • 1981-03-31
    • William A. Mallow
    • William A. Mallow
    • A62C2/00A62C3/16C04B40/06F16L5/04H02G3/22A62C1/00
    • F16L5/04C04B40/06H02G3/22
    • This specification discloses a means for providing a barrier against the passage of fire through that portion of a wall aperture surrounding an electrical conduit, pipe, or the like. This is accomplished by placing a sleeve around that portion of the conduit passing through the wall, which sleeve is the central portion of an envelope which is anchored peripherally to the wall or to a more or less rigid material blocking the aperture through the wall and which sleeve connects to end portions of the envelope, each of which end portions extends to connect with the conduit on an opposite side of the wall. The annular region between the conduit and the surrounding envelope is filled with an intumescent gel. The boot is flexible and capable of some movement to compensate for thermal expansion, vibration or other forces during the life of the installation. In the event of heat and fire, the gel within the envelope intumesces, providing protection against passage of flames and gas through the annular region surrounding the conduit, which annular region is now occupied by a fire resistant mass formed by the solidification of the gel. The intumescible gel comprises sodium silicate solution, a filler, and a hardener.
    • 本说明书公开了一种用于提供阻挡火通过围绕电导管,管等的壁孔的那部分的阻挡件的装置。 这是通过将套管围绕穿过壁的导管的该部分来实现的,该套管是封套的中心部分,该外壳围绕壁被锚固,或者是或多或少的刚性材料通过壁阻挡孔,并且其中 套筒连接到信封的端部,每个端部部分延伸以在壁的相对侧上与导管连接。 导管和周围信封之间的环形区域填充有膨胀凝胶。 靴子是灵活的,并且能够进行一些运动以补偿在安装期间的热膨胀,振动或其他力。 在发生热和火的情况下,信封内的凝胶膨胀,提供防止火焰和气体通过导管周围的环形区域的保护,该环形区域现在由凝胶凝固形成的耐火材料占据。 可膨胀凝胶包括硅酸钠溶液,填料和硬化剂。