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1. 发明授权

US5459067A Method for producing optically active norborneol by ester hydrolysis 失效
标题翻译：通过酯水解制备光学活性的降冰片烯的方法
公开(公告)号：US5459067A
公开(公告)日：1995-10-17
申请号：US98403
申请日：1993-08-05
申请人： Bunji Kageyama , Masanori Nakae , Takayasu Sonoyama , Kyozo Kawata
发明人： Bunji Kageyama , Masanori Nakae , Takayasu Sonoyama , Kyozo Kawata
IPC分类号： C12P41/00 , C12N1/20
CPC分类号： C12P41/004 , Y10S435/823 , Y10S435/83 , Y10S435/875 , Y10S435/94
摘要： A method for producing an optically active norborneol is provided, which includes the step of bringing a microorganism or treated cells thereof into contact with (.+-.)-exo-norbornane type ester represented by Formula (I), wherein the microorganism is selected from the group consisting of the genus Pseudomonas, the genus Acetobacter, the genus Arthrobacter, the genus Rhodotorula, and the genus Saccharomyces. According to this method, (+)- and/or (-)-exo-norbornane type alcohol can be obtained with high yield and high purity by a simple treatment.
摘要翻译： PCT No.PCT / JP92 / 01588 Sec。 371日期：1993年8月5日 102（e）日期1993年8月5日PCT提交1992年12月4日PCT公布。公开号WO93 / 11256 提供了一种光学活性降冰片烯的制造方法，其包括使微生物或其处理细胞与式（I）所示的（+/-） - 外降冰片烷型酯接触的步骤，其中所述微生物选自假单胞菌属，醋杆菌属，节节杆菌属，红酵母属和酵母属。根据该方法，可以通过简单的处理以高产率和高纯度获得（+） - 和/或（ - ） - 外降冰片烷型醇。

2. 发明授权

US4748122A 2,5-diketo-D-gluconic acid reductase 失效
标题翻译： 2,5-二酮-D-葡萄糖酸还原酶
公开(公告)号：US4748122A
公开(公告)日：1988-05-31
申请号：US665965
申请日：1984-10-29
申请人： Takayasu Sonoyama , Bunji Kageyama , Kobee Kobayashi , Masahiro Tanimoto
发明人： Takayasu Sonoyama , Bunji Kageyama , Kobee Kobayashi , Masahiro Tanimoto
IPC分类号： C12N9/04 , C12P7/60 , C12P19/02 , C12R1/15 , C12N9/02
CPC分类号： C12N9/0006 , C12P19/02 , C12P7/60 , Y10S435/843
摘要： A novel reductase is produced from a microorganism which belongs to genus Corynebacterium and is useful as a catalyst which catalizes, in the presence of NADPH, reduction of 2, 5-diketo-D-gluconic acid or its salts to 2-keto-L-gulonate or the corresponding salts thereof. It also catalizes reduction of 5-keto-D-fructose to sorbose, in the presence of NADPH.
摘要翻译：一种新的还原酶由属于棒杆菌属的微生物产生，可用作催化剂，在NADPH存在下，将2,5-二酮-D-葡萄糖酸或其盐还原成2-酮-L- 葡萄糖酸盐或其相应的盐。还可以在NADPH存在下催化5-酮-D-果糖还原成山梨糖。

3. 再颁专利

USRE30872E Process for producing 2-keto-L-gulonic acid 失效
标题翻译： 2-酮-L-古洛糖酸的制备方法
公开(公告)号：USRE30872E
公开(公告)日：1982-02-23
申请号：US114252
申请日：1980-01-22
申请人： Takayasu Sonoyama , Bunji Kageyama , Tahiko Honjo
发明人： Takayasu Sonoyama , Bunji Kageyama , Tahiko Honjo
IPC分类号： C07C59/215 , C07H7/027 , C12P7/60
CPC分类号： C12P7/60 , C07C59/215 , C07H7/027 , Y10S435/83 , Y10S435/837 , Y10S435/84 , Y10S435/859 , Y10S435/874 , Y10S435/883
摘要： 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism used for this microbial conversion includes strains which belong to genera of Brevibacterium, Arthrobacter, Micrococcus, Staphylococcus, Pseudomonas and Bacillus. Both the incubation of the microorganism in a medium containing 2,5-diketo-L-gluconic acid and the direct contact of any products obtained from the cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.

4. 发明授权

US5234819A Method for preparing 2,5-diketo-D-gluconic acid 失效
标题翻译：制备2,5-二酮-D-葡萄糖酸的方法
公开(公告)号：US5234819A
公开(公告)日：1993-08-10
申请号：US834341
申请日：1992-02-12
申请人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama , Masahiro Tanimoto
发明人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama , Masahiro Tanimoto
IPC分类号： C12P7/58
CPC分类号： C12R1/18 , C12P7/58 , Y10S435/847
摘要： 2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of D-glucose. The production is also possibly by simple contact of said microorganisms or their processed products therefrom, with D-glucose.
摘要翻译：通过在D-葡萄糖存在下，在含水营养培养基中培养新分离的欧文氏菌属微生物，以高产量和高培养液浓度制备2,5-二酮-D-葡糖酸。生产也可能通过所述微生物或其加工产物与D-葡萄糖的简单接触。

5. 发明授权

US5134077A Microorganisms of the genus Erwinia useful for preparing 2,5-diketo-D-gluconic acid 失效
标题翻译：用于制备2,5-二酮-D-葡萄糖酸的欧文氏菌属的微生物
公开(公告)号：US5134077A
公开(公告)日：1992-07-28
申请号：US403298
申请日：1989-09-05
申请人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama , Masahiro Tanimoto
发明人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama , Masahiro Tanimoto
IPC分类号： C12P7/60 , C12P7/58 , C12R1/18
CPC分类号： C12R1/18 , C12P7/58 , Y10S435/847
摘要： 2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of D-glucose. The production is also possible by simple contact of said microorganisms or their processed products therefrom, with D-glucose.
摘要翻译：通过在D-葡萄糖存在下，在含水营养培养基中培养新分离的欧文氏菌属微生物，以高产量和高培养液浓度制备2,5-二酮-D-葡糖酸。通过所述微生物或其加工产物与D-葡萄糖的简单接触也可以进行生产。

6. 发明授权

US4879229A Method for preparing 2,5-diketo-D-gluconic acid 失效
标题翻译：制备2,5-二酮-D-葡萄糖酸的方法
公开(公告)号：US4879229A
公开(公告)日：1989-11-07
申请号：US243215
申请日：1988-09-12
申请人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama , Masahiro Tanimoto
发明人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama , Masahiro Tanimoto
IPC分类号： C12P7/60 , C12P7/58 , C12R1/18
CPC分类号： C12R1/18 , C12P7/58 , Y10S435/847
摘要： 2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of D-glucose. The production is also possible by simple contact of said microorganisms or their processed products therefrom, with D-glucose.
摘要翻译：通过在D-葡萄糖存在下，在含水营养培养基中培养新分离的欧文氏菌属微生物，以高产量和高培养液浓度制备2,5-二酮-D-葡糖酸。通过所述微生物或其加工产物与D-葡萄糖的简单接触也可以进行生产。

7. 发明授权

US3998697A Process for preparing 2-keto-L-gulonic acid 失效
标题翻译：制备2-酮-L-古洛糖酸的方法
公开(公告)号：US3998697A
公开(公告)日：1976-12-21
申请号：US569852
申请日：1975-04-21
申请人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
发明人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
IPC分类号： C07H7/027 , C12P7/42 , C12P7/58 , C12P7/60 , C12D1/06
CPC分类号： C07H7/027 , C12P7/58 , C12P7/60 , Y10S435/823 , Y10S435/84 , Y10S435/843
摘要： 2-Keto-L-gulonic acid is prepared directly from D-glucose by microbial conversion utilizing mixed culturing on or mixed contacting with a medium containing D-glucose, employing at least two kind of microorganisms; 2,5-diketo-D-gluconic acid producing strains which belong to the genera of Acetobacter, Acetomonas and Gluconobacter and strains capable of converting the 2,5-diketo-D-gluconic acid into 2-keto-L-gulonic acid which belong to the general of Brevibacterium and Corynebacterium. Both the incubation of the microorganisms in a medium containing D-glucose and the direct contact of any products obtained from the cells of the microorganisms with the substrate may be used in the disclosed process. By-production of the undesired optical isomer, 2-keto-D-gluconic acid, of the intended product is effectively prevented by employing the mixed culturing or contacting because of the presence of the 2,5-diketo-D-gluconic acid producing strain or any products thereof in the medium during at least part of the entire process.
摘要翻译：通过使用至少两种微生物的混合培养或与含有D-葡萄糖的培养基混合接触，通过微生物转化直接由D-葡萄糖制备2-酮-L-古洛糖酸; 属于醋杆菌属，醋酸杆菌属和葡萄糖酸杆菌属的2,5-二酮-D-葡萄糖酸生产菌株和能够将2,5-二酮-D-葡萄糖酸转化成2-酮-L-古洛糖酸的菌株，其属于到短杆菌属和棒杆菌属的一般。在所公开的方法中可以使用在含有D-葡萄糖的培养基中培养微生物和从微生物细胞获得的任何产物与底物的直接接触。由于存在2,5-二酮-D-葡糖酸生产菌株，通过使用混合培养或接触有效地防止了所需产物的不需要的光学异构体2-酮-D-葡萄糖酸的副产物或其整个过程的至少部分期间在介质中的任何产物。

8. 发明授权

US3963574A Process for producing 2-keto-L-gulonic acid 失效
标题翻译： 2-酮-L-古洛糖酸的制备方法
公开(公告)号：US3963574A
公开(公告)日：1976-06-15
申请号：US560886
申请日：1975-03-21
申请人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
发明人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
IPC分类号： C12P7/60 , C12D1/02
CPC分类号： C12P7/60 , Y10S435/84
摘要： 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism available for this microbial conversion includes strains which belong to the species of the Brevibacterium nov. sp. ASM-856-4, ATCC 31083. The incubation of the microorganism in a medium containing 2,5-diketo-D-gluconic acid as well as the direct contact of any products obtained from the microbial cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.
摘要翻译： 2-酮-L-古洛糖酸通过微生物转化由2,5-二酮-D-葡萄糖酸制备。可用于该微生物转化的2-酮-L-古洛糖酸生物微生物包括属于Brevibacterium nov的物种的菌株。 sp。 ASM-856-4，ATCC 31083.微生物在含有2,5-二酮-D-葡萄糖酸的培养基中的温育以及从微生物细胞获得的任何产物与含有所述2,5 - 二酮-D-葡萄糖酸可用于所公开的方法。

9. 发明授权

US3959076A Process for producing 2-keto-L-gulonic acid 失效
标题翻译： 2-酮-L-古洛糖酸的制备方法
公开(公告)号：US3959076A
公开(公告)日：1976-05-25
申请号：US560885
申请日：1975-03-21
申请人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
发明人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
IPC分类号： C12P7/60 , C12D1/02
CPC分类号： C12P7/60 , Y10S435/843
摘要： 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism available for this microbial conversion includes strains which belong to the genus Corynebacterium. The incubation of the microorganism in a medium containing 2,5-diketo-D-gliconic acid as well as the direct contact of any products obtained from the microbial cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.
摘要翻译： 2-酮-L-古洛糖酸通过微生物转化由2,5-二酮-D-葡萄糖酸制备。可用于该微生物转化的2-酮-L-古洛糖酸生产微生物包括属于棒杆菌属的菌株。微生物在含有2,5-二酮-D-葡萄糖酸的培养基中的培养以及从微生物细胞获得的任何产物与含有2,5-二酮-D-葡萄糖酸的底物的直接接触可以是用于所公开的过程。

10. 发明授权

US4696897A Process for preparing 2-keto-L-gulonic acid 失效
标题翻译：制备2-酮-L-古洛糖酸的方法
公开(公告)号：US4696897A
公开(公告)日：1987-09-29
申请号：US747393
申请日：1985-06-21
申请人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama
发明人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama
IPC分类号： C12P7/58 , C12P7/60 , C12P39/00 , C12R1/13 , C12R1/15 , C12R1/18
CPC分类号： C12P39/00 , C12P7/58 , C12P7/60
摘要： 2-Keto-L-gulonic acid is prepared directly from D-glucose by microbial conversion utilizing mixed culturing on a medium containing D-glucose, employing two kinds of microorganisms; the first, a 2,5-diketo-D-gluconic acid producing microorganism which belongs to genus Erwinia and the second, a 2-keto-L-gulonic acid producing microorganism which belongs to genus Brevibacterium or Corynebacterium. The incubation of the microorganisms in a medium containing D-glucose is used in the disclosed process. By-production of 2-keto-D-gluconic acid, the undesired isomer of the intended product is effectively prevented by employing mixed culturing because of the co-existence of both microorganisms in the medium during at least part of the entire cultivation. Namely, 2-keto-D-gluconic acid produced by the second microorganism is utilized by the first microorganism to produce 2,5-diketo-D-gluconic acid which is subsequently converted into 2-keto-L-gulonic acid by the second microorganism.
摘要翻译：通过使用两种微生物在含有D-葡萄糖的培养基上进行混合培养，通过微生物转化从D-葡萄糖直接制备2-酮-L-古洛糖酸; 第一个属于欧文氏菌属的2,5-二酮-D-葡萄糖酸生产微生物，其次是属于短杆菌属或棒状杆菌属的2-酮-L-古洛糖酸生产微生物。在所公开的方法中使用微生物在含有D-葡萄糖的培养基中培养。由于2-酮-D-葡萄糖酸的副产物，因为在整个培养的至少一部分期间由于培养基中的两种微生物的共存，因此通过采用混合培养来有效地防止了所需产物的不需要的异构体。也就是说，由第二微生物产生的2-酮-D-葡萄糖酸被第一微生物利用以产生2,5-二酮-D-葡萄糖酸，随后由第二微生物转化成2-酮-L-古洛糖酸。

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