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1. 发明授权

US5874089A Protecting against canine oral papillomavirus (copy) 失效
标题翻译：防止犬口腔乳头瘤病毒（复制）
公开(公告)号：US5874089A
公开(公告)日：1999-02-23
申请号：US724281
申请日：1996-10-01
申请人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
发明人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
IPC分类号： A61K39/00 , A61K39/12 , A61P31/12 , C07K14/025 , C12N7/01
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K39/00 , C12N2710/14143 , C12N2710/20022 , C12N2710/20034 , G01N2333/025 , Y10S977/802 , Y10S977/918
摘要： Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. Such antibodies are useful in the diagnosis and treatment of viral infection.
摘要翻译：提供了重组产生的L1主要衣壳蛋白，其模拟人和动物乳头瘤病毒粒子上的构象归化表位，包括犬和马乳头瘤病毒粒子。这些重组蛋白质可用作赋予乳头瘤病毒感染保护的疫苗。还提供了重组蛋白的抗体。这些抗体可用于病毒感染的诊断和治疗。

2. 发明授权

US06887478B2 Formalin-treated human papillomavirus L1 protein vaccine 有权
标题翻译：福尔马林处理的人乳头瘤病毒L1蛋白疫苗
公开(公告)号：US06887478B2
公开(公告)日：2005-05-03
申请号：US10665537
申请日：2003-09-22
申请人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
发明人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
IPC分类号： A61K39/00 , A61K39/12 , A61P31/12 , C07K14/025 , C12N7/01
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2710/14143 , C12N2710/20022 , C12N2710/20034 , G01N2333/025 , Y10S977/802 , Y10S977/918
摘要： Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. Such antibodies are useful in the diagnosis and treatment of viral infection.
摘要翻译：提供了重组产生的L1主要衣壳蛋白，其模拟人和动物乳头瘤病毒粒子上的构象归化表位，包括犬和马乳头瘤病毒粒子。这些重组蛋白质可用作赋予乳头瘤病毒感染保护的疫苗。还提供了重组蛋白的抗体。这些抗体可用于病毒感染的诊断和治疗。

3. 发明授权

US06485728B2 Formalin-Inactivated human papillomavirus L1 protein vaccine 失效
标题翻译：福尔马林灭活人乳头瘤病毒L1蛋白疫苗
公开(公告)号：US06485728B2
公开(公告)日：2002-11-26
申请号：US09134377
申请日：1998-08-14
申请人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
发明人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2710/14143 , C12N2710/20022 , C12N2710/20034 , G01N2333/025 , Y10S977/802 , Y10S977/918
摘要： Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. such antibodies are useful in the diagnosis and treatment of viral infection.
摘要翻译：提供了重组产生的L1主要衣壳蛋白，其模拟人和动物乳头瘤病毒粒子上的构象归化表位，包括犬和马乳头瘤病毒粒子。这些重组蛋白质可用作赋予乳头瘤病毒感染保护的疫苗。还提供了重组蛋白的抗体。这样的抗体可用于诊断和治疗病毒感染。

4. 发明申请

US20080160040A1 PLANT-PRODUCED COMPOSITIONS FOR TREATING PAPILLOMAVIRUS INFECTION AND RELATED METHODS 审中-公开
标题翻译：用于治疗斑马鱼感染的植物生产组合物及相关方法
公开(公告)号：US20080160040A1
公开(公告)日：2008-07-03
申请号：US12028721
申请日：2008-02-08
申请人： Shin-je Ghim , A. Bennett Jenson , Amanda B. Lasnik , Donald M. Miller , Kenneth Palmer , Mark L. Smith
发明人： Shin-je Ghim , A. Bennett Jenson , Amanda B. Lasnik , Donald M. Miller , Kenneth Palmer , Mark L. Smith
IPC分类号： A61K39/12 , A61K35/76 , C12N15/37 , C12Q1/70 , A61P31/20
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/6075 , A61K2039/70 , C07K14/005 , C07K2319/22 , C07K2319/735 , C12N7/00 , C12N15/8257 , C12N15/8258 , C12N2710/20022 , C12N2710/20034 , C12N2770/00022
摘要： Compositions for treating papillomavirus (PV) infection in a subject include a PV L2 polypeptide produced from a eukaryotic expression system.
摘要翻译：用于治疗受试者乳头瘤病毒（PV）感染的组合物包括由真核表达系统产生的PV L2多肽。

5. 发明申请

US20100221280A1 PLANT-PRODUCED COMPOSITIONS FOR TREATING PAPILLOMAVIRUS INFECTION AND RELATED METHODS 审中-公开
标题翻译：用于治疗斑马鱼感染的植物生产组合物及相关方法
公开(公告)号：US20100221280A1
公开(公告)日：2010-09-02
申请号：US12764183
申请日：2010-04-21
申请人： Shin-je Ghim , A. Bennett Jenson , Amanda B. Lasnik , Donald M. Miller , Kenneth Palmer , Mark L. Smith
发明人： Shin-je Ghim , A. Bennett Jenson , Amanda B. Lasnik , Donald M. Miller , Kenneth Palmer , Mark L. Smith
IPC分类号： A61K39/00 , C07K14/025 , A61K39/295 , A61K39/12 , A61P31/12 , C12P21/06
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/6075 , A61K2039/70 , C07K14/005 , C07K2319/22 , C07K2319/735 , C12N7/00 , C12N15/8257 , C12N15/8258 , C12N2710/20022 , C12N2710/20034 , C12N2770/00022
摘要： Compositions for treating papillomavirus (PV) infection in a subject include a PV L2 polypeptide produced from a eukaryotic expression system.
摘要翻译：用于治疗受试者乳头瘤病毒（PV）感染的组合物包括由真核表达系统产生的PV L2多肽。

6. 发明申请

US20100317567A1 DIAGNOSING AND PROTECTING HORSES AGAINST PAPILLOMAVIRUS 审中-公开
标题翻译：诊断和保护马尾TING虫
公开(公告)号：US20100317567A1
公开(公告)日：2010-12-16
申请号：US12861409
申请日：2010-08-23
申请人： A. Bennett Jenson , Shin-je Ghim , Victoria B. Kyle , Joongho Joh
发明人： A. Bennett Jenson , Shin-je Ghim , Victoria B. Kyle , Joongho Joh
IPC分类号： A61K38/02 , C12Q1/70 , A61P31/20
CPC分类号： C12Q1/708 , A61K38/162 , A61K39/12 , A61K2039/5258 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , G01N33/6854 , G01N2333/025
摘要： Compositions for conferring protection against Equus caballus papillomavirus (EcPV) and Bovine papillomavirus (BPV) infection in a subject are provided and include a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods for protecting a subject against EcPV and BPV infection are further provided and include administering to the subject a composition comprised of a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods of diagnosing EcPV and/or BPV infection in a subject are also provided and include providing a virus-like particle assembled from a papillomavirus L1 protein selected from an EcPV L1 protein and a BPV L1 protein; contacting the virus-like particle with serum from the subject; and identifying the subject as having an infection if an antibody capable of binding the virus-like particle is detected in the serum.
摘要翻译：提供了在受试者中赋予对马尾猴乳头瘤病毒（EcPV）和牛乳头瘤病毒（BPV）感染的保护作用的组合物，包括由EcPV L1蛋白组装的病毒样颗粒和由BPV L1蛋白组装的病毒样颗粒。还提供了保护受试者免受EcPV和BPV感染的方法，包括向受试者施用由EcPV L1蛋白组装的病毒样颗粒和由BPV L1蛋白组装的病毒样颗粒组成的组合物。还提供了诊断受试者中EcPV和/或BPV感染的方法，包括提供从选自EcPV L1蛋白和BPV L1蛋白的乳头瘤病毒L1蛋白组装的病毒样颗粒; 使病毒样颗粒与受试者的血清接触; 并且如果在血清中检测到能够结合病毒样颗粒的抗体，则将受试者识别为感染。

7. 发明申请

US20090011996A1 DIAGNOSING AND PROTECTING HORSES AGAINST PAPILLOMAVIRUS 审中-公开
标题翻译：诊断和保护马尾TING虫
公开(公告)号：US20090011996A1
公开(公告)日：2009-01-08
申请号：US12167581
申请日：2008-07-03
申请人： A. Bennett Jenson , Shin-je Ghim , Victoria B. Kyle , Joongho Joh
发明人： A. Bennett Jenson , Shin-je Ghim , Victoria B. Kyle , Joongho Joh
IPC分类号： A61K38/16 , C12Q1/70 , A61P31/12
CPC分类号： C12Q1/708 , A61K38/162 , A61K39/12 , A61K2039/5258 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , G01N33/6854 , G01N2333/025
摘要： Compositions for conferring protection against Equus caballus papillomavirus (EcPV) and Bovine papillomavirus (BPV) infection in a subject are provided and include a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods for protecting a subject against EcPV and BPV infection are further provided and include administering to the subject a composition comprised of a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods of diagnosing EcPV and/or BPV infection in a subject are also provided and include providing a virus-like particle assembled from a papillomavirus L1 protein selected from an EcPV L1 protein and a BPV L1 protein; contacting the virus-like particle with serum from the subject; and identifying the subject as having an infection if an antibody capable of binding the virus-like particle is detected in the serum.
摘要翻译：提供了在受试者中赋予对马尾猴乳头瘤病毒（EcPV）和牛乳头瘤病毒（BPV）感染的保护作用的组合物，包括由EcPV L1蛋白组装的病毒样颗粒和由BPV L1蛋白组装的病毒样颗粒。还提供了保护受试者免受EcPV和BPV感染的方法，包括向受试者施用由EcPV L1蛋白组装的病毒样颗粒和由BPV L1蛋白组装的病毒样颗粒组成的组合物。还提供了诊断受试者中EcPV和/或BPV感染的方法，包括提供从选自EcPV L1蛋白和BPV L1蛋白的乳头瘤病毒L1蛋白组装的病毒样颗粒; 使病毒样颗粒与受试者的血清接触; 并且如果在血清中检测到能够结合病毒样颗粒的抗体，则将受试者识别为感染。

8. 发明授权

US07445786B1 Diagnosing and protecting against tursiops truncatus papillomavirus 失效
标题翻译：诊断和防止蠕形切除乳头瘤病毒
公开(公告)号：US07445786B1
公开(公告)日：2008-11-04
申请号：US11733557
申请日：2007-04-10
申请人： Manuela Rehtanz , A. Bennett Jenson , Shin-je Ghim , Gregory D. Bossart
发明人： Manuela Rehtanz , A. Bennett Jenson , Shin-je Ghim , Gregory D. Bossart
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5258 , C12N2710/20023 , C12N2710/20034
摘要： Composition for conferring protection against Tursiops truncatus papillomavirus (TtPV) infection in a subject includes a virus-like particle assembled from at least one type of TtPV L1 protein. Methods for protecting a subject against TtPV infection include administering to the subject an immunogenic composition including a virus-like particle assembled from at least one type of TtPV L1 protein. Methods for diagnosing TtPV infection in a subject include providing a virus-like particle assembled from at least one TtPV L1 protein; contacting the virus-like particle with serum obtained from the subject; and identifying the subject as having TtPV infection if a TtPV antibody capable of binding the virus-like particle is detected in the serum.
摘要翻译：用于赋予受试者针对Tursiops truncatus papillomavirus（TtPV）感染的组合物包括由至少一种类型的TtPV L1蛋白组装的病毒样颗粒。用于保护受试者免受TtPV感染的方法包括向受试者施用包含由至少一种类型的TtPV L1蛋白组装的病毒样颗粒的免疫原性组合物。在受试者中诊断TtPV感染的方法包括提供由至少一种TtPV L1蛋白组装的病毒样颗粒; 使病毒样颗粒与从受试者获得的血清接触; 并且如果在血清中检测到能够结合病毒样颗粒的TtPV抗体，则鉴定受试者具有TtPV感染。

9. 发明授权

US08012679B1 Papillomavirus vaccines 失效
标题翻译：乳头瘤病毒疫苗
公开(公告)号：US08012679B1
公开(公告)日：2011-09-06
申请号：US08764926
申请日：1996-12-16
申请人： C. Richard Schlegel , A. Bennett Jenson
发明人： C. Richard Schlegel , A. Bennett Jenson
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/20022 , C12N2710/20034
摘要： Seven polyclonal and monoclonal antibodies were characterized for their ability to react specifically with either conformational or non-conformational epitopes of the HPV-1 virion. Using these antibodies, it was shown that the HPV-1 L1 protein (when expressed by an SV40 vector in cos cells) displayed conformational epitopes characteristic of intact viral particles. In addition, the L1 capsid protein was translocated normally into cell nuclei, was of appropriate size (57kD), and could be isolated in native form by immunoprecipitation techniques. Most importantly, the screening of expressed papillomavirus capsid proteins for reactivity with conformation-dependent antibodies represents a new, general methodology for ensuring that such proteins will be suitable for use in vaccine development or in the serologic detection/typing of human papillomavirus infections.
摘要翻译：表征了七种多克隆和单克隆抗体与HPV-1病毒体的构象或非构象表位特异性反应的能力。使用这些抗体，显示HPV-1 L1蛋白质（当在COS细胞中由SV40载体表达时）显示完整病毒颗粒特征的构象表位。此外，L1衣壳蛋白通常转位到细胞核中，具有适当的大小（57kD），并且可以通过免疫沉淀技术以天然形式分离。最重要的是，筛选表达的乳头状瘤病毒衣壳蛋白与构象依赖性抗体的反应性代表了一种新的通用方法，用于确保这些蛋白质适用于疫苗开发或人乳头状瘤病毒感染的血清学检测/分型。

10. 发明申请

US20080172184A1 PROTEOMIC PROFILING METHOD USEFUL FOR CONDITION DIAGNOSIS AND MONITORING, COMPOSITION SCREENING, AND THERAPEUTIC MONITORING 审中-公开
标题翻译：用于条件诊断和监测，组合筛查和治疗监测的有效分析方法
公开(公告)号：US20080172184A1
公开(公告)日：2008-07-17
申请号：US11972921
申请日：2008-01-11
申请人： Jonathan B. Chaires , Nichola C. Garbett , A. Bennett Jenson
发明人： Jonathan B. Chaires , Nichola C. Garbett , A. Bennett Jenson
IPC分类号： G01N33/48
CPC分类号： G01N33/6803 , G01N2500/00 , Y02A50/53 , Y02A50/57
摘要： A method of diagnosing or monitoring a condition of interest in a subject includes comparing thermograms generated using differential scanning calorimetery. A signature thermogram contains a protein composition pattern for a sample obtained from the subject. The signature thermogram is compared to a standard thermogram. Standard thermograms can include a negative standard thermogram containing a protein composition pattern associated with an absence of the condition of interest, and a positive standard thermogram containing a protein composition pattern associated with a presence of the condition of interest.
摘要翻译：诊断或监测受试者感兴趣的病症的方法包括比较使用差示扫描量热法产生的热分析图。签名温谱图包含从受试者获得的样品的蛋白质组成模式。将标记温谱图与标准温谱图进行比较。标准热分析图可以包括含有与不存在感兴趣条件相关的蛋白质组成模式的负标准温谱图，以及含有与感兴趣条件存在相关的蛋白质组成模式的正标准温谱图。

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